{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:07:02Z","timestamp":1783544822600,"version":"3.55.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T00:00:00Z","timestamp":1558656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100007705","name":"Astellas Pharma Global Development","doi-asserted-by":"publisher","award":["123"],"award-info":[{"award-number":["123"]}],"id":[{"id":"10.13039\/100007705","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infect Dis Ther"],"published-print":{"date-parts":[[2019,9,1]]},"DOI":"10.1007\/s40121-019-0248-z","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T08:03:41Z","timestamp":1558685021000},"page":"429-444","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Polymerase Chain Reaction Versus Blood Culture to Detect Candida Species in High-Risk Patients with Suspected Invasive Candidiasis: The MICAFEM Study"],"prefix":"10.1007","volume":"8","author":[{"given":"Mercedes","family":"Nieto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Robles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Causse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Cruz Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricard","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Xercavins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenio","family":"Herrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Sirvent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Anguita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the MICAFEM Study Group, GEIPC (SEIMC) and GTEIS (SEMICYUC)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"248_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/2110-5820-1-37","volume":"1","author":"P Eggimann","year":"2011","unstructured":"Eggimann P, Bille J, Marchetti O. Diagnosis of invasive candidiasis in the ICU. Ann Intensive Care. 2011;1:37.","journal-title":"Ann Intensive Care."},{"key":"248_CR2","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.diagmicrobio.2012.06.012","volume":"73","author":"N Azie","year":"2012","unstructured":"Azie N, Neofytos D, Pfaller M, Meier-Kriesche HU, Quan SP, Horn D. The PATH (Prospective Antifungal Therapy) Alliance(R) registry and invasive fungal infections: update 2012. Diagn Microbiol Infect Dis. 2012;73:293\u2013300.","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"Suppl 6","key":"248_CR3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/1469-0691.12539","volume":"20","author":"J Guinea","year":"2014","unstructured":"Guinea J. Global trends in the distribution of Candida species causing candidemia. Clin Microbiol Infect. 2014;20(Suppl 6):5\u201310.","journal-title":"Clin Microbiol Infect"},{"key":"248_CR4","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s15010-013-0432-0","volume":"41","author":"MT Montagna","year":"2013","unstructured":"Montagna MT, Caggiano G, Lovero G, et al. Epidemiology of invasive fungal infections in the intensive care unit: results of a multicenter Italian survey (AURORA Project). Infection. 2013;41:645\u201353.","journal-title":"Infection"},{"key":"248_CR5","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1056\/NEJMra1315399","volume":"373","author":"BJ Kullberg","year":"2015","unstructured":"Kullberg BJ, Arendrup MC. Invasive candidiasis. N Engl J Med. 2015;373:1445\u201356.","journal-title":"N Engl J Med"},{"key":"248_CR6","first-page":"B4698","volume":"60","author":"MC Arendrup","year":"2013","unstructured":"Arendrup MC. Candida and candidaemia. Susceptibility and epidemiology. Dan Med J. 2013;60:B4698.","journal-title":"Dan Med J."},{"key":"248_CR7","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1086\/599039","volume":"48","author":"DL Horn","year":"2009","unstructured":"Horn DL, Neofytos D, Anaissie EJ, et al. Epidemiology and outcomes of candidemia in 2019 patients: data from the prospective antifungal therapy alliance registry. Clin Infect Dis. 2009;48:1695\u2013703.","journal-title":"Clin Infect Dis"},{"key":"248_CR8","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/CCM.0b013e318206c1ca","volume":"39","author":"DH Kett","year":"2011","unstructured":"Kett DH, Azoulay E, Echeverria PM, Vincent JL, Extended Prevalence of Infection in ICU Study (EPIC II) Group of Investigators. Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Crit Care Med. 2011;39:665\u201370.","journal-title":"Crit Care Med."