{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:56:30Z","timestamp":1763686590043,"version":"3.41.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmol Ther"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s40123-025-01147-6","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T13:09:20Z","timestamp":1746536960000},"page":"1453-1464","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Corneal Findings in Patients Treated with Belantamab Mafodotin: A Prospective Case Series Focusing on Corneal Nerves"],"prefix":"10.1007","volume":"14","author":[{"given":"Jakob","family":"Schweighofer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermine","family":"Agis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Krauth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Donner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Funk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Lammer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Klimek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Schmidinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1880-8345","authenticated-orcid":false,"given":"Julia","family":"Aschauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"issue":"1","key":"1147_CR1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4065\/78.1.21","volume":"78","author":"RA Kyle","year":"2003","unstructured":"Kyle RA, Gertz MA, Witzig TE, et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc. 2003;78(1):21\u201333.","journal-title":"Mayo Clin Proc"},{"key":"1147_CR2","doi-asserted-by":"publisher","unstructured":"Turesson I, Bjorkholm M, Blimark CH, Kristinsson S, Velez R, Landgren O. Rapidly changing myeloma epidemiology in the general population: Increased incidence, older patients, and longer survival. Eur J Haematol. 2018. https:\/\/doi.org\/10.1111\/ejh.13083.","DOI":"10.1111\/ejh.13083"},{"issue":"20","key":"1147_CR3","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1182\/blood-2014-11-568923","volume":"125","author":"AK Nooka","year":"2015","unstructured":"Nooka AK, Kastritis E,  Dimopoulos MA, Lonial S. Treatment options for relapsed and refractory multiple myeloma. Blood. 2015;125(20):3085\u201399.","journal-title":"Blood"},{"issue":"10","key":"1147_CR4","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.1038\/s41375-019-0561-2","volume":"33","author":"AH Bazarbachi","year":"2019","unstructured":"Bazarbachi AH, Al Hamed R, Malard F, Harousseau JL, Mohty M. Relapsed refractory multiple myeloma: a comprehensive overview. Leukemia. 2019;33(10):2343\u201357.","journal-title":"Leukemia"},{"issue":"2","key":"1147_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S1470-2045(19)30788-0","volume":"21","author":"S Lonial","year":"2020","unstructured":"Lonial S, Lee HC, Badros A, et al. Belantamab mafodotin for relapsed or refractory multiple myeloma (DREAMM-2): a two-arm, randomised, open-label, phase\u00a02 study. Lancet Oncol. 2020;21(2):207\u201321.","journal-title":"Lancet Oncol"},{"issue":"1","key":"1147_CR6","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/onco.13592","volume":"26","author":"K Tzogani","year":"2021","unstructured":"Tzogani K, Penttil\u00e4 K, L\u00e4hteenvuo J, et al. EMA review of belantamab mafodotin (Blenrep) for the treatment of adult patients with relapsed\/refractory multiple myeloma. Oncologist. 2021;26(1):70\u20136.","journal-title":"Oncologist"},{"issue":"12","key":"1147_CR7","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/S1470-2045(18)30576-X","volume":"19","author":"S Trudel","year":"2018","unstructured":"Trudel S, Lendvai N, Popat R, et al. Targeting B-cell maturation antigen with GSK2857916 antibody-drug conjugate in relapsed or refractory multiple myeloma (BMA117159): a dose escalation and expansion phase\u00a01 trial. Lancet Oncol. 2018;19(12):1641\u201353.","journal-title":"Lancet Oncol"},{"issue":"10","key":"1147_CR8","doi-asserted-by":"publisher","first-page":"e801","DOI":"10.1016\/S2352-3026(23)00243-0","volume":"10","author":"MA Dimopoulos","year":"2023","unstructured":"Dimopoulos MA, Hungria VTM, Radinoff A, et al. Efficacy and safety of single-agent belantamab mafodotin versus pomalidomide plus low-dose dexamethasone in patients with relapsed or refractory multiple myeloma (DREAMM-3): a phase\u00a03, open-label, randomised study. Lancet Haematol. 