{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:44:37Z","timestamp":1790837077503,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Consejer\u00eda de Desarrollo Econ\u00f3mico de La Rioja","award":["ORDEN 27\/2018"],"award-info":[{"award-number":["ORDEN 27\/2018"]}]},{"name":"Consejer\u00eda de Desarrollo Econ\u00f3mico de La Rioja","award":["DE ABRIL DE 2018"],"award-info":[{"award-number":["DE ABRIL DE 2018"]}]},{"name":"Fundaci\u00f3n Rioja Salud"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infect Dis Ther"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s40121-022-00654-4","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T19:02:56Z","timestamp":1653591776000},"page":"1541-1557","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Integrase Inhibitors Partially Restore Bacterial Translocation, Inflammation and Gut Permeability Induced by HIV Infection: Impact on Gut Microbiota"],"prefix":"10.1007","volume":"11","author":[{"given":"Pablo","family":"Villoslada-Blanco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2232-7971","authenticated-orcid":false,"given":"Patricia","family":"P\u00e9rez-Matute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"\u00cd\u00f1iguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Recio-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Blanco-Navarrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Metola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valvanera","family":"Ibarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Alba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"de Toro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Oteo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"654_CR1","doi-asserted-by":"crossref","unstructured":"Wandeler G, Johnson LF, Egger M. Trends in life expectancy of HIV-positive adults on ART across the globe: comparisons with general population. Curr Opin HIV AIDS. 2016;11:492.","DOI":"10.1097\/COH.0000000000000298"},{"key":"654_CR2","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1016\/S0140-6736(13)61809-7","volume":"382","author":"SG Deeks","year":"2013","unstructured":"Deeks SG, Lewin SR, Havlir DV. The end of AIDS: HIV infection as a chronic disease. Lancet. 2013;382:1523\u201333.","journal-title":"Lancet"},{"key":"654_CR3","doi-asserted-by":"crossref","unstructured":"Ancona G, Merlini E, Tincati C, et al. Long-term suppressive cART is not sufficient to restore intestinal permeability and gut microbiota compositional changes. Front Immunol Front. 2021;12:459.","DOI":"10.3389\/fimmu.2021.639291"},{"key":"654_CR4","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/QAI.0000000000002185","volume":"82","author":"SM Zaidan","year":"2019","unstructured":"Zaidan SM, Leyre L, Bunet R, et al. Upregulation of IL-32 isoforms in virologically-suppressed HIV-infected individuals: potential role in persistent inflammation and transcription from stable HIV-1 reservoirs. J Acquir Immune Defic Syndr. 2019;82:503.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"654_CR5","doi-asserted-by":"publisher","first-page":"6837","DOI":"10.3390\/ijerph18136837","volume":"18","author":"P Villoslada-Blanco","year":"2021","unstructured":"Villoslada-Blanco P, P\u00e9rez-Matute P, Oteo JA. Lights and shadows of microbiota modulation and cardiovascular risk in HIV patients. Int J Environ Res Public Health. 2021;18:6837.","journal-title":"Int J Environ Res Public Health"},{"key":"654_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12866-020-02060-7","volume":"21","author":"Y Xie","year":"2021","unstructured":"Xie Y, Sun J, Wei L, et al. Altered gut microbiota correlate with different immune responses to HAART in HIV-infected individuals. BMC Microbiol. 