{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:20:33Z","timestamp":1791584433934,"version":"4.3.4"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","award":["484"],"award-info":[{"award-number":["484"]}],"id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["DARU J Pharm Sci"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s40199-020-00344-x","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T01:02:26Z","timestamp":1586480546000},"page":"305-317","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["A review of the hepatoprotective effects of hesperidin, a flavanon glycoside in citrus fruits, against natural and chemical toxicities"],"prefix":"10.1007","volume":"28","author":[{"given":"Jamshid","family":"Tabeshpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Hosseinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Hashemzaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Karimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"key":"344_CR1","doi-asserted-by":"publisher","unstructured":"Shirani K, Yousefsani BS, Shirani M, Karimi G. Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: a review. Phytother Res 2020:1\u201311. https:\/\/doi.org\/10.1002\/ptr.6641.","DOI":"10.1002\/ptr.6641"},{"issue":"3","key":"344_CR2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.31254\/phyto.2017.6308","volume":"6","author":"M Thompson","year":"2017","unstructured":"Thompson M, Jaiswal Y, Wang I, Williams L. Hepatotoxicity: treatment, causes and applications of medicinal plants as therapeutic agents. J Phytopharmacol. 2017;6(3):186\u201393.","journal-title":"J Phytopharmacol"},{"key":"344_CR3","first-page":"1330","volume":"4","author":"S Bhawna","year":"2009","unstructured":"Bhawna S, Kumar SU. Hepatoprotective activity of some indigenous plants. Int J Pharm Tech Res. 2009;4:1330\u20134.","journal-title":"Int J Pharm Tech Res"},{"issue":"7","key":"344_CR4","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0891-5849(95)02227-9","volume":"20","author":"CA Rice-Evans","year":"1996","unstructured":"Rice-Evans CA, Miller NJ, Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic Biol Med. 1996;20(7):933\u201356.","journal-title":"Free Radic Biol Med"},{"issue":"17","key":"344_CR5","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1080\/10408398.2016.1246413","volume":"57","author":"SD Hughes","year":"2017","unstructured":"Hughes SD, Ketheesan N, Haleagrahara N. The therapeutic potential of plant flavonoids on rheumatoid arthritis. Crit Rev Food Sci Nutr. 2017;57(17):3601\u201313.","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"1","key":"344_CR6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1080\/13880209.2016.1231695","volume":"55","author":"B Hemanth Kumar","year":"2017","unstructured":"Hemanth Kumar B, Dinesh Kumar B, Diwan PV. Hesperidin, a citrus flavonoid, protects against l-methionine-induced hyperhomocysteinemia by abrogation of oxidative stress, endothelial dysfunction and neurotoxicity in Wistar rats. Pharm Biol. 2017;55(1):146\u201355.","journal-title":"Pharm Biol"},{"issue":"6","key":"344_CR7","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1007\/s11064-015-1571-8","volume":"40","author":"O Ciftci","year":"2015","unstructured":"Ciftci O, Ozcan C, Kamisli O, Cetin A, Basak N, Aytac B. Hesperidin, a Citrus flavonoid, has the ameliorative effects against experimental autoimmune encephalomyelitis (EAE) in a C57BL\/J6 mouse model. Neurochem Res. 2015;40(6):1111\u201320.","journal-title":"Neurochem Res"},{"key":"344_CR8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.lfs.2014.12.030","volume":"124","author":"A Roohbakhsh","year":"2015","unstructured":"Roohbakhsh A, Parhiz H, Soltani F, Rezaee R, Iranshahi M. Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases. Life Sci. 2015;124:64\u201374.","journal-title":"Life Sci"},{"key":"344_CR9","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/B978-0-12-398456-2.00076-1","volume-title":"Polyphenols in human health and disease","author":"AA Zanwar","year":"2014","unstructured":"Zanwar AA, Badole SL, Shende PS, Hegde MV, Bodhankar SL. Chapter 76 - cardiovascular effects of hesperidin: a Flavanone glycoside. In: Watson RR, Preedy VR, Zibadi S, editors. Polyphenols in human health and disease. San Diego: Academic Press; 2014. p. 989\u201392."