{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:46:44Z","timestamp":1792025204805,"version":"4.4.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      Extrapulmonary nontuberculous mycobacterial (EPNTM) infections of bone, joint, and soft tissue are difficult to treat and lack species-specific outcome data. We sought to describe antimicrobial regimens and surgical management by\n                      <jats:italic>Mycobacterium<\/jats:italic>\n                      spp. and to identify predictors of a clinical cure within 12 months in this adult cohort with EPNTM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicentre retrospective cohort study across five tertiary hospitals in Australia and New Zealand 2014\u20132020. Adults with culture-confirmed EPNTM infection from sterile or intraoperative specimens were included. Primary outcome was clinical cure at 12 months. Secondary outcomes included relapse, drug toxicity and host factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 107 patients, six species groups were identified, most commonly\n                      <jats:italic>M. abscessus<\/jats:italic>\n                      complex (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926, 25%),\n                      <jats:italic>Mycobacterium marinum<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925, 24%), and\n                      <jats:italic>M. fortuitum<\/jats:italic>\n                      complex (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924, 23%). Clinical cure within 12 months differed significantly by species, with high cure proportions for\n                      <jats:italic>M. abscessus<\/jats:italic>\n                      complex (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922, 92%) in surgically accessible infections and lower cure rates for\n                      <jats:italic>M. chelonae<\/jats:italic>\n                      (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096, 60%) and amalgamated slow growing mycobacteria (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094, 36%). Younger age (median 47 vs. 60 years,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and\n                      <jats:italic>Mycobacterium<\/jats:italic>\n                      spp. was associated with cure whereas antimicrobial class and surgical intervention were not. Of antibiotic classes used, only macrolide duration was associated with cure. Relapse was uncommon (8%) and occurred predominantly in immunosuppressed patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This first multicentre Australasian cohort demonstrates substantial species-specific variation in outcomes of EPNTM osteoarticular and soft-tissue infections. This study highlights the need for species-specific management pathways and prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s15010-026-02988-4","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:07:47Z","timestamp":1792022867000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of non-tuberculous mycobacterial infection of the bone, joint and soft tissue: a seven-year multicentre retrospective study"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5218-680X","authenticated-orcid":false,"given":"Angus","family":"Lane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burcu","family":"Isler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanthi","family":"Vemuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earlleen","family":"Gunning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Burke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Simos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Grey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Mausolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Garnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumudu","family":"Britton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"issue":"3","key":"2988_CR1","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.det.2015.03.017","volume":"33","author":"TM Gonzalez-Santiago","year":"2015","unstructured":"Gonzalez-Santiago TM, Drage LA. 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