2021;21:1\u201312.","journal-title":"BMC Microbiol"},{"key":"654_CR7","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1097\/COH.0000000000000234","volume":"11","author":"AS Zevin","year":"2016","unstructured":"Zevin AS, McKinnon L, Burgener A, Klatt NR. Microbial translocation and microbiome dysbiosis in HIV-associated immune activation. Curr Opin HIV AIDS. 2016;11:182\u201390.","journal-title":"Curr Opin HIV AIDS"},{"key":"654_CR8","doi-asserted-by":"publisher","first-page":"21526","DOI":"10.7448\/IAS.20.1.21526","volume":"20","author":"MJ Villanueva-Mill\u00e1n","year":"2017","unstructured":"Villanueva-Mill\u00e1n MJ, P\u00e9rez-Matute P, Recio-Fern\u00e1ndez E, Rosales JML, Oteo JA. Differential effects of antiretrovirals on microbial translocation and gut microbiota composition of HIV-infected patients. J Int AIDS Soc. 2017;20:21526.","journal-title":"J Int AIDS Soc"},{"key":"654_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-80247-8","volume":"11","author":"M Imahashi","year":"2021","unstructured":"Imahashi M, Ode H, Kobayashi A, et al. Impact of long-term antiretroviral therapy on gut and oral microbiotas in HIV-1-infected patients. Sci Rep. 2021;11:1\u201310.","journal-title":"Sci Rep"},{"key":"654_CR10","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ejim.2019.06.005","volume":"67","author":"P P\u00e9rez-Matute","year":"2019","unstructured":"P\u00e9rez-Matute P, \u00cd\u00f1iguez M, Villanueva-Mill\u00e1n MJ, et al. Short-term effects of direct-acting antiviral agents on inflammation and gut microbiota in hepatitis\u00a0C-infected patients. Eur J Intern Med. 2019;67:47\u201358.","journal-title":"Eur J Intern Med"},{"key":"654_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s40168-017-0312-4","volume":"5","author":"JA Caparr\u00f3s-Mart\u00edn","year":"2017","unstructured":"Caparr\u00f3s-Mart\u00edn JA, Lareu RR, Ramsay JP, et al. Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism. Microbiome. 2017;5:95.","journal-title":"Microbiome"},{"key":"654_CR12","first-page":"G488","volume":"312","author":"JA Nolan","year":"2017","unstructured":"Nolan JA, Skuse PH, Govindarajan K, et al. The influence of rosuvastatin upon the gastrointestinal microbiota and host gene expression profiles. Am J Physiol Circ Physiol. 2017;312:G488\u201397.","journal-title":"Am J Physiol Circ Physiol"},{"key":"654_CR13","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/BF00280883","volume":"28","author":"DR Matthews","year":"1985","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412\u20139.","journal-title":"Diabetologia"},{"key":"654_CR14","unstructured":"Qiime2. Available from: https:\/\/qiime2.org\/. Accessed 17 Oct 2021."},{"key":"654_CR15","unstructured":"SILVA. Available from: https:\/\/www.arb-silva.de\/. Accessed 17 Oct 2021."},{"key":"654_CR16","first-page":"27663","volume":"26","author":"S Mandal","year":"2015","unstructured":"Mandal S, Van Treuren W, White RA, Eggesb\u00f8 M, Knight R, Peddada SD. Analysis of composition of microbiomes: a novel method for studying microbial composition. Microb Ecol Health Dis. 2015;26:27663.","journal-title":"Microb Ecol Health Dis"},{"key":"654_CR17","unstructured":"EEUU HIV guidelines. Available from: https:\/\/clinicalinfo.hiv.gov\/en\/guidelines. Accessed 22 Apr 2022."},{"key":"654_CR18","unstructured":"EACS guidelines. Available from: https:\/\/eacs.sanfordguide.com\/. Accessed 22 Apr 2022."},{"key":"654_CR19","unstructured":"GESIDA guidelines. Available from: https:\/\/gesida-seimc.org\/category\/guias-clinicas\/. Accessed 22 Apr 2022."},{"key":"654_CR20","doi-asserted-by":"crossref","unstructured":"Richter E, Bornemann L, Korencak M, et al. Reduction of CD8 T cell functionality but not inhibitory capacity by integrase inhibitors. J Virol Am Soc Microbiol. 2022;JVI-01730.","DOI":"10.1128\/jvi.01730-21"},{"key":"654_CR21","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.1210\/jc.2006-2190","volume":"92","author":"VA Triant","year":"2007","unstructured":"Triant VA, Lee H, Hadigan C, Grinspoon SK. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab. 2007;92:2506\u201312.","journal-title":"J Clin Endocrinol Metab"},{"key":"654_CR22","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1093\/infdis\/jiq118","volume":"203","author":"NG Sandler","year":"2011","unstructured":"Sandler NG, Wand H, Roque A, et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis. 2011;203:780\u201390.","journal-title":"J Infect Dis"},{"key":"654_CR23","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1093\/infdis\/jir520","volume":"204","author":"TH Burdo","year":"2011","unstructured":"Burdo TH, Lo J, Abbara S, et al. Soluble CD163, a novel marker of activated macrophages, is elevated and associated with noncalcified coronary plaque in HIV-infected patients. J Infect Dis. 2011;204:1227\u201336.","journal-title":"J Infect Dis"},{"key":"654_CR24","doi-asserted-by":"publisher","first-page":"154884","DOI":"10.1016\/j.cyto.2019.154884","volume":"126","author":"E Quiros-Roldan","year":"2020","unstructured":"Quiros-Roldan E, Castelli F, Bonito A, et al. The impact of integrase inhibitor-based regimens on markers of inflammation among HIV na\u00efve patients. Cytokine. 