},{"key":"344_CR10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.yrtph.2019.04.001","volume":"105","author":"Y Li","year":"2019","unstructured":"Li Y, Kandhare AD, Mukherjee AA, Bodhankar SL. Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats. Regul Toxicol Pharmacol. 2019;105:77\u201385.","journal-title":"Regul Toxicol Pharmacol"},{"issue":"11","key":"344_CR11","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1002\/ptr.6168","volume":"32","author":"J Tabeshpour","year":"2018","unstructured":"Tabeshpour J, Mehri S, Shaebani Behbahani F, Hosseinzadeh H. Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: a comprehensive review. Phytother Res. 2018;32(11):2164\u201390.","journal-title":"Phytother Res"},{"issue":"1","key":"344_CR12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/biof.1458","volume":"45","author":"N Hedayati","year":"2018","unstructured":"Hedayati N, Naeini MB, Nezami A, Hosseinzadeh H, Wallace Hayes A, Hosseini S, et al. Protective effect of lycopene against chemical and natural toxins: a review. BioFactors. 2018;45(1):5\u201323.","journal-title":"BioFactors"},{"key":"344_CR13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2019.02.004","volume":"850","author":"M Iranshahy","year":"2019","unstructured":"Iranshahy M, Rezaee R, Karimi G. Hepatoprotective activity of metformin: a new mission for an old drug? Eur J Pharmacol. 2019;850:1\u20137.","journal-title":"Eur J Pharmacol"},{"key":"344_CR14","doi-asserted-by":"crossref","unstructured":"Fanoudi S, Alavi MS, Karimi G, Hosseinzadeh H. Milk thistle (Silybum Marianum) as an antidote or a protective agent against natural or chemical toxicities: a review. Drug Chem Toxicol 2018:1\u201315.","DOI":"10.1080\/01480545.2018.1485687"},{"issue":"1","key":"344_CR15","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1186\/1472-6882-14-392","volume":"14","author":"OR Ajuwon","year":"2014","unstructured":"Ajuwon OR, Oguntibeju OO, Marnewick JL. Amelioration of lipopolysaccharide-induced liver injury by aqueous rooibos (Aspalathus linearis) extract via inhibition of pro-inflammatory cytokines and oxidative stress. BMC Complement Altern Med. 2014;14(1):392.","journal-title":"BMC Complement Altern Med"},{"issue":"2\u20133","key":"344_CR16","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.tox.2006.06.018","volume":"226","author":"G Kaur","year":"2006","unstructured":"Kaur G, Tirkey N, Chopra K. Beneficial effect of hesperidin on lipopolysaccharide-induced hepatotoxicity. Toxicology. 2006;226(2\u20133):152\u201360.","journal-title":"Toxicology."},{"issue":"5","key":"344_CR17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1248\/bpb.27.679","volume":"27","author":"K Kawaguchi","year":"2004","unstructured":"Kawaguchi K, Kikuchi S, Hasunuma R, Maruyama H, Yoshikawa T, Kumazawa Y. A citrus flavonoid hesperidin suppresses infection-induced endotoxin shock in mice. Biol Pharm Bull. 2004;27(5):679\u201383.","journal-title":"Biol Pharm Bull"},{"issue":"3","key":"344_CR18","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/cmi.2015.104","volume":"13","author":"C Ju","year":"2016","unstructured":"Ju C, Tacke F. Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies. Cell Mol Immunol. 2016;13(3):316\u201327.","journal-title":"Cell Mol Immunol"},{"issue":"2","key":"344_CR19","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.intimp.2014.05.018","volume":"21","author":"G Li","year":"2014","unstructured":"Li G, Chen MJ, Wang C, Nie H, Huang WJ, Yuan TD, et al. Protective effects of hesperidin on concanavalin A-induced hepatic injury in mice. Int Immunopharmacol. 2014;21(2):406\u201311.","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"344_CR20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10646-014-1399-z","volume":"24","author":"Y Shi","year":"2015","unstructured":"Shi Y, Jiang J, Shan Z, Bu Y, Deng Z, Cheng Y. Oxidative stress and histopathological alterations in liver of Cyprinus carpio L. induced by intraperitoneal injection of microcystin-LR. Ecotoxicology. 