{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:53:05Z","timestamp":1782942785139,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001734","name":"Copenhagen University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate bacteriology, antibiotic treatment and adverse birth outcomes (ABOs) in pregnancies with and without bacteriuria and urinary tract infections (UTIs) based on urine cultures and clinical diagnoses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Registry-based cohort study. Population: Pregnancies with at least one urine culture analysed at one of two hospitals in the Capital Region, Denmark, between 2015 and 2021. Data were collected from clinical and national health registries. Descriptive statistics, t-tests, and logistic regressions were applied. Main outcome measures: Odds of ABOs (low birth weight (LBW), small for gestational age (SGA), prematurity), and the impact of antibiotic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      74,253 pregnancies in 62,439 women with 178,599 urine cultures were included; 3,498 (4.7%) with a positive urine culture, of whom 2,786 had bacteriuria (no UTI\/ASB diagnosis), 533 with a UTI diagnosis, and 179 with an ASB diagnosis, and 70,755 pregnancies without a significantly positive urine culture (comparison group).\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      (9.3%) was the most common uropathogen. Of included pregnancies, 43% received antibiotic treatments, and the average treatment timing was empirical. Bacteriuria and UTIs in pregnancy increased the odds of ABOs, and antibiotic treatment was associated with reduced odds. ASB was not associated with ABOs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Bacteriuria and UTIs in pregnancy, but not ASB, were significantly associated with ABOs and a lowering of odds of LBW when antibiotically treated. Our findings highlight the importance of pregnancy diagnostics, the consequences of bacteriuria, but also that further research on ASB is highly needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s15010-025-02631-8","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T09:01:07Z","timestamp":1757494867000},"page":"2821-2831","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bacteriology, antibiotic treatment effect and adverse birth outcomes in pregnant women with and without bacteriuria: a registry study"],"prefix":"10.1007","volume":"53","author":[{"given":"Jon Dissing","family":"Sund","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde Sif Frydensberg","family":"Nicolaisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny Dahl","family":"Knudsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Hofman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Moseholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"2631_CR1","unstructured":"Sundhed.dk. 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Through the unique PIN-number, all analyses were anonymized and non-person-applicable. All data were stored in accordance with the Danish Protection Council Guidelines. Ethical approval from the Capital Region Committee on Health Research Ethics was not relevant as no new analyses were being conducted on the urine samples.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"E.M reports unrestricted grants from the Novo Nordisk Foundation and Gilead Sciences, outside of the submitted work, and personal fees from Gilead, Bristol Myers Squibb, and GlaxoSmithKline, outside of the submitted work: honorarium paid to her institution.The remaining authors declare no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}