{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:32:56Z","timestamp":1782124376154,"version":"3.54.5"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100012940","name":"Universit\u00e4tsklinikum T\u00fcbingen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012940","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>The consequent use of malaria rapid diagnostic tests (RDTs) preceding a treatment decision has improved the global management of malaria. A combination RDT, including an inflammation marker to potentially guide antibiotic prescription, could improve the management of acute febrile illness (AFI).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We performed a prospective, cross-sectional study in Gabon evaluating the STANDARD Malaria\/CRP DUO (S-DUO) RDT. Participants aged 2 to 17 years with fever at presentation and\/or a history of fever\u2009&lt;\u20097 days were enrolled. Expert microscopy, SD Bioline Malaria Ag P.f\/Pan test for malaria detection, and NycoCard CRP device for CRP were used as comparators. AFI cases were classified on a spectrum encompassing bacterial vs. non-bacterial infection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>415 participants with AFI were enrolled. S-DUO RDT sensitivity and specificity for malaria detection vs. microscopy were 99\u00b71% (95\u00b72\u2013100%) and 72\u00b77% (64\u00b73\u201380\u00b71%); and for CRP detection (20\u00a0mg\/L and above) 86\u00b79% (80\u201392%) and 87% (79\u00b72\u201392\u00b77%), respectively. The difference in CRP levels between bacterial infection (mean\u2009=\u200941\u00b72\u00a0mg\/L) and other causes of fever, measured from our study population using the Nycocard device, was statistically significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090\u00b701); CRP precision-recall AUC to distinguish bacterial infection class vs. non-bacterial classifications was 0\u00b779.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>S-DUO RDT is suitable for malaria detection in moderate-to-high malaria transmission settings such as in Lambar\u00e9n\u00e9; however, a CRP band detection limit\u2009&gt;\u200940\u00a0mg\/L is more adequate for indication of antibiotic prescription for AFI cases in Gabon.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s15010-024-02366-y","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T22:45:29Z","timestamp":1724453129000},"page":"285-295","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Performance evaluation of a combination Plasmodium dual-antigen CRP rapid diagnostic test in Lambar\u00e9n\u00e9, Gabon"],"prefix":"10.1007","volume":"53","author":[{"given":"Ayodele","family":"Alabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fungai P.","family":"Musangomunei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Lotola-Mougeni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juste C.","family":"Bie-Ondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulin N.","family":"Essone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita L.","family":"Kabwende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saidou","family":"Mahmoudou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lien","family":"Mac\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ramharter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin P.","family":"Grobusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yazdanbakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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