2015;24(3):511\u20139.","journal-title":"Ecotoxicology."},{"issue":"4","key":"344_CR21","first-page":"354","volume":"6","author":"M Wahsha","year":"2010","unstructured":"Wahsha M, Al-Jassabi S, Sofian-Azirun M, Abdul-Aziz K. Biochemical screening of hesperidin and Naringin against liver damage in Balb\/c mice exposed to microcystin-LR. Middle-East J Sci Res. 2010;6(4):354\u20139.","journal-title":"Middle-East J Sci Res"},{"issue":"5","key":"344_CR22","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jhep.2014.06.007","volume":"61","author":"B Bakhautdin","year":"2014","unstructured":"Bakhautdin B, Das D, Mandal P, Roychowdhury S, Danner J, Bush K, et al. Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice. J Hepatol. 2014;61(5):1029\u201337.","journal-title":"J Hepatol"},{"issue":"1\u20134","key":"344_CR23","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.foodchem.2013.01.044","volume":"139","author":"HY Park","year":"2013","unstructured":"Park HY, Choi HD, Eom H, Choi I. Enzymatic modification enhances the protective activity of citrus flavonoids against alcohol-induced liver disease. Food Chem. 2013;139(1\u20134):231\u201340.","journal-title":"Food Chem"},{"issue":"3","key":"344_CR24","first-page":"1","volume":"2017","author":"Z Zhou","year":"2017","unstructured":"Zhou Z, Zhong W, Lin H, Huang P, Ma N, Zhang Y, et al. Hesperidin protects against acute alcoholic injury through improving lipid metabolism and cell damage in Zebrafish larvae. Evid Based Complement Alternat Med. 2017;2017(3):1\u20139.","journal-title":"Evid Based Complement Alternat Med"},{"key":"344_CR25","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.biopha.2017.03.013","volume":"89","author":"AEE El-Sisi","year":"2017","unstructured":"El-Sisi AEE, Sokar SS, Shebl AM, Mohamed DZ. Antifibrotic effect of diethylcarbamazine combined with hesperidin against ethanol induced liver fibrosis in rats. Biomed Pharmacother. 2017;89:1196\u2013206.","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"344_CR26","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3109\/07853899409148346","volume":"26","author":"CS Lieber","year":"1994","unstructured":"Lieber CS. Hepatic and metabolic effects of ethanol: pathogenesis and prevention. Ann Med. 1994;26(5):325\u201330.","journal-title":"Ann Med"},{"issue":"3","key":"344_CR27","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.toxlet.2008.11.018","volume":"184","author":"MH Yeh","year":"2009","unstructured":"Yeh MH, Kao ST, Hung CM, Liu CJ, Lee KH, Yeh CC. Hesperidin inhibited acetaldehyde-induced matrix metalloproteinase-9 gene expression in human hepatocellular carcinoma cells. Toxicol Lett. 2009;184(3):204\u201310.","journal-title":"Toxicol Lett"},{"issue":"12","key":"344_CR28","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1289\/ehp.1205432","volume":"120","author":"RM LoPachin","year":"2012","unstructured":"LoPachin RM, Gavin T. Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry. Environ Health Perspect. 2012;120(12):1650\u20137.","journal-title":"Environ Health Perspect"},{"issue":"8","key":"344_CR29","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.etp.2017.05.004","volume":"69","author":"SM Hamdy","year":"2017","unstructured":"Hamdy SM, Shabaan AM, Abdel Latif AKM, Abdel-Aziz AM, Amin AM. Protective effect of hesperidin and Tiger nut against acrylamide toxicity in female rats. Exp Toxicol Pathol. 2017;69(8):580\u20138.","journal-title":"Exp Toxicol Pathol"},{"issue":"2","key":"344_CR30","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.intimp.2014.01.019","volume":"19","author":"H Yu","year":"2014","unstructured":"Yu H, Zheng L, Yin L, Xu L, Qi Y, Han X, et al. Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation. Int Immunopharmacol. 2014;19(2):233\u201344.","journal-title":"Int Immunopharmacol"},{"issue":"4","key":"344_CR31","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/j.jff.2013.07.001","volume":"5","author":"S-Y Chen","year":"2013","unstructured":"Chen S-Y, Chyau C-C, Chu C-C, Chen Y-H, Chen T-H, Duh P-D. Hepatoprotection using sweet orange peel and its bioactive compound, hesperidin, for CCl4-induced liver injury in vivo. J Funct Foods. 