{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:19:03Z","timestamp":1788884343645,"version":"build-2803163510"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pain Ther"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s40122-016-0049-y","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T19:52:02Z","timestamp":1458330722000},"page":"1-17","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":99,"title":["Melatonin in Chronic Pain Syndromes"],"prefix":"10.1007","volume":"5","author":[{"given":"Andrei","family":"Danilov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Kurganova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,16]]},"reference":[{"key":"49_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-444-59427-3.00001-0","volume":"199","author":"RJ Lucas","year":"2012","unstructured":"Lucas RJ, Lall GS, Allen AE, Brown TM. How rod, cone, and melanopsin photoreceptors come together to enlighten the mammalian circadian clock. Prog Brain Res. 2012;199:1\u201318.","journal-title":"Prog Brain Res"},{"key":"49_CR2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF03033887","volume":"7","author":"V Srinivasan","year":"2005","unstructured":"Srinivasan V, Pandi-Perumal SR, Maestroni GJ, Esquifino AI, Hardeland R, Cardinali DP. Role of melatonin in neurodegenerative diseases. Neurotox Res. 2005;7:293\u2013318.","journal-title":"Neurotox Res"},{"key":"49_CR3","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1111\/j.1742-4658.2006.05322.x","volume":"273","author":"SR Pandi-Perumal","year":"2006","unstructured":"Pandi-Perumal SR, Srinivasan V, Maestroni GJM, Cardinali DP, Poeggeler B, Hardeland R. Melatonin: nature\u2019s most versatile biological signal? FEBS J. 2006;273:2813\u201338.","journal-title":"FEBS J"},{"key":"49_CR4","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4236\/pst.2014.22009","volume":"2","author":"Y Liu","year":"2014","unstructured":"Liu Y, He H, Huang F. Melatonin in pain modulation: analgesic or proalgesic? Pain Stud Treat. 2014;2:50\u20135.","journal-title":"Pain Stud Treat"},{"key":"49_CR5","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-2999(91)90119-B","volume":"194","author":"DA Golombek","year":"1991","unstructured":"Golombek DA, Escolar E, Burin LJ, Bristo-Sanchez MG, Cardinali DP. Time-dependent melatonin analgesia in mice: inhibition by opiate or benzodiazepine antagonism. Eur J Pharmacol. 1991;194:25\u201330.","journal-title":"Eur J Pharmacol"},{"key":"49_CR6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0014-2999(00)00421-0","volume":"403","author":"CX Yu","year":"2000","unstructured":"Yu CX, Zhu B, Xu SF, Cao XD, Wu GC. The analgesic effects of peripheral and central administration of melatonin in rats. Eur J Pharmacol. 2000;403:49\u201353.","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"49_CR7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1043-6618(02)00094-4","volume":"46","author":"SM El-Shenawy","year":"2002","unstructured":"El-Shenawy SM, Abdel-Salam OM, Baiuomy AR, El-Batran S, Arbid MS. Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat. Pharmacol Res. 2002;46(3):235\u201343.","journal-title":"Pharmacol Res"},{"issue":"4","key":"49_CR8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1600-079X.2010.00796.x","volume":"49","author":"E Esposito","year":"2010","unstructured":"Esposito E, Paterniti I, Mazzon E, Bramanti P, Cuzzocrea S. Melatonin reduces hyperalgesia associated with inflammation. J Pineal Res. 2010;49(4):321\u201331.","journal-title":"J Pineal Res"},{"issue":"1","key":"49_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3940(03)00306-9","volume":"343","author":"M Mantovani","year":"2003","unstructured":"Mantovani M, P\u00e9rtile R, Calixto JB, Santos AR, Rodrigues AL. Melatonin exerts an antidepressant-like effect in the tail suspension test in mice: evidence for involvement of N-methyl-d-aspartate receptors and the l-arginine-nitric oxide pathway. Neurosci Lett. 2003;343(1):1\u20134.","journal-title":"Neurosci Lett."},{"issue":"3","key":"49_CR10","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pain.2004.01.027","volume":"109","author":"Y Tu","year":"2004","unstructured":"Tu Y, Sun RQ, Willis WD. Effects of intrathecal injections of melatonin analogs on capsaicin-induced secondary mechanical allodynia and hyperalgesia in rats. Pain. 2004;109(3):340\u201350.","journal-title":"Pain"},{"issue":"14","key":"49_CR11","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.lfs.2005.07.002","volume":"78","author":"A Ulugol","year":"2006","unstructured":"Ulugol A, Dokmeci D, Guray G, Sapolyo N, Ozyigit F, Tamer M. Antihyperalgesic, but not antiallodynic, effect of melatonin in nerve-injured neuropathic mice: possible involvements of the l-arginine-NO pathway and opioid system. Life Sci. 2006;78(14):1592\u20137.","journal-title":"Life Sci."