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Fleming, Girish Prajapati, Milena Murray, and Samira Saad are employees of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA, and shareholders of Merck & Co., Inc., Rahway, NJ, USA. Kyung Min Lee, Wenying Quan, Kyle Roney, Shweta Kamat, and Viktor Chirikov are employees of OPEN Health, which was paid to conduct the study under contract with Merck & Co., Inc., Rahway, NJ, USA. Princy N. Kumar has received grant\/research support from GSK, Merck, Gilead and Thera-technology; has stock ownership with Merck, Pfizer, Johnson & Johnson, GSK, and Gilead; and serves or has served as consultant\/advisory board member with GSK, Merck, and Gilead.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Optum\u2019s de-identified Clinformatics\u00ae Data Mart Database is fully de-identified and compliant with the Health Insurance Portability and Accountability Act of 1996. 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