2013;5(4):1591\u2013600.","journal-title":"J Funct Foods"},{"key":"344_CR32","first-page":"127","volume":"5","author":"A AbdulazizAhmeedahRabee","year":"2018","unstructured":"AbdulazizAhmeedahRabee A, Bennasir HA. Hesperidin an antioxidant flavonoid prevents carbon tetrachloride-induced hepatic toxicity in male albino rats. JIPBS. 2018;5:127\u201332.","journal-title":"JIPBS"},{"issue":"1\u20132","key":"344_CR33","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000366206","volume":"94","author":"JE Perez-Vargas","year":"2014","unstructured":"Perez-Vargas JE, Zarco N, Shibayama M, Segovia J, Tsutsumi V, Muriel P. Hesperidin prevents liver fibrosis in rats by decreasing the expression of nuclear factor-kappaB, transforming growth factor-beta and connective tissue growth factor. Pharmacology. 2014;94(1\u20132):80\u20139.","journal-title":"Pharmacology"},{"key":"344_CR34","unstructured":"Tirkey N, Pilkhwal S, Kuhad A, Chopra K. Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacol. 2005;5(1, article 2):1\u20138."},{"issue":"4","key":"344_CR35","first-page":"1191","volume":"31","author":"AA Hassan","year":"2018","unstructured":"Hassan AA, Thabet NM, Abdel-Rafei MK. Hyaluronan as a mediator for the hepatoprotective effect of Diosmin\/hesperidin complex. Pak J Pharm Sci. 2018;31(4):1191\u2013201.","journal-title":"Pak J Pharm Sci"},{"issue":"6","key":"344_CR36","first-page":"986","volume":"50","author":"AA Timoshin","year":"2005","unstructured":"Timoshin AA, Dorkina EG, Paukova EO, Vanin AF. Quercetin and hesperidin suppress the formation of nitric oxide radicals in rat liver and heart under acute hepatosis conditions. Biophysics. 2005;50(6):986\u20139.","journal-title":"Biophysics"},{"issue":"3","key":"344_CR37","doi-asserted-by":"crossref","first-page":"486","DOI":"10.5114\/aoms.2015.49484","volume":"12","author":"A Cetin","year":"2016","unstructured":"Cetin A, Ciftci O, Otlu A. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats. Arch Med Sci. 2016;12(3):486\u201393.","journal-title":"Arch Med Sci"},{"issue":"11","key":"344_CR38","first-page":"20328","volume":"8","author":"ABTAA Halim","year":"2017","unstructured":"Halim ABTAA, Nur NM, El-Agamy E-S, Ibrahim A. Protective effect of hesperidin (HDN) on carbon tetrachloride (CCl4)-induced hepatic toxicity in male albino rats. AIJCR. 2017;8(11):20328\u201338.","journal-title":"AIJCR"},{"key":"344_CR39","doi-asserted-by":"publisher","unstructured":"Abd-Elhakim YM, Ghoneim MH, Khairy MH, Eissa SA. Single or combined protective and therapeutic impact of taurine and hesperidin on carbon tetrachloride-induced acute hepatic injury in rat. Environ Sci Pollut Res Int. 2020. https:\/\/doi.org\/10.1007\/s11356-020-07895-1.","DOI":"10.1007\/s11356-020-07895-1"},{"issue":"7","key":"344_CR40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.22159\/ijpps.2017v9i7.17611","volume":"9","author":"AR Abdel-Sttar","year":"2017","unstructured":"Abdel-Sttar AR, Khalaf MM, Aboyoussef AM, Abosaif A. Ameliorative effect of hesperidin on carbon tetrachloride induced liver fibrosis in rats. Int J Pharm Pharm Sci. 2017;9(7):45\u201351.","journal-title":"Int J Pharm Pharm Sci"},{"key":"344_CR41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxlet.2017.04.008","volume":"274","author":"X Chen","year":"2017","unstructured":"Chen X, Ding HW, Li HD, Huang HM, Li XF, Yang Y, et al. Hesperetin derivative-14 alleviates inflammation by activating PPAR-gamma in mice with CCl4-induced acute liver injury and LPS-treated RAW264.7 cells. Toxicol Lett. 2017;274:51\u201363.","journal-title":"Toxicol Lett"},{"issue":"2\u20133","key":"344_CR42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.toxlet.2009.09.016","volume":"191","author":"DH Park","year":"2009","unstructured":"Park DH, Shin JW, Park SK, Seo JN, Li L, Jang JJ, et al. Diethylnitrosamine (DEN) induces irreversible hepatocellular carcinogenesis through overexpression of G1\/S-phase regulatory proteins in rat. Toxicol Lett. 2009;191(2\u20133):321\u20136.","journal-title":"Toxicol Lett"},{"key":"344_CR43","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cbi.2017.09.015","volume":"277","author":"AM Mahmoud","year":"2017","unstructured":"Mahmoud AM, Mohammed HM, Khadrawy SM, Galaly SR. Hesperidin protects against chemically induced hepatocarcinogenesis via modulation of Nrf2\/ARE\/HO-1, PPARgamma and TGF-beta1\/Smad3 signaling, and amelioration of oxidative stress and inflammation. Chem Biol Interact. 