2023;10(10):e801\u201312.","journal-title":"Lancet Haematol"},{"issue":"2","key":"1147_CR9","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/bcp.12044","volume":"76","author":"JM Lambert","year":"2013","unstructured":"Lambert JM. Drug-conjugated antibodies for the treatment of cancer. Br J Clin Pharmacol. 2013;76(2):248\u201362.","journal-title":"Br J Clin Pharmacol"},{"issue":"5","key":"1147_CR10","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1097\/01.ico.0000154384.05614.8f","volume":"24","author":"RF Guthoff","year":"2005","unstructured":"Guthoff RF, Wienss H, Hahnel H, et al. Epithelial innervation of human cornea: a three-dimensional study using confocal laser scanning fluorescence microscopy. Cornea. 2005;24(5):608\u201313.","journal-title":"Cornea"},{"key":"1147_CR11","doi-asserted-by":"publisher","first-page":"1425617","DOI":"10.3389\/fphar.2024.1425617","volume":"15","author":"K Mao","year":"2024","unstructured":"Mao K, Chen P, Sun H, Zhong S, Zheng H, Xu L, et al. Ocular adverse events associated with antibody-drug conjugates in oncology: a pharmacovigilance study based on FDA adverse event reporting system (FAERS). Front Pharmacol. 2024;15:1425617.","journal-title":"Front Pharmacol"},{"key":"1147_CR12","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.ajo.2022.06.009","volume":"242","author":"J Aschauer","year":"2022","unstructured":"Aschauer J, Donner R, Lammer J, et al. Corneal toxicity associated with belantamab mafodotin is not restricted to the epithelium: neuropathy studied with confocal microscopy. Am J Ophthalmol. 2022;242:116\u201324.","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"1147_CR13","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/s41408-021-00494-4","volume":"11","author":"S Lonial","year":"2021","unstructured":"Lonial S, Nooka AK, Thulasi T, et al. Management of belantamab mafodotin-associated corneal events in patients with relapsed or refractory multiple myeloma (RRMM). Blood Cancer J. 2021;11(5):103.","journal-title":"Blood Cancer J"},{"issue":"4","key":"1147_CR14","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1007\/s40123-020-00280-8","volume":"9","author":"AV Farooq","year":"2020","unstructured":"Farooq AV, Degli Esposti S, Popat R, et al. Corneal epithelial findings in patients with multiple myeloma treated with antibody-drug conjugate belantamab mafodotin in the pivotal, randomized, DREAMM-2 study. Ophthalmol Ther. 2020;9(4):889\u2013911.","journal-title":"Ophthalmol Ther"},{"issue":"2","key":"1147_CR15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/OPX.0000000000000472","volume":"92","author":"C Chao","year":"2015","unstructured":"Chao C, Stapleton F, Badarudin E, Golebiowski B. Ocular surface sensitivity repeatability with Cochet\u2013Bonnet esthesiometer. Optom Vis Sci. 2015;92(2):183\u20139.","journal-title":"Optom Vis Sci"},{"issue":"5","key":"1147_CR16","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1001\/archopht.118.5.615","volume":"118","author":"RM Schiffman","year":"2000","unstructured":"Schiffman RM, Christianson MD, Jacobsen G, Hirsch JD, Reis BL. Reliability and validity of the Ocular Surface Disease\u00a0Index. Arch Ophthalmol. 2000;118(5):615\u201321.","journal-title":"Arch Ophthalmol"},{"issue":"5","key":"1147_CR17","doi-asserted-by":"publisher","first-page":"e83","DOI":"10.1097\/ICO.0b013e3182749419","volume":"32","author":"IN Petropoulos","year":"2013","unstructured":"Petropoulos IN, Manzoor T, Morgan T, et al. Repeatability of in vivo corneal confocal microscopy to quantify corneal nerve morphology. Cornea. 2013;32(5):e83\u20139.","journal-title":"Cornea"},{"issue":"6","key":"1147_CR18","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.2337\/dc14-2422","volume":"38","author":"X Chen","year":"2015","unstructured":"Chen X, Graham J, Dabbah MA, et al. Small nerve fiber quantification in the diagnosis of diabetic sensorimotor polyneuropathy: comparing corneal confocal microscopy with intraepidermal nerve fiber density. Diabetes Care. 2015;38(6):1138\u201344.","journal-title":"Diabetes Care"},{"issue":"Pt 1","key":"1147_CR19","first-page":"300","volume":"13","author":"MA Dabbah","year":"2010","unstructured":"Dabbah MA, Graham J, Petropoulos I, Tavakoli M, Malik RA. Dual-model automatic detection of nerve-fibres in corneal confocal microscopy images. Med Image Comput Comput Assist Interv. 