{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:14:43Z","timestamp":1773850483534,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"Chongqing Science and Health Joint Medical Scientific Research Project","award":["2023MSXM0688"],"award-info":[{"award-number":["2023MSXM0688"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Infect Dis Ther"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s40121-025-01196-1","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T08:34:59Z","timestamp":1752827699000},"page":"1899-1916","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Association Between Elevated Estimated Glomerular Filtration Rate and Poor Clinical Outcomes of Pediatric Patients with\u00a0Community-Acquired Bacterial Meningitis Receiving Vancomycin: A Ten-Year Retrospective Cohort Study"],"prefix":"10.1007","volume":"14","author":[{"given":"Cuiyao","family":"He","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingsong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqi","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaogang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"1196_CR1","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1001\/jama.2022.20521","volume":"328","author":"R Hasbun","year":"2022","unstructured":"Hasbun R. Progress and challenges in bacterial meningitis: a review. JAMA. 2022;328:2147\u201354.","journal-title":"JAMA"},{"key":"1196_CR2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/S1473-3099(09)70306-8","volume":"10","author":"KS Kim","year":"2010","unstructured":"Kim KS. Acute bacterial meningitis in infants and children. Lancet Infect Dis. 2010;10:32\u201342.","journal-title":"Lancet Infect Dis"},{"key":"1196_CR3","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s15010-007-6202-0","volume":"35","author":"D Lepur","year":"2007","unstructured":"Lepur D, Barsi\u0107 B. Community-acquired bacterial meningitis in adults: antibiotic timing in disease course and outcome. Infection. 2007;35:225\u201331.","journal-title":"Infection"},{"key":"1196_CR4","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1007\/s00431-012-1733-5","volume":"171","author":"F Bargui","year":"2012","unstructured":"Bargui F, D\u2019Agostino I, Mariani-Kurkdjian P, et al. Factors influencing neurological outcome of children with bacterial meningitis at the emergency department. Eur J Pediatr. 2012;171:1365\u201371.","journal-title":"Eur J Pediatr"},{"key":"1196_CR5","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.1056\/NEJMoa1005384","volume":"364","author":"MC Thigpen","year":"2011","unstructured":"Thigpen MC, Whitney CG, Messonnier NE, et al. Bacterial meningitis in the United States, 1998\u20132007. N Engl J Med. 2011;364:2016\u201325.","journal-title":"N Engl J Med"},{"issue":"10","key":"1196_CR6","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13756-021-00895-x","volume":"30","author":"X Peng","year":"2021","unstructured":"Peng X, Zhu Q, Liu J, et al. Prevalence and antimicrobial resistance patterns of bacteria isolated from cerebrospinal fluid among children with bacterial meningitis in China from 2016 to 2018: a multicenter retrospective study. Antimicrob Resist Infect Control. 2021;30(10):24.","journal-title":"Antimicrob Resist Infect Control"},{"key":"1196_CR7","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.ijantimicag.2017.11.013","volume":"51","author":"C Carri\u00e9","year":"2018","unstructured":"Carri\u00e9 C, Petit L, d\u2019Houdain N, et al. Association between augmented renal clearance, antibiotic exposure and clinical outcome in critically ill septic patients receiving high doses of \u03b2-lactams administered by continuous infusion: a prospective observational study. Int J Antimicrob Agents. 2018;51:443\u20139.","journal-title":"Int J Antimicrob Agents"},{"key":"1196_CR8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00897-21","volume":"65","author":"CY He","year":"2021","unstructured":"He CY, Ye PP, Liu B, Song L, van den Anker J, Zhao W. Population pharmacokinetics and dosing optimization of vancomycin in infants, children, and adolescents with augmented renal clearance. Antimicrob Agents Chemother. 