{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:36:00Z","timestamp":1786703760176,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Manipal Academy of Higher Education, Manipal"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Leptospirosis is a globally prevalent zoonotic infection caused by Leptospira species. Cardiac involvement is increasingly recognized, yet large-scale studies comprehensively evaluating electrocardiographic and echocardiographic manifestations, including myocarditis, remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included adult patients with clinically suspected leptospirosis and positive IgM ELISA admitted to a tertiary care hospital in South India between January 2016 and September 2020. Clinical features, electrocardiographic (ECG) findings, two-dimensional echocardiographic parameters, and in-hospital outcomes were analyzed. Binomial logistic regression was performed to identify independent predictors of all-cause mortality and myocarditis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 510 patients were analyzed (mean age 48.4\u2009\u00b1\u200913.7 years; 66.5% male). The mean hospital stay was 10.1\u2009\u00b1\u20096.1 days, with 40% requiring hospitalization beyond 10 days. Diabetes mellitus and hypertension were present in 16.7% and 16.9% of patients, respectively. Acute respiratory distress syndrome occurred in 10.6%, and 28% developed multiorgan dysfunction syndrome; 17.8% required hemodialysis. The most common ECG abnormalities were corrected QT interval prolongation (21.0%) and sinus tachycardia (20.8%). Echocardiographic evidence of myocarditis was observed in 10.4% of patients, including isolated left ventricular dysfunction (4.1%), isolated right ventricular dysfunction (3.9%), and biventricular dysfunction (2.4%). The overall in-hospital mortality rate was 8%. Increasing age, sinus tachycardia, QTc prolongation, hypertension, hemodialysis requirement, and myocarditis were independent predictors of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Myocarditis represents a significant cardiac complication in leptospirosis and is associated with increased mortality. Routine cardiac evaluation may facilitate early detection and risk stratification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>Not applicable, as this study was retrospective in nature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s15010-026-02806-x","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:22:05Z","timestamp":1777886525000},"page":"1875-1882","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular manifestations and outcomes in patients with leptospirosis admitted to a tertiary care center in the Coastal Karnataka region in India"],"prefix":"10.1007","volume":"54","author":[{"given":"M.","family":"Sudhakar Rao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothi","family":"Samanth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Padmakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmitha G.","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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