{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:46:22Z","timestamp":1789055182868,"version":"build-2803163510"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Project of Zhejiang Provincial Department of Health","award":["2023KY1296"],"award-info":[{"award-number":["2023KY1296"]}]},{"name":"Quzhou Bureau of Science and Technology","award":["2022K71"],"award-info":[{"award-number":["2022K71"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s15010-025-02520-0","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:17:25Z","timestamp":1745414245000},"page":"1911-1927","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical impact of bronchoalveolar lavage fluid metagenomic next-generation sequencing in immunocompromised patients with severe community-acquired pneumonia in ICU: a multicenter retrospective study"],"prefix":"10.1007","volume":"53","author":[{"given":"Junjie","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runxi","family":"Zhuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bangchuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yesong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingmin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youqin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidan","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancheng","family":"Zhuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"2520_CR1","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s00134-019-05906-5","volume":"46","author":"E Azoulay","year":"2020","unstructured":"Azoulay E, Russell L, Van De Louw A, et al. Diagnosis of severe respiratory infections in immunocompromised patients. Intensive Care Med. 2020;46:298\u2013314. https:\/\/doi.org\/10.1007\/s00134-019-05906-5.","journal-title":"Intensive Care Med"},{"key":"2520_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21442","volume":"68","author":"RL Siegel","year":"2018","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68:7\u201330. https:\/\/doi.org\/10.3322\/caac.21442.","journal-title":"CA Cancer J Clin"},{"key":"2520_CR3","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.idc.2009.04.014","volume":"23","author":"PK Linden","year":"2009","unstructured":"Linden PK. Approach to the immunocompromised host with infection in the intensive care unit. Infect Dis Clin North Am. 2009;23:535\u201356. https:\/\/doi.org\/10.1016\/j.idc.2009.04.014.","journal-title":"Infect Dis Clin North Am"},{"key":"2520_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00210-5","volume":"2","author":"TLH Longevity","year":"2021","unstructured":"Longevity TLH. Community-acquired pneumonia. Lancet Healthy Longevity. 2021;2: e528. https:\/\/doi.org\/10.1016\/S2666-7568(21)00210-5.","journal-title":"Lancet Healthy Longevity"},{"key":"2520_CR5","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/S2213-2600(18)30345-X","volume":"7","author":"E Azoulay","year":"2019","unstructured":"Azoulay E, Mokart D, Kouatchet A, et al. Acute respiratory failure in immunocompromised adults. Lancet Respir Med. 2019;7:173\u201386. https:\/\/doi.org\/10.1016\/S2213-2600(18)30345-X.","journal-title":"Lancet Respir Med"},{"key":"2520_CR6","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1001\/jama.2019.21118","volume":"323","author":"G Olson","year":"2020","unstructured":"Olson G, Davis AM. Diagnosis and treatment of adults with community-acquired pneumonia. JAMA. 2020;323:885. https:\/\/doi.org\/10.1001\/jama.2019.21118.","journal-title":"JAMA"},{"key":"2520_CR7","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/s40121-020-00353-y","volume":"9","author":"X Wu","year":"2020","unstructured":"Wu X, Li Y, Zhang M, et al. Etiology of severe community-acquired pneumonia in adults based on metagenomic next-generation sequencing: a prospective multicenter study. Infect Dis Ther. 2020;9:1003\u201315. https:\/\/doi.org\/10.1007\/s40121-020-00353-y.","journal-title":"Infect Dis Ther"},{"key":"2520_CR8","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1111\/aas.12863","volume":"61","author":"H Lenz","year":"2017","unstructured":"Lenz H, Norby GO, Dahl V, et al. Five-year mortality in patients treated for severe community-acquired pneumonia\u2014a retrospective study. Acta Anaesthesiol Scand. 