{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:58:34Z","timestamp":1791446314486,"version":"4.3.3"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pain Ther"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s40122-021-00275-8","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T20:02:29Z","timestamp":1622836949000},"page":"1155-1169","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Preemptive Intravenous Nalbuphine for the Treatment of Post-Operative Visceral Pain: A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial"],"prefix":"10.1007","volume":"10","clinical-trial-number":[{"clinical-trial-number":"chictr1800014379","registry":"10.18810\/chictr"}],"author":[{"given":"Xiaofen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0627-7057","authenticated-orcid":false,"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijing","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiong","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuting","family":"Men","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"275_CR1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006231","author":"F Keus","year":"2006","unstructured":"Keus F, de Jong JA, Gooszen HG, van Laarhoven CJ. Laparoscopic versus open cholecystectomy for patients with symptomatic cholecystolithiasis. Cochrane Database Syst Rev. 2006. https:\/\/doi.org\/10.1002\/14651858.CD006231.","journal-title":"Cochrane Database Syst Rev"},{"key":"275_CR2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jss.2017.05.071","volume":"219","author":"EB Rosero","year":"2017","unstructured":"Rosero EB, Joshi GP. Hospital readmission after ambulatory laparoscopic cholecystectomy: incidence and predictors. J Surg Res. 2017;219:108\u201315.","journal-title":"J Surg Res"},{"issue":"4","key":"275_CR3","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/00000542-200604000-00030","volume":"104","author":"T Bisgaard","year":"2006","unstructured":"Bisgaard T. Analgesic treatment after laparoscopic cholecystectomy: a critical assessment of the evidence. Anesthesiology. 2006;104(4):835\u201346.","journal-title":"Anesthesiology"},{"issue":"3","key":"275_CR4","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/bja\/79.3.369","volume":"79","author":"JI Alexander","year":"1997","unstructured":"Alexander JI. Pain after laparoscopy. Br J Anaesth. 1997;79(3):369\u201378.","journal-title":"Br J Anaesth"},{"issue":"6","key":"275_CR5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1533-2500.2011.00513.x","volume":"12","author":"S Mitra","year":"2012","unstructured":"Mitra S, Khandelwal P, Roberts K, Kumar S, Vadivelu N. Pain relief in laparoscopic cholecystectomy\u2014a review of the current options. Pain Pract. 2012;12(6):485\u201396.","journal-title":"Pain Pract"},{"issue":"2","key":"275_CR6","first-page":"379","volume":"81","author":"J Joris","year":"1995","unstructured":"Joris J, Thiry E, Paris P, Weerts J, Lamy M. Pain after laparoscopic cholecystectomy: characteristics and effect of intraperitoneal bupivacaine. Anesth Analg. 1995;81(2):379\u201384.","journal-title":"Anesth Analg"},{"issue":"11","key":"275_CR7","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1016\/j.pain.2014.09.019","volume":"155","author":"MR Blichfeldt-Eckhardt","year":"2014","unstructured":"Blichfeldt-Eckhardt MR, Ording H, Andersen C, Licht PB, Toft P. Early visceral pain predicts chronic pain after laparoscopic cholecystectomy. Pain. 2014;155(11):2400\u20137.","journal-title":"Pain"},{"issue":"11","key":"275_CR8","first-page":"907","volume":"62","author":"GE Lane","year":"1996","unstructured":"Lane GE, Lathrop JC, Boysen DA, Lane RC. Effect of intramuscular intraoperative pain medication on narcotic usage after laparoscopic cholecystectomy. Am Surg. 1996;62(11):907\u201310.","journal-title":"Am Surg"},{"issue":"3","key":"275_CR9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1213\/00000539-199109000-00004","volume":"73","author":"M Rosenblum","year":"1991","unstructured":"Rosenblum M, Weller RS, Conard PL, Falvey EA, Gross JB. Ibuprofen provides longer lasting analgesia than fentanyl after laparoscopic surgery. Anesth Analg. 