{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:04:49Z","timestamp":1775084689738,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/501100008089","name":"Fondazione Internazionale Menarini","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pain Ther"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s40122-020-00228-7","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T18:10:57Z","timestamp":1613067057000},"page":"485-503","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Tramadol\/Dexketoprofen Analgesic Efficacy Compared with Tramadol\/Paracetamol in Moderate to Severe Postoperative Acute Pain: Subgroup Analysis of a Randomized, Double-Blind, Parallel Group Trial\u2014DAVID Study"],"prefix":"10.1007","volume":"10","author":[{"given":"Magdi","family":"Hanna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Montero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Perrot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giustino","family":"Varrassi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"228_CR1","unstructured":"National Pharmaceutical Council (NPC). Pain: current understanding of assessment, management, and treatments. Reston, VA: NPC, Joint Commission on Accreditation of Health Care Organization; 2001. https:\/\/www.npcnow.org\/system\/files\/research\/download\/Pain-Current-Understanding-of-Assessment-Management-and-Treatments.pdf. Accessed 15 July 2019."},{"key":"228_CR2","doi-asserted-by":"publisher","first-page":"927","DOI":"10.2147\/JPR.S171013","volume":"12","author":"ER Viscusi","year":"2019","unstructured":"Viscusi ER, Skobieranda F, Soergel DG, et al. APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the \u00b5-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy. J Pain Res. 2019;12:927\u201343.","journal-title":"J Pain Res"},{"key":"228_CR3","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1080\/03007995.2017.1310092","volume":"33","author":"G Varrassi","year":"2017","unstructured":"Varrassi G, Hanna M, Macheras G, et al. Multimodal analgesia in moderate-to-severe pain: a role for a new fixed combination of dexketoprofen and tramadol. Curr Med Res Opin. 2017;33:1165\u201373.","journal-title":"Curr Med Res Opin"},{"key":"228_CR4","unstructured":"International Association for the Study of Pain. Management of postsurgical pain in adults. IASP. 2017. https:\/\/www.europeanpainfederation.eu\/wp-content\/uploads\/2017\/01\/05.-Management-of-Postsurgical-Pain-Management.pdf. Accessed 15 July 2019"},{"key":"228_CR5","doi-asserted-by":"publisher","first-page":"320","DOI":"10.2165\/00044011-199611060-00002","volume":"11","author":"C Gay","year":"1996","unstructured":"Gay C, Planas E, Donado M, et al. Analgesic efficacy of low doses of dexketoprofen in the dental pain model: a randomised, double-blind, placebo-controlled study. Clin Drug Invest. 1996;11:320\u201330.","journal-title":"Clin Drug Invest"},{"key":"228_CR6","doi-asserted-by":"publisher","first-page":"46S","DOI":"10.1002\/jcph.1998.38.s1.46","volume":"38","author":"M McGurk","year":"1998","unstructured":"McGurk M, Robinson P, Rajayogeswaran V, et al. Clinical comparison of dexketoprofen trometamol, ketoprofen, and placebo in postoperative dental pain. J Clin Pharmacol. 1998;38:46S-54S.","journal-title":"J Clin Pharmacol"},{"key":"228_CR7","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2217\/pmt.11.42","volume":"1","author":"JS Walczak","year":"2011","unstructured":"Walczak JS. Analgesic properties of dexketoprofen trometamol. Pain Manag. 2011;1:409\u201316.","journal-title":"Pain Manag"},{"key":"228_CR8","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1080\/03007995.2018.1457016","volume":"35","author":"H Hanna","year":"2019","unstructured":"Hanna H, Moon JY. A review of dexketoprofen trometamol in acute pain. Curr Med Res Opin. 2019;35:189\u2013202.","journal-title":"Curr Med Res Opin"},{"key":"228_CR9","doi-asserted-by":"publisher","first-page":"i4857","DOI":"10.1136\/bmj.i4857","volume":"354","author":"A Arfie","year":"2016","unstructured":"Arfie A, Scotti L, Varas-Lorenzo C. Nonsteroidal anti-inflammatory drugs and risk of heart failure in four European countries: nested case\u2013control study. BMJ. 2016;354:i4857.","journal-title":"BMJ"},{"key":"228_CR10","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1358\/mf.2009.31.8.1419070","volume":"31","author":"X Carne","year":"2009","unstructured":"Carne X, Rios J, Torres F. Postmarketing cohort study to assess the safety profile of oral dexketoprofen trometamol for mild to moderate acute pain treatment in primary care. Methods Find Exp Clin Pharmacol. 