2017;277:146\u201358.","journal-title":"Chem Biol Interact"},{"issue":"6","key":"344_CR44","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/mc.22621","volume":"56","author":"Z Fernandez-Bedmar","year":"2017","unstructured":"Fernandez-Bedmar Z, Anter J, Alonso-Moraga A. Martin de Las Mulas J, Millan-Ruiz Y, Guil-Luna S. Demethylating and anti-hepatocarcinogenic potential of hesperidin, a natural polyphenol of Citrus juices. Mol Carcinog. 2017;56(6):1653\u201362.","journal-title":"Mol Carcinog"},{"issue":"2\u20133","key":"344_CR45","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-483X(00)00352-8","volume":"156","author":"J George","year":"2001","unstructured":"George J, Rao KR, Stern R, Chandrakasan G. Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen. Toxicology. 2001;156(2\u20133):129\u201338.","journal-title":"Toxicology."},{"issue":"6","key":"344_CR46","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00210-014-0968-2","volume":"387","author":"SM Elshazly","year":"2014","unstructured":"Elshazly SM, Mahmoud AA. Antifibrotic activity of hesperidin against dimethylnitrosamine-induced liver fibrosis in rats. Naunyn Schmiedeberg's Arch Pharmacol. 2014;387(6):559\u201367.","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"issue":"5","key":"344_CR47","doi-asserted-by":"crossref","first-page":"8863","DOI":"10.3390\/ijms15058863","volume":"15","author":"D-S Lee","year":"2014","unstructured":"Lee D-S, Kim K-S, Ko W, Li B, Jeong G-S, Jang J-H, et al. The Cytoprotective effect of Sulfuretin against tert-butyl Hydroperoxide-induced hepatotoxicity through Nrf2\/ARE and JNK\/ERK MAPK-mediated Heme Oxygenase-1 expression. Int J Mol Sci. 2014;15(5):8863\u201377.","journal-title":"Int J Mol Sci"},{"issue":"10","key":"344_CR48","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1016\/j.fct.2010.07.037","volume":"48","author":"M Chen","year":"2010","unstructured":"Chen M, Gu H, Ye Y, Lin B, Sun L, Deng W, et al. Protective effects of hesperidin against oxidative stress of tert-butyl hydroperoxide in human hepatocytes. Food Chem Toxicol. 2010;48(10):2980\u20137.","journal-title":"Food Chem Toxicol"},{"key":"344_CR49","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.fct.2018.07.024","volume":"120","author":"M Iranshahy","year":"2018","unstructured":"Iranshahy M, Iranshahi M, Abtahi SR, Karimi G. The role of nuclear factor erythroid 2-related factor 2 in hepatoprotective activity of natural products: a review. Food Chem Toxicol. 2018;120:261\u201376.","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"344_CR50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0300-483X(95)03199-P","volume":"107","author":"AC Reddy","year":"1996","unstructured":"Reddy AC, Lokesh BR. Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicology. 1996;107(1):39\u201345.","journal-title":"Toxicology."},{"key":"344_CR51","doi-asserted-by":"crossref","unstructured":"Centeno JA, Mullick FG, Ishak KG, Franks TJ, Burke AP, Koss MN et al. Environmental pathology. In: Selinus O, editor. Essentials of medical geology: Revised Edition. Dordrecht: Springer Netherlands; 2013. p. 569\u201396.","DOI":"10.1007\/978-94-007-4375-5_25"},{"key":"344_CR52","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.toxrep.2014.11.003","volume":"2","author":"L Pari","year":"2015","unstructured":"Pari L, Karthikeyan A, Karthika P, Rathinam A. Protective effects of hesperidin on oxidative stress, dyslipidaemia and histological changes in iron-induced hepatic and renal toxicity in rats. Toxicol Rep. 2015;2:46\u201355.","journal-title":"Toxicol