{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:35:25Z","timestamp":1790350525008,"version":"4.1.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p><jats:italic>Listeria monocytogenes<\/jats:italic> causes severe bacterial infections with the highest mortality rate among foodborne pathogens in Europe. Combination treatment with ampicillin and gentamicin is recommended for invasive manifestations. However, evidence to support this treatment approach remains limited due to a lack of randomised controlled trials. To explore this critical issue further, we conducted this retrospective, single-center study.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We identified all patients hospitalized with invasive listeriosis at the University Medical Center Hamburg-Eppendorf between 2009 and 2020 and analyzed the effect of gentamicin combination treatment versus monotherapy on 90-day mortality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total, 36 patients with invasive listeriosis were included, of which 21 patients received gentamicin combination treatment and 15 received monotherapy. The mean age-adjusted Charlson Comorbidity Index (aaCCI) value was lower in the gentamicin combination treatment group (5.4 vs. 7.4). Neurolisteriosis was more common in the gentamicin group (81% vs. 20%). The 90-day mortality was with significantly lower in the gentamicin combination treatment group (10%) compared to the monotherapy group (60%). Multivariable cox regression analysis, adjusted for a propensity score computed based on neurolisteriosis, aaCCI and sex, revealed a significantly reduced hazard ratio of 0.07 (95% CI: 0.01\u20130.53, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) for 90-day mortality for the gentamicin combination treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This retrospective study highlights the benefit of gentamicin combination treatment in reducing the 90-day mortality rate among patients with invasive listeriosis. The high prevalence of monotherapy in this study cohort raises concerns about the adequacy of antibiotic therapy in clinical practice.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s15010-024-02330-w","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T15:02:33Z","timestamp":1720105353000},"page":"1601-1606","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Gentamicin combination treatment is associated with lower mortality in patients with invasive listeriosis: a retrospective analysis"],"prefix":"10.1007","volume":"52","author":[{"given":"Jan P.","family":"Sutter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"Kocheise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kempski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Christner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic","family":"Wichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Pinnschmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schmiedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar W.","family":"Lohse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Theo","family":"Brehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"2330_CR1","doi-asserted-by":"crossref","unstructured":"de Noordhout CM, Devleesschauwer B, Angulo FJ, Verbeke G, Haagsma J, Kirk M et al. The global burden of listeriosis: A systematic review and meta-analysis. Lancet Infect Dis [Internet]. 2014;14:1073\u201382. http:\/\/www.thelancet.com\/article\/S1473309914708709\/fulltext.","DOI":"10.1016\/S1473-3099(14)70870-9"},{"key":"2330_CR2","unstructured":"Charlier C, Perrodeau \u00c9, Leclercq A, Cazenave B, Pilmis B, Henry B et al. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study. Lancet Infect Dis [Internet]. 2017;17:510\u20139. http:\/\/www.thelancet.com\/article\/S1473309916305217\/fulltext."},{"key":"2330_CR3","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.jinf.2018.11.007","volume":"78","author":"A Scobie","year":"2019","unstructured":"Scobie A, Kanagarajah S, Harris RJ, Byrne L, Amar C, Grant K, et al. Mortality risk factors for listeriosis - A 10 year review of non-pregnancy associated cases in England 2006\u20132015. J Infect. 2019;78:208\u201314.","journal-title":"J Infect"},{"key":"2330_CR4","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0928-8244(02)00466-2","volume":"35","author":"H Hof","year":"2003","unstructured":"Hof H. Listeriosis: therapeutic options. FEMS Immunol Med Microbiol. 2003;35:203\u20135.","journal-title":"FEMS Immunol Med Microbiol"},{"key":"2330_CR5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s15010-022-01872-1","volume":"51","author":"M Rivera-Izquierdo","year":"2023","unstructured":"Rivera-Izquierdo M, Galicia-Garc\u00eda MD, L\u00e1inez-Ramos-Bossini AJ, Redruello-Guerrero P, Fern\u00e1ndez-Mart\u00ednez NF. Risk factors associated with early mortality after recovery from severe listeriosis: a multicentre 17-year longitudinal study. Infection. 2023;51:181\u201391.","journal-title":"Infection"},{"key":"2330_CR6","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373\u201383.","journal-title":"J Chronic Dis"},{"key":"2330_CR7","first-page":"845","volume":"64","author":"A Kvistholm Jensen","year":"2017","unstructured":"Kvistholm Jensen A, Simonsen J, Ethelberg S. Use of Proton Pump inhibitors and the risk of listeriosis: a Nationwide Registry-based Case-Control Study. Clin Infect Dis. 2017;64:845\u201351.","journal-title":"Clin Infect Dis"},{"key":"2330_CR8","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1186\/1471-2334-10-324","volume":"10","author":"R Amaya-Villar","year":"2010","unstructured":"Amaya-Villar R, Garc\u00eda-Cabrera E, Sulleiro-Igual E, Fern\u00e1ndez-Viladrich P, Fontanals-Aymerich D, Catal\u00e1n-Alonso P, et al. Three-year multicenter surveillance of community-acquired Listeria monocytogenes meningitis in adults. BMC Infect Dis. 2010;10:324.","journal-title":"BMC Infect Dis"},{"key":"2330_CR9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1093\/infdis\/167.1.173","volume":"167","author":"JS Bertino","year":"1993","unstructured":"Bertino JS, Booker LA, Franck PA, Jenkins PL, Franck KR, Nafziger AN. Incidence of and significant risk factors for aminoglycoside-associated nephrotoxicity in patients dosed by using individualized pharmacokinetic monitoring. 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Eur J Clin Pharmacol. 2022;78:657\u201367.","journal-title":"Eur J Clin Pharmacol"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-024-02330-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-024-02330-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-024-02330-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T18:52:20Z","timestamp":1722365540000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s15010-024-02330-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["2330"],"URL":"https:\/\/doi.org\/10.1007\/s15010-024-02330-w","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,4]]},"assertion":[{"value":"8 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We received a waiver for consent to participate and consent to publish from the Ethics Committee of the Hamburg Medical Association since we used only anonymized data (Application No. 2024-300474-WF).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and consent to publish"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}