{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T03:10:47Z","timestamp":1783825847120,"version":"3.55.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmol Ther"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s40123-024-00916-z","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T10:01:53Z","timestamp":1712052113000},"page":"1479-1498","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ocular Manifestations in Juvenile Beh\u00e7et\u2019s Disease: A Registry-Based Analysis from the AIDA Network"],"prefix":"10.1007","volume":"13","author":[{"given":"Carla","family":"Gaggiano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman","family":"Tufan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Guerriero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaafar","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Sota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gentileschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Costi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A.","family":"Almaghlouth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Hinojosa-Azaola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar","family":"Tharwat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros P.","family":"Sfikakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lopalco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Piga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Conti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Fragoulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi D.","family":"Batu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seza","family":"Ozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tarsia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"La Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perla A.","family":"Kawakami-Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Caggiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riza C.","family":"Karda\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Marco","family":"Tosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Frediani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadej","family":"Av\u010din","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Hern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7352-1275","authenticated-orcid":false,"given":"Luca","family":"Cantarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fabiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the AIDA Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,30]]},"reference":[{"key":"916_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.627192","volume":"8","author":"M Yildiz","year":"2021","unstructured":"Yildiz M, Haslak F, Adrovic A, et al. Pediatric Beh\u00e7et\u2019s disease. Front Med (Lausanne). 2021;8: 627192. https:\/\/doi.org\/10.3389\/fmed.2021.627192.","journal-title":"Front Med (Lausanne)"},{"issue":"2","key":"916_CR2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s12016-020-08809-2","volume":"61","author":"YC Hu","year":"2021","unstructured":"Hu YC, Chiang BL, Yang YH. Clinical manifestations and management of pediatric Beh\u00e7et\u2019s disease. Clin Rev Allergy Immunol. 2021;61(2):171\u201380. https:\/\/doi.org\/10.1007\/s12016-020-08809-2.","journal-title":"Clin Rev Allergy Immunol"},{"key":"916_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108381","volume":"214","author":"CE Pain","year":"2020","unstructured":"Pain CE. Juvenile-onset Beh\u00e7et\u2019s syndrome and mimics. Clin Immunol. 2020;214: 108381. https:\/\/doi.org\/10.1016\/j.clim.2020.108381.","journal-title":"Clin Immunol"},{"issue":"4","key":"916_CR4","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/j.1600-0420.1996.tb00718.x","volume":"74","author":"LS Atmaca","year":"1996","unstructured":"Atmaca LS, Idil A, Batio\u011dlu F. A descriptive study on Beh\u00e7et\u2019s disease. Acta Ophthalmol Scand. 