2021;65:e0089721.","journal-title":"Antimicrob Agents Chemother"},{"key":"1196_CR9","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s13318-019-00568-6","volume":"44","author":"K Sridharan","year":"2019","unstructured":"Sridharan K, Al Daylami A, Ajjawi R, Al-Ajooz H, Veeramuthu S. Clinical pharmacokinetics of vancomycin in critically ill children. Eur J Drug Metab Pharmacokinet. 2019;44:807\u201316.","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"1196_CR10","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.3390\/antibiotics10101182","volume":"10","author":"M Gijsen","year":"2021","unstructured":"Gijsen M, Vlasselaers D, Spriet I, Allegaert K. Pharmacokinetics of antibiotics in pediatric intensive care: fostering variability to attain precision medicine. Antibiotics (Basel). 2021;10:1182.","journal-title":"Antibiotics (Basel)"},{"key":"1196_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.904322","volume":"13","author":"C He","year":"2022","unstructured":"He C, Hu X, Li T, et al. Risk factors associated with prolonged antibiotic use in pediatric bacterial meningitis. Front Pharmacol. 2022;13:904322.","journal-title":"Front Pharmacol"},{"key":"1196_CR12","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1159\/000516647","volume":"146","author":"AS Levey","year":"2022","unstructured":"Levey AS. Defining AKD: the spectrum of AKI, AKD, and CKD. Nephron. 2022;146:302\u20135.","journal-title":"Nephron"},{"key":"1196_CR13","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1053\/j.ackd.2017.10.002","volume":"25","author":"H Pottel","year":"2018","unstructured":"Pottel H, Dubourg L, Goffin K, Delanaye P. Alternatives for the bedside Schwartz equation to estimate glomerular filtration rate in children. Adv Chronic Kidney Dis. 2018;25:57\u201366.","journal-title":"Adv Chronic Kidney Dis"},{"key":"1196_CR14","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1542\/peds.58.2.259","volume":"58","author":"GJ Schwartz","year":"1976","unstructured":"Schwartz GJ, Haycock GB, Edelmann CM Jr, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics. 1976;58:259\u201363.","journal-title":"Pediatrics"},{"key":"1196_CR15","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1093\/brain\/awg113","volume":"126","author":"S Kastenbauer","year":"2003","unstructured":"Kastenbauer S, Pfister HW. Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain. 2003;126:1015\u201325.","journal-title":"Brain"},{"key":"1196_CR16","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/S0140-6736(75)92830-5","volume":"1","author":"B Jennett","year":"1975","unstructured":"Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet. 1975;1:480\u20134.","journal-title":"Lancet"},{"issue":"6","key":"1196_CR17","doi-asserted-by":"publisher","first-page":"2586","DOI":"10.1177\/0962280215601873","volume":"26","author":"I Barrio","year":"2017","unstructured":"Barrio I, Arostegui I, Rodr\u00edguez-\u00c1lvarez MX, Quintana JM. A new approach to categorising continuous variables in prediction models: proposal and validation. Stat Methods Med Res. 2017;26(6):2586\u2013602.","journal-title":"Stat Methods Med Res"},{"issue":"15","key":"1196_CR18","doi-asserted-by":"publisher","first-page":"e1678","DOI":"10.1212\/WNL.0000000000007261","volume":"92","author":"WJ Tu","year":"2019","unstructured":"Tu WJ, Qiu HC, Zhang Y, et al. Lower serum retinoic acid level for prediction of higher risk of mortality in ischemic stroke. Neurology. 2019;92(15):e1678\u201387.","journal-title":"Neurology"},{"issue":"4","key":"1196_CR19","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1007\/s13311-018-0651-2","volume":"15","author":"WJ Tu","year":"2018","unstructured":"Tu WJ, Qiu HC, Cao JL, Liu Q, Zeng XW, Zhao JZ. Decreased concentration of irisin is associated with poor functional outcome in ischemic stroke. Neurotherapeutics. 2018;15(4):1158\u201367.","journal-title":"Neurotherapeutics"},{"key":"1196_CR20","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.jped.2012.10.001","volume":"89","author":"S Namani","year":"2013","unstructured":"Namani S, Milenkovi\u0107 Z, Koci B. A prospective study of risk factors for neurological complications in childhood bacterial meningitis. J Pediatr (Rio J). 