{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:40:55Z","timestamp":1789267255633,"version":"build-2803163510"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["D43TW009343"],"award-info":[{"award-number":["D43TW009343"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"All May See Foundation"},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Ophthalmol Rep"],"DOI":"10.1007\/s40135-022-00302-7","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:02:46Z","timestamp":1668038566000},"page":"198-208","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Outcomes of Pythium keratitis: A Meta-Analysis of Individual Patient Data"],"prefix":"10.1007","volume":"10","author":[{"given":"Binh","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu Teja","family":"Gonugunta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveen","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajna","family":"Lalitha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Gurnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirandeep","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskar","family":"Srinivasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy D.","family":"Keenan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. Venkatesh","family":"Prajna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"302_CR1","unstructured":"Gurnani B, Kaur K. Pythium keratitis. In: StatPearls. StatPearls Publishing; 2022. Accessed March 31, 2022. http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK573072\/."},{"issue":"4","key":"302_CR2","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.4103\/ijo.IJO_1534_21","volume":"70","author":"B Gurnani","year":"2022","unstructured":"Gurnani B, Kaur K, Venugopal A, et al. Pythium insidiosum keratitis - a review. Indian J Ophthalmol. 2022;70(4):1107\u201320. https:\/\/doi.org\/10.4103\/ijo.IJO_1534_21.","journal-title":"Indian J Ophthalmol"},{"issue":"5","key":"302_CR3","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.4103\/ijo.IJO_1808_20","volume":"69","author":"B Gurnani","year":"2021","unstructured":"Gurnani B, Christy J, Narayana S, Rajkumar P, Kaur K, Gubert J. Retrospective multifactorial analysis of Pythium keratitis and review of literature. Indian J Ophthalmol. 2021;69(5):1095\u2013101. https:\/\/doi.org\/10.4103\/ijo.IJO_1808_20.","journal-title":"Indian J Ophthalmol"},{"key":"302_CR4","doi-asserted-by":"publisher","unstructured":"Gurnani B, Kaur K, Agarwal S, et al. Pythium insidiosum keratitis: past, present, and future. Ophthalmol Ther. Published online July 5, 2022. https:\/\/doi.org\/10.1007\/s40123-022-00542-7.","DOI":"10.1007\/s40123-022-00542-7"},{"issue":"8","key":"302_CR5","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/j.1442-9071.2009.02135.x","volume":"37","author":"PR Badenoch","year":"2009","unstructured":"Badenoch PR, Mills RA, Chang JH, Sadlon TA, Klebe S, Coster DJ. Pythium insidiosum keratitis in an Australian child. Clin Experiment Ophthalmol. 2009;37(8):806\u20139. https:\/\/doi.org\/10.1111\/j.1442-9071.2009.02135.x.","journal-title":"Clin Experiment Ophthalmol"},{"issue":"4","key":"302_CR6","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3109\/08820538.2013.788676","volume":"28","author":"IS Barequet","year":"2013","unstructured":"Barequet IS, Lavinsky F, Rosner M. Long-term follow-up after successful treatment of Pythium insidiosum keratitis in Israel. Semin Ophthalmol. 