},{"issue":"Suppl 6","key":"248_CR9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/1469-0691.12622","volume":"20","author":"M Ruhnke","year":"2014","unstructured":"Ruhnke M. Antifungal stewardship in invasive Candida infections. Clin Microbiol Infect. 2014;20(Suppl 6):11\u20138.","journal-title":"Clin Microbiol Infect"},{"key":"248_CR10","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.1517\/14656566.8.11.1643","volume":"8","author":"JJ Gagne","year":"2007","unstructured":"Gagne JJ, Goldfarb NI. Candidemia in the in-patient setting: treatment options and economics. Expert Opin Pharmacother. 2007;8:1643\u201350.","journal-title":"Expert Opin Pharmacother"},{"key":"248_CR11","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1086\/502581","volume":"26","author":"J Morgan","year":"2005","unstructured":"Morgan J, Meltzer MI, Plikaytis BD, et al. Excess mortality, hospital stay, and cost due to candidemia: a case-control study using data from population-based candidemia surveillance. Infect Control Hosp Epidemiol. 2005;26:540\u20137.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"248_CR12","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1086\/514955","volume":"27","author":"AM Rentz","year":"1998","unstructured":"Rentz AM, Halpern MT, Bowden R. The impact of candidemia on length of hospital stay, outcome, and overall cost of illness. Clin Infect Dis. 1998;27:781\u20138.","journal-title":"Clin Infect Dis"},{"key":"248_CR13","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1128\/CMR.00029-06","volume":"20","author":"MA Pfaller","year":"2007","unstructured":"Pfaller MA, Diekema DJ. Epidemiology of invasive candidiasis: a persistent public health problem. Clin Microbiol Rev. 2007;20:133\u201363.","journal-title":"Clin Microbiol Rev"},{"key":"248_CR14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2334-13-10","volume":"13","author":"SP Yang","year":"2013","unstructured":"Yang SP, Chen YY, Hsu HS, Wang FD, Chen LY, Fung CP. A risk factor analysis of healthcare-associated fungal infections in an intensive care unit: a retrospective cohort study. BMC Infect Dis. 2013;13:10.","journal-title":"BMC Infect Dis"},{"issue":"554","key":"248_CR15","first-page":"e1","volume":"33","author":"A Holley","year":"2009","unstructured":"Holley A, Dulhunty J, Blot S, et al. Temporal trends, risk factors and outcomes in albicans and non-albicans candidaemia: an international epidemiological study in four multidisciplinary intensive care units. Int J Antimicrob Agents. 2009;33(554):e1\u20137.","journal-title":"Int J Antimicrob Agents"},{"key":"248_CR16","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/j.1439-0507.2007.01366.x","volume":"50","author":"R Jorda-Marcos","year":"2007","unstructured":"Jorda-Marcos R, Alvarez-Lerma F, Jurado M, et al. Risk factors for candidaemia in critically ill patients: a prospective surveillance study. Mycoses. 2007;50:302\u201310.","journal-title":"Mycoses"},{"key":"248_CR17","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1097\/01.CCM.0000202208.37364.7D","volume":"34","author":"C Leon","year":"2006","unstructured":"Leon C, Ruiz-Santana S, Saavedra P, et al. A bedside scoring system (\u201cCandida score\u201d) for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization. Crit Care Med. 2006;34:730\u20137.","journal-title":"Crit Care Med"},{"key":"248_CR18","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1097\/CCM.0b013e31819daa14","volume":"37","author":"C Leon","year":"2009","unstructured":"Leon C, Ruiz-Santana S, Saavedra P, et al. Usefulness of the \u201cCandida score\u201d for discriminating between Candida colonization and invasive candidiasis in non-neutropenic critically ill patients: a prospective multicenter study. Crit Care Med. 2009;37:1624\u201333.","journal-title":"Crit Care Med"},{"key":"248_CR19","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1097\/00000658-199412000-00008","volume":"220","author":"D Pittet","year":"1994","unstructured":"Pittet D, Monod M, Suter PM, Frenk E, Auckenthaler R. Candida colonization and subsequent infections in critically ill surgical patients. Ann Surg. 1994;220:751\u20138.","journal-title":"Ann Surg"},{"key":"248_CR20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13054-016-1313-6","volume":"20","author":"T Calandra","year":"2016","unstructured":"Calandra T, Roberts JA, Antonelli M, Bassetti M, Vincent JL. Diagnosis and management of invasive candidiasis in the ICU: an updated approach to an old enemy. Crit Care. 2016;20:125.","journal-title":"Crit Care"},{"key":"248_CR21","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/j.ccc.2013.06.007","volume":"29","author":"Y