2017;61:418\u201326. https:\/\/doi.org\/10.1111\/aas.12863.","journal-title":"Acta Anaesthesiol Scand"},{"key":"2520_CR9","doi-asserted-by":"publisher","first-page":"1702215","DOI":"10.1183\/13993003.02215-2017","volume":"51","author":"C Cilloniz","year":"2018","unstructured":"Cilloniz C, Ferrer M, Liapikou A, et al. Acute respiratory distress syndrome in mechanically ventilated patients with community-acquired pneumonia. Eur Respir J. 2018;51:1702215. https:\/\/doi.org\/10.1183\/13993003.02215-2017.","journal-title":"Eur Respir J"},{"key":"2520_CR10","doi-asserted-by":"publisher","first-page":"R155","DOI":"10.1186\/cc11471","volume":"16","author":"N Mongardon","year":"2012","unstructured":"Mongardon N, Max A, Bougl\u00e9 A, et al. Epidemiology and outcome of severe pneumococcal pneumonia admitted to intensive care unit: a multicenter study. Crit Care. 2012;16:R155. https:\/\/doi.org\/10.1186\/cc11471.","journal-title":"Crit Care"},{"key":"2520_CR11","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1128\/JCM.02264-16","volume":"55","author":"K Messacar","year":"2017","unstructured":"Messacar K, Parker SK, Todd JK, et al. Implementation of rapid molecular infectious disease diagnostics: the role of diagnostic and antimicrobial stewardship. J Clin Microbiol. 2017;55:715\u201323. https:\/\/doi.org\/10.1128\/JCM.02264-16.","journal-title":"J Clin Microbiol"},{"key":"2520_CR12","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1186\/s12931-024-02991-z","volume":"25","author":"J Zhao","year":"2024","unstructured":"Zhao J, Sun Y, Tang J, et al. The clinical application of metagenomic next-generation sequencing in immunocompromised patients with severe respiratory infections in the ICU. Respir Res. 2024;25:360. https:\/\/doi.org\/10.1186\/s12931-024-02991-z.","journal-title":"Respir Res"},{"key":"2520_CR13","doi-asserted-by":"publisher","first-page":"1136588","DOI":"10.3389\/fcimb.2023.1136588","volume":"13","author":"T Lin","year":"2023","unstructured":"Lin T, Tu X, Zhao J, et al. Microbiological diagnostic performance of metagenomic next-generation sequencing compared with conventional culture for patients with community-acquired pneumonia. Front Cell Infect Microbiol. 2023;13:1136588. https:\/\/doi.org\/10.3389\/fcimb.2023.1136588.","journal-title":"Front Cell Infect Microbiol"},{"key":"2520_CR14","doi-asserted-by":"publisher","first-page":"1021320","DOI":"10.3389\/fcimb.2022.1021320","volume":"12","author":"J Zhang","year":"2022","unstructured":"Zhang J, Gao L, Zhu C, et al. Clinical value of metagenomic next-generation sequencing by illumina and nanopore for the detection of pathogens in bronchoalveolar lavage fluid in suspected community-acquired pneumonia patients. Front Cell Infect Microbiol. 2022;12:1021320. https:\/\/doi.org\/10.3389\/fcimb.2022.1021320.","journal-title":"Front Cell Infect Microbiol"},{"key":"2520_CR15","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1086\/511159","volume":"44","author":"LA Mandell","year":"2007","unstructured":"Mandell LA, Wunderink RG, Anzueto A, et al. Infectious diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44:S27-72. https:\/\/doi.org\/10.1086\/511159.","journal-title":"Clin Infect Dis"},{"key":"2520_CR16","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1007\/s00134-023-07295-2","volume":"50","author":"L Kreitmann","year":"2024","unstructured":"Kreitmann L, Helms J, Martin-Loeches I, et al. ICU-acquired infections in immunocompromised patients. Intensive Care Med. 2024;50:332\u201349. https:\/\/doi.org\/10.1007\/s00134-023-07295-2.","journal-title":"Intensive Care Med"},{"key":"2520_CR17","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1016\/j.chest.2020.05.598","volume":"158","author":"JA Ramirez","year":"2020","unstructured":"Ramirez JA, Musher DM, Evans SE, et al. Treatment of community-acquired pneumonia in immunocompromised adults. Chest. 2020;158:1896\u2013911. https:\/\/doi.org\/10.1016\/j.chest.2020.05.598.","journal-title":"Chest"},{"key":"2520_CR18","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for illumina sequence data. Bioinformatics. 