2013;28(4):247\u201350. https:\/\/doi.org\/10.3109\/08820538.2013.788676.","journal-title":"Semin Ophthalmol"},{"key":"302_CR7","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ijid.2019.06.011","volume":"86","author":"D Bernheim","year":"2019","unstructured":"Bernheim D, Dupont D, Aptel F, et al. Pythiosis: case report leading to new features in clinical and diagnostic management of this fungal-like infection. Int J Infect Dis. 2019;86:40\u20133. https:\/\/doi.org\/10.1016\/j.ijid.2019.06.011.","journal-title":"Int J Infect Dis"},{"issue":"2","key":"302_CR8","doi-asserted-by":"publisher","first-page":"270","DOI":"10.4269\/ajtmh.14-0380","volume":"92","author":"L Lelievre","year":"2015","unstructured":"Lelievre L, Borderie V, Garcia-Hermoso D, et al. Imported Pythium insidiosum keratitis after a swim in Thailand by a contact lens-wearing traveler. Am J Trop Med Hyg. 2015;92(2):270\u20133. https:\/\/doi.org\/10.4269\/ajtmh.14-0380.","journal-title":"Am J Trop Med Hyg"},{"key":"302_CR9","doi-asserted-by":"publisher","first-page":"100498","DOI":"10.1016\/j.ajoc.2019.100498","volume":"15","author":"S Maeno","year":"2019","unstructured":"Maeno S, Oie Y, Sunada A, et al. Successful medical management of Pythium insidiosum keratitis using a combination of minocycline, linezolid, and chloramphenicol. Am J Ophthalmol Case Rep. 2019;15:100498. https:\/\/doi.org\/10.1016\/j.ajoc.2019.100498.","journal-title":"Am J Ophthalmol Case Rep"},{"issue":"2","key":"302_CR10","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1442-9071.1997.tb01304.x","volume":"25","author":"D Murdoch","year":"1997","unstructured":"Murdoch D, Parr D. Pythium insidiosum keratitis. Aust N Z J Ophthalmol. 1997;25(2):177\u20139. https:\/\/doi.org\/10.1111\/j.1442-9071.1997.tb01304.x.","journal-title":"Aust N Z J Ophthalmol"},{"issue":"2","key":"302_CR11","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.1016\/j.jcjo.2017.07.002","volume":"53","author":"A Neufeld","year":"2018","unstructured":"Neufeld A, Seamone C, Maleki B, Heathcote JG. Pythium insidiosum keratitis: a pictorial essay of natural history. Can J Ophthalmol. 2018;53(2):e48\u201350. https:\/\/doi.org\/10.1016\/j.jcjo.2017.07.002.","journal-title":"Can J Ophthalmol"},{"issue":"11","key":"302_CR12","doi-asserted-by":"publisher","first-page":"821","DOI":"10.2146\/ajhp160248","volume":"74","author":"F Ros Castellar","year":"2017","unstructured":"Ros Castellar F, Sobrino-Jim\u00e9nez C, del-Hierro-Zarzuelo A, Herrero-Ambrosio A, Boto-de-los-Bueis A. Intraocular minocycline for the treatment of ocular pythiosis. Am J Health-Syst Pharm. 2017;74(11):821\u20135. https:\/\/doi.org\/10.2146\/ajhp160248.","journal-title":"Am J Health-Syst Pharm"},{"issue":"2","key":"302_CR13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1097\/ICL.0b013e3182043114","volume":"37","author":"TY Tanhehco","year":"2011","unstructured":"Tanhehco TY, Stacy RC, Mendoza L, Durand ML, Jakobiec FA, Colby KA. Pythium insidiosum Keratitis in Israel. Eye Contact Lens. 2011;37(2):96\u20138. https:\/\/doi.org\/10.1097\/ICL.0b013e3182043114.","journal-title":"Eye Contact Lens"},{"issue":"1","key":"302_CR14","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/00003226-199301000-00015","volume":"12","author":"R Virgile","year":"1993","unstructured":"Virgile R, Perry HD, Pardanani B, et al. Human infectious corneal ulcer caused by Pythium insidiosum. Cornea. 