{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:09:09Z","timestamp":1777586949430,"version":"3.51.4"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007817","name":"Alcon Research Institute","doi-asserted-by":"publisher","award":["76127871"],"award-info":[{"award-number":["76127871"]}],"id":[{"id":"10.13039\/100007817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmol Ther"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>We conducted an evaluation of capsular bag performance of the Clareon CNA0T0 intraocular lens (IOL), focusing on postoperative anterior chamber depth (ACD), IOL tilt, and IOL decentration.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Inclusion criteria were bilateral age-related cataract and the ability to provide informed consent. Exclusion criteria were prior surgeries, combined surgeries, and conditions posing a risk for postoperative capsular bag instability. Preoperative and 8-week postoperative assessments included optical biometry and high-resolution anterior segment optical coherence tomography (OCT). Subjective refraction was conducted only at 8\u00a0weeks postoperative visit.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In the first analysis, 49 right eyes of 49 patients were included. Mean preoperative and postoperative ACD were 3.10 and 4.69\u00a0mm, respectively. Mean preoperative tilt was 4.77\u00b0, increasing to 5.06\u00b0 postoperatively. Preoperative decentration was 0.16\u00a0mm, increasing to 0.26\u00a0mm postoperatively. Absolute refractive error (ARE) was\u2009+\u20090.31D, with 81% of eyes within\u2009\u00b1\u20090.5D limits. In analysis II (98 eyes of 49 patients), both eyes showed a moderate correlation in IOL tilt (Pearson correlation coefficient: 0.27, <jats:italic>p<\/jats:italic>\u2009=\u20090.061) and a low correlation in IOL decentration (Pearson correlation coefficient: 0.02, <jats:italic>p<\/jats:italic>\u2009=\u20090.892) and ARE (Spearman: 0.15, <jats:italic>p<\/jats:italic>\u2009=\u2009305) between right and left eyes of the same patient.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The Clareon CNA0T0 IOL demonstrated high mechanical stability, with low postoperative tilt and decentration values, resulting in excellent refractive outcomes and visual acuity. These findings confirm the IOL\u2019s high stability within the capsular bag and effectiveness in minimizing postoperative refractive error, requiring only minor A-constant adjustments for optimal cataract surgery outcomes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trial Registration<\/jats:title>\n            <jats:p>NCT06595693.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s40123-024-01075-x","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T05:58:42Z","timestamp":1733983122000},"page":"295-308","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Capsular Bag Performance of a Novel Hydrophobic Single-Piece Intraocular Lens"],"prefix":"10.1007","volume":"14","author":[{"given":"Klemens","family":"Waser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Stra\u00dfmair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Pomberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haidar","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Laubichler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Bolz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9596-4563","authenticated-orcid":false,"given":"Nino","family":"Hirnschall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"issue":"3","key":"1075_CR1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1136\/bjo.2008.148650","volume":"93","author":"R Lavanya","year":"2009","unstructured":"Lavanya R, Wong TY, Aung T, Tan DTH, Saw SM, Tay WT, et al. Prevalence of cataract surgery and post-surgical visual outcomes in an urban Asian population: The Singapore Malay Eye Study. Br J Ophthalmol. 