2014;30:2114\u201320. https:\/\/doi.org\/10.1093\/bioinformatics\/btu170.","journal-title":"Bioinformatics"},{"key":"2520_CR19","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9:357\u20139. https:\/\/doi.org\/10.1038\/nmeth.1923.","journal-title":"Nat Methods"},{"key":"2520_CR20","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1186\/s13059-019-1891-0","volume":"20","author":"DE Wood","year":"2019","unstructured":"Wood DE, Lu J, Langmead B. Improved metagenomic analysis with Kraken 2. Genome Biol. 2019;20:257. https:\/\/doi.org\/10.1186\/s13059-019-1891-0.","journal-title":"Genome Biol"},{"key":"2520_CR21","doi-asserted-by":"publisher","first-page":"S416","DOI":"10.1093\/cid\/ciaa1516","volume":"71","author":"H Chen","year":"2020","unstructured":"Chen H, Yin Y, Gao H, et al. Clinical utility of in-house metagenomic next-generation sequencing for the diagnosis of lower respiratory tract infections and analysis of the host immune response. Clin Infect Dis. 2020;71:S416\u201326. https:\/\/doi.org\/10.1093\/cid\/ciaa1516.","journal-title":"Clin Infect Dis"},{"key":"2520_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jare.2023.02.018","volume":"55","author":"H Chen","year":"2024","unstructured":"Chen H, Zheng Y, Zhang X, et al. Clinical evaluation of cell-free and cellular metagenomic next-generation sequencing of infected body fluids. J Adv Res. 2024;55:119\u201329. https:\/\/doi.org\/10.1016\/j.jare.2023.02.018.","journal-title":"J Adv Res"},{"key":"2520_CR23","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1164\/rccm.201706-1097LE","volume":"197","author":"C Langelier","year":"2018","unstructured":"Langelier C, Zinter MS, Kalantar K, et al. Metagenomic sequencing detects respiratory pathogens in hematopoietic cellular transplant patients. Am J Respir Crit Care Med. 2018;197:524\u20138. https:\/\/doi.org\/10.1164\/rccm.201706-1097LE.","journal-title":"Am J Respir Crit Care Med"},{"key":"2520_CR24","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.2147\/IDR.S401707","volume":"16","author":"Y-H Xiao","year":"2023","unstructured":"Xiao Y-H, Liu M-F, Wu H, et al. Clinical efficacy and diagnostic value of metagenomic next-generation sequencing for pathogen detection in patients with suspected infectious diseases: a retrospective study from a large tertiary hospital. IDR. 2023;16:1815\u201328. https:\/\/doi.org\/10.2147\/IDR.S401707.","journal-title":"IDR"},{"key":"2520_CR25","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1111\/crj.12674","volume":"12","author":"B Cao","year":"2018","unstructured":"Cao B, Huang Y, She D, et al. Diagnosis and treatment of community-acquired pneumonia in adults: 2016 clinical practice guidelines by the Chinese Thoracic Society. Chin Med Assoc Clin Respir J. 2018;12:1320\u201360. https:\/\/doi.org\/10.1111\/crj.12674.","journal-title":"Chin Med Assoc Clin Respir J"},{"key":"2520_CR26","doi-asserted-by":"publisher","first-page":"1439472","DOI":"10.3389\/fcimb.2024.1439472","volume":"14","author":"Y Liu","year":"2024","unstructured":"Liu Y, Wu W, Xiao Y, et al. Application of metagenomic next-generation sequencing and targeted metagenomic next-generation sequencing in diagnosing pulmonary infections in immunocompetent and immunocompromised patients. Front Cell Infect Microbiol. 2024;14:1439472. https:\/\/doi.org\/10.3389\/fcimb.2024.1439472.","journal-title":"Front Cell Infect Microbiol"},{"key":"2520_CR27","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.chest.2024.07.144","volume":"25","author":"X Wu","year":"2024","unstructured":"Wu X, Sun T, He H, et al. Effect of metagenomic next-generation sequencing on clinical outcomes of patients with severe community-acquired pneumonia in icu: a multicenter randomized controlled trial. Chest. 