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Anna Pokryszko-Dragan served as a speaker for Biogen, Bristol Myers Squibb, Merck,\u00a0Novartis, Roche. Alina Ku\u0142akowska has received compensation for speaking and consulting services from Biogen,\u00a0Bayer, Novartis, Roche, Merck, Teva, Bristol Myers Squibb,\u00a0Janssen-Cilag, and Sanofi Genzyme. Katarzyna Kapica-Topczewska has participated as a speaker at meetings sponsored by Novartis, Biogen, and AstraZeneca. Waldemar Brola has been involved in scientific advisory boards for Biogen,\u00a0Roche, Novartis, and Merck and has received honoraria for lecturing from Biogen, Merck, Novartis, Sanofi Genzyme, and Roche. Ewa Krzystanek has received compensation for speaking and consulting services from Biogen, Bayer, Novartis, Roche, Merck, Teva, TG Therapeutics, and Sanofi-Genzyme. None of these are relevant to the present manuscript. The other authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The study was conducted in accordance with the Helsinki declaration; the protocol of the project had been approved by the Bioethical Committee of Wroclaw Medical University (opinion No 164\/2023). Written informed consent was obtained from all individual participants, prior to their inclusion in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}