2009;93(3):299\u2013304.","journal-title":"Br J Ophthalmol"},{"key":"1075_CR2","doi-asserted-by":"crossref","unstructured":"Khoramnia R, Auffarth G, \u0141abuz G, Pettit G, Suryakumar R. Refractive outcomes after cataract surgery. Vol. 12, diagnostics. Multidisciplinary Digital Publishing Institute (MDPI); 2022.","DOI":"10.3390\/diagnostics12020243"},{"issue":"5","key":"1075_CR3","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.jcrs.2010.11.032","volume":"37","author":"NE De Vries","year":"2011","unstructured":"De Vries NE, Webers CAB, Touwslager WRH, Bauer NJC, De Brabander J, Berendschot TT, et al. Dissatisfaction after implantation of multifocal intraocular lenses. J Cataract Refract Surg. 2011;37(5):859\u201365.","journal-title":"J Cataract Refract Surg"},{"issue":"3","key":"1075_CR4","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.jcrs.2007.10.031","volume":"34","author":"S Norrby","year":"2008","unstructured":"Norrby S. Sources of error in intraocular lens power calculation. J Cataract Refract Surg. 2008;34(3):368\u201376.","journal-title":"J Cataract Refract Surg"},{"issue":"10","key":"1075_CR5","doi-asserted-by":"publisher","first-page":"646","DOI":"10.3928\/1081597X-20200729-03","volume":"36","author":"N Hirnschall","year":"2020","unstructured":"Hirnschall N, Findl O, Bayer N, Leisser C, Norrby S, Zimper E, et al. Sources of error in toric intraocular lens power calculation. J Refract Surg. 2020;36(10):646\u201352.","journal-title":"J Refract Surg"},{"issue":"4","key":"1075_CR6","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.jcrs.2018.10.043","volume":"45","author":"S Lane","year":"2019","unstructured":"Lane S, Collins S, Das KK, Maass S, Thatthamla I, Schatz H, et al. Evaluation of intraocular lens mechanical stability. J Cataract Refract Surg. 2019;45(4):501\u20136.","journal-title":"J Cataract Refract Surg"},{"issue":"10","key":"1075_CR7","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1016\/j.jcrs.2011.04.028","volume":"37","author":"A Crnej","year":"2011","unstructured":"Crnej A, Hirnschall N, Nishi Y, Gangwani V, Tabernero J, Artal P, et al. Impact of intraocular lens haptic design and orientation on decentration and tilt. J Cataract Refract Surg. 2011;37(10):1768\u201374.","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"1075_CR8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0886-3350(03)00459-0","volume":"30","author":"MG Wirtitsch","year":"2004","unstructured":"Wirtitsch MG, Findl O, Menapace R, Kriechbaum K, Koeppl C, Buehl W, et al. Effect of haptic design on change in axial lens position after cataract surgery. J Cataract Refract Surg. 2004;30(1):45\u201351.","journal-title":"J Cataract Refract Surg"},{"issue":"10","key":"1075_CR9","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.jcrs.2019.05.017","volume":"45","author":"L Werner","year":"2019","unstructured":"Werner L, Thatthamla I, Ong M, Schatz H, Garcia-Gonzalez M, Gros-Otero J, et al. Evaluation of clarity characteristics in a new hydrophobic acrylic IOL in comparison to commercially available IOLs. J Cataract Refract Surg. 2019;45(10):1490\u20137.","journal-title":"J Cataract Refract Surg"},{"issue":"6","key":"1075_CR10","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.jcrs.2018.12.004","volume":"45","author":"MA Nanavaty","year":"2019","unstructured":"Nanavaty MA, Zukaite I, Salvage J. Edge profile of commercially available square-edged intraocular lenses: Part 2. J Cataract Refract Surg. 2019;45(6):847\u201353.","journal-title":"J Cataract Refract Surg"},{"key":"1075_CR11","doi-asserted-by":"crossref","unstructured":"Negishi K, Masui S, Torii H, Nishi Y, Tsubota K. Refractive stability of a new single-piece hydrophobic acrylic intraocular lens and corneal wound repair after implantation using a new automated intraocular lens delivery system. PLoS One. 2020;15(9 September 2020).","DOI":"10.1371\/journal.pone.0238366"},{"issue":"5","key":"1075_CR12","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1097\/j.jcrs.0000000000000142","volume":"46","author":"T Oshika","year":"2020","unstructured":"Oshika T, Fujita Y, Inamura M, Miyata K. Mid-term and long-term clinical assessments of a new 1-piece hydrophobic acrylic IOL with hydroxyethyl methacrylate. J Cataract Refract Surg. 2020;46(5):682\u20137.","journal-title":"J Cataract Refract Surg"},{"key":"1075_CR13","doi-asserted-by":"crossref","unstructured":"Nuijts RMMA, Bhatt U, Nanavaty MA, Roberts T V., Peterson R, Teus MA. Three-year multinational clinical study on an aspheric hydrophobic acrylic intraocular lens. J Cataract Refract Surg. 2023:672\u20138.","DOI":"10.1097\/j.jcrs.0000000000001173"},{"issue":"10","key":"1075_CR14","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/S0161-6420(90)32422-3","volume":"97","author":"DL Guyton","year":"1990","unstructured":"Guyton DL, Uozato H, Wisnicki HJ. Rapid determination of intraocular lens tilt and decentration through the undilated pupil. Ophthalmology. 