{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:00:51Z","timestamp":1788170451475,"version":"build-2803163510"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pain Ther"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s40122-025-00752-4","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T01:59:47Z","timestamp":1749952787000},"page":"1399-1416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Progressive Response of Repeated Treatment with High-Concentration (179 mg) Capsaicin Patch in Peripheral Neuropathic Pain After Surgical or Traumatic Nerve Injury: Findings from the 12-Month German CASPAR Registry Study"],"prefix":"10.1007","volume":"14","author":[{"given":"Michael A.","family":"\u00dcberall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Simanski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Zellnig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00eblle","family":"Eerdekens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Engelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Heine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Percot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Freitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Garcia","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Quandel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,15]]},"reference":[{"issue":"1","key":"752_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/j.pain.0000000000001413","volume":"160","author":"SA Schug","year":"2019","unstructured":"Schug SA, Lavand\u2019homme P, Barke A, et al. The IASP classification of chronic pain for ICD-11: chronic postsurgical or posttraumatic pain. Pain. 2019;160(1):45\u201352.","journal-title":"Pain"},{"issue":"1","key":"752_CR2","doi-asserted-by":"publisher","first-page":"24.e1","DOI":"10.1016\/j.jpain.2013.08.014","volume":"15","author":"C Duale","year":"2014","unstructured":"Duale C, Ouchchane L, Schoeffler P, Group EI, Dubray C. Neuropathic aspects of persistent postsurgical pain: a French multicenter survey with a 6-month prospective follow-up. J Pain. 2014;15(1):24.e1-e0.","journal-title":"J Pain"},{"issue":"10","key":"752_CR3","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1097\/EJA.0000000000000319","volume":"32","author":"D Fletcher","year":"2015","unstructured":"Fletcher D, Stamer UM, Pogatzki-Zahn E, et al. Chronic postsurgical pain in Europe: an observational study. Eur J Anaesthesiol. 2015;32(10):725\u201334.","journal-title":"Eur J Anaesthesiol"},{"issue":"1","key":"752_CR4","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.pain.2012.09.010","volume":"154","author":"S Haroutiunian","year":"2013","unstructured":"Haroutiunian S, Nikolajsen L, Finnerup NB, Jensen TS. The neuropathic component in persistent postsurgical pain: a systematic literature review. Pain. 2013;154(1):95\u2013102.","journal-title":"Pain"},{"issue":"7","key":"752_CR5","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1111\/pme.12434","volume":"15","author":"CJ Simanski","year":"2014","unstructured":"Simanski CJ, Althaus A, Hoederath S, et al. Incidence of chronic postsurgical pain (CPSP) after general surgery. Pain Med. 2014;15(7):1222\u20139.","journal-title":"Pain Med"},{"issue":"2","key":"752_CR6","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/SPC.0b013e328360b09e","volume":"7","author":"R Cregg","year":"2013","unstructured":"Cregg R, Anwar S, Farquhar-Smith P. Persistent postsurgical pain. Curr Opin Support Palliat Care. 2013;7(2):144\u201352.","journal-title":"Curr Opin Support Palliat Care"},{"issue":"6","key":"752_CR7","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000627","volume":"2","author":"SA Schug","year":"2017","unstructured":"Schug SA, Bruce J. Risk stratification for the development of chronic postsurgical pain. Pain Rep. 2017;2(6): e627.","journal-title":"Pain Rep"},{"issue":"2","key":"752_CR8","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1097\/AJP.0b013e3181f7f9bb","volume":"27","author":"AL Browne","year":"2011","unstructured":"Browne AL, Andrews R, Schug SA, Wood F. Persistent pain outcomes and patient satisfaction with pain management after burn injury. Clin J Pain. 2011;27(2):136\u201345.","journal-title":"Clin J Pain"},{"issue":"5","key":"752_CR9","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/j.surg.2011.04.003","volume":"150","author":"T Gross","year":"2011","unstructured":"Gross T, Amsler F. Prevalence and incidence of longer term pain in survivors of polytrauma. Surgery. 