2010;13(Pt 1):300\u20137.","journal-title":"Med Image Comput Comput Assist Interv"},{"issue":"5","key":"1147_CR20","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.media.2011.05.016","volume":"15","author":"MA Dabbah","year":"2011","unstructured":"Dabbah MA, Graham J, Petropoulos IN, Tavakoli M, Malik RA. Automatic analysis of diabetic peripheral neuropathy using multi-scale quantitative morphology of nerve fibres in corneal confocal microscopy imaging. Med Image Anal. 2011;15(5):738\u201347.","journal-title":"Med Image Anal"},{"issue":"10","key":"1147_CR21","doi-asserted-by":"publisher","first-page":"4983","DOI":"10.1002\/mp.14431","volume":"47","author":"P Su","year":"2020","unstructured":"Su P, Chen T, Xie J, et al. Corneal nerve tortuosity grading via ordered weighted averaging-based feature extraction. Med Phys. 2020;47(10):4983\u201396.","journal-title":"Med Phys"},{"issue":"5","key":"1147_CR22","doi-asserted-by":"publisher","first-page":"838","DOI":"10.2337\/dc14-2311","volume":"38","author":"M Tavakoli","year":"2015","unstructured":"Tavakoli M, Ferdousi M, Petropoulos IN, et al. Normative values for corneal nerve morphology assessed using corneal confocal microscopy: a multinational normative data set. Diabetes Care. 2015;38(5):838\u201343.","journal-title":"Diabetes Care"},{"issue":"8","key":"1147_CR23","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.ophtha.2006.03.050","volume":"113","author":"A Labb\u00e9","year":"2006","unstructured":"Labb\u00e9 A, Nicola RD, Dupas B, Auclin F, Baudouin C. Epithelial basement membrane dystrophy: evaluation with the HRT II Rostock Cornea Module. Ophthalmology. 2006;113(8):1301\u20138.","journal-title":"Ophthalmology"},{"issue":"4","key":"1147_CR24","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0161-6420(98)94016-7","volume":"105","author":"E Hern\u00e1ndez-Quintela","year":"1998","unstructured":"Hern\u00e1ndez-Quintela E, Mayer F, Dighiero P, et al. Confocal microscopy of cystic disorders of the corneal epithelium. Ophthalmology. 1998;105(4):631\u20136.","journal-title":"Ophthalmology"},{"issue":"3","key":"1147_CR25","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1177\/112067210901900304","volume":"19","author":"B Bozkurt","year":"2009","unstructured":"Bozkurt B, Irkec M. In vivo laser confocal microscopic findings in patients with epithelial basement membrane dystrophy. Eur J Ophthalmol. 2009;19(3):348\u201354.","journal-title":"Eur J Ophthalmol"},{"issue":"4","key":"1147_CR26","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1136\/bjophthalmol-2011-300551","volume":"96","author":"A Miri","year":"2012","unstructured":"Miri A, Nubile M, Al-Aqaba M, et al. In vivo confocal microscopic findings in patients with limbal stem cell deficiency. Br J Ophthalmol. 2012;96(4):523\u20139.","journal-title":"Br J Ophthalmol"},{"key":"1147_CR27","unstructured":"Sharma A, Preuss CV. Bortezomib. Treasure Island (FL): StatPearls; 2023. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519559\/. Accessed 27 Apr 2025."},{"issue":"3","key":"1147_CR28","doi-asserted-by":"publisher","first-page":"318","DOI":"10.5966\/sctm.2013-0137","volume":"3","author":"AW Joe","year":"2014","unstructured":"Joe AW, Yeung SN. Concise review: identifying limbal stem cells: classical concepts and new challenges. Stem Cells Transl Med. 2014;3(3):318\u201322.","journal-title":"Stem Cells Transl Med"}],"container-title":["Ophthalmology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40123-025-01147-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40123-025-01147-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40123-025-01147-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,14]],"date-time":"2025-06-14T07:49:50Z","timestamp":1749887390000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40123-025-01147-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["1147"],"URL":"https:\/\/doi.org\/10.1007\/s40123-025-01147-6","relation":{},"ISSN":["2193-8245","2193-6528"],"issn-type":[{"type":"print","value":"2193-8245"},{"type":"electronic","value":"2193-6528"}],"subject":[],"published":{"date-parts":[[2025,5,6]]},"assertion":[{"value":"20 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We hereby confirm that Jakob Schweighofer, Hermine Agis, Maria Krauth, Ruth Donner, Marion Funk, Jan Lammer, Michael Klimek, Geral Schmidinger, and Julia Aschauer have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All study investigations complied with the tenets of the Declaration of Helsinki. All patients gave written oral consent to take part in the study. The study was approved by the Ethics Committee of the Medical University of Vienna (EK 1690\/2022).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}