{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:28:03Z","timestamp":1788456483147,"version":"build-2803163510"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T00:00:00Z","timestamp":1740009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100006302","name":"Universidad de Alcal\u00e1","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006302","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with recurrent cholangitis are at risk of developing life-threatening sepsis. Selective decontamination of the digestive tract (SDD) involving oral nonabsorbable antibiotics has been primarily applied to children undergoing Kasai portoenterostomy surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, SDD containing colistin, tobramycin, and nystatin was administered to eight patients with recurrent cholangitis, and the incidence density before and after SDD administration was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The overall incidence density of cholangitis requiring hospital admission was 0.37 per 100 patient days during the SDD period and was significantly lower than observed before SDD administration (1.05 per 100 patient days) [RR: 0.35 (95% CI: 0.21\u20130.59); p: &lt;0.001, two-sided]. This was not associated with an increased risk of resistance during SDD administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study SDD reduced by 65% the frequency and severity of recurrent cholangitis. In addition, this procedure is patient-friendly and microbiologically safe.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s15010-025-02491-2","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T06:23:39Z","timestamp":1740032619000},"page":"1219-1225","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oral nonabsorbable antibiotics for prevention of recurrent cholangitis; a brief report study"],"prefix":"10.1007","volume":"53","author":[{"given":"Jes\u00fas","family":"Fort\u00fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Rodr\u00edguez-Gand\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Pintado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Mart\u00edn-D\u00e1vila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Garc\u00eda-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Graus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Mart\u00edn-Mateos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Saez de la Fuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Muriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,20]]},"reference":[{"issue":"2","key":"2491_CR1","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1093\/clinids\/19.2.279","volume":"19","author":"SJ van den Hazel","year":"1994","unstructured":"van den Hazel SJ, Speelman P, Tytgat GN, Dankert J, van Leeuwen DJ. Role of antibiotics in the treatment and prevention of acute and recurrent cholangitis. Clin Infect Dis. 1994;19(2):279\u201386.","journal-title":"Clin Infect Dis"},{"issue":"5","key":"2491_CR2","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1097\/MPG.0000000000003935","volume":"77","author":"FS Alatas","year":"2023","unstructured":"Alatas FS, Lazarus G, Junaidi MC, Oswari H. Prophylactic antibiotics to prevent Cholangitis in children with biliary atresia after Kasai Portoenterostomy: a Meta-analysis. J Pediatr Gastroenterol Nutr. 2023;77(5):648\u201354.","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"19","key":"2491_CR3","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1001\/jama.2022.17927","volume":"328","author":"JA Myburgh","year":"2022","unstructured":"Myburgh JA, Seppelt IM, Goodman F, Billot L, Correa M, Davis JS, Gordon AC, Hammond NE, et al. Effect of selective decontamination of the Digestive Tract on Hospital Mortality in critically ill patients receiving mechanical ventilation: a Randomized Clinical Trial. JAMA. 2022;328(19):1911\u201321.","journal-title":"JAMA"},{"issue":"19","key":"2491_CR4","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1001\/jama.2022.19709","volume":"328","author":"NE Hammond","year":"2022","unstructured":"Hammond NE, Myburgh J, Seppelt I, Garside T, Vlok R, Mahendran S, Adigbli D, Finfer S, Gao Y, Goodman F, et al. Association between Selective Decontamination of the Digestive Tract and In-Hospital mortality in Intensive Care Unit patients receiving mechanical ventilation: a systematic review and Meta-analysis. 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Approval was granted by the Hospital Pharmacy Committee and Investigational Review Board (IRB) of the Ram\u00f3n y Cajal Hospital (Act 1 October 2015), Madrid, Spa.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Given that SDD administration had the approval of the Pharmacy Committee of the centre the need for informed consent from individual patients was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors accept the terms and conditions of the editorial for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}