{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T16:26:59Z","timestamp":1775320019422,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"name":"The Youth Beijing Scholars program","award":["NO.022"],"award-info":[{"award-number":["NO.022"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmol Ther"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s40123-021-00431-5","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T03:06:39Z","timestamp":1637809599000},"page":"261-270","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of a Novel Thermostatic Device on Meibomian Gland Dysfunction: A Randomized Controlled Trial in Chinese Patients"],"prefix":"10.1007","volume":"11","author":[{"given":"Siyuan","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-8241","authenticated-orcid":false,"given":"Ying","family":"Jie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"issue":"3","key":"431_CR1","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/sj.eye.6703101","volume":"23","author":"Y Jie","year":"2009","unstructured":"Jie Y, Xu L, Wu YY, Jonas JB. Prevalence of dry eye among adult Chinese in the Beijing Eye Study. Eye (Lond). 2009;23(3):688\u201393. https:\/\/doi.org\/10.1038\/sj.eye.6703101.","journal-title":"Eye (Lond)"},{"issue":"3","key":"431_CR2","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","volume":"15","author":"F Stapleton","year":"2017","unstructured":"Stapleton F, Alves M, Bunya VY, et al. TFOS DEWS II epidemiology report. Ocul Surf. 2017;15(3):334\u201365. https:\/\/doi.org\/10.1016\/j.jtos.2017.05.003.","journal-title":"Ocul Surf"},{"issue":"3","key":"431_CR3","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","volume":"15","author":"JP Craig","year":"2017","unstructured":"Craig JP, Nichols KK, Akpek EK, et al. TFOS DEWS II definition and classification report. Ocul Surf. 2017;15(3):276\u201383. https:\/\/doi.org\/10.1016\/j.jtos.2017.05.008.","journal-title":"Ocul Surf"},{"issue":"1\u20132","key":"431_CR4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s40123-014-0025-8","volume":"3","author":"HS Sim","year":"2014","unstructured":"Sim HS, Petznick A, Barbier S, et al. A randomized, controlled treatment trial of eyelid-warming therapies in meibomian gland dysfunction. Ophthalmol Ther. 2014;3(1\u20132):37\u201348. https:\/\/doi.org\/10.1007\/s40123-014-0025-8.","journal-title":"Ophthalmol Ther"},{"issue":"4","key":"431_CR5","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.jtos.2020.06.008","volume":"18","author":"CHY Teo","year":"2020","unstructured":"Teo CHY, Ong HS, Liu YC, Tong L. Meibomian gland dysfunction is the primary determinant of dry eye symptoms: analysis of 2346 patients. Ocul Surf. 2020;18(4):604\u201312. https:\/\/doi.org\/10.1016\/j.jtos.2020.06.008.","journal-title":"Ocul Surf"},{"issue":"4","key":"431_CR6","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1167\/iovs.10-6997g","volume":"52","author":"G Geerling","year":"2011","unstructured":"Geerling G, Tauber J, Baudouin C, et al. The international workshop on meibomian gland dysfunction: report of the subcommittee on management and treatment of meibomian gland dysfunction. Invest Ophthalmol Vis Sci. 2011;52(4):2050\u201364. https:\/\/doi.org\/10.1167\/iovs.10-6997g.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"431_CR7","doi-asserted-by":"publisher","first-page":"e327","DOI":"10.1097\/OPX.0000000000000675","volume":"92","author":"DK Murakami","year":"2015","unstructured":"Murakami DK, Blackie CA, Korb DR. All warm compresses are not equally efficacious. Optom Vis Sci. 2015;92(9):e327\u201333.","journal-title":"Optom Vis Sci"},{"issue":"2","key":"431_CR8","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3109\/02713683.2010.509529","volume":"36","author":"BR Friedland","year":"2011","unstructured":"Friedland BR, Fleming CP, Blackie CA, Korb DR. A novel thermodynamic treatment for meibomian gland dysfunction. Curr Eye Res. 2011;36(2):79\u201387. https:\/\/doi.org\/10.3109\/02713683.2010.509529.","journal-title":"Curr Eye Res"},{"issue":"8","key":"431_CR9","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1097\/ICO.0b013e3181ca36d6","volume":"29","author":"DR Korb","year":"2010","unstructured":"Korb DR, Blackie CA. Restoration of meibomian gland functionality with novel thermodynamic treatment device-a case report. Cornea. 2010;29(8):930\u20133.","journal-title":"Cornea"},{"key":"431_CR10","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.2147\/OPTH.S109663","volume":"10","author":"CA Blackie","year":"2016","unstructured":"Blackie CA, Coleman CA, Holland EJ. The sustained effect (12 months) of a single-dose vectored thermal pulsation procedure for meibomian gland dysfunction and evaporative dry eye. Clin Ophthalmol. 2016;10:1385\u201396. https:\/\/doi.org\/10.2147\/OPTH.S109663.","journal-title":"Clin Ophthalmol"},{"issue":"2","key":"431_CR11","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.jtos.2019.02.005","volume":"17","author":"D Borchman","year":"2019","unstructured":"Borchman D. The optimum temperature for the heat therapy for meibomian gland dysfunction. Ocul Surf. 2019;17(2):360\u20134. https:\/\/doi.org\/10.1016\/j.jtos.2019.02.005.","journal-title":"Ocul Surf"},{"issue":"1","key":"431_CR12","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000455087","volume":"8","author":"CJ Kenrick","year":"2017","unstructured":"Kenrick CJ, Alloo SS. The limitation of applying heat to the external lid surface: a case of recalcitrant meibomian gland dysfunction. Case Rep Ophthalmol. 