{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:15:55Z","timestamp":1784693755045,"version":"3.55.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Curr Otorhinolaryngol Rep"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s40136-014-0055-8","type":"journal-article","created":{"date-parts":[[2014,6,30]],"date-time":"2014-06-30T20:21:40Z","timestamp":1404159700000},"page":"137-143","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Intratympanic Therapies for Meni\u00e8re\u2019s Disease"],"prefix":"10.1007","volume":"2","author":[{"given":"Matthew W.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,1]]},"reference":[{"key":"55_CR1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1288\/00005537-196306000-00002","volume":"73","author":"H Schuknecht","year":"1963","unstructured":"Schuknecht H. Meniere\u2019s disease: a correlation of symptomatology and pathology. Laryngoscope. 1963;73:651\u201365.","journal-title":"Laryngoscope."},{"key":"55_CR2","doi-asserted-by":"crossref","unstructured":"\u2022 Casani AP, Cerchiai N, Navari E, Dallan I, Piaggi P, Sellari-Franceschini S. Intratympanic gentamicin for meniere\u2019s disease: short- and long-term follow-up of two regimens of treatment. Otolaryngol Head Neck Surg. 2014;150(5):847\u201352. This retrospective study compares the previous higher-dose intratympanic gentamicin regimen with a more recently used lower\u2010dose treatment. High control rates were achieved.","DOI":"10.1177\/0194599813520398"},{"key":"55_CR3","doi-asserted-by":"crossref","unstructured":"\u2022 Quaglieri S, Gatti O, Rebecchi E, Manfrin M, Tinelli C, Mira E, et al. Intratympanic gentamicin treatment \u201cas needed\u201d for meniere\u2019s disease. Long-term analysis using the Kaplan\u2013Meier method. Eur Arch Otorhinolaryngol. 2013;271(6):1443\u20139. This retrospective study reinforces the notion that patients can be treated with lower doses of intratympanic gentamicin, with repeat doses \"as needed\" should symptoms persist.","DOI":"10.1007\/s00405-013-2597-7"},{"key":"55_CR4","doi-asserted-by":"crossref","unstructured":"\u2022 Wasson J, Upile N, Pfleiderer A. Intratympanic gentamicin treatment for unilateral M\u00e9ni\u00e8re\u2019s disease: long-term follow up of a proven regime. J Laryngol Otol. 2013;127(1):20\u20134. This retrospective review is a follow-up of previously published results. Patients were contacted via telephone to survey ongoing symptom control following a high\u2010dose intratympanic gentamicin protocol.","DOI":"10.1017\/S0022215112002605"},{"key":"55_CR5","doi-asserted-by":"crossref","unstructured":"\u2022 Walther LE, Huelse R, Bl\u00e4ttner K, Bloching MB, Bl\u00f6dow A. Dynamic change of VOR and otolith function in intratympanic gentamicin treatment for M\u00e9ni\u00e8re\u2019s disease: case report and review of the literature. Case Rep Otolaryngol. 2013;2013:1\u20135. This case report describes the timecourse of the objective changes (video head impulse test, oVEMP, cVEMP, and bithermal calorics) in the weeks following a single dose of intratympanic getamicin.","DOI":"10.1155\/2013\/168391"},{"key":"55_CR6","doi-asserted-by":"crossref","unstructured":"\u2022 Martin Sanz E, Zschaeck C, Christiane ZL, Gonzalez M, Manuel GJ, Mato T, et al. Control of vertigo after intratympanic corticoid therapy for unilateral M\u00e9ni\u00e8re\u2019s disease: a comparison of weekly versus daily fixed protocols. Otol Neurotol. 2013;34(8):1429\u201333. This retrospective study reports no significant difference in vertigo control following a weekly intratympanic dexamethasone protocol compared to a daily protocol.","DOI":"10.1097\/MAO.0b013e31828d655f"},{"key":"55_CR7","doi-asserted-by":"crossref","unstructured":"\u2022 Martin-Sanz E, Luzardo CZ, Riesco LR, Patino TM, Sanz R. The use of electrocochleography to monitor the response of M\u00e9ni\u00e8re\u2019s disease patients to intratympanic steroids. Acta Otolaryngol. 2013;133(11):1158\u201364. This is the first prospective study evaluating the effects of intratympanic steroids (dexamethasone) with electrocochleography. The group also reports vertigo control rates using a weekly dosing regimen.","DOI":"10.3109\/00016489.2013.820344"},{"key":"55_CR8","doi-asserted-by":"crossref","unstructured":"\u2022 Gabra N, Saliba I. The effect of intratympanic methylprednisolone and gentamicin injection on M\u00e9ni\u00e8re\u2019s disease. Otolaryngol Head Neck Surg. 2013;148(4):642\u20137. This retrospective study compares vertigo control rates in patients receiving either intratympanic gentamicin or methylprednisolone. Significantly better vertigo control is achieved in the gentamicin group.","DOI":"10.1177\/0194599812472882"},{"key":"55_CR9","doi-asserted-by":"crossref","unstructured":"\u2022 Paradis J, Hu A, Parnes LS. Endolymphatic sac surgery versus intratympanic gentamicin for the treatment of intractable M\u00e9ni\u00e8re\u2019s disease: a retrospective review with survey. Otol Neurotol. 