Skrobik","year":"2013","unstructured":"Skrobik Y, Laverdiere M. Why Candida sepsis should matter to ICU physicians. Crit Care Clin. 2013;29:853\u201364.","journal-title":"Crit Care Clin"},{"key":"248_CR22","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1097\/CCM.0b013e31819efac0","volume":"37","author":"O Leroy","year":"2009","unstructured":"Leroy O, Gangneux JP, Montravers P, et al. Epidemiology, management, and risk factors for death of invasive Candida infections in critical care: a multicenter, prospective, observational study in France (2005\u20132006). Crit Care Med. 2009;37:1612\u20138.","journal-title":"Crit Care Med"},{"key":"248_CR23","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1086\/421946","volume":"39","author":"H Wisplinghoff","year":"2004","unstructured":"Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin Infect Dis. 2004;39:309\u201317.","journal-title":"Clin Infect Dis"},{"key":"248_CR24","doi-asserted-by":"publisher","first-page":"2519","DOI":"10.1097\/CCM.0b013e3181a0f95d","volume":"37","author":"AF Shorr","year":"2009","unstructured":"Shorr AF, Gupta V, Sun X, Johannes RS, Spalding J, Tabak YP. Burden of early-onset candidemia: analysis of culture-positive bloodstream infections from a large U.S. database. Crit Care Med. 2009;37:2519\u201326 (quiz 35).","journal-title":"Crit Care Med."},{"key":"248_CR25","doi-asserted-by":"publisher","first-page":"3134","DOI":"10.1093\/jac\/dku225","volume":"69","author":"J Fortun","year":"2014","unstructured":"Fortun J, Meije Y, Buitrago MJ, et al. Clinical validation of a multiplex real-time PCR assay for detection of invasive candidiasis in intensive care unit patients. J Antimicrob Chemother. 2014;69:3134\u201341.","journal-title":"J Antimicrob Chemother"},{"key":"248_CR26","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.eimc.2012.02.006","volume":"30","author":"PM Olaechea-Astigarraga","year":"2012","unstructured":"Olaechea-Astigarraga PM, Alvarez-Lerma F, Palomar-Martinez M, et al. Trends in systemic antifungal use in critically ill patients. Multicenter observational study, 2006\u20132010. Enferm Infecc Microbiol Clin. 2012;30:435\u201340.","journal-title":"Enferm Infecc Microbiol Clin."},{"key":"248_CR27","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1097\/CCM.0b013e318236f297","volume":"40","author":"E Azoulay","year":"2012","unstructured":"Azoulay E, Dupont H, Tabah A, et al. Systemic antifungal therapy in critically ill patients without invasive fungal infection. Crit Care Med. 2012;40:813\u201322.","journal-title":"Crit Care Med"},{"issue":"Suppl 7","key":"248_CR28","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/1469-0691.12039","volume":"18","author":"OA Cornely","year":"2012","unstructured":"Cornely OA, Bassetti M, Calandra T, et al. ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect. 2012;18(Suppl 7):19\u201337.","journal-title":"Clin Microbiol Infect"},{"key":"248_CR29","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1093\/cid\/ciy149","volume":"66","author":"LC McDonald","year":"2018","unstructured":"McDonald LC, Gerding DN, Johnson S, et al. Clinical practice guidelines for clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis. 2018;66:987\u201394.","journal-title":"Clin Infect Dis"},{"key":"248_CR30","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/civ933","volume":"62","author":"P Pappas","year":"2016","unstructured":"Pappas P, Kauffman C, Andes D, et al. Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;62:e1\u201350.","journal-title":"Clin Infect Dis"},{"key":"248_CR31","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1097\/QCO.0000000000000215","volume":"28","author":"RK Shields","year":"2015","unstructured":"Shields RK, Nguyen MH, Clancy CJ. Clinical perspectives on echinocandin resistance among Candida species. Curr Opin Infect Dis. 2015;28:514\u201322.","journal-title":"Curr Opin Infect Dis"},{"issue":"Suppl 2","key":"248_CR32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1111\/myc.12329","volume":"58","author":"P Munoz","year":"2015","unstructured":"Munoz P, Valerio M, Vena A, Bouza E. Antifungal stewardship in daily practice and health economic implications. Mycoses. 