2017;8(1):7\u201312. https:\/\/doi.org\/10.1159\/000455087.","journal-title":"Case Rep Ophthalmol"},{"issue":"3","key":"431_CR13","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.jtos.2017.05.001","volume":"15","author":"JS Wolffsohn","year":"2017","unstructured":"Wolffsohn JS, Arita R, Chalmers R, et al. TFOS DEWS II diagnostic methodology report. Ocul Surf. 2017;15(3):539\u201374. https:\/\/doi.org\/10.1016\/j.jtos.2017.05.001.","journal-title":"Ocul Surf"},{"issue":"6","key":"431_CR14","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.ajo.2015.08.021","volume":"160","author":"J Rose-Nussbaumer","year":"2015","unstructured":"Rose-Nussbaumer J, Lietman TM, Shiboski CH, et al. Inter-grader agreement of the ocular staining score in the Sjogren\u2019s International Clinical Collaborative Alliance (SICCA) registry. Am J Ophthalmol. 2015;160(6):1150\u20131153.e3. https:\/\/doi.org\/10.1016\/j.ajo.2015.08.021.","journal-title":"Am J Ophthalmol"},{"issue":"1","key":"431_CR15","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.clae.2012.10.074","volume":"36","author":"H Pult","year":"2013","unstructured":"Pult H, Riede-Pult B. Comparison of subjective grading and objective assessment in meibography. Cont Lens Anterior Eye. 2013;36(1):22\u20137. https:\/\/doi.org\/10.1016\/j.clae.2012.10.074.","journal-title":"Cont Lens Anterior Eye"},{"issue":"2","key":"431_CR16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/ICL.0000000000000166","volume":"42","author":"JV Greiner","year":"2016","unstructured":"Greiner JV. Long-term (3 year) effects of a single thermal pulsation system treatment on meibomian gland function and dry eye symptoms. Eye Contact Lens. 2016;42(2):99\u2013107. https:\/\/doi.org\/10.1097\/ICL.0000000000000166.","journal-title":"Eye Contact Lens"},{"key":"431_CR17","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/0197-2456(89)90005-6","volume":"10","author":"R Jaeschke","year":"1989","unstructured":"Jaeschke R, Singer J, Guyatt GH. Measurement of health status: ascertaining the minimal clinically important difference. Control Clin Trials. 1989;10:407\u201315.","journal-title":"Control Clin Trials"},{"issue":"1","key":"431_CR18","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1001\/archophthalmol.2009.356","volume":"128","author":"KL Miller","year":"2010","unstructured":"Miller KL, Walt JG, Mink DR, et al. Minimal clinically important difference for the ocular surface disease index. Arch Ophthalmol. 2010;128(1):94\u2013101.","journal-title":"Arch Ophthalmol"},{"issue":"3","key":"431_CR19","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.ophtha.2016.11.008","volume":"124","author":"J Vehof","year":"2017","unstructured":"Vehof J, Sillevis Smitt-Kamminga N, Nibourg SA, Hammond CJ. Predictors of discordance between symptoms and signs in dry eye disease. Ophthalmology. 2017;124(3):280\u20136. https:\/\/doi.org\/10.1016\/j.ophtha.2016.11.008.","journal-title":"Ophthalmology"},{"issue":"5","key":"431_CR20","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1097\/ICL.0b013e31821bc7c5","volume":"37","author":"DR Korb","year":"2011","unstructured":"Korb DR, Blackie CA. Meibomian gland therapeutic expression: quantifying the applied pressure and the limitation of resulting pain. Eye Contact Lens. 2011;37(5):298\u2013301. https:\/\/doi.org\/10.1097\/ICL.0b013e31821bc7c5.","journal-title":"Eye Contact Lens"},{"key":"431_CR21","doi-asserted-by":"publisher","first-page":"4287","DOI":"10.2147\/OPTH.S282081","volume":"14","author":"AS Hura","year":"2020","unstructured":"Hura AS, Epitropoulos AT, Czyz CN, Rosenberg ED. Visible meibomian gland structure increases after vectored thermal pulsation treatment in dry eye disease patients with meibomian gland dysfunction. Clin Ophthalmol. 2020;14:4287\u201396. https:\/\/doi.org\/10.2147\/OPTH.S282081.","journal-title":"Clin Ophthalmol"}],"container-title":["Ophthalmology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40123-021-00431-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40123-021-00431-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40123-021-00431-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T13:19:17Z","timestamp":1642598357000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40123-021-00431-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,25]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["431"],"URL":"https:\/\/doi.org\/10.1007\/s40123-021-00431-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-468283\/v1","asserted-by":"object"}]},"ISSN":["2193-8245","2193-6528"],"issn-type":[{"value":"2193-8245","type":"print"},{"value":"2193-6528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,25]]},"assertion":[{"value":"17 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}