2013;34(8):1434\u20137. This retrospective study is the only recent report comparing results of surgical intervention with intratympanic gentamicin for control of vertigo.","DOI":"10.1097\/MAO.0b013e3182908b28"},{"key":"55_CR10","doi-asserted-by":"crossref","unstructured":"\u2022 Lambert PR, Nguyen S, Maxwell KS, Tucci DL, Lustig LR, Fletcher M, et al. A randomized, double-blind, placebo-controlled clinical study to assess safety and clinical activity of OTO-104 given as a single intratympanic injection in patients with unilateral M\u00e9ni\u00e8re\u2019s disease. Otol Neurotol. 2012;33(7):1257\u201365. This is the only randomized, double\u2010blind, placebo\u2010controlled clinical study reviewed. In addition, the study introduces the use of a novel, longer\u2010acting steroid preparation.","DOI":"10.1097\/MAO.0b013e318263d35d"},{"issue":"3","key":"55_CR11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70100-1","volume":"113","author":"E Monsell","year":"1995","unstructured":"Monsell E, Balkany T, Gates G. Committee on hearing and equilibrium guidelines for the diagnosis and evaluation of therapy in Meni\u00e8re\u2019s disease. Otolaryngol Head Neck Surg. 1995;113(3):181\u20135.","journal-title":"Otolaryngol Head Neck Surg."},{"key":"55_CR12","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/00016489109131486","volume":"481","author":"A Itoh","year":"1991","unstructured":"Itoh A, Sakata E. Treatment of vestibular disorders. Acta Otolaryngol Suppl. 1991;481:617\u201323.","journal-title":"Acta Otolaryngol Suppl."},{"issue":"5","key":"55_CR13","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/MOO.0b013e32830ce796","volume":"16","author":"M Hamid","year":"2008","unstructured":"Hamid M, Trune D. Issues, indications, and controversies regarding intratympanic steroid perfusion. Curr Opin Otolaryngol Head Neck Surg. 2008;16(5):434\u201340.","journal-title":"Curr Opin Otolaryngol Head Neck Surg."},{"key":"55_CR14","doi-asserted-by":"crossref","unstructured":"Parnes LS, Sun AH, Freeman DJ. Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope. 1999;109(7 Pt 2):1\u201317.","DOI":"10.1097\/00005537-199907001-00001"},{"issue":"1\u20132","key":"55_CR15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.heares.2006.09.011","volume":"226","author":"DR Trune","year":"2007","unstructured":"Trune DR, Kempton JB, Harrison AR, Wobig JL. Glucocorticoid impact on cochlear function and systemic side effects in autoimmune C3.MRL-Faslpr and normal C3H\/HeJ mice. Hear Res. 2007;226(1\u20132):209\u201317.","journal-title":"Hear Res."},{"issue":"6","key":"55_CR16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000241894","volume":"14","author":"A Hu","year":"2009","unstructured":"Hu A, Parnes LS. Intratympanic steroids for inner ear disorders: a review. Audiol Neurootol. 2009;14(6):373\u201382.","journal-title":"Audiol Neurootol."},{"issue":"2","key":"55_CR17","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.otohns.2005.05.010","volume":"133","author":"MA Gardu\u00f1o-Anaya","year":"2005","unstructured":"Gardu\u00f1o-Anaya MA, Couthino De Toledo H, Hinojosa-Gonz\u00e1lez R, Pane-Pianese C, R\u00edos-Casta\u00f1eda LC. Dexamethasone inner ear perfusion by intratympanic injection in unilateral M\u00e9ni\u00e8re\u2019s disease: a two-year prospective, placebo-controlled, double-blind, randomized trial. Otolaryngol Head Neck Surg. 2005;133(2):285\u201394.","journal-title":"Otolaryngol Head Neck Surg."},{"issue":"5","key":"55_CR18","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1067\/mhn.2001.119485","volume":"125","author":"L Sennaroglu","year":"2001","unstructured":"Sennaroglu L, Sennaroglu G, Gursel B, Dini FM. Intratympanic dexamethasone, intratympanic gentamicin, and endolymphatic sac surgery for intractable vertigo in Meniere\u2019s disease. Otolaryngol Head Neck Surg. 2001;125(5):537\u201343.","journal-title":"Otolaryngol Head Neck Surg."},{"key":"55_CR19","first-page":"CD008514","volume":"7","author":"J Phillips","year":"2011","unstructured":"Phillips J, Westerberg B. Intratympanic steroids for M\u00e9ni\u00e8re\u2019s disease or syndrome. Cochrane Database Syst Rev. 2011;7:CD008514.","journal-title":"Cochrane Database Syst Rev."