{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:23:06Z","timestamp":1784258586976,"version":"3.55.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:00:00Z","timestamp":1706054400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Innovative Clinical Technique of Guangzhou","award":["2019GX04"],"award-info":[{"award-number":["2019GX04"]}]},{"name":"2019 Annual Research Project of The China Marrow Donor Program","award":["CMDP201902"],"award-info":[{"award-number":["CMDP201902"]}]},{"name":"Guang Zhou Basic and Applied Basic Research Foundation","award":["202201010062"],"award-info":[{"award-number":["202201010062"]}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202002030035"],"award-info":[{"award-number":["202002030035"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2018A0303130179"],"award-info":[{"award-number":["2018A0303130179"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and Technology Projects in Guangzhou","award":["202201010062"],"award-info":[{"award-number":["202201010062"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infect Dis Ther"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s40121-024-00917-2","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T14:14:08Z","timestamp":1706105648000},"page":"345-359","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Letermovir Effectively Prevents Cytomegalovirus Infection in Patients with Aplastic Anemia After Hematopoietic Stem Cell Transplantation: A Real-World Retrospective Cohort Study"],"prefix":"10.1007","volume":"13","author":[{"given":"Yuling","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cunte","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingfen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,24]]},"reference":[{"issue":"1","key":"917_CR1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1365-2141.2009.07842.x","volume":"147","author":"JC Marsh","year":"2009","unstructured":"Marsh JC, Ball SE, Cavenagh J, et al. Guidelines for the diagnosis and management of aplastic anaemia. Br J Haematol. 2009;147(1):43\u201370.","journal-title":"Br J Haematol"},{"issue":"9","key":"917_CR2","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/S1083-8791(03)00287-8","volume":"9","author":"M Boeckh","year":"2003","unstructured":"Boeckh M, Nichols WG, Papanicolaou G, et al. Cytomegalovirus in hematopoietic stem cell transplant recipients: Current status, known challenges, and future strategies. Biol Blood Marrow Transplant. 2003;9(9):543\u201358.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"917_CR3","doi-asserted-by":"publisher","first-page":"e119","DOI":"10.1016\/S2352-3026(15)00289-6","volume":"3","author":"ML Green","year":"2016","unstructured":"Green ML, Leisenring W, Xie H, et al. Cytomegalovirus viral load and mortality after haemopoietic stem cell transplantation in the era of pre-emptive therapy: a retrospective cohort study. Lancet Haematol. 2016;3(3):e119\u201327.","journal-title":"Lancet Haematol"},{"issue":"20","key":"917_CR4","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1182\/blood-2015-11-679639","volume":"127","author":"P Teira","year":"2016","unstructured":"Teira P, Battiwalla M, Ramanathan M, et al. Early cytomegalovirus reactivation remains associated with increased transplant-related mortality in the current era: a CIBMTR analysis. Blood. 2016;127(20):2427\u201338.","journal-title":"Blood"},{"issue":"1","key":"917_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/s13045-017-0398-y","volume":"10","author":"LP Xu","year":"2017","unstructured":"Xu LP, Jin S, Wang SQ, et al. Upfront haploidentical transplant for acquired severe aplastic anemia: registry-based comparison with matched related transplant. J Hematol Oncol. 2017;10(1):25.","journal-title":"J Hematol Oncol"},{"key":"917_CR6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev-med-042921-124739","volume":"74","author":"JL Saullo","year":"2023","unstructured":"Saullo JL, Miller RA. Cytomegalovirus therapy: role of letermovir in prophylaxis and treatment in transplant recipients. Annu Rev Med. 2023;74:89\u2013105.","journal-title":"Annu Rev Med"},{"key":"917_CR7","doi-asserted-by":"publisher","first-page":"900154","DOI":"10.3389\/fcimb.2022.900154","volume":"12","author":"W Mo","year":"2022","unstructured":"Mo W, Chen X, Zhang X, et al. The potential association of delayed t lymphocyte reconstitution within six months post-transplantation with the risk of cytomegalovirus retinitis in severe aplastic anemia recipients. Front Cell Infect Microbiol. 