1993;12(1):81\u20133. https:\/\/doi.org\/10.1097\/00003226-199301000-00015.","journal-title":"Cornea"},{"issue":"4","key":"302_CR15","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1097\/ICO.0000000000001504","volume":"37","author":"A Rathi","year":"2018","unstructured":"Rathi A, Chakrabarti A, Agarwal T, et al. Pythium keratitis leading to fatal cavernous sinus thrombophlebitis. Cornea. 2018;37(4):519\u201322. https:\/\/doi.org\/10.1097\/ICO.0000000000001504.","journal-title":"Cornea"},{"issue":"1","key":"302_CR16","doi-asserted-by":"publisher","first-page":"42","DOI":"10.4103\/ijo.IJO_445_18","volume":"67","author":"R Hasika","year":"2019","unstructured":"Hasika R, Lalitha P, Radhakrishnan N, Rameshkumar G, Prajna NV, Srinivasan M. Pythium keratitis in South India: incidence, clinical profile, management, and treatment recommendation. Indian J Ophthalmol. 2019;67(1):42\u20137. https:\/\/doi.org\/10.4103\/ijo.IJO_445_18.","journal-title":"Indian J Ophthalmol"},{"issue":"12","key":"302_CR17","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1136\/bjophthalmol-2017-311360","volume":"102","author":"B Bagga","year":"2018","unstructured":"Bagga B, Sharma S, Guda SJM, et al. Leap forward in the treatment of Pythium insidiosum keratitis. Br J Ophthalmol. 2018;102(12):1629\u201333. https:\/\/doi.org\/10.1136\/bjophthalmol-2017-311360.","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"302_CR18","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/mmy\/myz013","volume":"57","author":"N Permpalung","year":"2019","unstructured":"Permpalung N, Worasilchai N, Manothummetha K, et al. Clinical outcomes in ocular pythiosis patients treated with a combination therapy protocol in Thailand: a prospective study. Med Mycol. 2019;57(8):923\u20138. https:\/\/doi.org\/10.1093\/mmy\/myz013.","journal-title":"Med Mycol"},{"issue":"2","key":"302_CR19","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1136\/bjophthalmol-2017-310604","volume":"102","author":"S Agarwal","year":"2018","unstructured":"Agarwal S, Iyer G, Srinivasan B, Agarwal M, PanchalamSampath Kumar S, Therese LK. Clinical profile of Pythium keratitis: perioperative measures to reduce risk of recurrence. Br J Ophthalmol. 2018;102(2):153\u20137. https:\/\/doi.org\/10.1136\/bjophthalmol-2017-310604.","journal-title":"Br J Ophthalmol"},{"issue":"3","key":"302_CR20","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1136\/bjophthalmol-2017-311804","volume":"103","author":"S Agarwal","year":"2019","unstructured":"Agarwal S, Iyer G, Srinivasan B, et al. Clinical profile, risk factors and outcome of medical, surgical and adjunct interventions in patients with Pythium insidiosum keratitis. Br J Ophthalmol. 2019;103(3):296\u2013300. https:\/\/doi.org\/10.1136\/bjophthalmol-2017-311804.","journal-title":"Br J Ophthalmol"},{"issue":"9","key":"302_CR21","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1097\/ICO.0000000000002370","volume":"39","author":"S Agarwal","year":"2020","unstructured":"Agarwal S, Srinivasan B, Janakiraman N, et al. Role of topical ethanol in the treatment of Pythium insidiosum keratitis-a proof of concept. Cornea. 2020;39(9):1102\u20137. https:\/\/doi.org\/10.1097\/ICO.0000000000002370.","journal-title":"Cornea"},{"issue":"2","key":"302_CR22","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1097\/ICO.0000000000001466","volume":"37","author":"O Anutarapongpan","year":"2018","unstructured":"Anutarapongpan O, Thanathanee O, Worrawitchawong J, Suwan-Apichon O. Role of confocal microscopy in the diagnosis of Pythium insidiosum keratitis. Cornea. 