1996;74(4):403\u20136. https:\/\/doi.org\/10.1111\/j.1600-0420.1996.tb00718.x.","journal-title":"Acta Ophthalmol Scand"},{"issue":"3\u20134","key":"916_CR5","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.jaut.2009.02.011","volume":"32","author":"D Mendes","year":"2009","unstructured":"Mendes D, Correia M, Barbedo M, et al. Beh\u00e7et\u2019s disease\u2014a contemporary review. J Autoimmun. 2009;32(3\u20134):178\u201388. https:\/\/doi.org\/10.1016\/j.jaut.2009.02.011.","journal-title":"J Autoimmun"},{"issue":"1","key":"916_CR6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/s0022-3476(99)70333-1","volume":"135","author":"I Kon\u00e9-Paut","year":"1999","unstructured":"Kon\u00e9-Paut I, Geisler I, Wechsler B, et al. Familial aggregation in Beh\u00e7et\u2019s disease: high frequency in siblings and parents of pediatric probands. J Pediatr. 1999;135(1):89\u201393. https:\/\/doi.org\/10.1016\/s0022-3476(99)70333-1.","journal-title":"J Pediatr"},{"issue":"6","key":"916_CR7","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/j.1365-4632.2006.02754.x","volume":"45","author":"M Borlu","year":"2006","unstructured":"Borlu M, Uk\u015fal U, Ferahba\u015f A, et al. Clinical features of Beh\u00e7et\u2019s disease in children. Int J Dermatol. 2006;45(6):713\u20136. https:\/\/doi.org\/10.1111\/j.1365-4632.2006.02754.x.","journal-title":"Int J Dermatol"},{"issue":"2","key":"916_CR8","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3109\/09273948.2011.555592","volume":"19","author":"L Atmaca","year":"2011","unstructured":"Atmaca L, Boyvat A, Yal\u00e7\u0131nda\u011f FN, et al. Beh\u00e7et disease in children. Ocul Immunol Inflamm. 2011;19(2):103\u20137. https:\/\/doi.org\/10.3109\/09273948.2011.555592.","journal-title":"Ocul Immunol Inflamm"},{"issue":"5","key":"916_CR9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1093\/rheumatology\/38.5.457","volume":"38","author":"I Krause","year":"1999","unstructured":"Krause I, Uziel Y, Guedj D, et al. Childhood Beh\u00e7et\u2019s disease: clinical features and comparison with adult-onset disease. Rheumatology (Oxford). 1999;38(5):457\u201362. https:\/\/doi.org\/10.1093\/rheumatology\/38.5.457.","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"916_CR10","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1016\/j.jaad.2007.10.452","volume":"58","author":"Y Karincaoglu","year":"2008","unstructured":"Karincaoglu Y, Borlu M, Toker SC, et al. Demographic and clinical properties of juvenile-onset Beh\u00e7et\u2019s disease: a controlled multicenter study. J Am Acad Dermatol. 2008;58(4):579\u201384. https:\/\/doi.org\/10.1016\/j.jaad.2007.10.452.","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"916_CR11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000018197","volume":"199","author":"R Treudler","year":"1999","unstructured":"Treudler R, Orfanos CE, Zouboulis CC. Twenty-Eight Cases of Juvenile-Onset Adamantiades-Beh\u00e7et Disease in Germany. Dermatology. 1999;199(1):15\u20139. https:\/\/doi.org\/10.1159\/000018197.","journal-title":"Dermatology"},{"issue":"1","key":"916_CR12","first-page":"133","volume":"31","author":"I K\u00f6tter","year":"2004","unstructured":"K\u00f6tter I, Vonthein R, M\u00fcller CA, et al. Beh\u00e7et\u2019s disease in patients of German and Turkish origin living in Germany: a comparative analysis. J Rheumatol. 2004;31(1):133\u20139.","journal-title":"J Rheumatol"},{"issue":"1","key":"916_CR13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1136\/bjo.2007.137141","volume":"93","author":"GK Sungur","year":"2009","unstructured":"Sungur GK, Hazirolan D, Yalvac I, et al. Clinical and demographic evaluation of Beh\u00e7et disease among different paediatric age groups. Br J Ophthalmol. 