2024;25:362\u201373. https:\/\/doi.org\/10.1016\/j.chest.2024.07.144.","journal-title":"Chest"},{"key":"2520_CR28","doi-asserted-by":"publisher","first-page":"697","DOI":"10.2147\/IDR.S443953","volume":"17","author":"K Liu","year":"2024","unstructured":"Liu K, Wu L, Chen G, et al. Clinical characteristics of Chlamydia psittaci infection diagnosed by metagenomic next-generation sequencing: a retrospective multi-center study in Fujian. China IDR. 2024;17:697\u2013708. https:\/\/doi.org\/10.2147\/IDR.S443953.","journal-title":"China IDR"},{"key":"2520_CR29","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00134-019-05519-y","volume":"45","author":"A Torres","year":"2019","unstructured":"Torres A, Chalmers JD, Dela Cruz CS, et al. Challenges in severe community-acquired pneumonia: a point-of-view review. Intensive Care Med. 2019;45:159\u201371. https:\/\/doi.org\/10.1007\/s00134-019-05519-y.","journal-title":"Intensive Care Med"},{"key":"2520_CR30","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/j.1469-0691.2012.03765.x","volume":"19","author":"D Sousa","year":"2013","unstructured":"Sousa D, Justo I, Dom\u00ednguez A, et al. Community-acquired pneumonia in immunocompromised older patients: incidence, causative organisms and outcome. Clin Microbiol Infect. 2013;19:187\u201392. https:\/\/doi.org\/10.1111\/j.1469-0691.2012.03765.x.","journal-title":"Clin Microbiol Infect"},{"key":"2520_CR31","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1093\/cid\/ciy723","volume":"68","author":"MF Di Pasquale","year":"2019","unstructured":"Di Pasquale MF, Sotgiu G, Gramegna A, et al. Prevalence and etiology of community-acquired pneumonia in immunocompromised patients. Clin Infect Dis. 2019;68:1482\u201393. https:\/\/doi.org\/10.1093\/cid\/ciy723.","journal-title":"Clin Infect Dis"},{"key":"2520_CR32","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.lungcan.2008.03.015","volume":"62","author":"J-O Lee","year":"2008","unstructured":"Lee J-O, Kim D-Y, Lim JH, et al. Risk factors for bacterial pneumonia after cytotoxic chemotherapy in advanced lung cancer patients. Lung Cancer. 2008;62:381\u20134. https:\/\/doi.org\/10.1016\/j.lungcan.2008.03.015.","journal-title":"Lung Cancer"},{"key":"2520_CR33","doi-asserted-by":"publisher","first-page":"351","DOI":"10.3389\/fcimb.2019.00351","volume":"9","author":"X Zhou","year":"2019","unstructured":"Zhou X, Wu H, Ruan Q, et al. Clinical evaluation of diagnosis efficacy of active Mycobacterium tuberculosis complex infection via metagenomic next-generation sequencing of direct clinical samples. Front Cell Infect Microbiol. 2019;9:351. https:\/\/doi.org\/10.3389\/fcimb.2019.00351.","journal-title":"Front Cell Infect Microbiol"},{"key":"2520_CR34","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.transproceed.2008.10.045","volume":"41","author":"H Bonatti","year":"2009","unstructured":"Bonatti H, Pruett TL, Brandacher G, et al. Pneumonia in solid organ recipients: spectrum of pathogens in 217 episodes. Transpl Proc. 2009;41:371\u20134. https:\/\/doi.org\/10.1016\/j.transproceed.2008.10.045.","journal-title":"Transpl Proc"},{"key":"2520_CR35","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.ccm.2023.06.007","volume":"44","author":"CD Varley","year":"2023","unstructured":"Varley CD, Streifel AC, Bair AM, et al. Nontuberculous mycobacterial pulmonary disease in the immunocompromised host. Clin Chest Med. 2023;44:829\u201338. https:\/\/doi.org\/10.1016\/j.ccm.2023.06.007.","journal-title":"Clin Chest Med"},{"key":"2520_CR36","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1148\/rg.2017160032","volume":"37","author":"AC Nachiappan","year":"2017","unstructured":"Nachiappan AC, Rahbar K, Shi X, et al. Pulmonary tuberculosis: role of radiology in diagnosis and management. Radiographics. 2017;37:52\u201372. https:\/\/doi.org\/10.1148\/rg.2017160032.","journal-title":"Radiographics"},{"key":"2520_CR37","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3390\/jof3040057","volume":"3","author":"F Bongomin","year":"2017","unstructured":"Bongomin F, Gago S, Oladele R, et al. Global and multi-national prevalence of fungal diseases\u2014estimate precision. JoF. 2017;3:57. https:\/\/doi.org\/10.3390\/jof3040057.","journal-title":"JoF"},{"key":"2520_CR38","doi-asserted-by":"publisher","first-page":"5711","DOI":"10.1007\/s00415-023-11950-5","volume":"270","author":"H Yarmohammadi","year":"2023","unstructured":"Yarmohammadi H, Razavi A, Shahrabi Farahani M, et al. Characteristics of HHV-7 meningitis: a systematic review. J Neurol. 