2018;37(2):156\u201361. https:\/\/doi.org\/10.1097\/ICO.0000000000001466.","journal-title":"Cornea"},{"issue":"8","key":"302_CR23","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/j.1442-9071.2009.02135.x","volume":"37","author":"PR Badenoch","year":"2009","unstructured":"Badenoch PR, Mills RAD, Chang JH, Sadlon TA, Klebe S, Coster DJ. Pythium insidiosum keratitis in an Australian child. Clin Exp Ophthalmol. 2009;37(8):806\u20139. https:\/\/doi.org\/10.1111\/j.1442-9071.2009.02135.x.","journal-title":"Clin Exp Ophthalmol"},{"issue":"12","key":"302_CR24","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1136\/bjophthalmol-2017-311360","volume":"102","author":"B Bagga","year":"2018","unstructured":"Bagga B, Sharma S, Madhuri Guda SJ, et al. Leap forward in the treatment of Pythium insidiosum keratitis. Br J Ophthalmol. 2018;102(12):1629\u201333. https:\/\/doi.org\/10.1136\/bjophthalmol-2017-311360.","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"302_CR25","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3109\/08820538.2013.788676","volume":"28","author":"IS Barequet","year":"2013","unstructured":"Barequet IS, Lavinsky F, Rosner M. Long-term follow-up after successful treatment of Pythium insidiosum keratitis in Israel. Semin Ophthalmol. 2013;28(4):247\u201350. https:\/\/doi.org\/10.3109\/08820538.2013.788676.","journal-title":"Semin Ophthalmol"},{"key":"302_CR26","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ijid.2019.06.011","volume":"86","author":"D Bernheim","year":"2019","unstructured":"Bernheim D, Dupont D, Aptel F, et al. Pythiosis: case report leading to new features in clinical and diagnostic management of this fungal-like infection. Int J Infect Dis. 2019;86:40\u20133. https:\/\/doi.org\/10.1016\/j.ijid.2019.06.011.","journal-title":"Int J Infect Dis"},{"issue":"2","key":"302_CR27","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.1097\/ICO.0000000000001419","volume":"37","author":"S Chatterjee","year":"2018","unstructured":"Chatterjee S, Agrawal D. Azithromycin in the management of Pythium insidiosum keratitis. Cornea. 2018;37(2):e8\u20139. https:\/\/doi.org\/10.1097\/ICO.0000000000001419.","journal-title":"Cornea"},{"issue":"5","key":"302_CR28","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.4103\/ijo.IJO_1808_20","volume":"69","author":"B Gurnani","year":"2021","unstructured":"Gurnani B, Christy J, Narayana S, Rajkumar P, Kaur K, Gubert J. Retrospective multifactorial analysis of Pythium keratitis and review of literature. Indian J Ophthalmol. 2021;69(5):1095\u2013101. https:\/\/doi.org\/10.4103\/ijo.IJO_1808_20.","journal-title":"Indian J Ophthalmol"},{"issue":"1","key":"302_CR29","doi-asserted-by":"publisher","first-page":"42","DOI":"10.4103\/ijo.IJO_445_18","volume":"67","author":"R Hasika","year":"2019","unstructured":"Hasika R, Lalitha P, Radhakrishnan N, Rameshkumar G, Prajna NV, Srinivasan M. Pythium keratitis in South India: incidence, clinical profile, management, and treatment recommendation. Indian J Ophthalmol. 2019;67(1):42\u20137. https:\/\/doi.org\/10.4103\/ijo.IJO_445_18.","journal-title":"Indian J Ophthalmol"},{"key":"302_CR30","doi-asserted-by":"publisher","first-page":"982","DOI":"10.12659\/ajcr.901158","volume":"17","author":"H He","year":"2016","unstructured":"He H, Liu H, Chen X, Wu J, He M, Zhong X. Diagnosis and treatment of Pythium insidiosum corneal ulcer in a Chinese child: a case report and literature review. Am J Case Rep. 2016;17:982\u20138. https:\/\/doi.org\/10.12659\/ajcr.901158.","journal-title":"Am J Case