},{"key":"49_CR12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10194-008-0047-5","volume":"9","author":"MR Masruha","year":"2008","unstructured":"Masruha MR, de Souza Viera DS, Minett TS, Cipolla-Neto J, Zuckerman E, Vilanova LC, Peres MF. Low urinary 6-sulphatoxy-melatonin concentrations in acute migraine. J Headache Pain. 2008;9:221\u201334.","journal-title":"J Headache Pain"},{"key":"49_CR13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1212\/01.WNL.0000134653.35587.24","volume":"63","author":"MF Peres","year":"2004","unstructured":"Peres MF, Zukerman E, da Cunha Tanuri F, Moreira FR, Cipolla-Neto J. Melatonin, 3 mg, is effective for migraine prevention. Neurology. 2004;63:757.","journal-title":"Neurology"},{"issue":"9","key":"49_CR14","first-page":"32","volume":"111","author":"GR Tabeeva","year":"2011","unstructured":"Tabeeva GR, Sergeev AV, Gromova SA. Possibilities of preventive treatment of migraine with MT1 and MT2 agonist and 5-HT2c receptor antagonist agomelatine (Valdoxan). Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(9):32\u20136.","journal-title":"Zh Nevrol Psikhiatr Im S S Korsakova."},{"issue":"4","key":"49_CR15","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1517\/13543784.15.4.367","volume":"15","author":"MFP Peres","year":"2006","unstructured":"Peres MFP, Masruha MR, Zukerman E, et al. Potential therapeutic use of melatonin in migraine and other headache disorders. Expert Opin Investig Drugs. 2006;15(4):367\u201375.","journal-title":"Expert Opin Investig Drugs"},{"key":"49_CR16","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1046\/j.1468-2982.1996.1607494.x","volume":"16","author":"M Leone","year":"1996","unstructured":"Leone M, D\u2019Amico D, Moschiano F, et al. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia. 1996;16:494\u20136.","journal-title":"Cephalalgia"},{"key":"49_CR17","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1046\/j.1526-4610.2002.02181.x","volume":"42","author":"T Pringsheim","year":"2002","unstructured":"Pringsheim T, Magnoux E, Dobson CF, et al. Melatonin as adjunctive therapy in the prophylaxis of cluster headache: a pilot study. Headache. 2002;42:787\u201392.","journal-title":"Headache"},{"issue":"4","key":"49_CR18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10072-008-0983-5","volume":"29","author":"S Miano","year":"2008","unstructured":"Miano S, Parisi P, Pellicci A, Luchetti A, Paolino MC, Villa MP. Melatonin to prevent migraine or tension-type headache in children. Neurol Sci. 2008;29(4):285\u20137.","journal-title":"Neurol Sci"},{"key":"49_CR19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.17116\/jnevro20151154130-35","volume":"4","author":"JM Kurganova","year":"2015","unstructured":"Kurganova JM, Danilov AB. A role of melatonin in the treatment of low back pain. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;4:30\u20135.","journal-title":"Zh Nevrol Psikhiatr Im S S Korsakova"},{"issue":"33","key":"49_CR20","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.2174\/138161210794079254","volume":"16","author":"S Mozaffari","year":"2010","unstructured":"Mozaffari S, Rahimi R, Abdollahi M. Implications of melatonin therapy in irritable bowel syndrome: a systematic review. Curr Pharm Des. 2010;16(33):3646\u201355.","journal-title":"Curr Pharm Des"},{"issue":"1","key":"49_CR21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/MCG.0b013e31802df84c","volume":"41","author":"L Saha","year":"2007","unstructured":"Saha L, Malhotra S, Rana S, Bhasin D, Pandhi P. A preliminary study of melatonin in irritable bowel syndrome. J Clin Gastroenterol. 2007;41(1):29\u201332.","journal-title":"J Clin Gastroenterol"},{"key":"49_CR22","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1136\/gut.2004.062034","volume":"54","author":"GH Song","year":"2005","unstructured":"Song GH, Leng PH, Gwee KA, Moochhala SM, Ho KY. Melatonin improves abdominal pain in irritable bowel syndrome patients who have sleep disturbances: a randomised, double blind, placebo-controlled study. Gut. 2005;54:1402\u20137.","journal-title":"Gut"},{"issue":"10","key":"49_CR23","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1365-2036.2005.02673.x","volume":"22","author":"WZ Lu","year":"2005","unstructured":"Lu WZ, Gwee KA, Moochhalla S, Ho KY. Melatonin improves bowel symptoms in female patients with irritable bowel syndrome: a double-blind placebo-controlled study. Aliment Pharmacol Ther. 2005;22(10):927\u201334.","journal-title":"Aliment Pharmacol Ther"},{"key":"49_CR24","first-page":"114","volume":"64","author":"C Chojnacki","year":"2013","unstructured":"Chojnacki C, Walecka-Kapica E, Lokie\u0107 K, Paw\u0142owicz M, Winczyk K, Chojnacki J, Klupi\u0144ska G. Influence of melatonin on symptoms of irritable bowel syndrome in postmenopausal women. Endokrynol Pol. 2013;64:114\u201320.","journal-title":"Endokrynol Pol."