{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T16:19:20Z","timestamp":1771345160360,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pain Ther"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s40122-025-00805-8","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T09:48:53Z","timestamp":1765878533000},"page":"367-377","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real-World Data on the Efficacy of OnabotulinumtoxinA Injections as Prophylactic Treatment for Migraine: A Retrospective Study from Jeddah, Saudi Arabia (2016\u20132024)"],"prefix":"10.1007","volume":"15","author":[{"given":"Ahmed","family":"Attar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasser","family":"Aladdin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alqassem","family":"Hakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4020-0986","authenticated-orcid":false,"given":"Abdalmajed","family":"Alqsair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulaiman","family":"Baeisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Alsimsimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Alzebaidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"805_CR1","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s10194-025-02192-z","volume":"26","author":"A Hus\u00f8y","year":"2025","unstructured":"Hus\u00f8y A, Steiner T. GBD 2023: over twice the health loss from headache disorders among females compared with males, and one fifth of the loss is attributable to medication overuse. J Headache Pain. 2025;26:227. https:\/\/doi.org\/10.1186\/s10194-025-02192-z.","journal-title":"J Headache Pain"},{"issue":"1","key":"805_CR2","volume":"8","author":"HA Abo Taleb","year":"2021","unstructured":"Abo Taleb HA, Al-Hayani MM, Alghamdi BS. Migraine-related disabilities among Saudi migraine patients and its association with social factors. Arch Neurosci. 2021;8(1):e108778.","journal-title":"Arch Neurosci"},{"issue":"2","key":"805_CR3","first-page":"151","volume":"26","author":"L Santana","year":"2021","unstructured":"Santana L, Liu C. Experience of botulinum toxin A injections for chronic migraine headaches in a pediatric chronic pain clinic. J Pediatr Pharmacol Ther. 2021;26(2):151\u20136.","journal-title":"J Pediatr Pharmacol Ther"},{"issue":"5","key":"805_CR4","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s40265-018-0894-6","volume":"78","author":"JE Frampton","year":"2018","unstructured":"Frampton JE, Silberstein S. OnabotulinumtoxinA: a review in the prevention of chronic migraine. Drugs. 2018;78(5):589\u2013600.","journal-title":"Drugs"},{"issue":"6","key":"805_CR5","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/j.1526-4610.2010.01678.x","volume":"50","author":"DW Dodick","year":"2010","unstructured":"Dodick DW, Turkel CC, DeGryse RE, et al. OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the PREEMPT trials. Headache. 2010;50(6):921\u201336.","journal-title":"Headache"},{"issue":"7","key":"805_CR6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027953","volume":"9","author":"CP Herd","year":"2019","unstructured":"Herd CP, Tomlinson CL, Rick C, et al. Botulinum toxin for the prevention of migraine: Cochrane systematic review and meta-analysis. BMJ Open. 2019;9(7):e027953.","journal-title":"BMJ Open"},{"issue":"8","key":"805_CR7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nrneurol.2016.93","volume":"12","author":"A May","year":"2016","unstructured":"May A, Schulte LH. Chronic migraine: risk factors, mechanisms and treatment. Nat Rev Neurol. 2016;12(8):455\u201364.","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"805_CR8","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1007\/s13760-020-01521-0","volume":"121","author":"H Algahtani","year":"2021","unstructured":"Algahtani H, Shirah B, Sukkar G, et al. Botulinum toxin injection in the management of chronic migraine: the Saudi experience. Acta Neurol Belg. 2021;121(6):1783\u20137.","journal-title":"Acta Neurol Belg"},{"issue":"7","key":"805_CR9","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/s10072-016-2568-z","volume":"37","author":"M Russo","year":"2016","unstructured":"Russo M, Manzoni GC, Taga A, et al. Use of onabotulinumtoxinA in the treatment of chronic migraine at the Parma Headache Centre: a prospective observational study. Neurol Sci. 2016;37(7):1127\u201331.","journal-title":"Neurol Sci"},{"issue":"1","key":"805_CR10","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s10194-018-0840-8","volume":"19","author":"AM Blumenfeld","year":"2018","unstructured":"Blumenfeld AM, Stark RJ, Freeman MC, et al. COMPEL study: long-term efficacy and safety of onabotulinumtoxinA in chronic migraine. J Headache Pain. 2018;19(1):13.","journal-title":"J Headache Pain"},{"issue":"1","key":"805_CR11","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/1129-2377-15-54","volume":"15","author":"M Khalil","year":"2014","unstructured":"Khalil M, Zafar HW, Quarshie V, et al. Real-life use of onabotulinumtoxinA in chronic migraine: analysis of 254 patients. J Headache Pain. 2014;15(1):54.","journal-title":"J Headache Pain"},{"issue":"14","key":"805_CR12","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1177\/0333102417724150","volume":"37","author":"M Matharu","year":"2017","unstructured":"Matharu M, Pascual J, Nilsson Remahl I, et al. Utilization and safety of onabotulinumtoxinA for chronic migraine prophylaxis in Europe. Cephalalgia. 