Rep"},{"issue":"6","key":"344_CR53","doi-asserted-by":"crossref","first-page":"68","DOI":"10.22270\/jddt.v2i6.323","volume":"2","author":"M Ekambaram","year":"2012","unstructured":"Ekambaram M, Arul Ramalingam K, Balasubramanian A. Effect of solanum trilobatum Linn on mercury-induced hepatotoxicity in Swiss albino mice. JDDT. 2012;2(6):68\u201370.","journal-title":"JDDT"},{"issue":"1","key":"344_CR54","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.biomag.2013.10.002","volume":"4","author":"E Bharathi","year":"2014","unstructured":"Bharathi E, Jagadeesan G, Vijayakumar M. Hepato-ameliorative effect of hesperidin and ellagic acid on mercuric chloride intoxicated rats. Biomed Aging Pathol. 2014;4(1):17\u201321.","journal-title":"Biomed Aging Pathol"},{"issue":"1","key":"344_CR55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/49.1.5","volume":"49","author":"PL Goering","year":"1999","unstructured":"Goering PL, Aposhian HV, Mass MJ, Cebrian M, Beck BD, Waalkes MP. The enigma of arsenic carcinogenesis: role of metabolism. Toxicol Sci. 1999;49(1):5\u201314.","journal-title":"Toxicol Sci"},{"issue":"5","key":"344_CR56","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1080\/01926230490502566","volume":"32","author":"RN das Neves","year":"2004","unstructured":"das Neves RN, Carvalho F, Carvalho M, Fernandes E, Soares E, de Bastos ML, et al. Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice. Toxicol Pathol. 2004;32(5):527\u201335.","journal-title":"Toxicol Pathol"},{"key":"344_CR57","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s12011-018-1443-6","volume":"189","author":"E Turk","year":"2018","unstructured":"Turk E, Kandemir FM, Yildirim S, Caglayan C, Kucukler S, Kuzu M. Protective effect of hesperidin on sodium Arsenite-induced nephrotoxicity and hepatotoxicity in rats. Biol Trace Elem Res. 2018;189:95\u2013108.","journal-title":"Biol Trace Elem Res"},{"issue":"12","key":"344_CR58","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1177\/0960327116629530","volume":"35","author":"AK Srivastav","year":"2016","unstructured":"Srivastav AK, Kumar M, Ansari NG, Jain AK, Shankar J, Arjaria N, et al. A comprehensive toxicity study of zinc oxide nanoparticles versus their bulk in Wistar rats: toxicity study of zinc oxide nanoparticles. Hum Exp Toxicol. 2016;35(12):1286\u2013304.","journal-title":"Hum Exp Toxicol"},{"issue":"6","key":"344_CR59","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1517\/17425240902939143","volume":"6","author":"E Barbu","year":"2009","unstructured":"Barbu E, Molnar E, Tsibouklis J, Gorecki DC. The potential for nanoparticle-based drug delivery to the brain: overcoming the blood-brain barrier. Expert Opin Drug Deliv. 2009;6(6):553\u201365.","journal-title":"Expert Opin Drug Deliv"},{"issue":"1","key":"344_CR60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40360-018-0256-8","volume":"19","author":"S Ansar","year":"2018","unstructured":"Ansar S, Abudawood M, Alaraj ASA, Hamed SS. Hesperidin alleviates zinc oxide nanoparticle induced hepatotoxicity and oxidative stress. BMC Pharmacol Toxicol. 2018;19(1):1\u20136.","journal-title":"BMC Pharmacol Toxicol"},{"key":"344_CR61","doi-asserted-by":"crossref","unstructured":"Omar HA, Mohamed WR, Arafa el SA, Shehata BA, El Sherbiny GA, Arab HH et al. Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity. Pharmacol Rep 2016;68(2):349\u2013356.","DOI":"10.1016\/j.pharep.2015.09.007"},{"issue":"2","key":"344_CR62","first-page":"9","volume":"6","author":"K Kaltalioglu","year":"2019","unstructured":"Kaltalioglu K, Balabanli B, Coskun-Cevher S. Alleviation of Cisplatin-induced hepatotoxic damage: the synergistic effect of Morin and hesperidin against oxidative stress. Res J Pharmacogn. 2019;6(2):9\u201318.","journal-title":"Res J Pharmacogn"},{"issue":"11","key":"344_CR63","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1002\/cncr.22662","volume":"109","author":"TD Shanafelt","year":"2007","unstructured":"Shanafelt TD, Lin T, Geyer SM, Zent CS, Leung N, Kabat B, et al. Pentostatin, cyclophosphamide, and rituximab regimen in older patients with chronic lymphocytic leukemia. Cancer. 