},{"key":"49_CR25","first-page":"1034","volume":"86","author":"EB Klerman","year":"2001","unstructured":"Klerman EB, Goldenberg DL, Brown EN, Maliszewski AM, Adler GK. Circadian rhythms of women with fibromyalgia. J Clin Endocrinol Metab. 2001;86:1034\u20139.","journal-title":"J Clin Endocrinol Metab"},{"key":"49_CR26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1365-2265.1998.00503.x","volume":"49","author":"J Wikner","year":"1998","unstructured":"Wikner J, Hirsch U, Wetterberg L, Rojdmark S. Fibromyalgia\u2014a syndrome associated with decreased nocturnal melatonin secretion. Clin Endocrinol (Oxf). 1998;49:179\u201383.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"49_CR27","unstructured":"Levin Ya. I. Melatonin (Melaxen) in neurological practice. Consilium Medicum 2012;No 02, p. 111\u20135."},{"key":"49_CR28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s100670050003","volume":"19","author":"G Citera","year":"2000","unstructured":"Citera G, Arias MA, Maldonado-Cocco JA, et al. The effect of melatonin in patients with fibromyalgia: a pilot study. Clin Rheumatol. 2000;19:9\u201313.","journal-title":"Clin Rheumatol"},{"key":"49_CR29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1600-079X.2010.00836.x","volume":"50","author":"SA Hussain","year":"2011","unstructured":"Hussain SA, Al-Khalifa II, Jasim NA, Gorial FI. Adjuvant use of melatonin for treatment of fibromyalgia. J Pineal Res. 2011;50:267\u201371.","journal-title":"J Pineal Res"},{"key":"49_CR30","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/2050-6511-15-40","volume":"15","author":"SA Zanette de","year":"2014","unstructured":"de Zanette SA, Vercelino R, Laste G, Rozisky JR, Schwertner A, Machado CB, Xavier F, de Souza IC, Deitos A, Torres IL, Caumo W. Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial. BMC Pharmacol Toxicol. 2014;15:40.","journal-title":"BMC Pharmacol Toxicol"},{"issue":"2","key":"49_CR31","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/ard.2004.023416","volume":"64","author":"M Cutolo","year":"2005","unstructured":"Cutolo M, Maestroni GJM, Otsa K, et al. Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison. Ann Rheum Dis. 2005;64(2):212\u20136.","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"49_CR32","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00296-013-2930-x","volume":"34","author":"M Afkhamizadeh","year":"2014","unstructured":"Afkhamizadeh M, Sahebari M, Seyyed-Hoseini SR. Morning melatonin serum values do not correlate with disease activity in rheumatoid arthritis: a cross-sectional study. Rheumatol Int. 2014;34(8):1145\u201351.","journal-title":"Rheumatol Int"},{"issue":"8","key":"49_CR33","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1136\/ard.2005.038588","volume":"64","author":"M Cutolo","year":"2005","unstructured":"Cutolo M, Maestroni GJM. The melatonin\u2013cytokine connection in rheumatoid arthritis. Ann Rheum Dis. 2005;64(8):1109\u201311.","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"49_CR34","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/jpi.12034","volume":"54","author":"DS Rudra","year":"2013","unstructured":"Rudra DS, Pal U, Maiti NC, Reiter RJ, Swarnakar S. Melatonin inhibits matrix metalloproteinase-9 activity by binding to its active site. J Pineal Res. 2013;54(4):398\u2013405.","journal-title":"J Pineal Res"},{"key":"49_CR35","doi-asserted-by":"crossref","unstructured":"Reppert SM, Weaver DR, Ebisawa T. Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses. Neuron 1994;1177\u201385.","DOI":"10.1016\/0896-6273(94)90055-8"},{"issue":"3","key":"49_CR36","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1152\/physrev.1998.78.3.687","volume":"78","author":"J Vanecek","year":"1998","unstructured":"Vanecek J. Cellular mechanisms of melatonin action. Physiol Rev. 1998;78(3):687\u2013721.","journal-title":"Physiol Rev"},{"issue":"1","key":"49_CR37","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1034\/j.1600-079X.2003.00047.x","volume":"35","author":"PK Zahn","year":"2003","unstructured":"Zahn PK, Lansmann T, Berger E, Speckmann EJ, Musshoff U. Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation. J Pineal Res. 2003;35(1):24\u201331.","journal-title":"J Pineal Res"},{"issue":"3","key":"49_CR38","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1600-079X.2011.00895.x","volume":"51","author":"M Wilhelmsen","year":"2011","unstructured":"Wilhelmsen M, Amirian I, Reiter RJ, Rosenberg J, G\u00f6genur I. Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies. J Pineal Res. 2011;51(3):270\u20137.","journal-title":"J Pineal Res"},{"issue":"2","key":"49_CR39","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/01.j.pain.0000460311.71572.5f","volume":"156","author":"M Lopez-Canul","year":"2015","unstructured":"Lopez-Canul M, Palazzo E, Dominguez-Lopez S, Luongo L, Lacoste B, Comai S, Angeloni D, Fraschini F, Boccella S, Spadoni G, Bedini A, Tarzia G, Maione S, Granados-Soto V, Gobbi G. Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways. Pain. 2015;156(2):305\u201317.","journal-title":"Pain"},{"issue":"764","key":"49_CR40","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ejphar.2015.07.010","volume":"5","author":"M L\u00f3pez-Canul","year":"2015","unstructured":"L\u00f3pez-Canul M, Comai S, Dom\u00ednguez-L\u00f3pez S, Granados-Soto V, Gobbi G. Antinociceptive properties of selective MT2 melatonin receptor partial agonists. Eur J Pharmacol. 2015;5(764):424\u201332.","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"49_CR41","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/jpi.12224","volume":"58","author":"B Lacoste","year":"2015","unstructured":"Lacoste B, Angeloni D, Dominguez-Lopez S, Calderoni S, Mauro A, Fraschini F, Descarries L, Gobbi G. Anatomical and cellular localization of melatonin MT1 and MT2 receptors in the adult rat brain. J Pineal Res. 2015;58(4):397\u2013417.","journal-title":"J Pineal Res"},{"issue":"56","key":"49_CR42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev-pharmtox-010814-124742","volume":"6","author":"J Liu","year":"2016","unstructured":"Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Popovska-Gorevski M, Dubocovich ML. MT1 and MT2 melatonin receptors: a therapeutic perspective. Annu Rev Pharmacol Toxicol. 2016;6(56):361\u201383.","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"13","key":"49_CR43","doi-asserted-by":"crossref","first-page":"7037","DOI":"10.1074\/jbc.270.13.7037","volume":"270","author":"D Steinhilber","year":"1995","unstructured":"Steinhilber D, Brungs M, Werz O, Wiesenberg I, Danielsson C, Kahlen JP, Nayeri S, Schrader M, Carlberg C. The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes. J Biol Chem. 1995;270(13):7037\u201340.","journal-title":"J Biol Chem"},{"issue":"9","key":"49_CR44","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1111\/j.1460-9568.2005.04408.x","volume":"22","author":"LM Wang","year":"2005","unstructured":"Wang LM, Suthana NA, Chaudhury D, Weaver DR, Colwell CS. Melatonin inhibits hippocampal long-term potentiation. Eur J Neurosci. 2005;22(9):2231\u20137.","journal-title":"Eur J Neurosci"},{"issue":"1\u20132","key":"49_CR45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0304-3940(01)02188-7","volume":"313","author":"A Ayar","year":"2001","unstructured":"Ayar A, Duncan JM, Ozcan M, Kelestimur H. Melatonin inhibits high voltage activated calcium currents in cultured rat dorsal root ganglion neurons. Neurosci Lett. 2001;313(1\u20132):73\u20137.","journal-title":"Neurosci Lett"},{"issue":"3","key":"49_CR46","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1600-079X.2011.00895.x","volume":"51","author":"M Wilhelmsen","year":"2011","unstructured":"Wilhelmsen M, Amirian I, Reiter RJ, Rosenberg J, G\u00f6genur I. Analgesic effects of melatonin: a review of current evidence from experimental and clinical studies. J Pineal Res. 2011;51(3):270\u20137.","journal-title":"J Pineal Res"},{"key":"49_CR47","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1159\/000109446","volume":"4","author":"F Xu","year":"1995","unstructured":"Xu F, Li JC, Ma KC, et al. Effects of melatonin on hypothalamic gamma-aminobutyric acid, aspartic acid, glutamic acid, beta-endorphin and serotonin levels in male mice. Biol Signals. 1995;4:225\u201331.","journal-title":"Biol Signals"}],"container-title":["Pain and Therapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40122-016-0049-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T18:25:00Z","timestamp":1567707900000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40122-016-0049-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,16]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["49"],"URL":"https:\/\/doi.org\/10.1007\/s40122-016-0049-y","relation":{},"ISSN":["2193-8237","2193-651X"],"issn-type":[{"value":"2193-8237","type":"print"},{"value":"2193-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,16]]}}}