1991;73(3):255\u20139.","journal-title":"Anesth Analg"},{"issue":"5","key":"275_CR10","first-page":"1061","volume":"76","author":"J Liu","year":"1993","unstructured":"Liu J, Ding Y, White PF, Feinstein R, Shear JM. Effects of ketorolac on postoperative analgesia and ventilatory function after laparoscopic cholecystectomy. Anesth Analg. 1993;76(5):1061\u20136.","journal-title":"Anesth Analg"},{"issue":"4","key":"275_CR11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000129279","volume":"25","author":"K Iwase","year":"1993","unstructured":"Iwase K, Takenaka H, Ishizaka T, Ohata T, Oshima S, Sakaguchi K. Serial changes in renal function during laparoscopic cholecystectomy. Eur Surg Res. 1993;25(4):203\u201312.","journal-title":"Eur Surg Res"},{"issue":"1","key":"275_CR12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00000542-199607000-00003","volume":"85","author":"A Pasqualucci","year":"1996","unstructured":"Pasqualucci A, de Angelis V, Contardo R, et al. Preemptive analgesia: intraperitoneal local anesthetic in laparoscopic cholecystectomy. A randomized, double-blind, placebo-controlled study. Anesthesiology. 1996;85(1):11\u201320.","journal-title":"Anesthesiology"},{"issue":"1","key":"275_CR13","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s004649910011","volume":"10","author":"JW Szem","year":"1996","unstructured":"Szem JW, Hydo L, Barie PS. A double-blinded evaluation of intraperitoneal bupivacaine vs saline for the reduction of postoperative pain and nausea after laparoscopic cholecystectomy. Surg Endosc. 1996;10(1):44\u20138.","journal-title":"Surg Endosc"},{"issue":"4","key":"275_CR14","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1093\/bja\/aeu411","volume":"114","author":"JA Szental","year":"2015","unstructured":"Szental JA, Webb A, Weeraratne C, Campbell A, Sivakumar H, Leong S. Postoperative pain after laparoscopic cholecystectomy is not reduced by intraoperative analgesia guided by analgesia nociception index (ANI\u00ae) monitoring: a randomized clinical trial. Br J Anaesth. 2015;114(4):640\u20135.","journal-title":"Br J Anaesth"},{"issue":"3","key":"275_CR15","first-page":"1044","volume":"262","author":"CG Pick","year":"1992","unstructured":"Pick CG, Paul D, Pasternak GW. Nalbuphine, a mixed \u03ba1 and \u03ba3 analgesic in mice. J Pharmacol Exp Ther. 1992;262(3):1044\u201350.","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"275_CR16","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1440-1681.1984.tb00268.x","volume":"11","author":"CL Wong","year":"1984","unstructured":"Wong CL, Wai MK. Increased naloxone potency induced by pretreatment with morphine and nalbuphine in mice. Clin Exp Pharmacol Physiol. 1984;11(3):301\u20137.","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"4","key":"275_CR17","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s0054020060439","volume":"6","author":"A Stav","year":"1992","unstructured":"Stav A, Rabinowitz R, Korczyn AD. Action of opioid agonist-antagonist drugs on the pupil and nociceptive responses in mice. J Anesth. 1992;6(4):439\u201345.","journal-title":"J Anesth"},{"issue":"1","key":"275_CR18","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pbb.2007.07.003","volume":"88","author":"MI Ortiz","year":"2007","unstructured":"Ortiz MI, Ponce-Monter H, Fernandez-Martinez E, et al. Evaluation of the interaction between acemetacin and opioids on the Hargreaves model of thermal hyperalgesia. Pharmacol Biochem Behav. 