{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T19:28:03Z","timestamp":1793647683307,"version":"4.5.1"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Klinikum der Universit\u00e4t M\u00fcnchen","id":[{"id":"https:\/\/ror.org\/05591te55","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We are reporting on a rare case of a primary manifestation of Alveolar Echinococcosis in the spleen in a German patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The patient was initially presented to her gastroenterologist and subsequently referred to a district hospital for surgical management. The further antiparasitic treatment was taken over by the Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital Munich, Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case report<\/jats:title>\n                    <jats:p>A 59-year-old German woman presented to her gastroenterologist with weight loss and abdominal discomfort. An ultrasonographic finding of a splenic lesion was further evaluated by abdominal CT and MRI, interpreted initially as a hamartoma by the radiologists. Following partial splenectomy, where an accidental intra-operative cyst rupture occured, pathological examination raised suspicion of echinococcosis. An immune-histological analysis of the resected splenic tissue by the German Reference Laboratory for Echinococcosis confirmed Alveolar Echinococcosis. No additional lesions suggestive of echinococcosis were identified. The patient is currently successfully treated with continuous antiparasitic therapy with albendazole.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Primary manifestations of Alveolar Echinococcosis in the spleen are rare, and may be misleading towards other differential diagnoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s15010-026-02911-x","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T14:58:49Z","timestamp":1785769129000},"page":"2993-2997","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary splenic Alveolar Echinococcosis: a case report from Germany"],"prefix":"10.1007","volume":"54","author":[{"given":"Guenter","family":"Froeschl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Gehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F. E.","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Wallrauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Rothe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2911_CR1","unstructured":"Robert Koch Institut: RKI-Ratgeber Echinokokkose. 2025 [cited 2025 Nov 22]. https:\/\/www.rki.de\/DE\/Aktuelles\/Publikationen\/RKI-Ratgeber\/Ratgeber\/Ratgeber_Echinokokkose.html"},{"key":"2911_CR2","unstructured":"Robert Koch Institut: SurvStat. 2025 [cited 2025 Nov 22]. https:\/\/survstat.rki.de\/Content\/Query\/Create.aspx"},{"key":"2911_CR3","volume-title":"Echinococcus: Control and Elimination of Echinococcosis with a Focus on China and Europe","author":"J Hotz","year":"2024","unstructured":"Hotz J. Alveolar and cystic echinococcosis in central Europe: epidemiology, diagnosis, therapy, and prophylaxis. In: Li JW, Mehlhorn W, editors. Echinococcus: control and elimination of echinococcosis with a focus on China and Europe. Cham, Switzerland: Springer; 2024."},{"issue":"9","key":"2911_CR4","doi-asserted-by":"publisher","first-page":"e0013511","DOI":"10.1371\/journal.pntd.0013511","volume":"19","author":"L Bohard","year":"2025","unstructured":"Bohard L, et al. Unexplained subcutaneous swelling: keep echinococcosis in mind! Report of two primary extrahepatic subcutaneous echinococcosis cases and literature review. PLoS Negl Trop Dis. 2025;19(9):e0013511.","journal-title":"PLoS Negl Trop Dis"},{"issue":"45\u201346","key":"2911_CR5","first-page":"689","volume":"138","author":"W Karenovics","year":"2008","unstructured":"Karenovics W, Azagury DE, Groebli Y. Isolated Alveolar Echinococcosis of the spleen\u2014clinical presentation and management review. Swiss Med Wkly. 2008;138(45\u201346):689\u201390.","journal-title":"Swiss Med Wkly"},{"issue":"4","key":"2911_CR6","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/2047-783X-14-4-165","volume":"14","author":"G Meimarakis","year":"2009","unstructured":"Meimarakis G, et al. Surgical management of splenic echinococcal disease. Eur J Med Res. 2009;14(4):165\u201370.","journal-title":"Eur J Med Res"},{"issue":"3","key":"2911_CR7","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1016\/S1473-3099(17)30335-3","volume":"18","author":"TR Meinel","year":"2018","unstructured":"Meinel TR, et al. Vertebral Alveolar Echinococcosis-a case report, systematic analysis, and review of the literature. Lancet Infect Dis. 2018;18(3):e87\u201398.","journal-title":"Lancet Infect Dis"},{"key":"2911_CR8","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1476-0711-10-13","volume":"10","author":"M Nell","year":"2011","unstructured":"Nell M, et al. Primary extrahepatic Alveolar Echinococcosis of the lumbar spine and the psoas muscle. Ann Clin Microbiol Antimicrob. 2011;10:13.","journal-title":"Ann Clin Microbiol Antimicrob"},{"issue":"22","key":"2911_CR9","doi-asserted-by":"publisher","first-page":"CASE2187","DOI":"10.3171\/CASE2187","volume":"1","author":"AM Reuss","year":"2021","unstructured":"Reuss AM, et al. An immunocompetent farmer with isolated cerebral Alveolar Echinococcosis: illustrative case. J Neurosurg Case Lessons. 2021;1(22):CASE2187.","journal-title":"J Neurosurg Case Lessons"},{"issue":"3","key":"2911_CR10","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s150100050079","volume":"28","author":"S Reuter","year":"2000","unstructured":"Reuter S, et al. Extrahepatic Alveolar Echinococcosis without liver involvement: a rare manifestation. Infection. 2000;28(3):187\u201392.","journal-title":"Infection"},{"issue":"43","key":"2911_CR11","doi-asserted-by":"publisher","first-page":"12392","DOI":"10.3748\/wjg.v21.i43.12392","volume":"21","author":"W Kratzer","year":"2015","unstructured":"Kratzer W, et al. Proposal of an ultrasonographic classification for hepatic Alveolar Echinococcosis: echinococcosis multilocularis Ulm classification-ultrasound. World J Gastroenterol. 2015;21(43):12392\u2013402.","journal-title":"World J Gastroenterol"},{"issue":"1","key":"2911_CR12","doi-asserted-by":"publisher","first-page":"e0007110","DOI":"10.1371\/journal.pntd.0007110","volume":"13","author":"F Lotsch","year":"2019","unstructured":"Lotsch F, et al. Evaluation of direct costs associated with alveolar and cystic echinococcosis in Austria. 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