Rep"},{"issue":"1","key":"302_CR31","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1186\/s13256-021-03189-3","volume":"15","author":"H Hou","year":"2021","unstructured":"Hou H, Wang Y, Tian L, Wang F, Sun Z, Chen Z. Pythium insidiosum keratitis reported in China, raising the alertness to this fungus-like infection: a case series. J Med Case Rep. 2021;15(1):619. https:\/\/doi.org\/10.1186\/s13256-021-03189-3.","journal-title":"J Med Case Rep"},{"key":"302_CR32","doi-asserted-by":"publisher","unstructured":"Kate A, Bagga B, Ahirwar LK, Mishra DK, Sharma S. Unusual presentation of Pythium keratitis as peripheral ulcerative keratitis: clinical dilemma. Ocul Immunol Inflamm. Published online August 19, 2021; 1\u20134. https:\/\/doi.org\/10.1080\/09273948.2021.1952276.","DOI":"10.1080\/09273948.2021.1952276"},{"issue":"4","key":"302_CR33","first-page":"338","volume":"86","author":"S Kunavisarut","year":"2003","unstructured":"Kunavisarut S, Nimvorapan T, Methasiri S. Pythium corneal ulcer in Ramathibodi Hospital. J Med Assoc Thai. 2003;86(4):338\u201342.","journal-title":"J Med Assoc Thai"},{"issue":"10","key":"302_CR34","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1097\/ICO.0b013e318199fa41","volume":"28","author":"K Lekhanont","year":"2009","unstructured":"Lekhanont K, Chuckpaiwong V, Chongtrakool P, Aroonroch R, Vongthongsri A. Pythium insidiosum keratitis in contact lens wear: a case report. Cornea. 2009;28(10):1173\u20137. https:\/\/doi.org\/10.1097\/ICO.0b013e318199fa41.","journal-title":"Cornea"},{"issue":"2","key":"302_CR35","doi-asserted-by":"publisher","first-page":"270","DOI":"10.4269\/ajtmh.14-0380","volume":"92","author":"L Lelievre","year":"2015","unstructured":"Lelievre L, Borderie V, Garcia-Hermoso D, et al. Imported Pythium insidiosum keratitis after a swim in Thailand by a contact lens-wearing traveler. Am J Trop Med Hyg. 2015;92(2):270\u20133. https:\/\/doi.org\/10.4269\/ajtmh.14-0380.","journal-title":"Am J Trop Med Hyg"},{"key":"302_CR36","doi-asserted-by":"publisher","first-page":"100498","DOI":"10.1016\/j.ajoc.2019.100498","volume":"15","author":"S Maeno","year":"2019","unstructured":"Maeno S, Oie Y, Sunada A, et al. Successful medical management of Pythium insidiosum keratitis using a combination of minocycline, linezolid, and chloramphenicol. Am J Ophthalmol Case Rep. 2019;15:100498. https:\/\/doi.org\/10.1016\/j.ajoc.2019.100498.","journal-title":"Am J Ophthalmol Case Rep"},{"issue":"9","key":"302_CR37","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1097\/ICO.0000000000001244","volume":"36","author":"R Mittal","year":"2017","unstructured":"Mittal R, Jena SK, Desai A, Agarwal S. Pythium insidiosum keratitis: histopathology and rapid novel diagnostic staining technique. Cornea. 2017;36(9):1124\u201332. https:\/\/doi.org\/10.1097\/ICO.0000000000001244.","journal-title":"Cornea"},{"issue":"2","key":"302_CR38","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1442-9071.1997.tb01304.x","volume":"25","author":"D Murdoch","year":"1997","unstructured":"Murdoch D, Parr D. Pythium insidiosum keratitis. Aust N Z J Ophthalmol. 1997;25(2):177\u20139. https:\/\/doi.org\/10.1111\/j.1442-9071.1997.tb01304.x.","journal-title":"Aust N Z J Ophthalmol"},{"issue":"11","key":"302_CR39","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1097\/ICO.0000000000002651","volume":"40","author":"M Nonpassopon","year":"2021","unstructured":"Nonpassopon M, Jongkhajornpong P, Aroonroch R, Koovisitsopit A, Lekhanont K. Predisposing factors, clinical presentations, and outcomes of contact lens-related Pythium keratitis. Cornea. 