2009;31:533\u201340.","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"228_CR11","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.biopha.2015.01.022","volume":"70","author":"M Vazzana","year":"2015","unstructured":"Vazzana M, Andreani T, Fangueiro J, et al. Tramadol hydrochloride: pharmacokinetics, pharmacodynamics, adverse side effects, co-administration of drugs and new drug delivery systems. Biomed Pharmacother. 2015;70:234\u20138.","journal-title":"Biomed Pharmacother"},{"key":"228_CR12","doi-asserted-by":"publisher","first-page":"139","DOI":"10.2165\/00003495-200060010-00008","volume":"60","author":"LJ Scott","year":"2000","unstructured":"Scott LJ, Perry CM. Tramadol a review of its use in perioperative pain. Drugs. 2000;60:139\u201376.","journal-title":"Drugs"},{"key":"228_CR13","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/bja\/aev457","volume":"116","author":"HJ McQuay","year":"2016","unstructured":"McQuay HJ, Moore RA, Berta A, et al. Randomized clinical trial of dexketoprofen\/tramadol 25 mg\/75 mg in moderate-to-severe pain after total hip arthroplasty. Br J Anaesth. 2016;116:269\u201376.","journal-title":"Br J Anaesth"},{"key":"228_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s12871-016-0174-5","volume":"16","author":"RA Moore","year":"2016","unstructured":"Moore RA, McQuay HJ, Tomaszewski J, et al. Dexketoprofen\/tramadol 25 mg\/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy. BMC Anesthesiol. 2016;16:9.","journal-title":"BMC Anesthesiol"},{"key":"228_CR15","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1186\/s10194-015-0541-5","volume":"16","author":"RA Moore","year":"2015","unstructured":"Moore RA, Gay-Escoda C, Figueiredo R, et al. Dexketoprofen\/tramadol: randomised double-blind trial and confirmation of empirical theory of combination analgesics in acute pain. J Headache Pain. 2015;16:541.","journal-title":"J Headache Pain"},{"key":"228_CR16","doi-asserted-by":"publisher","first-page":"e023715","DOI":"10.1136\/bmjopen-2018-023715","volume":"9","author":"C Gay-Escoda","year":"2019","unstructured":"Gay-Escoda C, Hanna M, Montero A, et al. Tramadol\/dexketoprofen (TRAM\/DKP) compared with tramadol\/paracetamol in moderate to severe acute pain: results of a randomised, double-blind, placebo and active-controlled, parallel group trial in the impacted third molar extraction pain model (DAVID study). BMJ Open. 2019;9:e023715.","journal-title":"BMJ Open"},{"key":"228_CR17","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1097\/j.pain.0000000000000375","volume":"15","author":"SA Cooper","year":"2016","unstructured":"Cooper SA, Desjardins PJ, Turk DC, et al. Research design considerations for single-dose analgesic clinical trials in acute pain: IMMPACT recommendations. Pain. 2016;15:288\u2013301.","journal-title":"Pain"},{"key":"228_CR18","unstructured":"Committee for Medicinal Products for Human Use (CHMP). Guideline on the clinical development of medicinal products intended for the treatment of pain. EMA\/CHMP\/970057\/2011. 15 December 2016. https:\/\/www.ema.europa.eu\/en\/documents\/scientific-guideline\/guideline-clinical-development-medicinal-products-intended-treatment-pain-first-version_en.pdf. Accessed 15 July 2019."},{"key":"228_CR19","unstructured":"Tramacet\u00ae (tramadol hydrochloride\/paracetamol 37.5 mg\/325 mg) UK SmPC. https:\/\/www.medicines.org.uk\/emc\/product\/6630\/smpc. Accessed 15 July 2019"},{"key":"228_CR20","unstructured":"Skudexa\u00ae (tramadol hydrochloride\/dexketoprofen 75 mg\/25 mg) UK SmPC. https:\/\/www.medicines.org.uk\/emc\/product\/8849. Accessed 15 July 2019"},{"key":"228_CR21","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/S0196-0644(96)70238-X","volume":"27","author":"KH Todd","year":"1996","unstructured":"Todd KH, Funk KG, Funk JP, et al. Clinical significance of reported changes in pain severity. Ann Emerg Med. 1996;27:485\u20139.","journal-title":"Ann Emerg Med"},{"key":"228_CR22","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1067\/mem.2001.118863","volume":"38","author":"EJ Gallagher","year":"2001","unstructured":"Gallagher EJ, Liebman M, Bijur PE. Prospective validation of clinically important changes in pain severity measured on a visual analog scale. Ann Emerg Med. 2001;38:633\u20138.","journal-title":"Ann Emerg Med"},{"issue":"1\u20132","key":"228_CR23","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0304-3959(03)00176-3","volume":"105","author":"MS Cepeda","year":"2003","unstructured":"Cepeda MS, Africano JM, Polo R, et al. What decline in pain intensity is meaningful to patients with acute pain? Pain. 2003;105(1\u20132):151\u20137.","journal-title":"Pain"},{"key":"228_CR24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/S0885-3924(01)00404-3","volume":"23","author":"JE Edwards","year":"2002","unstructured":"Edwards JE, McQuay HJ, Moore RA. Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain. J Pain Symptom Manag. 2002;23:121\u201330.","journal-title":"J Pain Symptom Manag"},{"key":"228_CR25","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s40268-018-0235-y","volume":"18","author":"J L\u00f3pez-Cedr\u00fan","year":"2018","unstructured":"L\u00f3pez-Cedr\u00fan J, Videla S, Burgue\u00f1o M, et al. Co-crystal of tramadol-celecoxib in patients with moderate to severe acute post-surgical oral pain: a dose-finding, randomised, double-blind, placebo- and active-controlled, multicentre, phase II trial. Drugs R D. 2018;18:137\u201348.","journal-title":"Drugs R D"},{"key":"228_CR26","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1001\/jama.2017.16190","volume":"318","author":"AK Chang","year":"2017","unstructured":"Chang AK, Bijur PE, Esses D, et al. Effect of a single dose of oral opioid and nonopioid analgesics on acute extremity pain in the emergency department: a randomized clinical trial. JAMA. 2017;318:1661\u20137.","journal-title":"JAMA"},{"key":"228_CR27","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s11739-018-02014-y","volume":"14","author":"F Lemoel","year":"2019","unstructured":"Lemoel F, Contenti J, Cibiera C, et al. Intranasal sufentanil given in the emergency department triage zone for severe acute traumatic pain: a randomized double-blind controlled trial. Intern Emerg Med. 2019;14:571\u20139.","journal-title":"Intern Emerg Med"},{"key":"228_CR28","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/j.pain.2013.09.002","volume":"155","author":"NK Singla","year":"2014","unstructured":"Singla NK, Desjardins PJ, Chang PD. A comparison of the clinical and experimental characteristics of four acute surgical pain models: dental extraction, bunionectomy, joint replacement, and soft tissue surgery. Pain. 2014;155:441\u201356.","journal-title":"Pain"},{"key":"228_CR29","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1358\/dot.2011.47.10.1608924","volume":"47","author":"P Sawaddiruk","year":"2011","unstructured":"Sawaddiruk P. Tramadol hydrochloride\/acetaminophen combination for the relief of acute pain. Drugs Today (Barc). 2011;47:763\u201372.","journal-title":"Drugs Today (Barc)"},{"key":"228_CR30","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1358\/dot.2017.53.6.2636487","volume":"53","author":"A Montero Matamala","year":"2017","unstructured":"Montero Matamala A, Bertolotti M, Contini MP, et al. Tramadol hydrochloride 75 mg\/dexketoprofen 25 mg oral fixed-dose combination in moderate-to-severe acute pain: sustained analgesic effect over a 56-h period in the postoperative setting. Drugs Today (Barc). 2017;53:339\u201347.","journal-title":"Drugs Today (Barc)"}],"container-title":["Pain and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40122-020-00228-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40122-020-00228-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40122-020-00228-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T01:38:30Z","timestamp":1697852310000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40122-020-00228-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["228"],"URL":"https:\/\/doi.org\/10.1007\/s40122-020-00228-7","relation":{},"ISSN":["2193-8237","2193-651X"],"issn-type":[{"value":"2193-8237","type":"print"},{"value":"2193-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,11]]},"assertion":[{"value":"16 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}