},{"issue":"s132","key":"55_CR20","first-page":"1","volume":"47","author":"H Schuknecht","year":"1957","unstructured":"Schuknecht H. Ablation therapy in the management of M\u00e9ni\u00e8re\u2019s disease. Acta Otolaryngol Suppl. 1957;47(s132):1\u201342.","journal-title":"Acta Otolaryngol Suppl."},{"issue":"5","key":"55_CR21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF00463571","volume":"246","author":"G Lange","year":"1989","unstructured":"Lange G. Gentamicin and other ototoxic antibiotics for the transtympanic treatment of Meniere\u2019s disease. Arch Otorhinolaryngol. 1989;246(5):269\u201370.","journal-title":"Arch Otorhinolaryngol."},{"issue":"4","key":"55_CR22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s10162-007-0093-8","volume":"8","author":"S Lyford-Pike","year":"2007","unstructured":"Lyford-Pike S, Vogelheim C, Chu E, Della Santina CC, Carey JP. Gentamicin is primarily localized in vestibular type I hair cells after intratympanic administration. J Assoc Res Otolaryngol. 2007;8(4):497\u2013508.","journal-title":"J Assoc Res Otolaryngol."},{"key":"55_CR23","doi-asserted-by":"crossref","unstructured":"\u2022 Huon L, Fang T, Wang P. Outcomes of intratympanic gentamicin injection to treat Meniere\u2019s disease. Otol Neurotol. 2012;33(5):706\u201314. This meta\u2010analysis reviews vertigo control, tinnitus, aural fullness and hearing outcomes following intratympanic gentamicin therapy, with multiple dosing strategies included in the pooled data.","DOI":"10.1097\/MAO.0b013e318259b3b1"},{"issue":"4","key":"55_CR24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/MAO.0b013e3181dd13ac","volume":"31","author":"MJ Derebery","year":"2010","unstructured":"Derebery MJ, Fisher LM, Berliner K, Chung J, Green K. Outcomes of endolymphatic shunt surgery for M\u00e9ni\u00e8re\u2019s disease: comparison with intratympanic gentamicin on vertigo control and hearing loss. Otol Neurotol. 2010;31(4):649\u201355.","journal-title":"Otol Neurotol."},{"key":"55_CR25","doi-asserted-by":"crossref","unstructured":"\u2022 Casani AP, Piaggi P, Cerchiai N, Seccia V, Franceschini SS, Dallan I. Intratympanic treatment of intracts unilateral Meniere disease: gentamicin or dexamethasone? A randomized controlled trial. Otolaryngol Head Neck Surg. 2012;146(3):430\u20137. This randomized controlled trial compares results of intratympanic gentamicin with dexamethasone. Significantly higher vertigo control rates were obtained in the gentamicin group.","DOI":"10.1177\/0194599811429432"},{"issue":"4","key":"55_CR26","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/00129492-200407000-00023","volume":"25","author":"SH Chia","year":"2004","unstructured":"Chia SH, Gamst AC, Anderson JP, Harris JP. Intratympanic gentamicin therapy for M\u00e9ni\u00e8re\u2019s disease: a meta-analysis. Otol Neurotol. 2004;25(4):544\u201352.","journal-title":"Otol Neurotol."},{"issue":"11","key":"55_CR27","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1212\/01.WNL.0000036903.22461.39","volume":"59","author":"A Radtke","year":"2002","unstructured":"Radtke A, Lempert T, Gresty MA, Brookes GB, Bronstein AM, Neuhauser H. Migraine and Meniere\u2019s disease: is there a link? Neurology. 2002;59(11):1700\u20134.","journal-title":"Neurology."},{"key":"55_CR28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/019459988910000102","volume":"100","author":"H Silverstein","year":"1989","unstructured":"Silverstein H, Smouha E, Jones R. Natural history vs. surgery for Meniere's disease. Otolaryngol Head Neck Surg. 1989;100:6\u201316.","journal-title":"Otolaryngol Head Neck Surg."},{"issue":"4","key":"55_CR29","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/lary.20055","volume":"119","author":"KD Nguyen","year":"2009","unstructured":"Nguyen KD, Minor LB, Della Santina CC, Carey JP. Time course of repeated intratympanic gentamicin for M\u00e9ni\u00e8re\u2019s disease. Laryngoscope. 2009;119(4):792\u20138.","journal-title":"Laryngoscope."}],"container-title":["Current Otorhinolaryngology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40136-014-0055-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40136-014-0055-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40136-014-0055-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T00:56:41Z","timestamp":1649552201000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40136-014-0055-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,1]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["55"],"URL":"https:\/\/doi.org\/10.1007\/s40136-014-0055-8","relation":{},"ISSN":["2167-583X"],"issn-type":[{"value":"2167-583X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,1]]}}}