2013;89:256\u201362.","journal-title":"J Pediatr (Rio J)"},{"key":"1196_CR21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jped.2019.07.003","volume":"96","author":"DC Teixeira","year":"2020","unstructured":"Teixeira DC, Diniz LMO, Guimar\u00e3es NS, Moreira HMAS, Teixeira CC, Romanelli RMC. Risk factors associated with the outcomes of pediatric bacterial meningitis: a systematic review. J Pediatr (Rio J). 2020;96:159\u201367.","journal-title":"J Pediatr (Rio J)"},{"key":"1196_CR22","doi-asserted-by":"publisher","first-page":"e707","DOI":"10.1016\/j.ijid.2013.02.009","volume":"17","author":"K Theodoridou","year":"2013","unstructured":"Theodoridou K, Vasilopoulou VA, Katsiaflaka A, et al. Association of treatment for bacterial meningitis with the development of sequelae. Int J Infect Dis. 2013;17:e707\u201313.","journal-title":"Int J Infect Dis"},{"key":"1196_CR23","doi-asserted-by":"publisher","first-page":"e22","DOI":"10.1111\/apa.13228","volume":"105","author":"LY Wee","year":"2016","unstructured":"Wee LY, Tanugroho RR, Thoon KC, et al. A 15-year retrospective analysis of prognostic factors in childhood bacterial meningitis. Acta Paediatr. 2016;105:e22\u20139.","journal-title":"Acta Paediatr"},{"key":"1196_CR24","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1086\/533448","volume":"46","author":"I Roine","year":"2008","unstructured":"Roine I, Peltola H, Fern\u00e1ndez J, et al. Influence of admission findings on death and neurological outcome from childhood bacterial meningitis. Clin Infect Dis. 2008;46:1248\u201352.","journal-title":"Clin Infect Dis"},{"key":"1196_CR25","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/1471-2334-11-214","volume":"11","author":"VA Vasilopoulou","year":"2011","unstructured":"Vasilopoulou VA, Karanika M, Theodoridou K, Katsioulis AT, Theodoridou MN, Hadjichristodoulou CS. Prognostic factors related to sequelae in childhood bacterial meningitis: data from a Greek meningitis registry. BMC Infect Dis. 2011;11:214.","journal-title":"BMC Infect Dis"},{"key":"1196_CR26","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/j.jcrc.2013.03.003","volume":"28","author":"BO Claus","year":"2013","unstructured":"Claus BO, Hoste EA, Colpaert K, Robays H, Decruyenaere J, De Waele JJ. Augmented renal clearance is a common finding with worse clinical outcome in critically ill patients receiving antimicrobial therapy. J Crit Care. 2013;28:695\u2013700.","journal-title":"J Crit Care"},{"issue":"Suppl 3","key":"1196_CR27","doi-asserted-by":"publisher","first-page":"S37","DOI":"10.1016\/j.cmi.2016.01.007","volume":"22","author":"D van de Beek","year":"2016","unstructured":"van de Beek D, Cabellos C, Dzupova O, et al. ESCMID guideline: diagnosis and treatment of acute bacterial meningitis. Clin Microbiol Infect. 2016;22(Suppl 3):S37-62.","journal-title":"Clin Microbiol Infect"},{"key":"1196_CR28","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1086\/425368","volume":"39","author":"AR Tunkel","year":"2004","unstructured":"Tunkel AR, Hartman BJ, Kaplan SL, et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004;39:1267\u201384.","journal-title":"Clin Infect Dis"}],"container-title":["Infectious Diseases and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40121-025-01196-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40121-025-01196-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40121-025-01196-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T15:24:02Z","timestamp":1757258642000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40121-025-01196-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,18]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1196"],"URL":"https:\/\/doi.org\/10.1007\/s40121-025-01196-1","relation":{},"ISSN":["2193-8229","2193-6382"],"issn-type":[{"value":"2193-8229","type":"print"},{"value":"2193-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,18]]},"assertion":[{"value":"12 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Yuanyuan Luo, Yuhua Deng, Tingsong Li, Dongmei Deng, Fengjun Lv, Yuan Qu, Li Jiang, Siqi Hong, Cuiyao He and Xiaogang Hu have no conflicts of interest to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study was approved by the Ethics Professional Committee of CHCMU (Ethical Approval No. 2021-88-1) and was conducted in accordance with the Helsinki Declaration of 1964 and its subsequent amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}