{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T10:44:58Z","timestamp":1786790698249,"version":"build-2736575974"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100017590","name":"Universit\u00e4tsklinikum Essen","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100017590","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Lemierre Syndrome is a condition that appears to have been overlooked in recent decades in clinical practice, often resulting in death or long-lasting sequelae when left undetected and untreated. Typically, it occurs following an upper respiratory tract infection, often stemming from tonsillitis, leading to thrombosis of the internal jugular vein and subsequent multiple septic emboli. Here, we present a case a 46-year-old patient with the clinical presentation of pneumogenic sepsis. Remarkably, we were able to diagnose the simultaneous presence of chronic pulmonary aspergillosis and Lemierre syndrome.<\/jats:p>","DOI":"10.1007\/s15010-024-02440-5","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T09:52:58Z","timestamp":1731923578000},"page":"747-751","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Rare and risky: a unique case of concurrent chronic pulmonary aspergillosis and lemierre syndrome"],"prefix":"10.1007","volume":"53","author":[{"given":"Peter","family":"Weber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Rohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Witzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.-M.","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zettler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"2440_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)57035-4","author":"A Lemierre","year":"1936","unstructured":"Lemierre A. On certain septic\u00e6mias due to anaerobic organisms. Lancet. 1936. https:\/\/doi.org\/10.1016\/S0140-6736(00)57035-4.","journal-title":"Lancet"},{"issue":"3","key":"2440_CR2","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/joim.13114","volume":"289","author":"L Valerio","year":"2021","unstructured":"Valerio L, et al. Patients with Lemierre syndrome have a high risk of new thromboembolic complications, clinical sequelae and death: an analysis of 712 cases. J Intern Med. 2021;289(3):325\u201339. https:\/\/doi.org\/10.1111\/joim.13114. Epub 2020 Jun 18. PMID: 32445216.","journal-title":"J Intern Med"},{"key":"2440_CR3","doi-asserted-by":"publisher","unstructured":"Radovanovic N Fusobacterium necrophorum subsp. necrophorum Liver Abscess with Pylephlebitis: An Abdominal Variant of Lemierre\u2019s Syndrome. Case Rep Infect Dis. 2020 Jan 13;2020:9237267.https:\/\/doi.org\/10.1155\/2020\/9237267.","DOI":"10.1155\/2020\/9237267"},{"key":"2440_CR4","doi-asserted-by":"publisher","unstructured":"Sabaka P et al. Lemierre syndrome caused by Klebsiella pneumoniae complicated by epidural abscess - Case report. IDCases. 2019;19:e00664. https:\/\/doi.org\/10.1016\/j.idcr.2019.e00664","DOI":"10.1016\/j.idcr.2019.e00664"},{"issue":"8","key":"2440_CR5","doi-asserted-by":"publisher","first-page":"e43685","DOI":"10.7759\/cureus.43685","volume":"15","author":"A Tiwari","year":"2023","unstructured":"Tiwari A. Lemierre\u2019s syndrome in the 21st Century: A literature review. Cureus. 2023;15(8):e43685. https:\/\/doi.org\/10.7759\/cureus.43685.","journal-title":"Cureus"},{"issue":"4","key":"2440_CR6","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.amjms.2020.12.009","volume":"361","author":"B Moldoveanu","year":"2021","unstructured":"Moldoveanu B, et al. Pulmonary aspergillosis: Spectrum of Disease. Am J Med Sci. 2021;361(4):411\u20139. https:\/\/doi.org\/10.1016\/j.amjms.2020.12.009.","journal-title":"Am J Med Sci"},{"issue":"166","key":"2440_CR7","doi-asserted-by":"publisher","first-page":"220114","DOI":"10.1183\/16000617.0114-2022","volume":"31","author":"F Lamoth","year":"2022","unstructured":"Lamoth F, et al. Pulmonary aspergillosis: diagnosis and treatment. Eur Respir Rev. 2022;31(166):220114. https:\/\/doi.org\/10.1183\/16000617.0114-2022.","journal-title":"Eur Respir Rev"},{"key":"2440_CR8","doi-asserted-by":"publisher","unstructured":"Denning DW, European Society for Clinical Microbiology and Infectious Diseases and European Respiratory Society. Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management. Eur Respir J.2016 Jan;47(1):45\u201368. https:\/\/doi.org\/10.1183\/13993003.00583-2015.","DOI":"10.1183\/13993003.00583-2015"},{"key":"2440_CR9","doi-asserted-by":"publisher","unstructured":"Valerio L et al. Septic Pulmonary Embolism: A Contemporary Profile. Semin Thromb Hemost. 2023;49(8):840\u2013847. https:\/\/doi.org\/10.1055\/s-0042-1758742. Epub 2022 Nov 23. Erratum in: Semin Thromb Hemost. 2023;49(8):e1. https:\/\/doi.org\/10.1055\/s-0043-1760843. PMID: 36417928.","DOI":"10.1055\/s-0042-1758742 10.1055\/s-0043-1760843"},{"issue":"03","key":"2440_CR10","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1055\/a-1177-5127","volume":"40","author":"L Valerio","year":"2020","unstructured":"Valerio L, et al. Head, neck, and abdominopelvic septic thrombophlebitis: current evidence and challenges in diagnosis and treatment. H\u00e4mostaseologie. 2020;40(03):301\u201310.","journal-title":"H\u00e4mostaseologie"},{"issue":"4","key":"2440_CR11","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1128\/CMR.00011-07","volume":"20","author":"T Riordan","year":"2007","unstructured":"Riordan T. Human infection with Fusobacterium necrophorum (Necrobacillosis), with a focus on Lemierre\u2019s syndrome. Clin Microbiol Rev. 2007;20(4):622\u201359. https:\/\/doi.org\/10.1128\/CMR.00011-07.","journal-title":"Clin Microbiol Rev"},{"issue":"4","key":"2440_CR12","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/pubmed\/fdh179","volume":"26","author":"GE Smith","year":"2004","unstructured":"Smith GE, et al. What has happened to antimicrobial usage in primary care in the United Kingdom since the SMAC report? - description of trends in antimicrobial usage using the General Practice Research Database. J Public Health (Oxf). 2004;26(4):359\u201364. https:\/\/doi.org\/10.1093\/pubmed\/fdh179.","journal-title":"J Public Health (Oxf)"},{"issue":"2","key":"2440_CR13","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1111\/j.0307-7772.2004.00771.x","volume":"29","author":"EH Van Den Akker","year":"2004","unstructured":"Van Den Akker EH, et al. Large international differences in (adeno)tonsillectomy rates. Clin Otolaryngol Allied Sci. 2004;29(2):161\u20134. https:\/\/doi.org\/10.1111\/j.0307-7772.2004.00771.x.","journal-title":"Clin Otolaryngol Allied Sci"},{"issue":"1","key":"2440_CR14","doi-asserted-by":"publisher","first-page":"ofaa585","DOI":"10.1093\/ofid\/ofaa585","volume":"8","author":"D Nygren","year":"2020","unstructured":"Nygren D, et al. Jugular vein thrombosis and anticoagulation therapy in Lemierre\u2019s Syndrome-A Post Hoc Observational and Population-based study of 82 patients. Open Forum Infect Dis. 2020;8(1):ofaa585. https:\/\/doi.org\/10.1093\/ofid\/ofaa585.","journal-title":"Open Forum Infect Dis"},{"issue":"5","key":"2440_CR15","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1177\/1060028020957620","volume":"55","author":"A Adedeji","year":"2021","unstructured":"Adedeji A, et al. Anticoagulation strategies in the management of Lemierre Syndrome: a systematic review of the literature. Ann Pharmacother. 2021;55(5):658\u201365. https:\/\/doi.org\/10.1177\/1060028020957620.","journal-title":"Ann Pharmacother"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-024-02440-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-024-02440-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-024-02440-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T16:39:09Z","timestamp":1743871149000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s15010-024-02440-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["2440"],"URL":"https:\/\/doi.org\/10.1007\/s15010-024-02440-5","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]},"assertion":[{"value":"21 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This case report was in line with the declaration of Helsinki principles. There are no name tags or identity reveals throughout this case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The patient reported in this case has given us her explicit consent for publication and the use of her health data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and publish"}},{"value":"The authors have no relevant financial or non-financial interests to disclose. Oliver Witzke is an editor of Infection.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}