2007;109(11):2291\u20138.","journal-title":"Cancer."},{"issue":"1","key":"344_CR64","first-page":"9","volume":"1","author":"AM Mahmoud","year":"2013","unstructured":"Mahmoud AM, Hussein OE, Ramadan SA. Amelioration of cyclophosphamide-induced hepatotoxicity by the brown seaweed Turbenaria ornata. Int J Clin Toxicol. 2013;1(1):9\u201317.","journal-title":"Int J Clin Toxicol"},{"issue":"9","key":"344_CR65","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1139\/cjpp-2014-0204","volume":"92","author":"AM Mahmoud","year":"2014","unstructured":"Mahmoud AM. Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARgamma and abrogation of oxidative stress and inflammation. Can J Physiol Pharmacol. 2014;92(9):717\u201324.","journal-title":"Can J Physiol Pharmacol"},{"key":"344_CR66","first-page":"385","volume":"3","author":"F Cainelli","year":"2009","unstructured":"Cainelli F, Vallone A. Safety and efficacy of pegylated liposomal doxorubicin in HIV-associated Kaposi's sarcoma. Biologics. 2009;3:385\u201390.","journal-title":"Biologics."},{"issue":"1","key":"344_CR67","first-page":"11","volume":"2","author":"WG Hozayen","year":"2014","unstructured":"Hozayen WG, Seif HSA, Amin S. Protective effects of Ruitn and \/ or hesperidin against doxorubicin-induced hepatotoxicity. Int J Clin Nutr. 2014;2(1):11\u20137.","journal-title":"Int J Clin Nutr"},{"key":"344_CR68","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.biopha.2018.10.192","volume":"109","author":"E Dokumacioglu","year":"2019","unstructured":"Dokumacioglu E, Iskender H, Musmul A. Effect of hesperidin treatment on alpha-Klotho\/FGF-23 pathway in rats with experimentally-induced diabetes. Biomed Pharmacother. 2019;109:1206\u201310.","journal-title":"Biomed Pharmacother"},{"key":"344_CR69","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.biopha.2017.03.102","volume":"90","author":"H Iskender","year":"2017","unstructured":"Iskender H, Dokumacioglu E, Sen TM, Ince I, Kanbay Y, Saral S. The effect of hesperidin and quercetin on oxidative stress, NF-kappaB and SIRT1 levels in a STZ-induced experimental diabetes model. Biomed Pharmacother. 2017;90:500\u20138.","journal-title":"Biomed Pharmacother"},{"key":"344_CR70","first-page":"55","volume":"1","author":"M Ilankeswaran","year":"2011","unstructured":"Ilankeswaran M, Senthil Kumar G, Rajadurai M, Stephan R. Hepatoprotective effect of hesperidin on normal and streptozotocin-induced diabetic rats: biochemical and histological evidences. Int J Environ Sci Ecotechnol. 2011;1:55\u201366.","journal-title":"Int J Environ Sci Ecotechnol"},{"issue":"4","key":"344_CR71","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2174\/1567202612666150812150249","volume":"12","author":"MS Parmar","year":"2015","unstructured":"Parmar MS, Syed I, Gray JP, Ray SD. Curcumin, hesperidin, and Rutin selectively interfere with apoptosis signaling and attenuate Streptozotocin-induced oxidative stress-mediated hyperglycemia. Curr Neurovasc Res. 2015;12(4):363\u201374.","journal-title":"Curr Neurovasc Res"},{"issue":"2","key":"344_CR72","first-page":"131","volume":"4","author":"E Yoon","year":"2016","unstructured":"Yoon E, Babar A, Choudhary M, Kutner M, Pyrsopoulos N. Acetaminophen-induced hepatotoxicity: a comprehensive update. JCTH. 2016;4(2):131\u201342.","journal-title":"JCTH."},{"issue":"2","key":"344_CR73","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.toxlet.2011.10.023","volume":"208","author":"ST Ahmad","year":"2012","unstructured":"Ahmad ST, Arjumand W, Nafees S, Seth A, Ali N, Rashid S, et al. Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation. Toxicol Lett. 2012;208(2):149\u201361.","journal-title":"Toxicol Lett"},{"issue":"14","key":"344_CR74","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.11569\/wcjd.v21.i14.1278","volume":"21","author":"XJ Chen","year":"2013","unstructured":"Chen XJ, Wang C, Shu KG, Lei J, Nie H, Zhang YX, et al. Effect of hesperidin pretreatment on the expression of apoptosis-related genes in the liver of mice with acetaminophen-induced acute liver injury. World Chin J Digestol. 