{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:38:49Z","timestamp":1792809529659,"version":"4.5.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ophthalmol Ther"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1007\/s40123-026-01495-x","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:17:24Z","timestamp":1788869844000},"page":"3669-3680","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-Risk Characteristics of Eyelid Basal Cell Carcinoma in Young Patients: A Retrospective Cohort Study"],"prefix":"10.1007","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9487-9479","authenticated-orcid":false,"given":"Maxim","family":"Bez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly","family":"Yacubovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orr","family":"Zimerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lipaz","family":"Varkel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Abumanhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igal","family":"Leibovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Ben Cnaan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"1495_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1136\/BJOPHTHALMOL-2015-308261","volume":"101","author":"GM Saleh","year":"2017","unstructured":"Saleh GM, Desai P, Collin JRO, et al. Incidence of eyelid basal cell carcinoma in England: 2000\u20132010. Br J Ophthalmol. 2017;101:209\u201312. https:\/\/doi.org\/10.1136\/BJOPHTHALMOL-2015-308261.","journal-title":"Br J Ophthalmol"},{"key":"1495_CR2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0002-9394(14)71523-5","volume":"113","author":"GR Howard","year":"1992","unstructured":"Howard GR, Nerad JA, Carter KD, et al. Clinical characteristics associated with orbital invasion of cutaneous basal cell and squamous cell tumors of the eyelid. Am J Ophthalmol. 1992;113:123\u201333. https:\/\/doi.org\/10.1016\/S0002-9394(14)71523-5.","journal-title":"Am J Ophthalmol"},{"key":"1495_CR3","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000083263","volume":"219","author":"J Allali","year":"2005","unstructured":"Allali J, D\u2019Hermies F, Renard G. Basal cell carcinomas of the eyelids. Ophthalmologica. 2005;219:57\u201371. https:\/\/doi.org\/10.1159\/000083263.","journal-title":"Ophthalmologica"},{"key":"1495_CR4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1046\/J.1524-4725.2001.00330.X","volume":"27","author":"AM Feasel","year":"2001","unstructured":"Feasel AM, Brown TJ, Bogle MA, et al. Perineural invasion of cutaneous malignancies. Dermatol Surg. 2001;27:531\u201342. https:\/\/doi.org\/10.1046\/J.1524-4725.2001.00330.X.","journal-title":"Dermatol Surg"},{"key":"1495_CR5","doi-asserted-by":"publisher","first-page":"36","DOI":"10.4081\/ONCOL.2020.420","volume":"14","author":"A Furdova","year":"2020","unstructured":"Furdova A, Kapitanova K, Kollarova A, et al. Periocular basal cell carcinoma\u2014clinical perspectives. Oncol Rev. 2020;14:36\u201342. https:\/\/doi.org\/10.4081\/ONCOL.2020.420.","journal-title":"Oncol Rev"},{"key":"1495_CR6","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/j.ophtha.2004.11.036","volume":"112","author":"I Leibovitch","year":"2005","unstructured":"Leibovitch I, McNab A, Sullivan T, et al. Orbital invasion by periocular basal cell carcinoma. Ophthalmology. 2005;112:717\u201323. https:\/\/doi.org\/10.1016\/j.ophtha.2004.11.036.","journal-title":"Ophthalmology"},{"key":"1495_CR7","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1605::AID-CNCR15>3.0.CO;2-Y","volume":"88","author":"D Ratner","year":"2000","unstructured":"Ratner D, Lowe L, Johnson TM, et al. Perineural spread of basal cell carcinomas treated with Mohs micrographic surgery. Cancer. 2000;88:1605\u201313. https:\/\/doi.org\/10.1002\/(SICI)1097-0142(20000401)88:7%3c1605::AID-CNCR15%3e3.0.CO;2-Y.","journal-title":"Cancer"},{"key":"1495_CR8","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.2147\/OTT.S130371","volume":"10","author":"Y Shi","year":"2017","unstructured":"Shi Y, Jia R, Fan X. Ocular basal cell carcinoma: a brief literature review of clinical diagnosis and treatment. Onco Targets Ther. 2017;10:2483\u20139. https:\/\/doi.org\/10.2147\/OTT.S130371.","journal-title":"Onco Targets Ther"},{"key":"1495_CR9","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/j.1524-4725.1992.tb03509.x","volume":"18","author":"SM Dinehart","year":"1992","unstructured":"Dinehart SM, Dodge R, Stanley WE, et al. Basal cell carcinoma treated with Mohs surgery: a comparison of 54 younger patients with 1050 older patients. J Dermatol Surg Oncol. 1992;18:560\u20136. https:\/\/doi.org\/10.1111\/j.1524-4725.1992.tb03509.x.","journal-title":"J Dermatol Surg Oncol"},{"key":"1495_CR10","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/J.1365-2230.2011.04246.X","volume":"37","author":"AM Skellett","year":"2012","unstructured":"Skellett AM, Hafiji J, Greenberg DC, et al. The incidence of basal cell carcinoma in the under-30s in the UK. Clin Exp Dermatol. 2012;37:227\u20139. https:\/\/doi.org\/10.1111\/J.1365-2230.2011.04246.X.","journal-title":"Clin Exp Dermatol"},{"key":"1495_CR11","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1001\/JAMA.294.6.681","volume":"294","author":"LJ Christenson","year":"2005","unstructured":"Christenson LJ, Borrowman TA, Vachon CM, et al. Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years. JAMA. 2005;294:681\u201390. https:\/\/doi.org\/10.1001\/JAMA.294.6.681.","journal-title":"JAMA"},{"key":"1495_CR12","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1067\/MJD.2002.120467","volume":"46","author":"AS Boyd","year":"2002","unstructured":"Boyd AS, Shyr Y, King LE. Basal cell carcinoma in young women: an evaluation of the association of tanning bed use and smoking. J Am Acad Dermatol. 2002;46:706\u20139. https:\/\/doi.org\/10.1067\/MJD.2002.120467.","journal-title":"J Am Acad Dermatol"},{"key":"1495_CR13","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1097\/DSS.0000000000001541","volume":"44","author":"KM Nemer","year":"2018","unstructured":"Nemer KM, Bauman TM, Boyd AS. Risk factors for basal cell carcinoma in men younger than 40 years: a case-control study. Dermatol Surg. 2018;44:1373\u20138. https:\/\/doi.org\/10.1097\/DSS.0000000000001541.","journal-title":"Dermatol Surg"},{"key":"1495_CR14","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/S41433-018-0290-1","volume":"33","author":"E Saxby","year":"2019","unstructured":"Saxby E, Wright M, Davies R. Periocular basal cell carcinoma in under 40\u2019s\u2014Is more aggressive treatment warranted? Eye (Lond). 2019;33:517\u20138. https:\/\/doi.org\/10.1038\/S41433-018-0290-1.","journal-title":"Eye (Lond)"},{"key":"1495_CR15","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1054\/bjps.1999.3267","volume":"53","author":"CJ Milroy","year":"2000","unstructured":"Milroy CJ, Horlock N, Wilson GD, et al. Aggressive basal cell carcinoma in young patients: fact or fiction? Br J Plast Surg. 2000;53:393\u20136. https:\/\/doi.org\/10.1054\/bjps.1999.3267.","journal-title":"Br J Plast Surg"},{"key":"1495_CR16","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jcjo.2024.12.003","volume":"60","author":"X Hou","year":"2025","unstructured":"Hou X, Rokohl AC, Berndt K, et al. Risk factors analysis and nomogram for predicting recurrence in periocular basal cell carcinoma. Can J Ophthalmol. 2025;60:230\u20137. https:\/\/doi.org\/10.1016\/j.jcjo.2024.12.003.","journal-title":"Can J Ophthalmol"},{"key":"1495_CR17","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/J.JAAD.2011.11.940","volume":"67","author":"LM Ferrucci","year":"2012","unstructured":"Ferrucci LM, Cartmel B, Molinaro AM, et al. Indoor tanning and risk of early-onset basal cell carcinoma. J Am Acad Dermatol. 2012;67:552\u201362. https:\/\/doi.org\/10.1016\/J.JAAD.2011.11.940.","journal-title":"J Am Acad Dermatol"},{"key":"1495_CR18","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1055\/s-0028-1095889","volume":"22","author":"J Ahmad","year":"2008","unstructured":"Ahmad J, Mathes D, Itani K. Reconstruction of the eyelids after Mohs surgery. Semin Plast Surg. 2008;22:306\u201318. https:\/\/doi.org\/10.1055\/s-0028-1095889.","journal-title":"Semin Plast Surg"},{"key":"1495_CR19","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.4103\/IJO.IJO_2829_22","volume":"71","author":"P Ganguly","year":"2023","unstructured":"Ganguly P, Bhunia J, Das K, et al. Evaluation of post-operative dry eye in upper and lower eyelid reconstruction: a cross-sectional study. Indian J Ophthalmol. 2023;71:1561\u20135. https:\/\/doi.org\/10.4103\/IJO.IJO_2829_22.","journal-title":"Indian J Ophthalmol"},{"key":"1495_CR20","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1111\/aos.12034","volume":"92","author":"A Klein-Theyer","year":"2014","unstructured":"Klein-Theyer A, Horwath-Winter J, Dieter FR, et al. Evaluation of ocular surface and tear film function following modified Hughes tarsoconjunctival flap procedure. Acta Ophthalmol. 2014;92:286\u201390. https:\/\/doi.org\/10.1111\/aos.12034.","journal-title":"Acta Ophthalmol"},{"key":"1495_CR21","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/CEO.13142","volume":"46","author":"MTM Wang","year":"2018","unstructured":"Wang MTM, Kersey TL, Sloan BH, et al. Evaporative dry eye following modified Hughes flap reconstruction. Clin Exp Ophthalmol. 2018;46:700\u20132. https:\/\/doi.org\/10.1111\/CEO.13142.","journal-title":"Clin Exp Ophthalmol"}],"container-title":["Ophthalmology and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40123-026-01495-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40123-026-01495-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40123-026-01495-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:04:52Z","timestamp":1792807492000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40123-026-01495-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["1495"],"URL":"https:\/\/doi.org\/10.1007\/s40123-026-01495-x","relation":{},"ISSN":["2193-8245","2193-6528"],"issn-type":[{"value":"2193-8245","type":"print"},{"value":"2193-6528","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"31 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Maxim Bez, Shelly Yacubovich, Orr Zimerman, Lipaz Varkel, Muhammad Abumanhal, Igal Leibovitch, and Ran Ben Cnaan declare that they have no financial or non-financial competing interests relevant to this work.","order":1,"name":"Ethics","label":"Conflict of Interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study was conducted in accordance with the Declaration of Helsinki. Institutional review board approval was obtained from Tel Aviv Sourasky Medical Center (approval no. TLV0201-25), and the requirement for informed consent was waived because of the retrospective design and use of routinely collected clinical data. Patients were not involved in the design, conduct, reporting, or dissemination plans of this retrospective study.","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}