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Ekaterina Maslova, Chengbin Wang, Charlotte Lupton, Yao Qiao, and Malin Fageras are employees of AstraZeneca and may hold stock and\/or stock options in the company. All other authors; Quinn Rafferty, Jiali Lei, Jam Suba, Maja Pasovic, Samuel Ewald, Darwin Del Castillo and Catherine W. Gillespie declare no conflicts of interest.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This analysis used fully deidentified data and did not involve direct interaction with human participants; it was determined to be exempt from formal ethical review and informed consent requirements in accordance with applicable institutional and regulatory guidelines. The authors confirm they had full institutional permission to access and analyse all underlying databases utilized in this study.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}