1990;97(10):1259\u201364.","journal-title":"Ophthalmology"},{"key":"1075_CR15","doi-asserted-by":"crossref","unstructured":"Kimura S, Morizane Y, Shiode Y, Hirano M, Doi S, Toshima S, et al. Assessment of tilt and decentration of crystalline lens and intraocular lens relative to the corneal topographic axis using anterior segment optical coherence tomography. PLoS One. 2017;12(9).","DOI":"10.1371\/journal.pone.0184066"},{"issue":"6","key":"1075_CR16","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.jcrs.2017.01.026","volume":"43","author":"N Hirnschall","year":"2017","unstructured":"Hirnschall N, Buehren T, Bajramovic F, Trost M, Teuber T, Findl O. Prediction of postoperative intraocular lens tilt using swept-source optical coherence tomography. J Cataract Refract Surg. 2017;43(6):732\u20136.","journal-title":"J Cataract Refract Surg"},{"issue":"12","key":"1075_CR17","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.12998\/wjcc.v10.i12.3639","volume":"10","author":"XY Chen","year":"2022","unstructured":"Chen XY, Wang YC, Zhao TY, Wang ZZ, Wang W. Tilt and decentration with various intraocular lenses: a narrative review. World J Clin Cases. 2022;10(12):3639\u201346.","journal-title":"World J Clin Cases"},{"issue":"6","key":"1075_CR18","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.jcrs.2009.01.034","volume":"35","author":"T Eppig","year":"2009","unstructured":"Eppig T, Scholz K, L\u00f6ffler A, Me\u00dfner A, Langenbucher A. Effect of decentration and tilt on the image quality of aspheric intraocular lens designs in a model eye. J Cataract Refract Surg. 2009;35(6):1091\u2013100.","journal-title":"J Cataract Refract Surg"},{"issue":"11","key":"1075_CR19","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1097\/j.jcrs.0000000000000997","volume":"48","author":"J Zhang","year":"2022","unstructured":"Zhang J, Han X, Zhang M, Liu Z, Chen X, Qiu X, et al. Predicting the risk of clinically significant intraocular lens tilt and decentration in vitrectomized eyes. J Cataract Refract Surg. 2022;48(11):1318\u201324.","journal-title":"J Cataract Refract Surg"},{"key":"1075_CR20","doi-asserted-by":"crossref","unstructured":"Waser K, Honeder A, Hirnschall N, Khalil H, Pomberger L, Laubichler P, et al. Predicting intraocular lens tilt using a machine learning concept. J Cataract Refract Surg. 2024.","DOI":"10.1097\/j.jcrs.0000000000001452"}],"container-title":["Ophthalmology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40123-024-01075-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40123-024-01075-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40123-024-01075-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T15:38:06Z","timestamp":1737560286000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40123-024-01075-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,12]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1075"],"URL":"https:\/\/doi.org\/10.1007\/s40123-024-01075-x","relation":{},"ISSN":["2193-8245","2193-6528"],"issn-type":[{"value":"2193-8245","type":"print"},{"value":"2193-6528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,12]]},"assertion":[{"value":"30 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Klaus Stra\u00dfmaier, Haidar Khalil, Leon Pomberger and Peter Laubichler declare that they have no competing interest. Matthias Bolz: consultant to Carl Zeiss Meditec AG. Nino Hirnschall: consultant to Carl Zeiss Meditec AG and Hoya Surgical Optics GmbH None of the authors have any financial or proprietary interest in any material or method mentioned. Klemens Waser1,2,3 declares that the addition of an affiliation reflects an updated institutional association and does not influence the content, interpretation, or conclusions of this study. 1Kepler University Clinic Linz\/ Austria. 2Johannes Kepler University Linz\/ Austria. 3SMILE Eyes clinic Trier\/ Germany.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Valid ethics vote of the JKU ethics committee Linz, Austria was obtained (EK Nr. 1044\/2023) and the study adheres to the Declaration of Helsinki. All patients provided informed consent prior to inclusion.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}