2023;270:5711\u20138. https:\/\/doi.org\/10.1007\/s00415-023-11950-5.","journal-title":"J Neurol"},{"key":"2520_CR39","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1093\/cid\/ciad708","volume":"78","author":"E Kampouri","year":"2024","unstructured":"Kampouri E, Ibrahimi SS, Xie H, et al. Cytomegalovirus (CMV) reactivation and CMV-specific cell-mediated immunity after chimeric antigen receptor T-cell therapy. Clin Infect Dis. 2024;78:1022\u201332. https:\/\/doi.org\/10.1093\/cid\/ciad708.","journal-title":"Clin Infect Dis"},{"key":"2520_CR40","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.jid.2021.07.171","volume":"142","author":"P Speth","year":"2022","unstructured":"Speth P, Jargosch M, Seiringer P, et al. Immunocompromised patients with therapy-refractory chronic skin diseases show reactivation of latent EBV and CMV infection. J Invest Dermatol. 2022;142:549-558.e6. https:\/\/doi.org\/10.1016\/j.jid.2021.07.171.","journal-title":"J Invest Dermatol"},{"key":"2520_CR41","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1186\/s12931-024-02887-y","volume":"25","author":"Q Gao","year":"2024","unstructured":"Gao Q, Li L, Su T, et al. A single-center, retrospective study of hospitalized patients with lower respiratory tract infections: clinical assessment of metagenomic next-generation sequencing and identification of risk factors in patients. Respir Res. 2024;25:250. https:\/\/doi.org\/10.1186\/s12931-024-02887-y.","journal-title":"Respir Res"},{"key":"2520_CR42","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/COC.0b013e318209aa41","volume":"35","author":"HS Lee","year":"2012","unstructured":"Lee HS, Park JY, Shin SH, et al. Herpesviridae viral infections after chemotherapy without antiviral prophylaxis in patients with malignant lymphoma: incidence and risk factors. Am J Clin Oncol. 2012;35:146\u201350. https:\/\/doi.org\/10.1097\/COC.0b013e318209aa41.","journal-title":"Am J Clin Oncol"},{"key":"2520_CR43","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1164\/rccm.200609-1322OC","volume":"175","author":"C-E Luyt","year":"2007","unstructured":"Luyt C-E, Combes A, Deback C, et al. Herpes simplex virus lung infection in patients undergoing prolonged mechanical ventilation. Am J Respir Crit Care Med. 2007;175:935\u201342. https:\/\/doi.org\/10.1164\/rccm.200609-1322OC.","journal-title":"Am J Respir Crit Care Med"},{"key":"2520_CR44","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1093\/infdis\/jiae343","volume":"231","author":"G Yin","year":"2024","unstructured":"Yin G, Yin Y, Guo Y, et al. Clinical impact of plasma metagenomic next-generation sequencing on infection diagnosis and antimicrobial therapy in immunocompromised patients. J Infect Dis. 2024;231:344\u201354. https:\/\/doi.org\/10.1093\/infdis\/jiae343.","journal-title":"J Infect Dis"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-025-02520-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-025-02520-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-025-02520-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T13:40:50Z","timestamp":1758721250000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s15010-025-02520-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["2520"],"URL":"https:\/\/doi.org\/10.1007\/s15010-025-02520-0","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,23]]},"assertion":[{"value":"27 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"The retrospective studies involving humans were approved by the ethics committee of Quzhou People\u2019s Hospital (Quzhou People\u2019s Hospital, Quzhou, China: Number B 2024\u2013150). The studies were conducted in accordance with local legislation and institutional requirements. Written informed consent for participation was not required from the participants or the participants\u2019 legal guardians\/next of kin in accordance with the national legislation and institutional requirements.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}