2022;12:900154.","journal-title":"Front Cell Infect Microbiol"},{"issue":"7","key":"917_CR8","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1182\/blood-2013-02-487074","volume":"122","author":"ML Green","year":"2013","unstructured":"Green ML, Leisenring WM, Xie H, et al. CMV reactivation after allogeneic HCT and relapse risk: evidence for early protection in acute myeloid leukemia. Blood. 2013;122(7):1316\u201324.","journal-title":"Blood"},{"issue":"8","key":"917_CR9","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1016\/j.bbmt.2019.03.020","volume":"25","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Wu L, Mo W, et al. Comparable outcomes of first-line hematopoietic stem cell transplantation from unrelated and matched sibling donors in adult patients with aplastic anemia: a retrospective single-center study. Biol Blood Marrow Transplant. 2019;25(8):1567\u201375.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"3","key":"917_CR10","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13810","volume":"34","author":"YY Zhang","year":"2020","unstructured":"Zhang YY, Mo WJ, Zuo YY, et al. Comparable survival outcome between transplantation from haploidentical donor and matched related donor or unrelated donor for severe aplastic anemia patients aged 40 years and older: A retrospective multicenter cohort study. Clin Transplant. 2020;34(3): e13810.","journal-title":"Clin Transplant"},{"issue":"8","key":"917_CR11","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1080\/21505594.2016.1221022","volume":"7","author":"E Blyth","year":"2016","unstructured":"Blyth E, Withers B, Clancy L, et al. CMV-specific immune reconstitution following allogeneic stem cell transplantation. Virulence. 2016;7(8):967\u201380.","journal-title":"Virulence"},{"issue":"25","key":"917_CR12","doi-asserted-by":"publisher","first-page":"2433","DOI":"10.1056\/NEJMoa1706640","volume":"377","author":"FM Marty","year":"2017","unstructured":"Marty FM, Ljungman P, Chemaly RF, et al. Letermovir prophylaxis for cytomegalovirus in hematopoietic-cell transplantation. N Engl J Med. 2017;377(25):2433\u201344.","journal-title":"N Engl J Med"},{"issue":"5","key":"917_CR13","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1358\/dof.2013.38.5.1946425","volume":"38","author":"PS Verghese","year":"2013","unstructured":"Verghese PS, Schleiss MR. Letermovir treatment of human cytomegalovirus infection antiinfective agent. Drugs Future. 2013;38(5):291\u20138.","journal-title":"Drugs Future"},{"issue":"8","key":"917_CR14","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1086\/339329","volume":"34","author":"P Ljungman","year":"2002","unstructured":"Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis. 2002;34(8):1094\u20137.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"917_CR15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/cid\/ciw668","volume":"64","author":"P Ljungman","year":"2017","unstructured":"Ljungman P, Boeckh M, Hirsch HH, et al. Definitions of cytomegalovirus infection and disease in transplant patients for use in clinical trials. Clin Infect Dis. 2017;64(1):87\u201391.","journal-title":"Clin Infect Dis"},{"key":"917_CR16","first-page":"333","volume":"325","author":"C Powers","year":"2008","unstructured":"Powers C, Defilippis V, Malouli D, et al. Cytomegalovirus immune evasion. Curr Top Microbiol Immunol. 2008;325:333\u201359.","journal-title":"Curr Top Microbiol Immunol"},{"issue":"4","key":"917_CR17","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1093\/cid\/ciu364","volume":"59","author":"P Ljungman","year":"2014","unstructured":"Ljungman P, Brand R, Hoek J, et al. Donor cytomegalovirus status influences the outcome of allogeneic stem cell transplant: a study by the European group for blood and marrow transplantation. Clin Infect Dis. 2014;59(4):473\u201381.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"917_CR18","doi-asserted-by":"publisher","first-page":"263","DOI":"10.2478\/ahp-2020-0046","volume":"51","author":"J Styczy\u0144ski","year":"2020","unstructured":"Styczy\u0144ski J, Czy\u017cewski K, D\u0119bski R. Primary prophylaxis with letermovir for prevention of CMV infection in two children. Acta Haematol Pol. 2020;51(4):263\u20134.","journal-title":"Acta Haematol Pol"},{"key":"917_CR19","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.2147\/IDR.S296927","volume":"14","author":"A Chiereghin","year":"2021","unstructured":"Chiereghin A, Belotti T, Borgatti EC, et al. Off-label use of letermovir as preemptive anti-cytomegalovirus therapy in a pediatric allogeneic peripheral blood stem cell transplant. Infect Drug Resist. 