2021;40(11):1413\u20139. https:\/\/doi.org\/10.1097\/ICO.0000000000002651.","journal-title":"Cornea"},{"issue":"6","key":"302_CR40","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1093\/jac\/dkv008","volume":"70","author":"N Permpalung","year":"2015","unstructured":"Permpalung N, Worasilchai N, Plongla R, et al. Treatment outcomes of surgery, antifungal therapy and immunotherapy in ocular and vascular human pythiosis: a retrospective study of 18 patients. J Antimicrob Chemother. 2015;70(6):1885\u201392. https:\/\/doi.org\/10.1093\/jac\/dkv008.","journal-title":"J Antimicrob Chemother"},{"key":"302_CR41","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.2147\/OPTH.S303721","volume":"15","author":"V Puangsricharern","year":"2021","unstructured":"Puangsricharern V, Chotikkakamthorn P, Tulvatana W, et al. Clinical characteristics, histopathology, and treatment outcomes of Pythium keratitis: a retrospective cohort study. Clin Ophthalmol. 2021;15:1691\u2013701. https:\/\/doi.org\/10.2147\/OPTH.S303721.","journal-title":"Clin Ophthalmol"},{"issue":"1","key":"302_CR42","doi-asserted-by":"publisher","first-page":"bcr-2018-226386","DOI":"10.1136\/bcr-2018-226386","volume":"11","author":"A Raghavan","year":"2018","unstructured":"Raghavan A, Bellamkonda P, Mendoza L, Rammohan R. Pythium insidiosum and acanthamoeba keratitis in a contact lens user. BMJ Case Rep. 2018;11(1):bcr-2018-226386. https:\/\/doi.org\/10.1136\/bcr-2018-226386.","journal-title":"BMJ Case Rep"},{"issue":"4","key":"302_CR43","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1097\/ICO.0000000000001162","volume":"36","author":"M Ramappa","year":"2017","unstructured":"Ramappa M, Nagpal R, Sharma S, Chaurasia S. Successful medical management of presumptive Pythium insidiosum keratitis. Cornea. 2017;36(4):511\u20134. https:\/\/doi.org\/10.1097\/ICO.0000000000001162.","journal-title":"Cornea"},{"issue":"4","key":"302_CR44","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1097\/ICO.0000000000001504","volume":"37","author":"A Rathi","year":"2018","unstructured":"Rathi A, Chakrabarti A, Agarwal T, et al. Pythium keratitis leading to fatal cavernous sinus thrombophlebitis. Cornea. 2018;37(4):519\u201322. https:\/\/doi.org\/10.1097\/ICO.0000000000001504.","journal-title":"Cornea"},{"issue":"11","key":"302_CR45","doi-asserted-by":"publisher","first-page":"821","DOI":"10.2146\/ajhp160248","volume":"74","author":"F Ros Castellar","year":"2017","unstructured":"Ros Castellar F, Sobrino Jim\u00e9nez C, del Hierro Zarzuelo A, Herrero Ambrosio A, Boto de Los Bueis A. Intraocular minocycline for the treatment of ocular pythiosis. Am J Health Syst Pharm. 2017;74(11):821\u20135. https:\/\/doi.org\/10.2146\/ajhp160248.","journal-title":"Am J Health Syst Pharm"},{"issue":"4","key":"302_CR46","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1097\/ICO.0000000000000349","volume":"34","author":"S Sharma","year":"2015","unstructured":"Sharma S, Balne PK, Motukupally SR, et al. Pythium insidiosum keratitis: clinical profile and role of DNA sequencing and zoospore formation in diagnosis. Cornea. 2015;34(4):438\u201342. https:\/\/doi.org\/10.1097\/ICO.0000000000000349.","journal-title":"Cornea"},{"issue":"12","key":"302_CR47","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1097\/ICO.0000000000002725","volume":"40","author":"S Sharma","year":"2021","unstructured":"Sharma S, Rathi VM, Murthy SI, Garg P, Sharma S. Application of trypan blue stain in the microbiological diagnosis of infectious keratitis-a case series. Cornea. 