2009;93(1):83\u20137. https:\/\/doi.org\/10.1136\/bjo.2007.137141.","journal-title":"Br J Ophthalmol"},{"issue":"7","key":"916_CR14","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1136\/ard.61.7.655","volume":"61","author":"I Kon\u00e9-Paut","year":"2002","unstructured":"Kon\u00e9-Paut I, Gorchakoff-Molinas A, Weschler B, et al. Paediatric Beh\u00e7et\u2019s disease in France. Ann Rheum Dis. 2002;61(7):655\u20136. https:\/\/doi.org\/10.1136\/ard.61.7.655.","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"916_CR15","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1136\/annrheumdis-2015-208491","volume":"75","author":"I Kon\u00e9-Paut","year":"2016","unstructured":"Kon\u00e9-Paut I, Shahram F, Darce-Bello M, et al. Consensus classification criteria for paediatric Beh\u00e7et\u2019s disease from a prospective observational cohort: PEDBD. Ann Rheum Dis. 2016;75(6):958\u201364. https:\/\/doi.org\/10.1136\/annrheumdis-2015-208491.","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"916_CR16","first-page":"309","volume":"39","author":"P Pivetti-Pezzi","year":"1995","unstructured":"Pivetti-Pezzi P, Accorinti M, Abdulaziz MA, et al. Beh\u00e7ets disease in children. Jpn J Ophthalmol. 1995;39(3):309\u201314.","journal-title":"Jpn J Ophthalmol"},{"issue":"2","key":"916_CR17","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1111\/j.1525-1470.1994.tb00559.x","volume":"11","author":"DK Kim","year":"1994","unstructured":"Kim DK, Chang SN, Bang D, et al. Clinical analysis of 40 cases of childhood-onset Beh\u00e7et\u2019s disease. Pediatr Dermatol. 1994;11(2):95\u2013101. https:\/\/doi.org\/10.1111\/j.1525-1470.1994.tb00559.x.","journal-title":"Pediatr Dermatol"},{"issue":"2","key":"916_CR18","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1111\/j.1365-4362.1996.tb03272.x","volume":"35","author":"R Sarica","year":"1996","unstructured":"Sarica R, Azizlerli G, K\u00f6se A, et al. Juvenile Beh\u00e7et\u2019s disease among 1784 Turkish Beh\u00e7et\u2019s patients. Int J Dermatol. 1996;35(2):109\u201311. https:\/\/doi.org\/10.1111\/j.1365-4362.1996.tb03272.x.","journal-title":"Int J Dermatol"},{"issue":"3","key":"916_CR19","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/art.1780330317","volume":"33","author":"BA Lang","year":"1990","unstructured":"Lang BA, Laxer RM, Thorner P, et al. Pediatric onset of Beh\u00e7et\u2019s syndrome with myositis: case report and literature review illustrating unusual features. Arthritis Rheum. 1990;33(3):418\u201325. https:\/\/doi.org\/10.1002\/art.1780330317.","journal-title":"Arthritis Rheum"},{"issue":"5","key":"916_CR20","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1080\/03009740410005980","volume":"33","author":"F Allali","year":"2004","unstructured":"Allali F, Benomar A, Karim A, et al. Beh\u00e7et\u2019s disease in Moroccan children: a report of 12 cases. Scand J Rheumatol. 2004;33(5):362\u20133. https:\/\/doi.org\/10.1080\/03009740410005980.","journal-title":"Scand J Rheumatol"},{"issue":"8","key":"916_CR21","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1007\/s11739-021-02725-9","volume":"16","author":"J Sota","year":"2021","unstructured":"Sota J, Rigante D, Lopalco G, et al. Clinical profile and evolution of patients with juvenile-onset Beh\u00e7et\u2019s syndrome over a 25-year period: insights from the AIDA network. Intern Emerg Med. 2021;16(8):2163\u201371. https:\/\/doi.org\/10.1007\/s11739-021-02725-9.","journal-title":"Intern Emerg Med"},{"issue":"7","key":"916_CR22","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1007\/s11739-022-03038-1","volume":"17","author":"A Vitale","year":"2022","unstructured":"Vitale A, Della Casa F, Ragab G, et al. Development and implementation of the AIDA International Registry for patients with Beh\u00e7et\u2019s disease. Intern Emerg Med. 2022;17(7):1977\u201386. https:\/\/doi.org\/10.1007\/s11739-022-03038-1.","journal-title":"Intern Emerg Med"},{"issue":"8697","key":"916_CR23","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1016\/0140-6736(90)92643-V","volume":"335","author":"International Study Group for Beh\u00e7et\u2019s Disease","year":"1990","unstructured":"International Study Group for Beh\u00e7et\u2019s Disease. Criteria for diagnosis of Beh\u00e7et\u2019s disease. Lancet. 