2007;88(1):47\u201354.","journal-title":"Pharmacol Biochem Behav"},{"issue":"2","key":"275_CR19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1089\/109264201750162310","volume":"11","author":"S Endo","year":"2001","unstructured":"Endo S, Souda S, Nezu R, et al. A new method of laparoscopic cholecystectomy using three trocars combined with suture retraction of gallbladder. J Laparoendosc Adv Surg Tech A. 2001;11(2):85\u20138.","journal-title":"J Laparoendosc Adv Surg Tech A"},{"issue":"3","key":"275_CR20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0304-3959(00)00406-1","volume":"90","author":"T Bisgaard","year":"2001","unstructured":"Bisgaard T, Klarskov B, Rosenberg J, Kehlet H. Characteristics and prediction of early pain after laparoscopic cholecystectomy. Pain. 2001;90(3):261\u20139.","journal-title":"Pain"},{"issue":"2","key":"275_CR21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.5055\/jom.2018.0441","volume":"14","author":"MP Davis","year":"2018","unstructured":"Davis MP, Fernandez C, Regel S, McPherson ML. Does nalbuphine have a niche in managing pain? J Opioid Manag. 2018;14(2):143\u201351.","journal-title":"J Opioid Manag"},{"issue":"15","key":"275_CR22","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.1523\/JNEUROSCI.20-15-05874.2000","volume":"20","author":"SK Joshi","year":"2000","unstructured":"Joshi SK, Su X, Porreca F, Gebhart GF. \u03ba-opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action. J Neurosci. 2000;20(15):5874\u20139.","journal-title":"J Neurosci"},{"issue":"3","key":"275_CR23","doi-asserted-by":"crossref","first-page":"G434","DOI":"10.1152\/ajpgi.00324.2002","volume":"284","author":"EH Kamp","year":"2003","unstructured":"Kamp EH, Jones RC 3rd, Tillman SR, Gebhart GF. Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice. Am J Physiol Gastrointest Liver Physiol. 2003;284(3):G434\u201344.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"8","key":"275_CR24","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/sj.bjp.0705763","volume":"141","author":"PJ Riviere","year":"2004","unstructured":"Riviere PJ. Peripheral kappa-opioid agonists for visceral pain. Br J Pharmacol. 2004;141(8):1331\u20134.","journal-title":"Br J Pharmacol"},{"issue":"4","key":"275_CR25","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1213\/ane.0b013e3181b0f0bb","volume":"109","author":"H Lenz","year":"2009","unstructured":"Lenz H, Sandvik L, Qvigstad E, Bjerkelund CE, Raeder J. A comparison of intravenous oxycodone and intravenous morphine in patient-controlled postoperative analgesia after laparoscopic hysterectomy. Anesth Analg. 2009;109(4):1279\u201383.","journal-title":"Anesth Analg"},{"issue":"3","key":"275_CR26","first-page":"1","volume":"151","author":"SEJ Golzari","year":"2015","unstructured":"Golzari SEJ, Nader ND, Mahmoodpoor A. Underlying mechanisms of postoperative pain after laparoscopic surgery. JAMA Surg. 2015;151(3):1.","journal-title":"JAMA Surg"},{"key":"275_CR27","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-020-00967-3","author":"OA Lyubashina","year":"2020","unstructured":"Lyubashina OA, Sivachenko IB, Panteleev SS. Supraspinal mechanisms of intestinal hypersensitivity. Cell Mol Neurobiol. 2020. https:\/\/doi.org\/10.1007\/s10571-020-00967-3.","journal-title":"Cell Mol Neurobiol"},{"issue":"10","key":"275_CR28","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1136\/gut.2008.170811","volume":"58","author":"PA Hughes","year":"2009","unstructured":"Hughes PA, Brierley SM, Martin CM, Brookes SJ, Linden DR, Blackshaw LA. Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses. Gut. 2009;58(10):1333\u201341.","journal-title":"Gut"},{"key":"275_CR29","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.2147\/JPR.S257018","volume":"13","author":"J Hu","year":"2020","unstructured":"Hu J, Chen S, Zhu M, et al. Preemptive nalbuphine attenuates remifentanil-induced postoperative hyperalgesia after laparoscopic cholecystectomy: a prospective randomized double-blind clinical trial. J Pain Res. 2020;13:1915\u201324.","journal-title":"J Pain Res"},{"issue":"8","key":"275_CR30","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1007\/s00464-010-0895-3","volume":"24","author":"HY Shin","year":"2010","unstructured":"Shin HY, Kim SH, Lee YJ, Kim DK. The effect of mechanical ventilation tidal volume during pneumoperitoneum on shoulder pain after a laparoscopic appendectomy. Surg Endosc. 