2011;150(5):985\u201395.","journal-title":"Surgery"},{"issue":"8","key":"752_CR10","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/j.injury.2016.05.022","volume":"47","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Liu P, Rui J, Zhao X, Lao J. The clinical characteristics of neuropathic pain in patients with total brachial plexus avulsion: a 30-case study. Injury. 2016;47(8):1719\u201324.","journal-title":"Injury"},{"issue":"1","key":"752_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1515\/sjpain-2019-0111","volume":"20","author":"A Miclescu","year":"2019","unstructured":"Miclescu A, Straatmann A, Gkatziani P, Butler S, Karlsten R, Gordh T. Chronic neuropathic pain after traumatic peripheral nerve injuries in the upper extremity: prevalence, demographic and surgical determinants, impact on health and on pain medication. Scand J Pain. 2019;20(1):95\u2013108.","journal-title":"Scand J Pain"},{"issue":"2","key":"752_CR12","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(14)70251-0","volume":"14","author":"NB Finnerup","year":"2015","unstructured":"Finnerup NB, Attal N, Haroutounian S, et al. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol. 2015;14(2):162\u201373.","journal-title":"Lancet Neurol"},{"issue":"5","key":"752_CR13","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1302\/2058-5241.2.160071","volume":"2","author":"LB Dahlin","year":"2017","unstructured":"Dahlin LB, Wiberg M. Nerve injuries of the upper extremity and hand. EFORT Open Rev. 2017;2(5):158\u201370.","journal-title":"EFORT Open Rev"},{"issue":"12","key":"752_CR14","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1016\/j.pain.2011.09.014","volume":"152","author":"N Attal","year":"2011","unstructured":"Attal N, Lanteri-Minet M, Laurent B, Fermanian J, Bouhassira D. The specific disease burden of neuropathic pain: results of a French nationwide survey. Pain. 2011;152(12):2836\u201343.","journal-title":"Pain"},{"issue":"2","key":"752_CR15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090014","volume":"9","author":"Z Peng","year":"2014","unstructured":"Peng Z, Li H, Zhang C, Qian X, Feng Z, Zhu S. A retrospective study of chronic post-surgical pain following thoracic surgery: prevalence, risk factors, incidence of neuropathic component, and impact on qualify of life. PLoS ONE. 2014;9(2): e90014.","journal-title":"PLoS ONE"},{"issue":"10","key":"752_CR16","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1097\/EJA.0000000000000682","volume":"34","author":"A Steyaert","year":"2017","unstructured":"Steyaert A, Lavand\u2019homme P. Acute and chronic neuropathic pain after surgery: still a lot to learn. Eur J Anaesthesiol. 2017;34(10):650\u20131.","journal-title":"Eur J Anaesthesiol"},{"issue":"1","key":"752_CR17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3111\/13696998.2012.729548","volume":"16","author":"PC Langley","year":"2013","unstructured":"Langley PC, Van Litsenburg C, Cappelleri JC, Carroll D. The burden associated with neuropathic pain in Western Europe. J Med Econ. 2013;16(1):85\u201395.","journal-title":"J Med Econ"},{"key":"752_CR18","first-page":"483","volume":"6","author":"C Schaefer","year":"2014","unstructured":"Schaefer C, Sadosky A, Mann R, et al. Pain severity and the economic burden of neuropathic pain in the United States: BEAT Neuropathic Pain Observational Study. Clinicoecon Outcomes Res. 2014;6:483\u201396.","journal-title":"Clinicoecon Outcomes Res"},{"issue":"4","key":"752_CR19","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1002\/ejp.1915","volume":"26","author":"C Allen","year":"2022","unstructured":"Allen C, Walker AM, Premji ZA, et al. Preventing persistent postsurgical pain: a systematic review and component network meta-analysis. Eur J Pain. 2022;26(4):771\u201385.","journal-title":"Eur J Pain"},{"key":"752_CR20","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev.med.55.091902.105248","volume":"55","author":"SA Darzi","year":"2004","unstructured":"Darzi SA, Munz Y. The impact of minimally invasive surgical techniques. Annu Rev Med. 2004;55:223\u201337.","journal-title":"Annu Rev Med"},{"key":"752_CR21","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev-pharmtox-010818-021524","volume":"60","author":"K Bannister","year":"2020","unstructured":"Bannister K, Sachau J, Baron R, Dickenson AH. Neuropathic pain: mechanism-based therapeutics. Annu Rev Pharmacol Toxicol. 