2020;126:154884.","journal-title":"Cytokine"},{"key":"654_CR25","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1097\/QAI.0000000000002357","volume":"84","author":"JA O\u2019Halloran","year":"2020","unstructured":"O\u2019Halloran JA, Sahrmann J, Butler AM, Olsen MA, Powderly WG. Brief report: integrase strand transfer inhibitors are associated with lower risk of incident cardiovascular disease in people living with HIV. J Acquir Immune Defic Syndr. 2020;84:396\u20139.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"654_CR26","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1080\/10408363.2019.1619159","volume":"56","author":"A Ricciuto","year":"2019","unstructured":"Ricciuto A, Griffiths AM. Clinical value of fecal calprotectin. Crit Rev Clin Lab Sci. 2019;56:307\u201320.","journal-title":"Crit Rev Clin Lab Sci"},{"key":"654_CR27","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1097\/QAI.0000000000002538","volume":"86","author":"AR Eckard","year":"2021","unstructured":"Eckard AR, Hughes HY, Hagood NL, et al. Fecal calprotectin is elevated in HIV and related to systemic inflammation. J Acquir Immune Defic Syndr. 2021;86:231\u20139.","journal-title":"J Acquir Immune Defic Syndr"},{"key":"654_CR28","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1093\/cid\/ciz258","volume":"70","author":"SA Tuddenham","year":"2020","unstructured":"Tuddenham SA, Koay WLA, Zhao N, White JR, Ghanem KG, Sears CL. The impact of human immunodeficiency virus infection on gut microbiota \u03b1-diversity: an individual-level meta-analysis. Clin Infect Dis. 2020;70:615\u201327.","journal-title":"Clin Infect Dis"},{"key":"654_CR29","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s40121-014-0047-5","volume":"3","author":"PG Clay","year":"2014","unstructured":"Clay PG, Crutchley RD. Noninfectious diarrhea in HIV seropositive individuals: a review of prevalence rates, etiology, and management in the era of combination antiretroviral therapy. Infect Dis Ther. 2014;3:103\u201322.","journal-title":"Infect Dis Ther"},{"key":"654_CR30","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/QCO.0000000000000026","volume":"27","author":"NM Archin","year":"2014","unstructured":"Archin NM, Margolis DM. Emerging strategies to deplete the HIV reservoir. Curr Opin Infect Dis. 2014;27:29.","journal-title":"Curr Opin Infect Dis"},{"key":"654_CR31","first-page":"30","volume":"11","author":"A Hill","year":"2009","unstructured":"Hill A, Balkin A. Risk factors for gastrointestinal adverse events in HIV treated and untreated patients. AIDS Rev. 2009;11:30\u20138.","journal-title":"AIDS Rev"},{"key":"654_CR32","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1007\/s10461-007-9229-4","volume":"11","author":"MO Johnson","year":"2007","unstructured":"Johnson MO, Neilands TB. Coping with HIV treatment side effects: conceptualization, measurement, and linkages. AIDS Behav. 2007;11:575\u201385.","journal-title":"AIDS Behav"},{"key":"654_CR33","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/imm.12760","volume":"151","author":"JM Larsen","year":"2017","unstructured":"Larsen JM. The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017;151:363\u201374.","journal-title":"Immunology"},{"key":"654_CR34","doi-asserted-by":"publisher","first-page":"645","DOI":"10.3389\/fimmu.2020.00645","volume":"11","author":"J Ouyang","year":"2020","unstructured":"Ouyang J, Lin J, Isnard S, et al. The bacterium Akkermansia muciniphila: a sentinel for gut permeability and its relevance to HIV-related inflammation. Front Immunol. 2020;11:645.","journal-title":"Front Immunol"},{"key":"654_CR35","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.biopha.2018.10.118","volume":"109","author":"YI Mahmoud","year":"2019","unstructured":"Mahmoud YI, Abd El-Ghffar EA. Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. Biomed Pharmacother. 