1990;335(8697):1078\u201380. https:\/\/doi.org\/10.1016\/0140-6736(90)92643-V.","journal-title":"Lancet"},{"issue":"3","key":"916_CR24","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/jdv.12107","volume":"28","author":"International Team for the Revision of the International Criteria for Beh\u00e7et\u2019s Disease (ITR-ICBD)","year":"2014","unstructured":"International Team for the Revision of the International Criteria for Beh\u00e7et\u2019s Disease (ITR-ICBD). The International Criteria for Beh\u00e7et\u2019s Disease (ICBD): a collaborative study of 27 countries on the sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol. 2014;28(3):338\u201347. https:\/\/doi.org\/10.1111\/jdv.12107.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"916_CR25","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","volume":"140","author":"DA Jabs","year":"2005","unstructured":"Jabs DA, Nussenblatt RB, Rosenbaum JT, Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data. Results of the First InternationalWorkshop. Am J Ophthalmol. 2005;140:509\u201316.","journal-title":"Am J Ophthalmol"},{"key":"916_CR26","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0161-6420(85)34001-0","volume":"92","author":"RB Nussenblatt","year":"1985","unstructured":"Nussenblatt RB, Palestine AG, Chan CC, et al. Standardization of vitreal inflammatory activity in intermediate and posterior uveitis. Ophthalmology. 1985;92:467\u201371.","journal-title":"Ophthalmology"},{"issue":"6","key":"916_CR27","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1001\/archopht.1993.01090060119035","volume":"111","author":"LT Chylack Jr","year":"1993","unstructured":"Chylack LT Jr, Wolfe JK, Singer DM, et al. The lens opacities classification system III. The Longitudinal Study of Cataract Study Group. Arch Ophthalmol. 1993;111(6):831\u20136.","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"916_CR28","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s10792-008-9263-x","volume":"30","author":"I Tugal-Tutkun","year":"2010","unstructured":"Tugal-Tutkun I, Herbort CP, Khairallah M, Angiography Scoring for Uveitis Working Group (ASUWOG). Scoring of dual fluorescein and ICG inflammatory angiographic signs for the grading of posterior segment inflammation (dual fluorescein and ICG angiographic scoring system for uveitis). Int Ophthalmol. 2010;30(5):539\u201352. https:\/\/doi.org\/10.1007\/s10792-008-9263-x.","journal-title":"Int Ophthalmol"},{"issue":"2","key":"916_CR29","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001192","volume":"6","author":"M Piga","year":"2020","unstructured":"Piga M, Floris A, Espinosa G, et al. Development and preliminary validation of the Beh\u00e7et\u2019s syndrome Overall Damage Index (BODI). RMD Open. 2020;6(2): e001192. https:\/\/doi.org\/10.1136\/rmdopen-2020-001192.","journal-title":"RMD Open"},{"issue":"5","key":"916_CR30","doi-asserted-by":"publisher","first-page":"94","DOI":"10.55563\/clinexprheumatol\/pt60bc","volume":"39 Suppl 132","author":"MA Turk","year":"2021","unstructured":"Turk MA, Hayworth JL, Nevskaya T, et al. Ocular manifestations of Beh\u00e7et\u2019s disease in children and adults: a systematic review and meta-analysis. Clin Exp Rheumatol. 2021;39 Suppl 132(5):94\u2013101. https:\/\/doi.org\/10.55563\/clinexprheumatol\/pt60bc.","journal-title":"Clin Exp Rheumatol"},{"issue":"10","key":"916_CR31","doi-asserted-by":"publisher","first-page":"4728","DOI":"10.1093\/rheumatology\/keab084","volume":"60","author":"CE Pain","year":"2021","unstructured":"Pain CE, Beresford MW, Fortune F, et al. Beh\u00e7et\u2019s syndrome in children and young people in the United Kingdom and the Republic of Ireland: a prospective epidemiological study. Rheumatology (Oxford). 2021;60(10):4728\u201336. https:\/\/doi.org\/10.1093\/rheumatology\/keab084.","journal-title":"Rheumatology (Oxford)"},{"issue":"4","key":"916_CR32","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.jaapos.2009.04.016","volume":"13","author":"M Citirik","year":"2009","unstructured":"Citirik M, Berker N, Songur MS, et al. Ocular findings in childhood-onset Beh\u00e7et disease. J AAPOS. 2009;13(4):391\u20135. https:\/\/doi.org\/10.1016\/j.jaapos.2009.04.016.","journal-title":"J AAPOS"},{"issue":"4","key":"916_CR33","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/j.jaapos.2005.04.005","volume":"9","author":"R Friling","year":"2005","unstructured":"Friling R, Kramer M, Snir M, et al. Clinical course and outcome of uveitis in children. J AAPOS. 2005;9(4):379\u201382. https:\/\/doi.org\/10.1016\/j.jaapos.2005.04.005.","journal-title":"J AAPOS"},{"issue":"2","key":"916_CR34","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3390\/biomedicines11020624","volume":"11","author":"M Ostrovsky","year":"2023","unstructured":"Ostrovsky M, Rosenblatt A, Iriqat S, et al. Ocular Beh\u00e7et disease-clinical manifestations, treatments and outcomes according to age at disease onset. Biomedicines. 2023;11(2):624. https:\/\/doi.org\/10.3390\/biomedicines11020624.","journal-title":"Biomedicines"},{"issue":"3","key":"916_CR35","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s12016-017-8642-3","volume":"56","author":"M Cattalini","year":"2019","unstructured":"Cattalini M, Soliani M, Caparello MC, et al. Sex differences in pediatric rheumatology. Clin Rev Allergy Immunol. 2019;56(3):293\u2013307. https:\/\/doi.org\/10.1007\/s12016-017-8642-3.","journal-title":"Clin Rev Allergy Immunol"},{"issue":"3","key":"916_CR36","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1093\/mr\/roac044","volume":"33","author":"F Demir","year":"2023","unstructured":"Demir F, S\u00f6nmez HE, Ba\u011flan E, et al. Cluster analysis of paediatric Beh\u00e7et\u2019s disease: data from the Pediatric Rheumatology Academy-Research Group. Mod Rheumatol. 2023;33(3):574\u20138. https:\/\/doi.org\/10.1093\/mr\/roac044.","journal-title":"Mod Rheumatol"},{"issue":"6 Suppl 115","key":"916_CR37","first-page":"135","volume":"36","author":"F Shahram","year":"2018","unstructured":"Shahram F, Nadji A, Akhlaghi M, et al. Paediatric Beh\u00e7et\u2019s disease in Iran: report of 204 cases. Clin Exp Rheumatol. 2018;36(6 Suppl 115):135\u201340.","journal-title":"Clin Exp Rheumatol"},{"issue":"10","key":"916_CR38","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1002\/art.24642","volume":"61","author":"M de Menthon","year":"2009","unstructured":"de Menthon M, Lavalley MP, Maldini C, et al. HLA-B51\/B5 and the risk of Beh\u00e7et\u2019s disease: a systematic review and meta-analysis of case-control genetic association studies. Arthritis Rheum. 2009;61(10):1287\u201396. https:\/\/doi.org\/10.1002\/art.24642.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"916_CR39","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/BOR.0000000000000003","volume":"26","author":"A G\u00fcl","year":"2014","unstructured":"G\u00fcl A. Genetics of Beh\u00e7et\u2019s disease: lessons learned from genomewide association studies. CUrr Opin Rheumatol. 2014;26(1):56\u201363. https:\/\/doi.org\/10.1097\/BOR.0000000000000003.","journal-title":"CUrr Opin Rheumatol"},{"issue":"5","key":"916_CR40","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1093\/rheumatology\/ker428","volume":"51","author":"C Maldini","year":"2012","unstructured":"Maldini C, Lavalley MP, Cheminant M, et al. Relationships of HLA-B51 or B5 genotype with Behcet\u2019s disease clinical characteristics: systematic review and meta-analyses of observational studies. Rheumatology (Oxford). 