2010;24(8):2002\u20137.","journal-title":"Surg Endosc"},{"issue":"24","key":"275_CR31","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1097\/BRS.0000000000003679","volume":"45","author":"C Kraiwattanapong","year":"2020","unstructured":"Kraiwattanapong C, Arnuntasupakul V, Kantawan R, Woratanarat P, Keorochana G, Langsanam N. Effect of multimodal drugs infiltration on postoperative pain in split laminectomy of lumbar Spine: a randomized controlled trial. Spine (Phila Pa 1976). 2020;45(24):1687\u201395.","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"275_CR32","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0020-7489(92)90016-A","volume":"29","author":"SJ Closs","year":"1992","unstructured":"Closs SJ. Patients\u2019 night-time pain, analgesic provision and sleep after surgery. Int J Nurs Stud. 1992;29(4):381\u201392.","journal-title":"Int J Nurs Stud"},{"issue":"1","key":"275_CR33","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/00000542-199007000-00009","volume":"73","author":"RL Knill","year":"1990","unstructured":"Knill RL, Moote CA, Skinner MI, Rose EA. Anesthesia with abdominal surgery leads to intense REM sleep during the first postoperative week. Anesthesiology. 1990;73(1):52\u201361.","journal-title":"Anesthesiology"},{"issue":"5","key":"275_CR34","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/BF00403581","volume":"14","author":"DC Kay","year":"1969","unstructured":"Kay DC, Eisenstein RB, Jasinski DR. Morphine effects on human REM state, waking state and NREM sleep. Psychopharmacologia. 1969;14(5):404\u201316.","journal-title":"Psychopharmacologia"},{"issue":"6","key":"275_CR35","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1159\/000484573","volume":"46","author":"VS Mathur","year":"2017","unstructured":"Mathur VS, Kumar J, Crawford PW, Hait H, Sciascia T, Investigators TRS. A multicenter, randomized, double-blind, placebo-controlled trial of nalbuphine ER tablets for uremic pruritus. Am J Nephrol. 2017;46(6):450\u20138.","journal-title":"Am J Nephrol"},{"issue":"4","key":"275_CR36","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2044.1988.tb08974.x","volume":"43","author":"MR Sury","year":"1988","unstructured":"Sury MR, Cole PV. Nalbuphine combined with midazolam for outpatient sedation. An assessment in fibreoptic bronchoscopy patients. Anaesthesia. 1988;43(4):285\u20138.","journal-title":"Anaesthesia"},{"issue":"6","key":"275_CR37","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1365-2125.1994.tb04395.x","volume":"38","author":"AA van den Berg","year":"1994","unstructured":"van den Berg AA, Honjol NM, Prabhu NV, Analgesics and ENT surgery, et al. A clinical comparison of the intraoperative, recovery and postoperative effects of buprenorphine, diclofenac, fentanyl, morphine, nalbuphine, pethidine and placebo given intravenously with induction of anaesthesia. Br J Clin Pharmacol. 1994;38(6):533\u201343.","journal-title":"Br J Clin Pharmacol"},{"key":"275_CR38","doi-asserted-by":"crossref","first-page":"10927","DOI":"10.1038\/srep10927","volume":"5","author":"Z Zeng","year":"2015","unstructured":"Zeng Z, Lu J, Shu C, et al. A comparison of nalbuphine with morphine for analgesic effects and safety: meta-analysis of randomized controlled trials. Sci Rep. 2015;5:10927.","journal-title":"Sci Rep"},{"key":"275_CR39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.neuropharm.2017.12.032","volume":"131","author":"MZ Imam","year":"2018","unstructured":"Imam MZ, Kuo A, Ghassabian S, Smith MT. Progress in understanding mechanisms of opioid-induced gastrointestinal adverse effects and respiratory depression. Neuropharmacology. 