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Clinical cure was achieved in 85.5% of patients; recurrence and failure occurred in 6.2% and 7.9%, respectively. Most frequent indications were skin\/soft tissue and surgical site infections (25.9%), complicated urinary tract infections (22.4%), and bone\/joint infections (16.4%). Pathogens were mainly Gram-negative (70.7%), including\n                      <jats:italic>Enterobacterales<\/jats:italic>\n                      (40.2%, 57.6% ESBL-producing),\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      (26.8%), and\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (17.1%, 28.6% methicillin-resistant\n                      <jats:italic>S. aureus<\/jats:italic>\n                      ). The most used antibiotics were piperacillin\/tazobactam (51.3%), cefepime (12.5%) and ceftolozane\/tazobactam (7.5%). Adverse events were observed in 13.75% of treatments, primarily vascular access-related (5.7 events\/1,000 OPAT-days); drug-related adverse events occurred in 7.8% of patients (3.1 events\/1,000 OPAT-days). Among contacted patients (75% response rate), 83.7% expressed willingness to reuse the pump. Total OPAT costs were \u20ac62,190.64 compared to an estimated \u20ac773,600.00 for inpatient care, yielding a 92% cost reduction (\u20ac711,409 saved).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elastomeric pump-based OPAT is a clinically effective, well-tolerated, and economically advantageous option for selected infections. Its integration into stewardship programs supports broader implementation within modern, sustainable infectious disease care models.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s15010-025-02671-0","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:55:49Z","timestamp":1761904549000},"page":"365-375","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Continuous infusion OPAT via elastomeric pumps: effectiveness, safety, and cost-saving potential in a real-world Italian cohort"],"prefix":"10.1007","volume":"54","author":[{"given":"Stella","family":"Babich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Di Bella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"De Rivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyewole Christopher","family":"Durojaiye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Lovecchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Misin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madalina","family":"Straciug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylenia","family":"Gobbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dellaluce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Palmolungo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Fabricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo Giorgio","family":"Di Girolamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Roni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacopo","family":"Monticelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"2671_CR1","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1093\/jac\/dky224","volume":"73","author":"R Voumard","year":"2018","unstructured":"Voumard R, Gardiol C, Andr\u00e9 P, Arensdorff L, Cochet C, Boillat-Blanco N, Decosterd L, Buclin T, de Valli\u00e8re S. 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