2017;37(14):1384\u201397.","journal-title":"Cephalalgia"},{"issue":"7","key":"805_CR13","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1177\/0333102410364676","volume":"30","author":"SK Aurora","year":"2010","unstructured":"Aurora SK, Dodick DW, Turkel CC, et al. PREEMPT 1 trial: onabotulinumtoxinA for treatment of chronic migraine. Cephalalgia. 2010;30(7):793\u2013803.","journal-title":"Cephalalgia"},{"issue":"7","key":"805_CR14","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1177\/0333102410364677","volume":"30","author":"HC Diener","year":"2010","unstructured":"Diener HC, Dodick DW, Aurora SK, et al. PREEMPT 2 trial: onabotulinumtoxinA efficacy and safety. Cephalalgia. 2010;30(7):804\u201314.","journal-title":"Cephalalgia"},{"issue":"9","key":"805_CR15","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1111\/j.1526-4610.2010.01766.x","volume":"50","author":"A Blumenfeld","year":"2010","unstructured":"Blumenfeld A, Silberstein SD, Dodick DW, et al. Injection paradigm for chronic migraine treatment with onabotulinumtoxinA. Headache. 2010;50(9):1406\u201318.","journal-title":"Headache"},{"issue":"1","key":"805_CR16","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s10194-019-0976-1","volume":"20","author":"F Ahmed","year":"2019","unstructured":"Ahmed F, Gaul C, Garc\u00eda-Monc\u00f3 JC, et al. Real-life use of onabotulinumtoxinA: the REPOSE study. J Headache Pain. 2019;20(1):26.","journal-title":"J Headache Pain"},{"issue":"7","key":"805_CR17","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027953","volume":"9","author":"CP Herd","year":"2019","unstructured":"Herd CP, Tomlinson CL, Rick C, et al. Updated Cochrane systematic review: botulinum toxin for migraine prevention. BMJ Open. 2019;9(7):e027953.","journal-title":"BMJ Open"},{"issue":"1","key":"805_CR18","doi-asserted-by":"publisher","first-page":"201","DOI":"10.31083\/j.jin.2020.01.1240","volume":"19","author":"B Shen","year":"2020","unstructured":"Shen B, Wang L. Impact of botulinum-A toxin on adult migraine prevention. J Integr Neurosci. 2020;19(1):201\u20138.","journal-title":"J Integr Neurosci"},{"issue":"11","key":"805_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14740338.2021.1948531","volume":"20","author":"F Cheng","year":"2021","unstructured":"Cheng F, Ahmed F. Safety evaluation of onabotulinumtoxinA for chronic migraine prophylaxis. Expert Opin Drug Saf. 2021;20(11):1\u201315.","journal-title":"Expert Opin Drug Saf"},{"issue":"5","key":"805_CR20","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3390\/toxins15050342","volume":"15","author":"J Jankovic","year":"2023","unstructured":"Jankovic J, Carruthers J, Naumann M, et al. Neutralizing antibodies with onabotulinumtoxinA treatment: meta-analysis. Toxins (Basel). 2023;15(5):342.","journal-title":"Toxins (Basel)"},{"key":"805_CR21","doi-asserted-by":"publisher","first-page":"1292994","DOI":"10.3389\/fpain.2023.1292994","volume":"4","author":"L Pellesi","year":"2023","unstructured":"Pellesi L. Combining onabotulinumtoxin A with a CGRP antagonist for chronic migraine prophylaxis: where do we stand? Front Pain Res (Lausanne). 2023;4:1292994. https:\/\/doi.org\/10.3389\/fpain.2023.1292994. PMID: 37965209; PMCID: PMC10641512.","journal-title":"Front Pain Res (Lausanne)"}],"container-title":["Pain and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40122-025-00805-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40122-025-00805-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40122-025-00805-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:48:15Z","timestamp":1771343295000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40122-025-00805-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,16]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["805"],"URL":"https:\/\/doi.org\/10.1007\/s40122-025-00805-8","relation":{},"ISSN":["2193-8237","2193-651X"],"issn-type":[{"value":"2193-8237","type":"print"},{"value":"2193-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,16]]},"assertion":[{"value":"19 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this article was revised to update the affiliations for author Ahmed Attar.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors (Ahmed Attar, Yasser Aladdin, Alqassem Hakami, Abdalmajed Alqsair, Sulaiman Baeisa, Ahmed Alzahrani, Ahmed Alsimsimi and Sarah Alzebaidi) declared no potential conflicts of interest with respect to the research, authorship and\/or publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study received ethical approval from the Institutional Review Board (IRB) of King Abdulaziz Medical City, Jeddah, Saudi Arabia (reference number H-01-R-005). The study was conducted in accordance with the Helsinki Declaration of 1964 and its later amendments. An informed consent was given to each patient prior to participating in the study. Confidentiality was maintained by anonymizing patient data and replacing all identifiers with coded serial numbers.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}