2018;131:238\u201355.","journal-title":"Neuropharmacology"},{"issue":"1","key":"275_CR40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0165-5728(95)00159-X","volume":"64","author":"C Alicea","year":"1996","unstructured":"Alicea C, Belkowski S, Eisenstein TK, Adler MW, Rogers TJ. Inhibition of primary murine macrophage cytokine production in vitro following treatment with the kappa-opioid agonist U50,488H. J Neuroimmunol. 1996;64(1):83\u201390.","journal-title":"J Neuroimmunol"},{"issue":"1\u20132","key":"275_CR41","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0165-5728(97)00018-0","volume":"75","author":"L Guan","year":"1997","unstructured":"Guan L, Eisenstein TK, Adler MW, Rogers TJ. Inhibition of T cell superantigen responses following treatment with the kappa-opioid agonist U50,488H. J Neuroimmunol. 1997;75(1\u20132):163\u20138.","journal-title":"J Neuroimmunol"},{"issue":"1","key":"275_CR42","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/bja\/aet153","volume":"111","author":"M Al-Hashimi","year":"2013","unstructured":"Al-Hashimi M, Scott SWM, Thompson JP, Lambert DG. Opioids and immune modulation: more questions than answers. Br J Anaesth. 2013;111(1):80\u20138.","journal-title":"Br J Anaesth"},{"issue":"3","key":"275_CR43","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1172\/JCI72230","volume":"124","author":"T Berta","year":"2014","unstructured":"Berta T, Park CK, Xu ZZ, et al. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-alpha secretion. J Clin Invest. 2014;124(3):1173\u201386.","journal-title":"J Clin Invest"},{"issue":"9","key":"275_CR44","doi-asserted-by":"crossref","first-page":"G788","DOI":"10.1152\/ajpgi.00318.2013","volume":"306","author":"DD Song","year":"2014","unstructured":"Song DD, Li Y, Tang D, Huang LY, Yuan YZ. Neuron-glial communication mediated by TNF-alpha and glial activation in dorsal root ganglia in visceral inflammatory hypersensitivity. Am J Physiol Gastrointest Liver Physiol. 2014;306(9):G788\u201395.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"275_CR45","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12871-019-0775-x","volume":"19","author":"Y An","year":"2019","unstructured":"An Y, Zhao L, Wang T, et al. Preemptive oxycodone is superior to equal dose of sufentanil to reduce visceral pain and inflammatory markers after surgery: a randomized controlled trail. BMC Anesthesiol. 2019;19(1):96.","journal-title":"BMC Anesthesiol"},{"issue":"4","key":"275_CR46","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.bja.2018.06.023","volume":"121","author":"AWH Barazanchi","year":"2018","unstructured":"Barazanchi AWH, MacFater WS, Rahiri JL, et al. Evidence-based management of pain after laparoscopic cholecystectomy: a PROSPECT review update. Br J Anaesth. 2018;121(4):787\u2013803.","journal-title":"Br J Anaesth"},{"issue":"2","key":"275_CR47","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0304-3959(99)00119-0","volume":"83","author":"RW Gear","year":"1999","unstructured":"Gear RW, Miaskowski C, Gordon NC, Paul SM, Heller PH, Levine JD. The kappa opioid nalbuphine produces gender- and dose-dependent analgesia and antianalgesia in patients with postoperative pain. Pain. 1999;83(2):339\u201345.","journal-title":"Pain"}],"container-title":["Pain and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40122-021-00275-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40122-021-00275-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40122-021-00275-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T16:41:11Z","timestamp":1636648871000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40122-021-00275-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,4]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["275"],"URL":"https:\/\/doi.org\/10.1007\/s40122-021-00275-8","relation":{},"ISSN":["2193-8237","2193-651X"],"issn-type":[{"value":"2193-8237","type":"print"},{"value":"2193-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,4]]},"assertion":[{"value":"22 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}