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This study aimed to investigate the circulation of respiratory viruses in community-dwelling older adults in Germany.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants aged\u2009\u2265\u200950 years in Germany performed multi-pathogen rapid antigen self-tests (MAK5) detecting adenovirus (AdV), severe acute respiratory syndrome coronavirus 2 (SARS\u2011CoV\u20112), influenza A and B, and respiratory syncytial virus (RSV) on June 1 and December 15, 2024. Participants reported test results, ARI symptoms and duration, medical consultations, work absenteeism, comorbidities, vaccination history, and prior infections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      2,654 participants enrolled in the point prevalence assessment on June 1, 2024 and 2,385 on December 15, 2024. Most tests were negative (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094,807; 93.9%), with an overall detection rate of 5.7%. In June, 153 pathogens were detected, compared to 138 in December. AdV was the most frequently detected pathogen in both June (59\/153; 38.6%) and December (44\/138; 31.9%), followed by SARS-CoV-2 and influenza A. Among participants with a positive test, at least one ARI symptom was reported by 47.7% in June and 58.7% in December. SARS-CoV-2 was associated with the highest clinical burden, resulting in healthcare utilization in 10.0% and 19.4% of cases and work absenteeism in 10.0% and 13.9% of cases in June and December, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Point prevalence testing revealed substantial AdV circulation, underrepresented in routine surveillance. Its frequent co-detection with other viruses suggests a role as a co-infecting agent. Community-based screening can help identify asymptomatic reservoirs and underreported viral circulation, linking viral detection to clinical and economic impact.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s15010-026-02917-5","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:53:08Z","timestamp":1787644388000},"page":"2725-2738","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Point prevalence assessments of five respiratory viruses in adults\u2009\u2265\u200950 years of age in Germany by multi-pathogen rapid antigen testing on June 1, 2024, and December 15, 2024"],"prefix":"10.1007","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3783-3419","authenticated-orcid":false,"given":"Miranda","family":"Anggitakirana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5327-2937","authenticated-orcid":false,"given":"Julia A.","family":"Nacov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-8297","authenticated-orcid":false,"given":"Jon","family":"Salmanton-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4669-690X","authenticated-orcid":false,"given":"Julia","family":"Jakobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7680-0344","authenticated-orcid":false,"given":"Sarah","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina","family":"Leckler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"K\u00f6be","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1425-7352","authenticated-orcid":false,"given":"Louise M.","family":"Cremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0400-0748","authenticated-orcid":false,"given":"Pauline","family":"Wipfler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9152-2469","authenticated-orcid":false,"given":"Jannik","family":"Stemler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0378-5697","authenticated-orcid":false,"given":"Heinz-Josef","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9979-1671","authenticated-orcid":false,"given":"Ullrich","family":"Bethe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver A.","family":"Cornely","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"2917_CR1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.ijid.2022.05.032","volume":"121","author":"S Gupta","year":"2022","unstructured":"Gupta S, Gupta T, Gupta N. 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Clin Microbiol Infect. 2026. https:\/\/doi.org\/10.1016\/j.cmi.2026.03.005.","journal-title":"Clin Microbiol Infect"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-026-02917-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-026-02917-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-026-02917-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:49:37Z","timestamp":1793645377000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-026-02917-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["2917"],"URL":"https:\/\/doi.org\/10.1007\/s15010-026-02917-5","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"assertion":[{"value":"26 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"JN has received speaker honoraria by Hikma and AKM. JSG has received grants from AstraZeneca, as well as honoraria for lectures from AstraZeneca and Menarini. LMC has received research and travel grants from DZIF. HJS has received consultancy or speaker honoraria from Pfizer. OAC reports grants or contracts from iMi, iHi, DFG, BMFTR, Cidara, DZIF, EU-DG RTD, F2G, Gilead, G-BA, MedPace, MSD, Mundipharma, Octapharma, Pfizer, Scynexis; Consulting fees from Abbvie, AiCuris, Basilea, Cidara, Elion, Gilead, GSK, IQVIA, Janssen, MedPace, Menarini, Melinta, Mundipharma, Octapharma, Pardes, Pfizer, PSI, Scynexis, Seqirus, Shionogi; Honoraria for lectures from Abbott, Abbvie, Hikma, Asahi Kasei, AstraZeneca, Gilead, GSK, Knight, InfectoPharm, Ipsen, Medscape\/WebMD, MSD, Moderna, Mundipharma, Noscendo, Paul-Martini-Stiftung, Pfizer, Sandoz, Seqirus, Shionogi, Universimed, Vitis; Participation on a Data Safety Monitoring Board or Advisory Board from AstraZeneca, Cidara, IQVIA, Janssen, MedPace, Melinta, PSI, Pulmocide, Vedanta; A patent at the German Patent and Trade Mark Office (DE 10 2021 113 007.7); Stocks from CoRe Consulting, EasyRadiology. JS has received research grants by the Ministry of Education and Research (BMBF), the Medical Faculty of the University of Cologne, Basilea Pharmaceuticals, Noscendo, Scynexis; has received speaker honoraria by AbbVie, Akademie f\u00fcr Infektionsmedizin, FoMF, Hikma, Eli-Lilly, Mundipharma and Pfizer; has served on advisory boards for Kite-Gilead and Micron Research; has received travel grants and\/or support from Page Medical, Deutsche Gesellschaft f\u00fcr Infektiologie e.V. and Meta Alexander Foundation; has received payment for expert testimony from Shionogi; has been a consultant to AiCuris, Basilea, Gilead, Mundipharma, and Alvea Vax; and has served in leadership or fiduciary role in Infectious Disease Working Party of the German Society for Hematology and Medical Oncology. All remaining authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Institutional Review Board of the Medical Faculty of the University of Cologne (identifier 23-1315_1), and all procedures comply with relevant ethical guidelines and the principles of the Declaration of Helsinki. The VACCELERATE Volunteer Registry (V-Reg) operates under ethical approval from the Institutional Review Board of the Medical Faculty, University of Cologne (approval number 20-1536). Participants provided electronic consent via electronic case report form (eCRF) prior to enrolment and at each point data submission.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent to be contacted for clinical studies was obtained from all individual participants included in the study when they registered for the VACCELERATE volunteer registry. Participants provided informed consent for this specific study via electronic case report form (eCRF) prior to enrolment and at each point data submission.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All participants were informed about the intention to published anonymized results and consented via their participation.","order":4,"name":"Ethics","label":"Consent to publish","group":{"name":"EthicsHeading","label":"Declarations"}}]}}