2020;60:257\u201374.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"752_CR22","unstructured":"Schlereth T, et al. Diagnosis and non-interventional therapy of neuropathic pain [Diagnose und nicht interventionelle Therapie neuropathischer Schmerzen]; S2k-level guideline of the Deutsche Gesellschaft f\u00fcr Neurologie; Guidelines for Diagnostics and Therapy in Neurology. 2019. https:\/\/www.dgn.org\/leitlinien. Accessed 13 Nov 2019"},{"issue":"5","key":"752_CR23","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/S1474-4422(25)00068-7","volume":"24","author":"N Soliman","year":"2025","unstructured":"Soliman N, Moisset X, Ferraro MC, et al. Pharmacotherapy and non-invasive neuromodulation for neuropathic pain: a systematic review and meta-analysis. Lancet Neurol. 2025;24(5):413\u201328.","journal-title":"Lancet Neurol"},{"issue":"5","key":"752_CR24","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1111\/papr.12989","volume":"21","author":"T Schubert","year":"2021","unstructured":"Schubert T, Kern KU, Schneider S, Baron R. Oral or topical pain therapy\u2014how would patients decide? A discrete choice experiment in patients with peripheral neuropathic pain (pNP). Pain Pract. 2021;21(5):536\u201346.","journal-title":"Pain Pract"},{"issue":"10","key":"752_CR25","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1093\/pm\/pnab113","volume":"22","author":"R Freynhagen","year":"2021","unstructured":"Freynhagen R, Argoff C, Eerdekens M, Engelen S, Perrot S. Progressive response to repeat application of capsaicin 179 mg (8% w\/w) cutaneous patch in peripheral neuropathic pain: comprehensive new analysis and clinical implications. Pain Med. 2021;22(10):2324\u201336.","journal-title":"Pain Med"},{"issue":"10","key":"752_CR26","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1097\/AJP.0000000000000473","volume":"33","author":"R Galvez","year":"2017","unstructured":"Galvez R, Navez ML, Moyle G, et al. Capsaicin 8% patch repeat treatment in nondiabetic peripheral neuropathic pain: a 52-week, open-label, single-arm, safety study. Clin J Pain. 2017;33(10):921\u201331.","journal-title":"Clin J Pain"},{"issue":"5","key":"752_CR27","doi-asserted-by":"publisher","first-page":"E541","DOI":"10.36076\/ppj.2020\/23\/E541","volume":"23","author":"D Goncalves","year":"2020","unstructured":"Goncalves D, Rebelo V, Barbosa P, Gomes A. 8% capsaicin patch in treatment of peripheral neuropathic pain. Pain Physician. 2020;23(5):E541\u20138.","journal-title":"Pain Physician"},{"issue":"5","key":"752_CR28","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1002\/ejp.1180","volume":"22","author":"P Hansson","year":"2018","unstructured":"Hansson P, Jensen TS, Kvarstein G, Stromberg M. Pain-relieving effectiveness, quality of life and tolerability of repeated capsaicin 8% patch treatment of peripheral neuropathic pain in Scandinavian clinical practice. Eur J Pain. 2018;22(5):941\u201350.","journal-title":"Eur J Pain"},{"issue":"6","key":"752_CR29","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1185\/03007995.2013.792246","volume":"29","author":"C Maih\u00f6fner","year":"2013","unstructured":"Maih\u00f6fner C, Heskamp ML. Prospective, non-interventional study on the tolerability and analgesic effectiveness over 12 weeks after a single application of capsaicin 8% cutaneous patch in 1044 patients with peripheral neuropathic pain: first results of the QUEPP study. Curr Med Res Opin. 2013;29(6):673\u201383.","journal-title":"Curr Med Res Opin"},{"issue":"1","key":"752_CR30","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12883-017-0836-z","volume":"17","author":"C Mankowski","year":"2017","unstructured":"Mankowski C, Poole CD, Ernault E, et al. Effectiveness of the capsaicin 8% patch in the management of peripheral neuropathic pain in European clinical practice: the ASCEND study. BMC Neurol. 2017;17(1):80.","journal-title":"BMC Neurol"},{"issue":"5\u20136","key":"752_CR31","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1159\/000487444","volume":"101","author":"J Tenreiro Pinto","year":"2018","unstructured":"Tenreiro Pinto J, Pereira FC, Loureiro MC, Gama R, Fernandes HL. Efficacy analysis of capsaicin 8% patch in neuropathic peripheral pain treatment. Pharmacology. 