2021;40(12):1624\u20138. https:\/\/doi.org\/10.1097\/ICO.0000000000002725.","journal-title":"Cornea"},{"issue":"2","key":"302_CR48","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1097\/ICL.0b013e3182043114","volume":"37","author":"TY Tanhehco","year":"2011","unstructured":"Tanhehco TY, Stacy RC, Mendoza L, Durand ML, Jakobiec FA, Colby KA. Pythium insidiosum keratitis in Israel. Eye Contact Lens. 2011;37(2):96\u20138. https:\/\/doi.org\/10.1097\/ICL.0b013e3182043114.","journal-title":"Eye Contact Lens"},{"issue":"1","key":"302_CR49","doi-asserted-by":"publisher","first-page":"110","DOI":"10.4269\/ajtmh.22-0015","volume":"107","author":"O Thanathanee","year":"2022","unstructured":"Thanathanee O, Bhoomibunchoo C, Anutarapongpan O, Suwan-Apichon O, Charoensuk K, Chindamporn A. Role of immunotherapy in Pythium insidiosum keratitis. Am J Trop Med Hyg. 2022;107(1):110\u20132. https:\/\/doi.org\/10.4269\/ajtmh.22-0015.","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"302_CR50","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1097\/ICO.0b013e3182535841","volume":"32","author":"O Thanathanee","year":"2013","unstructured":"Thanathanee O, Enkvetchakul O, Rangsin R, Waraasawapati S, Samerpitak K, Suwan-apichon O. Outbreak of Pythium keratitis during rainy season: a case series. Cornea. 2013;32(2):199\u2013204. https:\/\/doi.org\/10.1097\/ICO.0b013e3182535841.","journal-title":"Cornea"},{"issue":"1","key":"302_CR51","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/00003226-199301000-00015","volume":"12","author":"R Virgile","year":"1993","unstructured":"Virgile R, Perry HD, Pardanani B, et al. Human infectious corneal ulcer caused by Pythium insidiosum. Cornea. 1993;12(1):81\u20133. https:\/\/doi.org\/10.1097\/00003226-199301000-00015.","journal-title":"Cornea"},{"issue":"6","key":"302_CR52","doi-asserted-by":"publisher","first-page":"1544","DOI":"10.4103\/ijo.IJO_2356_20","volume":"69","author":"P Vishwakarma","year":"2021","unstructured":"Vishwakarma P, Mohanty A, Kaur A, et al. Pythium keratitis: clinical profile, laboratory diagnosis, treatment, and histopathology features post-treatment at a tertiary eye care center in Eastern India. Indian J Ophthalmol. 2021;69(6):1544\u201352. https:\/\/doi.org\/10.4103\/ijo.IJO_2356_20.","journal-title":"Indian J Ophthalmol"},{"issue":"8","key":"302_CR53","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1097\/ICO.0b013e3182883e9d","volume":"32","author":"GM Rogers","year":"2013","unstructured":"Rogers GM, Goins KM, Sutphin JE, Kitzmann AS, Wagoner MD. Outcomes of treatment of fungal keratitis at the University of Iowa Hospitals and Clinics: a 10-year retrospective analysis. Cornea. 2013;32(8):6.","journal-title":"Cornea"},{"issue":"6","key":"302_CR54","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1097\/ICO.0b013e318191695b","volume":"28","author":"U Jurkunas","year":"2009","unstructured":"Jurkunas U, Behlau I, Colby K. Fungal keratitis: changing pathogens and risk factors. Cornea. 2009;28(6):6.","journal-title":"Cornea"},{"issue":"4","key":"302_CR55","first-page":"275","volume":"23","author":"TY Wong","year":"1997","unstructured":"Wong TY, Ng TP, Fong KS, Tan DT. Risk factors and clinical outcomes between fungal and bacterial keratitis: a comparative study. CLAO J. 1997;23(4):275\u201381.","journal-title":"CLAO J"},{"issue":"7","key":"302_CR56","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.ophtha.2014.01.031","volume":"121","author":"D Robaei","year":"2014","unstructured":"Robaei D, Carnt N, Minassian DC, Dart JKG. The impact of topical corticosteroid use before diagnosis on the outcome of acanthamoeba keratitis. Ophthalmology. 