{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:48:48Z","timestamp":1792014528980,"version":"4.4.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infection"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To determine whether upper respiratory tract co-detection of human rhino-\/enterovirus is associated with a distinct clinical phenotype in children with\n                      <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                      infection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed 236 children with\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      infection detected by multiplex polymerase chain reaction (PCR) from 2022 to 2025 at the University Children\u2019s Hospital Zurich, comparing those without and with human rhino-\/enterovirus co-detection, and performing a secondary analysis after excluding other co-detections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No statistically significant differences were observed in demographic characteristics, clinical presentation, or inflammatory markers between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Human rhino-\/enterovirus co-detection may represent incidental viral detection rather than clinically relevant co-infection in children with\n                      <jats:italic>M. pneumoniae<\/jats:italic>\n                      infection, supporting cautious interpretation of multiplex PCR results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s15010-026-03003-6","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:08:34Z","timestamp":1792012114000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical significance of human rhino-\/enterovirus co-detection in pediatric Mycoplasma pneumoniae infections"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0077-4311","authenticated-orcid":false,"given":"Elena","family":"Robinson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5264-6394","authenticated-orcid":false,"given":"Stefanie","family":"von Felten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-9803","authenticated-orcid":false,"given":"Patrick M.","family":"Meyer Sauteur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"3003_CR1","doi-asserted-by":"publisher","unstructured":"Meyer Sauteur PM, Zhang X-S, Emborg H-D, Sidorov S, Pereyre S, Fischer A, et al. Global spatiotemporal dynamics of Mycoplasma pneumoniae re-emergence after COVID-19 pandemic restrictions: an epidemiological and transmission modelling study. Lancet Microbe. 2025;6:101019. https:\/\/doi.org\/10.1016\/j.lanmic.2024.101019","DOI":"10.1016\/j.lanmic.2024.101019"},{"key":"3003_CR2","doi-asserted-by":"publisher","unstructured":"Leber AL, Xu L, Oyeniran SJ, Wang H. Molecular detection of respiratory pathogens in tonsillar tissue from asymptomatic children: implications for result interpretation among the asymptomatic and symptomatic. Microbiol Spectr. 2026;14:e02872-25. https:\/\/doi.org\/10.1128\/spectrum.02872-25","DOI":"10.1128\/spectrum.02872-25"},{"key":"3003_CR3","doi-asserted-by":"publisher","first-page":"104493","DOI":"10.1016\/j.ebiom.2023.104493","volume":"90","author":"R Dagan","year":"2023","unstructured":"Dagan R, Van Der Beek BA, Ben-Shimol S, Greenberg D, Shemer-Avni Y, Weinberger DM, et al. The COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study. eBioMedicine. 2023;90:104493. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104493.","journal-title":"eBioMedicine"},{"key":"3003_CR4","doi-asserted-by":"publisher","first-page":"e2254909","DOI":"10.1001\/jamanetworkopen.2022.54909","volume":"6","author":"DA Rankin","year":"2023","unstructured":"Rankin DA, Spieker AJ, Perez A, Stahl AL, Rahman HK, Stewart LS, et al. Circulation of rhinoviruses and\/or enteroviruses in pediatric patients with acute respiratory illness before and during the COVID-19 pandemic in the US. JAMA Netw Open. 2023;6:e2254909. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.54909","journal-title":"JAMA Netw Open"},{"key":"3003_CR5","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.3390\/v17081040","volume":"17","author":"M Manno","year":"2025","unstructured":"Manno M, Pavia G, Gigliotti S, Pantanella M, Barreca GS, Peronace C, et al. Respiratory virus prevalence across pre-, during-, and post-SARS-CoV-2 pandemic periods. Viruses. 2025;17:1040. https:\/\/doi.org\/10.3390\/v17081040","journal-title":"Viruses"},{"key":"3003_CR6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s00431-026-07065-4","volume":"185","author":"MP Mapindra","year":"2026","unstructured":"Mapindra MP, Mahindra MP, McNamara P, Kartasasmita C, Semple MG, Clark H, et al. Prevalence of common respiratory viruses of infants with respiratory tract infections in European countries in the past decade: a systematic review and meta-analysis comparing between the pre-COVID-19, pandemic, and post-COVID-19 periods. Eur J Pediatr. 2026;185:401. https:\/\/doi.org\/10.1007\/s00431-026-07065-4.","journal-title":"Eur J Pediatr"},{"key":"3003_CR7","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1164\/rccm.201504-0749OC","volume":"193","author":"S Heinonen","year":"2016","unstructured":"Heinonen S, Jartti T, Garcia C, Oliva S, Smitherman C, Anguiano E, et al. Rhinovirus detection in symptomatic and asymptomatic children: value of host transcriptome analysis. Am J Respir Crit Care Med. 2016;193:772\u201382. https:\/\/doi.org\/10.1164\/rccm.201504-0749OC","journal-title":"Am J Respir Crit Care Med"},{"key":"3003_CR8","doi-asserted-by":"publisher","unstructured":"Brandlmeier E, Nagl C, Omony J, Kolberg L, Meyer-B\u00fchn M, Jakwerth C et al. Post-pandemic resurgence of Mycoplasma pneumoniae and its emerging link with rhinovirus in children. Infection. 2026;54:2041-51. https:\/\/doi.org\/10.1007\/s15010-026-02833-8","DOI":"10.1007\/s15010-026-02833-8"},{"key":"3003_CR9","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00431-025-06326-y","volume":"184","author":"E Robinson","year":"2025","unstructured":"Robinson E, Zellner M, Osuna E, Seiler M, Theiler M, Sidorov S, et al. Evolving clinical features of Mycoplasma pneumoniae infections following COVID-19 pandemic restrictions: a retrospective, comparative cohort study. Eur J Pediatr. 2025;184:535. https:\/\/doi.org\/10.1007\/s00431-025-06326-y","journal-title":"Eur J Pediatr"},{"key":"3003_CR10","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1128\/JCM.02339-15","volume":"54","author":"DR Shibib","year":"2016","unstructured":"Shibib DR, Matushek SM, Beavis KG, Gawel SH, Charnot-Katsikas A. BioFire FilmArray Respiratory Panel for detection of enterovirus D68. J Clin Microbiol. 2016;54:457\u20139. https:\/\/doi.org\/10.1128\/JCM.02339-15","journal-title":"J Clin Microbiol"},{"key":"3003_CR11","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1164\/rccm.201904-0860LE","volume":"200","author":"PM Meyer Sauteur","year":"2019","unstructured":"Meyer Sauteur PM, Seiler M, Tr\u00fcck J, Unger WWJ, Paioni P, Relly C, et al. Diagnosis of Mycoplasma pneumoniae pneumonia with measurement of specific antibody-secreting cells. Am J Respir Crit Care Med. 2019;200:1066\u20139. https:\/\/doi.org\/10.1164\/rccm.201904-0860LE","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-026-03003-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-026-03003-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s15010-026-03003-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:08:34Z","timestamp":1792012114000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s15010-026-03003-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":11,"alternative-id":["3003"],"URL":"https:\/\/doi.org\/10.1007\/s15010-026-03003-6","relation":{},"ISSN":["0300-8126","1439-0973"],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"10 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from every individual participant included in the study.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the Canton of Zurich (BASEC no. 2025-00039).","order":3,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}