{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:40:03Z","timestamp":1789926003101,"version":"4.0.1"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"University of Innsbruck and Medical University of Innsbruck"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Purpose<\/jats:title>\n            <jats:p>Pyogenic liver abscesses are challenging due to their diverse etiology and the risk of severe complications. In many cases, surgical interventions are initiated. However, these are only applicable in selected scenarios. We report the case of a 63-year-old woman with multiple large liver abscesses of up to 6.7\u00a0cm spread across both liver lobes, which could not be managed surgically.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods &amp; Results<\/jats:title>\n            <jats:p>\n              <jats:italic>Streptococcus intermedius<\/jats:italic> was isolated in blood culture and PCR positivity for this pathogen was obtained in liver puncture specimen. Following a two-weeks course of intravenous therapy with cefuroxime, metronidazole and fosfomycin, the patients received a consecutive, combined oral antibiotic treatment with clindamycin and cephalexin for four months. This resulted in complete resolution of the abscesses, with no evidence of relapse at follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This case illustrates the complex therapeutic challenges in the management of multiple, large hepatic abscesses, highlighting the potential of antibiotic therapy to cure even inoperable patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s15010-025-02480-5","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T10:44:08Z","timestamp":1738579448000},"page":"2235-2239","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Successful cure of multiple large, inoperable liver abscesses by antibiotic therapy"],"prefix":"10.1007","volume":"53","author":[{"given":"Sarah","family":"Niederreiter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Voelkerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Datz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenter","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"issue":"5","key":"2480_CR1","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s10620-019-05851-9","volume":"65","author":"VVPK Mukthinuthalapati","year":"2020","unstructured":"Mukthinuthalapati VVPK, Attar BM, Parra-Rodriguez L, Cabrera NL, Araujo T, Gandhi S. Risk factors, management, and outcomes of Pyogenic Liver Abscess in a US Safety Net Hospital. Dig Dis Sci. 2020;65(5):1529\u201338. https:\/\/doi.org\/10.1007\/s10620-019-05851-9.","journal-title":"Dig Dis Sci"},{"issue":"Suppl 3","key":"2480_CR2","doi-asserted-by":"publisher","first-page":"A66","DOI":"10.1136\/gutjnl-2022-BASL.98","volume":"71","author":"K Doherty","year":"2022","unstructured":"Doherty K, Papamargaritis I, Muir J, Corrigan M, Sieberhagen C. P47 presentation, management, and outcomes of pyogenic liver abscess in a single UK centre: a comparison between centres and an evaluation of liver abscess management. Gut. 2022;71(Suppl 3):A66\u20138. https:\/\/doi.org\/10.1136\/gutjnl-2022-BASL.98.","journal-title":"Gut"},{"key":"2480_CR3","doi-asserted-by":"publisher","unstructured":"Danson Y, Yuan TM, Shelat VG. Pyogenic Liver Abscess. In: Sartelli M, Bassetti M, Martin-Loeches I, editors. Abdominal Sepsis: a Multidisciplinary Approach. 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(Please see attachment\/Related files)","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}