2012;51(5):887\u2013900. https:\/\/doi.org\/10.1093\/rheumatology\/ker428.","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"916_CR41","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3109\/09273948.2015.1136422","volume":"25","author":"Y Horie","year":"2017","unstructured":"Horie Y, Meguro A, Ohta T, et al. HLA-B51 carriers are susceptible to ocular symptoms of Beh\u00e7et disease and the association between the two becomes stronger towards the east along the silk road: a literature survey. Ocul Immunol Inflamm. 2017;25(1):37\u201340. https:\/\/doi.org\/10.3109\/09273948.2015.1136422.","journal-title":"Ocul Immunol Inflamm"},{"issue":"2020","key":"916_CR42","doi-asserted-by":"publisher","first-page":"6872402","DOI":"10.1155\/2020\/6872402","volume":"15","author":"J Sota","year":"2020","unstructured":"Sota J, Cantarini L, Vitale A, et al. Long-term outcomes of Beh\u00e7et\u2019s syndrome-related uveitis: a monocentric italian experience. Mediators Inflamm. 2020;15(2020):6872402. https:\/\/doi.org\/10.1155\/2020\/6872402.","journal-title":"Mediators Inflamm"},{"key":"916_CR43","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/0-306-48382-3_24","volume":"528","author":"CC Zouboulis","year":"2003","unstructured":"Zouboulis CC, Turnbull JR, Martus P. Univariate and multivariate analyses comparing demographic, genetic, clinical, and serological risk factors for severe Adamantiades-Beh\u00e7et\u2019s disease. Adv Exp Med Biol. 2003;528:123\u20136. https:\/\/doi.org\/10.1007\/0-306-48382-3_24.","journal-title":"Adv Exp Med Biol"},{"issue":"10","key":"916_CR44","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/j.humimm.2013.06.036","volume":"74","author":"EH Kang","year":"2013","unstructured":"Kang EH, Park JW, Park C, et al. Genetic and non-genetic factors affecting the visual outcome of ocular Behcet\u2019s disease. Hum Immunol. 2013;74(10):1363\u20137. https:\/\/doi.org\/10.1016\/j.humimm.2013.06.036.","journal-title":"Hum Immunol"},{"issue":"2","key":"916_CR45","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3341\/kjo.1989.3.2.85","volume":"3","author":"MS Kim","year":"1989","unstructured":"Kim MS, Kim JH. Prognostic comparison of Beh\u00e7et\u2019s disease with or without HLA-Bw 51 antigen. Korean J Ophthalmol. 1989;3(2):85\u20139. https:\/\/doi.org\/10.3341\/kjo.1989.3.2.85.","journal-title":"Korean J Ophthalmol"},{"issue":"3","key":"916_CR46","doi-asserted-by":"publisher","first-page":"R116","DOI":"10.1186\/ar4569","volume":"16","author":"AB Kuranov","year":"2014","unstructured":"Kuranov AB, K\u00f6tter I, Henes JC, et al. Beh\u00e7et\u2019s disease in HLA-B*51 negative Germans and Turks shows association with HLA-Bw4-80I. Arthritis Res Ther. 2014;16(3):R116. https:\/\/doi.org\/10.1186\/ar4569.","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"916_CR47","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nrrheum.2015.147","volume":"11","author":"D McGonagle","year":"2015","unstructured":"McGonagle D, Aydin SZ, G\u00fcl A, et al. \u2018MHC-I-opathy\u2019\u2014unified concept for spondyloarthritis and Beh\u00e7et disease. Nat Rev Rheumatol. 2015;11(12):731. https:\/\/doi.org\/10.1038\/nrrheum.2015.147.","journal-title":"Nat Rev Rheumatol"},{"issue":"1","key":"916_CR48","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13317-019-0112-x","volume":"10","author":"A Khabbazi","year":"2019","unstructured":"Khabbazi A, Vahedi L, Ghojazadeh M, et al. Association of HLA-B27 and Behcet\u2019s disease: a systematic review and meta-analysis. Auto Immun Highlights. 2019;10(1):2. https:\/\/doi.org\/10.1186\/s13317-019-0112-x.","journal-title":"Auto Immun Highlights"},{"issue":"4","key":"916_CR49","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1399-0039.2008.01087.x","volume":"72","author":"A Bettencourt","year":"2008","unstructured":"Bettencourt A, Pereira C, Carvalho L, et al. New insights of HLA class I association to Beh\u00e7et\u2019s disease in Portuguese patients. Tissue Antigens. 