2019;109:314\u201321.","journal-title":"Biomed Pharmacother"},{"key":"654_CR36","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1006\/eesa.1999.1862","volume":"45","author":"DJ Schaeffer","year":"2000","unstructured":"Schaeffer DJ, Krylov VS. Anti-HIV activity of extracts and compounds from algae and cyanobacteria. Ecotoxicol Environ Saf. 2000;45:208\u201327.","journal-title":"Ecotoxicol Environ Saf"},{"key":"654_CR37","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1128\/CMR.00008-07","volume":"20","author":"HM Wexler","year":"2007","unstructured":"Wexler HM. Bacteroides: the good, the bad, and the nitty-gritty. Clin Microbiol Rev. 2007;20:593\u2013621.","journal-title":"Clin Microbiol Rev"},{"key":"654_CR38","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.micpath.2016.05.015","volume":"106","author":"G Dubourg","year":"2017","unstructured":"Dubourg G, Surenaud M, L\u00e9vy Y, H\u00fce S, Raoult D. Microbiome of HIV-infected people. Microb Pathog. 2017;106:85\u201393.","journal-title":"Microb Pathog"},{"key":"654_CR39","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/microorganisms7030078","volume":"7","author":"P Qin","year":"2019","unstructured":"Qin P, Zou Y, Dai Y, Luo G, Zhang X, Xiao L. Characterization a novel butyric acid-producing bacterium Collinsella aerofaciens Subsp. Shenzhenensis Subsp. Nov. Microorganisms. 2019;7:78.","journal-title":"Microorganisms"},{"key":"654_CR40","first-page":"925","volume":"7","author":"A O\u2019Callaghan","year":"2016","unstructured":"O\u2019Callaghan A, van Sinderen D. Bifidobacteria and their role as members of the human gut microbiota. Front Microbiol. 2016;7:925.","journal-title":"Front Microbiol"},{"key":"654_CR41","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.pharmthera.2016.04.007","volume":"164","author":"S Sivaprakasam","year":"2016","unstructured":"Sivaprakasam S, Prasad PD, Singh N. Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis. Pharmacol Ther. 2016;164:144\u201351.","journal-title":"Pharmacol Ther"},{"key":"654_CR42","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/nature08530","volume":"461","author":"KM Maslowski","year":"2009","unstructured":"Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009;461:1282\u20136.","journal-title":"Nature"},{"key":"654_CR43","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/carcin\/bgr254","volume":"33","author":"JM Clarke","year":"2012","unstructured":"Clarke JM, Young GP, Topping DL, et al. Butyrate delivered by butyrylated starch increases distal colonic epithelial apoptosis in carcinogen-treated rats. Carcinogenesis. 2012;33:197\u2013202.","journal-title":"Carcinogenesis"},{"key":"654_CR44","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.3389\/fimmu.2020.01390","volume":"11","author":"M Saresella","year":"2020","unstructured":"Saresella M, Marventano I, Barone M, et al. Alterations in circulating fatty acid are associated with gut microbiota dysbiosis and inflammation in multiple sclerosis. Front Immunol. 2020;11:1390.","journal-title":"Front Immunol"},{"key":"654_CR45","doi-asserted-by":"publisher","first-page":"3582","DOI":"10.1128\/AEM.70.6.3582-3587.2004","volume":"70","author":"F Van Immerseel","year":"2004","unstructured":"Van Immerseel F, De Buck J, Boyen F, et al. Medium-chain fatty acids decrease colonization and invasion through hilA suppression shortly after infection of chickens with Salmonella enterica serovar Enteritidis. Appl Environ Microbiol. 2004;70:3582\u20137.","journal-title":"Appl Environ Microbiol"}],"container-title":["Infectious Diseases and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40121-022-00654-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40121-022-00654-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40121-022-00654-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T07:59:34Z","timestamp":1659081574000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40121-022-00654-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["654"],"URL":"https:\/\/doi.org\/10.1007\/s40121-022-00654-4","relation":{},"ISSN":["2193-8229","2193-6382"],"issn-type":[{"value":"2193-8229","type":"print"},{"value":"2193-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]},"assertion":[{"value":"24 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}