2015;58(Suppl 2):14\u201325.","journal-title":"Mycoses"},{"key":"248_CR33","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1086\/504810","volume":"43","author":"KW Garey","year":"2006","unstructured":"Garey KW, Rege M, Pai MP, et al. Time to initiation of fluconazole therapy impacts mortality in patients with candidemia: a multi-institutional study. Clin Infect Dis. 2006;43:25\u201331.","journal-title":"Clin Infect Dis"},{"key":"248_CR34","doi-asserted-by":"publisher","first-page":"3640","DOI":"10.1128\/AAC.49.9.3640-3645.2005","volume":"49","author":"M Morrell","year":"2005","unstructured":"Morrell M, Fraser VJ, Kollef MH. Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother. 2005;49:3640\u20135.","journal-title":"Antimicrob Agents Chemother"},{"key":"248_CR35","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1093\/cid\/cit006","volume":"56","author":"CJ Clancy","year":"2013","unstructured":"Clancy CJ, Nguyen MH. Finding the \u201cmissing 50%\u201d of invasive candidiasis: how nonculture diagnostics will improve understanding of disease spectrum and transform patient care. Clin Infect Dis. 2013;56:1284\u201392.","journal-title":"Clin Infect Dis"},{"key":"248_CR36","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1128\/JCM.01602-10","volume":"49","author":"T Avni","year":"2011","unstructured":"Avni T, Leibovici L, Paul M. PCR diagnosis of invasive candidiasis: systematic review and meta-analysis. J Clin Microbiol. 2011;49:665\u201370.","journal-title":"J Clin Microbiol"},{"key":"248_CR37","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1586\/eri.12.128","volume":"10","author":"J Peman","year":"2012","unstructured":"Peman J, Zaragoza R. Combined use of nonculture-based lab techniques in the diagnosis and management of critically ill patients with invasive fungal infections. Expert Rev Anti Infect Ther. 2012;10:1321\u201330.","journal-title":"Expert Rev Anti Infect Ther."},{"key":"248_CR38","doi-asserted-by":"publisher","first-page":"276","DOI":"10.11613\/BM.2012.031","volume":"22","author":"ML McHugh","year":"2012","unstructured":"McHugh ML. Interrater reliability: the kappa statistic. Biochem Med (Zagreb). 2012;22:276\u201382.","journal-title":"Biochem Med (Zagreb)."},{"key":"248_CR39","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.1128\/JCM.00496-17","volume":"55","author":"JT Ramos","year":"2017","unstructured":"Ramos JT, Villar S, Bouza E, et al. Performance of a quantitative PCR-based assay and beta-d-glucan detection for diagnosis of invasive candidiasis in very-low-birth-weight preterm neonatal patients (CANDINEO Study). J Clin Microbiol. 2017;55:2752\u201364.","journal-title":"J Clin Microbiol"},{"key":"248_CR40","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13054-016-1324-3","volume":"20","author":"C Leon","year":"2016","unstructured":"Leon C, Ruiz-Santana S, Saavedra P, et al. Contribution of Candida biomarkers and DNA detection for the diagnosis of invasive candidiasis in ICU patients with severe abdominal conditions. Crit Care. 2016;20:149.","journal-title":"Crit Care"},{"key":"248_CR41","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s10096-016-2658-0","volume":"35","author":"L Lagunes","year":"2016","unstructured":"Lagunes L, Rello J. Invasive candidiasis: from mycobiome to infection, therapy, and prevention. Eur J Clin Microbiol Infect Dis. 2016;35:1221\u20136.","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"248_CR42","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1093\/cid\/cis200","volume":"54","author":"MH Nguyen","year":"2012","unstructured":"Nguyen MH, Wissel MC, Shields RK, et al. Performance of Candida real-time polymerase chain reaction, beta-d-glucan assay, and blood cultures in the diagnosis of invasive candidiasis. Clin Infect Dis. 2012;54:1240\u20138.","journal-title":"Clin Infect Dis"}],"container-title":["Infectious Diseases and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40121-019-0248-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40121-019-0248-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40121-019-0248-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T18:08:20Z","timestamp":1720116500000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40121-019-0248-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,24]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9,1]]}},"alternative-id":["248"],"URL":"https:\/\/doi.org\/10.1007\/s40121-019-0248-z","relation":{},"ISSN":["2193-8229","2193-6382"],"issn-type":[{"value":"2193-8229","type":"print"},{"value":"2193-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,24]]},"assertion":[{"value":"11 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2019","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}