2014;121(7):1383\u20138. https:\/\/doi.org\/10.1016\/j.ophtha.2014.01.031.","journal-title":"Ophthalmology"},{"issue":"2","key":"302_CR57","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/ICO.0b013e31826429bd","volume":"32","author":"N Bouheraoua","year":"2013","unstructured":"Bouheraoua N, Gaujoux T, Goldschmidt P, Chaumeil C, Laroche L, Borderie VM. Prognostic factors associated with the need for surgical treatments in acanthamoeba keratitis. Cornea. 2013;32(2):130\u20136. https:\/\/doi.org\/10.1097\/ICO.0b013e31826429bd.","journal-title":"Cornea"},{"key":"302_CR58","doi-asserted-by":"publisher","first-page":"e8555","DOI":"10.7717\/peerj.8555","volume":"8","author":"MN Chitasombat","year":"2020","unstructured":"Chitasombat MN, Jongkhajornpong P, Lekhanont K, Krajaejun T. Recent update in diagnosis and treatment of human pythiosis. PeerJ. 2020;8:e8555. https:\/\/doi.org\/10.7717\/peerj.8555.","journal-title":"PeerJ"},{"issue":"1","key":"302_CR59","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1128\/AAC.01480-15","volume":"60","author":"FPK Jesus","year":"2015","unstructured":"Jesus FPK, Loreto \u00c9S, Ferreiro L, et al. In vitro and in vivo antimicrobial activities of minocycline in combination with azithromycin, clarithromycin, or tigecycline against Pythium insidiosum. Antimicrob Agents Chemother. 2015;60(1):87\u201391. https:\/\/doi.org\/10.1128\/AAC.01480-15.","journal-title":"Antimicrob Agents Chemother"},{"key":"302_CR60","doi-asserted-by":"publisher","first-page":"108345","DOI":"10.1016\/j.exer.2020.108345","volume":"202","author":"LK Ahirwar","year":"2021","unstructured":"Ahirwar LK, Kalra P, Sharma S, et al. Linezolid shows high safety and efficacy in the treatment of Pythium insidiosum keratitis in a rabbit model. Exp Eye Res. 2021;202:108345. https:\/\/doi.org\/10.1016\/j.exer.2020.108345.","journal-title":"Exp Eye Res"},{"issue":"4","key":"302_CR61","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3390\/antibiotics11040450","volume":"11","author":"S Medhasi","year":"2022","unstructured":"Medhasi S, Chindamporn A, Worasilchai N. A review: antimicrobial therapy for human pythiosis. Antibiotics. 2022;11(4):450. https:\/\/doi.org\/10.3390\/antibiotics11040450.","journal-title":"Antibiotics"}],"container-title":["Current Ophthalmology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40135-022-00302-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40135-022-00302-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40135-022-00302-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T05:18:35Z","timestamp":1670390315000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40135-022-00302-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,10]]},"references-count":61,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["302"],"URL":"https:\/\/doi.org\/10.1007\/s40135-022-00302-7","relation":{},"ISSN":["2167-4868"],"issn-type":[{"value":"2167-4868","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,10]]},"assertion":[{"value":"24 October 2022","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2022","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or UCGHI.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclaimer"}}]}}