2018;101(5\u20136):290\u20137.","journal-title":"Pharmacology"},{"issue":"4","key":"752_CR32","first-page":"E641","volume":"25","author":"IF Vieira","year":"2022","unstructured":"Vieira IF, de Castro AM, Loureiro MDC, Pinto J, Cardoso C, Assuncao JP. Capsaicin 8% for peripheral neuropathic pain treatment: a retrospective cohort study. Pain Physician. 2022;25(4):E641\u20137.","journal-title":"Pain Physician"},{"issue":"1","key":"752_CR33","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s12883-016-0752-7","volume":"16","author":"AI Vinik","year":"2016","unstructured":"Vinik AI, Perrot S, Vinik EJ, et al. Capsaicin 8% patch repeat treatment plus standard of care (SOC) versus SOC alone in painful diabetic peripheral neuropathy: a randomised, 52-week, open-label, safety study. BMC Neurol. 2016;16(1):251.","journal-title":"BMC Neurol"},{"key":"752_CR34","first-page":"388","volume":"2","author":"AI Vinik","year":"2019","unstructured":"Vinik AI, Perrot S, Vinik EJ, et al. Repeat treatment with capsaicin 8% patch (179 mg capsaicin cutaneous patch): effects on pain, quality of life, and patient satisfaction in painful diabetic peripheral neuropathy: an open-label, randomized controlled clinical trial. Curr Med Res Opin. 2019;2:388\u2013401.","journal-title":"Curr Med Res Opin"},{"key":"752_CR35","doi-asserted-by":"publisher","first-page":"1452099","DOI":"10.3389\/fonc.2024.1452099","volume":"14","author":"MP Lux","year":"2024","unstructured":"Lux MP, Flother L, Fromter C, et al. Topical treatment of chemotherapy-induced peripheral neuropathy (CIPN) with high-concentration (179 mg) capsaicin patch in breast cancer patients \u2013 results of the QUCIP study. Front Oncol. 2024;14:1452099.","journal-title":"Front Oncol"},{"issue":"2","key":"752_CR36","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1002\/ejp.731","volume":"20","author":"M Haanp\u00e4\u00e4","year":"2016","unstructured":"Haanp\u00e4\u00e4 M, Cruccu G, Nurmikko TJ, et al. Capsaicin 8% patch versus oral pregabalin in patients with peripheral neuropathic pain. Eur J Pain. 2016;20(2):316\u201328.","journal-title":"Eur J Pain"},{"key":"752_CR37","unstructured":"SmPC. European Medicines Agency (EMA). Qutenza 179 mg cutaneous patch: EU summary of product characteristics. 2024. https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/qutenza-epar-product-information_en.pdf. Accessed 5 Dec 2024."},{"key":"752_CR38","unstructured":"FDA. U. S. Food and Rug Administration; Approval Letter Qutenza. 2010. https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2009\/022395s000Approv.pdf. Accessed 7 Apr 2024"},{"issue":"10","key":"752_CR39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0109144","volume":"9","author":"JM Bischoff","year":"2014","unstructured":"Bischoff JM, Ringsted TK, Petersen M, Sommer C, Uceyler N, Werner MU. A capsaicin (8%) patch in the treatment of severe persistent inguinal postherniorrhaphy pain: a randomized, double-blind, placebo-controlled trial. PLoS ONE. 2014;9(10): e109144.","journal-title":"PLoS ONE"},{"issue":"2","key":"752_CR40","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s11845-021-02632-0","volume":"191","author":"CF Mullins","year":"2022","unstructured":"Mullins CF, Walsh S, Rooney A, McCrory C, Das B. A preliminary prospective observational study of the effectiveness of high-concentration capsaicin cutaneous patch in the management of chronic post-surgical neuropathic pain. Ir J Med Sci. 2022;191(2):859\u201364.","journal-title":"Ir J Med Sci"},{"issue":"1","key":"752_CR41","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1177\/20494637231201502","volume":"18","author":"MP Santos","year":"2024","unstructured":"Santos MP, Lemos F, Gomes J, Rom\u00e3o JM, Veiga D. Topical capsaicin 8% patch in peripheral neuropathic pain: efficacy and quality of life. Br J Pain. 2024;18(1):42\u201356.","journal-title":"Br J Pain"},{"issue":"7","key":"752_CR42","doi-asserted-by":"publisher","first-page":"E1049","DOI":"10.36076\/ppj\/2016.19.E1049","volume":"19","author":"P Zis","year":"2016","unstructured":"Zis P, Bernali N, Argira E, Siafaka I, Vadalouka A. Effectiveness and impact of capsaicin 8% patch on quality of life in patients with lumbosacral pain: an open-label study. Pain Physician. 