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Inc, and the Charitable Hertie Foundation. He has received speaker\u2019s honoraria from UCB Pharma, Novartis, Sanofi, BIAL and MedUpdate and consulting fees from Bayer AG, Blue Rock Therapeutics and Coave Therapeutics, Ono Pharmaceutical, Lilly Deutschland GmbH, Roche Pharma AG, BIAL, Biogen MA Inc. and SciNeuro Therapeutics. Kathrin Brockmann has received research funding from the Michael J. Fox Foundation for Parkinson\u2019s Research, the German Society for Parkinson DPG, the Health Forum Baden Wuerttemberg, the Else Kr\u00f6ner-Fresenius-Stiftung, the University of Tuebingen, and from the German Research Foundation DFG. Kathrin Brockmann is a consultant for F. Hoffmann-La Roche Ltd., Vanqua Bio, and the Michael J. Fox Foundation for Parkinson\u2019s Research and has received speaker honoraria from Abbvie, Lundbeck, UCB and Zambon. Matthis Synofzik has received consultancy honoraria from UCB, Prevail, Orphazyme, Biogen, Servier, Reata, GenOrph, AviadoBio, Biohaven, Zevra, Lilly, Quince, Neurocrine, Insmed, and Solaxa, all unrelated to the present manuscript. Luis Concha-Marambio, Yihua Ma, and Carly M Farris are employees of Amprion and declares employee stock option ownership and invention of patents related to SAA technology assigned to Amprion. Roger Plaza-Clar, Maximilian Weber, Vaibhavi Kadam, Christian Deuschle, David Mengel, Marcello Rossi, Angela Mammana, Piero Parchi, have nothing to disclose.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Committee of the University of Tuebingen (353\/2022BO2). All participants gave written informed consent for participation in the study and for the use and publication of their anonymized data. This study was conducted in accordance with the principles of the Declaration of Helsinki.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}