2021;14:1185\u201390.","journal-title":"Infect Drug Resist"},{"issue":"7","key":"917_CR20","doi-asserted-by":"publisher","first-page":"3607","DOI":"10.21873\/anticanres.15848","volume":"42","author":"M Richert-Przygonska","year":"2022","unstructured":"Richert-Przygonska M, Jaremek K, Debski R, et al. Letermovir prophylaxis for cytomegalovirus infection in children after hematopoietic cell transplantation. Anticancer Res. 2022;42(7):3607\u201312.","journal-title":"Anticancer Res"},{"issue":"7","key":"917_CR21","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1093\/jpids\/piac017","volume":"11","author":"NP Daukshus","year":"2022","unstructured":"Daukshus NP, Cirincione A, Siver M, et al. Letermovir for cytomegalovirus prevention in adolescent patients following hematopoietic cell transplantation. J Pediatric Infect Dis Soc. 2022;11(7):337\u201340.","journal-title":"J Pediatric Infect Dis Soc"},{"issue":"4","key":"917_CR22","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/s41409-020-01082-z","volume":"56","author":"Y Mori","year":"2021","unstructured":"Mori Y, Jinnouchi F, Takenaka K, et al. Efficacy of prophylactic letermovir for cytomegalovirus reactivation in hematopoietic cell transplantation: a multicenter real-world data. Bone Marrow Transplant. 2021;56(4):853\u201362.","journal-title":"Bone Marrow Transplant"},{"issue":"7","key":"917_CR23","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13866","volume":"34","author":"A Anderson","year":"2020","unstructured":"Anderson A, Raja M, Vazquez N, et al. Clinical \u201creal-world\u201d experience with letermovir for prevention of cytomegalovirus infection in allogeneic hematopoietic cell transplant recipients. Clin Transplant. 2020;34(7): e13866.","journal-title":"Clin Transplant"},{"issue":"8","key":"917_CR24","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1007\/s00277-020-04362-2","volume":"100","author":"P Derigs","year":"2021","unstructured":"Derigs P, Radujkovic A, Schubert ML, et al. Letermovir prophylaxis is effective in preventing cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation: single-center real-world data. Ann Hematol. 2021;100(8):2087\u201393.","journal-title":"Ann Hematol"},{"issue":"3","key":"917_CR25","first-page":"944","volume":"29","author":"LL Wang","year":"2021","unstructured":"Wang LL, Mo WJ, Zhang YP, et al. Clinical analysis of cmv infection after allogeneic hematopoietic stem cell transplantation in severe aplastic anemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021;29(3):944\u201350.","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"issue":"1","key":"917_CR26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1182\/blood.2020009396","volume":"138","author":"D Zamora","year":"2021","unstructured":"Zamora D, Duke ER, Xie H, et al. Cytomegalovirus-specific T-cell reconstitution following letermovir prophylaxis after hematopoietic cell transplantation. Blood. 2021;138(1):34\u201343.","journal-title":"Blood"},{"issue":"9","key":"917_CR27","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.jtct.2021.05.001","volume":"27","author":"M Hakki","year":"2021","unstructured":"Hakki M, Aitken SL, Danziger-Isakov L, et al. American society for transplantation and cellular therapy series: #3-prevention of cytomegalovirus infection and disease after hematopoietic cell transplantation. Transplant Cell Ther. 2021;27(9):707\u201319.","journal-title":"Transplant Cell Ther"}],"container-title":["Infectious Diseases and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40121-024-00917-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40121-024-00917-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40121-024-00917-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T18:34:42Z","timestamp":1709231682000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40121-024-00917-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,24]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["917"],"URL":"https:\/\/doi.org\/10.1007\/s40121-024-00917-2","relation":{},"ISSN":["2193-8229","2193-6382"],"issn-type":[{"value":"2193-8229","type":"print"},{"value":"2193-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,24]]},"assertion":[{"value":"13 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This study was approved by the Ethics Committee of Guangzhou First People\u2019s Hospital and conducted in accordance with the principles of the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}