2016;19(7):E1049\u201353.","journal-title":"Pain Physician"},{"issue":"2","key":"752_CR43","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3390\/cancers17020313","volume":"17","author":"D Dupoiron","year":"2025","unstructured":"Dupoiron D, Bienfait F, Seegers V, et al. Evaluating treatment preferences and the efficacy of capsaicin 179 mg patch vs. pregabalin in a randomized trial for postsurgical neuropathic pain in breast cancer: CAPTRANE. Cancers (Basel). 2025;17(2):313.","journal-title":"Cancers (Basel)"},{"key":"752_CR44","unstructured":"Deutsche Gesellschaft f\u00fcr Schmerzmedizin e.V.; Dokumentationsplattform iDocLive\u00ae. www.dgschmerzmedizin.de [Internet]. Accessed 18 Apr 2025"},{"key":"752_CR45","unstructured":"Deutsche Schmerzgesellschaft e.V. www.schmerzgesellschaft.de [Internet]. Accessed 18 Apr 2025"},{"key":"752_CR46","unstructured":"Deutsche Schmerzliga e.V. www.schmerzliga.de [Internet]. Accessed 18 Apr 2025"},{"issue":"3 Suppl","key":"752_CR47","doi-asserted-by":"publisher","first-page":"S178","DOI":"10.1097\/00005650-198903001-00015","volume":"27","author":"LE Kazis","year":"1989","unstructured":"Kazis LE, Anderson JJ, Meenan RF. Effect sizes for interpreting changes in health status. Med Care. 1989;27(3 Suppl):S178\u201389.","journal-title":"Med Care"},{"key":"752_CR48","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2147\/JPR.S341378","volume":"15","author":"D Dupoiron","year":"2022","unstructured":"Dupoiron D, Jubier-Hamon S, Seegers V, et al. Peripheral neuropathic pain following breast cancer: effectiveness and tolerability of high-concentration capsaicin patch. J Pain Res. 2022;15:241\u201355.","journal-title":"J Pain Res"},{"issue":"3","key":"752_CR49","doi-asserted-by":"publisher","first-page":"202","DOI":"10.20408\/jti.2022.0019","volume":"35","author":"M\u00d6 Atar","year":"2022","unstructured":"Atar M\u00d6, Kamac\u0131 GK, \u00d6zcan F, Demir Y, Aydemir K. The effect of neuropathic pain on quality of life, depression levels, and sleep quality in patients with combat-related extremity injuries. J Trauma Injury. 2022;35(3):202\u20138.","journal-title":"J Trauma Injury"},{"issue":"10","key":"752_CR50","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1111\/aas.12579","volume":"59","author":"JR Duffy","year":"2015","unstructured":"Duffy JR, Warburg FE, Koelle SF, Werner MU, Nielsen PR. Pain-related psychological distress, self-rated health and significance of neuropathic pain in Danish soldiers injured in Afghanistan. Acta Anaesthesiol Scand. 2015;59(10):1367\u201376.","journal-title":"Acta Anaesthesiol Scand"},{"issue":"4","key":"752_CR51","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.clinthera.2017.02.010","volume":"39","author":"F van Nooten","year":"2017","unstructured":"van Nooten F, Treur M, Pantiri K, Stoker M, Charokopou M. Capsaicin 8% patch versus oral neuropathic pain medications for the treatment of painful diabetic peripheral neuropathy: a systematic literature review and network meta-analysis. Clin Ther. 2017;39(4):787-803.e18.","journal-title":"Clin Ther"},{"issue":"3","key":"752_CR52","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1080\/03007995.2018.1558850","volume":"35","author":"M Lanteri-Minet","year":"2019","unstructured":"Lanteri-Minet M, Perrot S. QAPSA: post-marketing surveillance of capsaicin 8% patch for long-term use in patients with peripheral neuropathic pain in France. Curr Med Res Opin. 2019;35(3):417\u201326.","journal-title":"Curr Med Res Opin"},{"issue":"6","key":"752_CR53","doi-asserted-by":"publisher","first-page":"453","DOI":"10.36076\/ppj.2021.24.453","volume":"24","author":"E Viel","year":"2021","unstructured":"Viel E, Eerdekens M, Kandaswamy P. Treatment impact on patient-reported outcomes in peripheral neuropathic pain: comparing single intervention with topical high-concentration capsaicin to daily oral pregabalin. Pain Physician. 2021;24(6):453\u201363.","journal-title":"Pain Physician"},{"issue":"1","key":"752_CR54","doi-asserted-by":"publisher","first-page":"18964","DOI":"10.1038\/s41598-020-75888-8","volume":"10","author":"TI Chang","year":"2020","unstructured":"Chang TI, Park H, Kim DW, et al. Polypharmacy, hospitalization, and mortality risk: a nationwide cohort study. Sci Rep. 2020;10(1):18964.","journal-title":"Sci Rep"},{"issue":"12","key":"752_CR55","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1007\/s40266-024-01151-8","volume":"41","author":"G Pickering","year":"2024","unstructured":"Pickering G, Kotlinska-Lemieszek A, Krcevski Skvarc N, et al. Pharmacological pain treatment in older persons. Drugs Aging. 