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Giovanni Grandi received honoraria for sponsored lectures and participation in advisory boards from Organon, Bayer AG, Teva\/Theramex, Exeltis, Italfarmaco, Opocrin and Gedeon Richter outside of the scope of this manuscript. Raffaele Ornello reports personal fees and non-financial support from AbbVie, Eli Lilly, Lundbeck, Novartis, Pfizer, and Teva; received research grants from Novartis; is Associate Editor for the Headache and Neurogenic Section of Frontiers in Neurology and for Arquivos de Neuropsiquiatria; is a Junior Editorial Board Member of The Journal of Headache and Pain; is an Editorial Board Member of Confinia Cephalalgica. Bianca Raffaelli is a member of the Editorial Board of The Journal of Headache and Pain; reports personal fees from AbbVie, Eli Lilly, Lundbeck, Novartis, Organon, Perfood and Teva for participating in advisory boards and\/or speaker activities as well as research funding from Lundbeck, Novartis, Else Kr\u00f6ner-Fresenius-Stiftung, German Research Foundation and German Migraine and Headache Society. Marcin Straburzy\u0144ski reports personal fees from Pfizer, Teva, Bausch, AbbVie, Neuca and Novartis for speaker activities. Claudio Tana is a member of the Editorial Board of The Journal of Headache and Pain and Editor of the Primary Care Section of Annals of Medicine. Paolo Martelletti is the Editor-in-Chief of The Journal of Headache and Pain and of SN Comprehensive Clinical Medicine. Paolo Martelletti and Raffaele Ornello are Editorial Board members of Neurology and Therapy. Paolo Martelletti and Raffaele Ornello were not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}