2008;72(4):379\u201382. https:\/\/doi.org\/10.1111\/j.1399-0039.2008.01087.x.","journal-title":"Tissue Antigens"},{"issue":"10","key":"916_CR50","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1001\/archopht.125.10.1375","volume":"125","author":"JK Ahn","year":"2007","unstructured":"Ahn JK, Park YG. Human leukocyte antigen B27 and B51 double-positive Beh\u00e7et uveitis. Arch Ophthalmol. 2007;125(10):1375\u201380. https:\/\/doi.org\/10.1001\/archopht.125.10.1375.","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"916_CR51","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1080\/09273948.2019.1611875","volume":"28","author":"M Balbaba","year":"2020","unstructured":"Balbaba M, Ula\u015f F, Postac\u0131 SA, et al. Clinical and demographic features of pediatric-onset Beh\u00e7et\u2019s disease and evaluation of optical coherence tomography findings. Ocul Immunol Inflamm. 2020;28(4):606\u201312. https:\/\/doi.org\/10.1080\/09273948.2019.1611875.","journal-title":"Ocul Immunol Inflamm"},{"issue":"11","key":"916_CR52","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1136\/bjophthalmol-2014-305333","volume":"98","author":"S Ishikawa","year":"2014","unstructured":"Ishikawa S, Taguchi M, Muraoka T, et al. Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Beh\u00e7et\u2019s disease. Br J Ophthalmol. 2014;98(11):1508\u201313. https:\/\/doi.org\/10.1136\/bjophthalmol-2014-305333.","journal-title":"Br J Ophthalmol"},{"issue":"6","key":"916_CR53","doi-asserted-by":"publisher","first-page":"440","DOI":"10.3109\/09273948.2013.817591","volume":"21","author":"E Coskun","year":"2013","unstructured":"Coskun E, Gurler B, Pehlivan Y, et al. Enhanced depth imaging optical coherence tomography findings in Beh\u00e7et disease. Ocul Immunol Inflamm. 2013;21(6):440\u20135. https:\/\/doi.org\/10.3109\/09273948.2013.817591.","journal-title":"Ocul Immunol Inflamm"},{"issue":"6","key":"916_CR54","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s40259-023-00613-6","volume":"37","author":"ED Batu","year":"2023","unstructured":"Batu ED, Sener S, Cam V, et al. Treatment with biologic drugs in pediatric Beh\u00e7et\u2019s disease: a comprehensive analysis of the published data. BioDrugs. 2023;37(6):813\u201328. https:\/\/doi.org\/10.1007\/s40259-023-00613-6.","journal-title":"BioDrugs"},{"issue":"6","key":"916_CR55","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1136\/annrheumdis-2018-213225","volume":"77","author":"G Hatemi","year":"2018","unstructured":"Hatemi G, Christensen R, Bang D, et al. 2018 update of the EULAR recommendations for the management of Beh\u00e7et\u2019s syndrome. Ann Rheum Dis. 2018;77(6):808\u201318. https:\/\/doi.org\/10.1136\/annrheumdis-2018-213225.","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"916_CR56","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/s13023-020-01620-4","volume":"16","author":"I Kone-Paut","year":"2021","unstructured":"Kone-Paut I, Barete S, Bodaghi B, et al. French recommendations for the management of Beh\u00e7et\u2019s disease. Orphanet J Rare Dis. 2021;16(Suppl 1):352. https:\/\/doi.org\/10.1186\/s13023-020-01620-4.","journal-title":"Orphanet J Rare Dis"},{"issue":"9","key":"916_CR57","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1007\/s10067-019-04570-w","volume":"38","author":"TA Gheita","year":"2019","unstructured":"Gheita TA, El-Latif EA, El-Gazzar II, Egyptian College of Rheumatology-Beh\u00e7et\u2019s Disease Study Group (ECR-BDSG), et al. Beh\u00e7et\u2019s disease in Egypt: a multicenter nationwide study on 1526 adult patients and review of the literature. Clin Rheumatol. 