2024;41(12):959\u201376.","journal-title":"Drugs Aging"},{"issue":"10","key":"752_CR56","doi-asserted-by":"publisher","first-page":"960","DOI":"10.3390\/jpm11100960","volume":"11","author":"LG Giaccari","year":"2021","unstructured":"Giaccari LG, Aurilio C, Coppolino F, et al. Capsaicin 8% patch and chronic postsurgical neuropathic pain. J Pers Med. 2021;11(10):960.","journal-title":"J Pers Med"},{"key":"752_CR57","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.conctc.2016.09.003","volume":"4","author":"AK Abdulahad","year":"2016","unstructured":"Abdulahad AK, Snijder RJ, Panni MK, Riaz FK, Karas AJ. A novel standard to evaluate the impact of therapeutic agents on patient safety\u2014the burden of therapy. Contemp Clin Trials Commun. 2016;4:186\u201391.","journal-title":"Contemp Clin Trials Commun"},{"key":"752_CR58","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.2147\/JPR.S140925","volume":"10","author":"R Privitera","year":"2017","unstructured":"Privitera R, Birch R, Sinisi M, Mihaylov IR, Leech R, Anand P. Capsaicin 8% patch treatment for amputation stump and phantom limb pain: a clinical and functional MRI study. J Pain Res. 2017;10:1623\u201334.","journal-title":"J Pain Res"}],"container-title":["Pain and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40122-025-00752-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40122-025-00752-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40122-025-00752-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T19:56:40Z","timestamp":1757188600000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40122-025-00752-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,15]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["752"],"URL":"https:\/\/doi.org\/10.1007\/s40122-025-00752-4","relation":{},"ISSN":["2193-8237","2193-651X"],"issn-type":[{"value":"2193-8237","type":"print"},{"value":"2193-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,15]]},"assertion":[{"value":"27 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Michael A. \u00dcberall is the director of the private Institute for Neurosciences and the Center of Excellence for Health Services Research in Nuremberg, honorary vice president of the German Pain Association, and president of the German Pain League. In the past 5\u00a0years, Michael A. \u00dcberall has received lecture and consulting fees as well as expense reimbursements for associated travel activities from Gr\u00fcnenthal. Christian Simanski: During the last 5\u00a0years, Christian Simanski received speaker and consultancy fees from Gr\u00fcnenthal. A professor at the Chair of Orthopedics and Trauma Surgery at the private University of Witten\/Herdecke, Campus Cologne-Merheim. Took part in expert and consulting activities for the German Statutory Accident Insurance (DGUV) and all affiliated professional associations. Took part in expert activity for the District Court of Essen and Cologne. Mike Zellnig: Fees and reimbursement of travel and congress costs in the last 3\u00a0years received from Gr\u00fcnenthal, Deutsche Schmerzgesellschaft, BG RCI, VBG, BGW, BG Bau, BG Verkehr, BGHW, Hochschule der Gesetzlichen Unfallversicherung, Hochschule Bonn-Rhein-Sieg, and HDI Versicherung. Mari\u00eblle Eerdekens, Sylvia Engelen, Myriam Heine, Fabienne Percot, Rita Freitas, Lucia Garcia Guerra, and Tamara Quandel are employees of Gr\u00fcnenthal GmbH, Germany, or its affiliates.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}},{"value":"This retrospective, non-interventional study used fully anonymized data from the GPeR registry. Ethical committee approval was not required, as no identifiable information was analyzed, and no study-specific interventions took place. The study concept and data use were endorsed by the steering committees of the German Pain Association and the German Pain League. Permission to use the data was granted to O.Meany-MDPM GmbH under formal contractual agreement, and all participating physicians and patients had provided prior written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}