2019;38(9):2565\u201375. https:\/\/doi.org\/10.1007\/s10067-019-04570-w.","journal-title":"Clin Rheumatol"},{"key":"916_CR58","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1111\/j.1365-2133.2007.08116.x","volume":"157","author":"E Alpsoy","year":"2007","unstructured":"Alpsoy E, Donmez L, Onder M, et al. Clinical features and natural course of Beh\u00e7et\u2019s disease in 661 cases: a multicentre study. Br J Dermatol. 2007;157:901\u20136. https:\/\/doi.org\/10.1111\/j.1365-2133.2007.08116.x.","journal-title":"Br J Dermatol"},{"key":"916_CR59","first-page":"748","volume":"52","author":"A Hamzaoui","year":"2014","unstructured":"Hamzaoui A, Jaziri F, Ben Salem T, et al. Comparison of clinical features of Behcet disease according to age in a Tunisian cohort. Acta Med Iran. 2014;52:748\u201351.","journal-title":"Acta Med Iran"},{"issue":"11","key":"916_CR60","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1136\/bjo.2008.154476","volume":"93","author":"N Kitaichi","year":"2009","unstructured":"Kitaichi N, Miyazaki A, Stanford MR, et al. Low prevalence of juvenile-onset Behcet\u2019s disease with uveitis in East\/South Asian people. Br J Ophthalmol. 2009;93(11):1428\u201330. https:\/\/doi.org\/10.1136\/bjo.2008.154476.","journal-title":"Br J Ophthalmol"},{"issue":"11","key":"916_CR61","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1038\/eye.2008.397","volume":"23","author":"M Kramer","year":"2009","unstructured":"Kramer M, Amer R, Mukamel M, et al. Uveitis in juvenile Beh\u00e7et\u2019s disease: clinical course and visual outcome compared with adult patients. Eye (Lond). 2009;23(11):2034\u201341. https:\/\/doi.org\/10.1038\/eye.2008.397.","journal-title":"Eye (Lond)"}],"container-title":["Ophthalmology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40123-024-00916-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40123-024-00916-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40123-024-00916-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T12:29:47Z","timestamp":1716294587000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40123-024-00916-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,30]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["916"],"URL":"https:\/\/doi.org\/10.1007\/s40123-024-00916-z","relation":{},"ISSN":["2193-8245","2193-6528"],"issn-type":[{"value":"2193-8245","type":"print"},{"value":"2193-6528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,30]]},"assertion":[{"value":"8 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Carla Gaggiano, Abdurrahman Tufan, Silvana Guerriero, Gaafar Ragab, Jurgen Sota, Stefano Gentileschi, Stefania Costi, Ibrahim A. Almaghlouth, Andrea Hinojosa-Azaola, Samar Tharwat, Petros P. Sfikakis, Giuseppe Lopalco, Matteo Piga, Giovanni Conti, Angela Mauro, Francesco La Torre, Ezgi Deniz Batu, Seza Ozen, Riza Can Karda\u015f, Maria Tarsia, Perla Ayumi Kawakami-Campos, George Fragoulis, Antonio Vitale, Valeria Caggiano, Gian Marco Tosi, Bruno Frediani, Tadej Av\u010din, Jos\u00e9 Hern\u00e1ndez-Rodr\u00edguez, and Luca Cantarini declare that they have no competing interests.\u00a0Claudia Fabiani is an Editorial Board member of <i>Ophthalmology and Therapy<\/i> and\u00a0was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The study protocol adheres to the principles outlined in the Helsinki Declaration. The AIDA Network BD registry conforms to the General Data Protection Regulation (GDPR) ensuring compliance with legal requirements regarding the processing of personal data. For eligibility in the registry, patients (or their parents\/legal guardians) must provide written consent, after receiving appropriate information. The protocol of the international AIDA Network BD registry was approved by the Ethics Committee of Siena University Hospital (Ref. 14951), and by the Ethics Committees of all the participating investigator centers.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}