2013;21(14):1278\u201385.","journal-title":"World Chin J Digestol"},{"issue":"5","key":"344_CR75","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.etp.2010.10.012","volume":"64","author":"P Selvaraj","year":"2012","unstructured":"Selvaraj P, Pugalendi KV. Efficacy of hesperidin on plasma, heart and liver tissue lipids in rats subjected to isoproterenol-induced cardiotoxicity. Exp Toxicol Pathol. 2012;64(5):449\u201352.","journal-title":"Exp Toxicol Pathol"},{"issue":"4","key":"344_CR76","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/15376510600970430","volume":"17","author":"A Balakrishnan","year":"2007","unstructured":"Balakrishnan A, Menon VP. Effect of hesperidin on nicotine toxicity and histopathological studies. Toxicol Mech Methods. 2007;17(4):233\u20139.","journal-title":"Toxicol Mech Methods"},{"issue":"2","key":"344_CR77","first-page":"194","volume":"45","author":"A Balakrishnan","year":"2007","unstructured":"Balakrishnan A, Menon VP. Protective effect of hesperidin on nicotine induced toxicity in rats. Indian J Exp Biol. 2007;45(2):194\u2013202.","journal-title":"Indian J Exp Biol"},{"issue":"10","key":"344_CR78","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.rmed.2006.01.014","volume":"100","author":"BE Gulbay","year":"2006","unstructured":"Gulbay BE, Gurkan OU, Yildiz OA, Onen ZP, Erkekol FO, Baccioglu A, et al. Side effects due to primary antituberculosis drugs during the initial phase of therapy in 1149 hospitalized patients for tuberculosis. Respir Med. 2006;100(10):1834\u201342.","journal-title":"Respir Med"},{"issue":"7","key":"344_CR79","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1002\/jbt.21799","volume":"30","author":"G Zhang","year":"2016","unstructured":"Zhang G, Zhu J, Zhou Y, Wei Y, Xi L, Qin H, et al. Hesperidin alleviates oxidative stress and Upregulates the multidrug resistance protein 2 in isoniazid and rifampicin-induced liver injury in rats. J Biochem Mol Toxicol. 2016;30(7):342\u20139.","journal-title":"J Biochem Mol Toxicol"},{"key":"344_CR80","first-page":"439","volume":"7","author":"S Nathiya","year":"2016","unstructured":"Nathiya S, Rajaram S, Abraham P. Hesperidin alleviates antitubercular drug induced oxidative stress, inflammation and apoptosis in rat liver. Int J Biomed Res. 2016;7:439\u201346.","journal-title":"Int J Biomed Res"},{"key":"344_CR81","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jchromb.2014.08.011","volume":"969","author":"T Huo","year":"2014","unstructured":"Huo T, Chen X, Lu X, Qu L, Liu Y, Cai S. An effective assessment of valproate sodium-induced hepatotoxicity with UPLC\u2013MS and 1HNMR-based metabonomics approach. J Chromatogr B. 2014;969:109\u201316.","journal-title":"J Chromatogr B"},{"issue":"2","key":"344_CR82","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bionut.2014.01.005","volume":"4","author":"M Suresh","year":"2014","unstructured":"Suresh M, Kishore Kumar SN, Ashok Kumar S, Thulasi Raman K, Uma M, Kalaiselvi P. Hesperidin safeguards hepatocytes from valproate-induced liver dysfunction in Sprague-Dawley rats. Biomed Prev Nutr. 2014;4(2):209\u201317.","journal-title":"Biomed Prev Nutr"},{"issue":"4","key":"344_CR83","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jbt.20030","volume":"18","author":"EA Hassoun","year":"2004","unstructured":"Hassoun EA, Vodhanel J, Abushaban A. The modulatory effects of ellagic acid and vitamin E succinate on TCDD-induced oxidative stress in different brain regions of rats after subchronic exposure. J Biochem Mol Toxicol. 2004;18(4):196\u2013203.","journal-title":"J Biochem Mol Toxicol"},{"issue":"2","key":"344_CR84","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1684\/ecn.2013.0337","volume":"24","author":"R Bentli","year":"2013","unstructured":"Bentli R, Ciftci O, Cetin A, Unlu M, Basak N, Cay M. Oral administration of hesperidin, a citrus flavonone, in rats counteracts the oxidative stress, the inflammatory cytokine production, and the hepatotoxicity induced by the ingestion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Eur Cytokine Netw. 2013;24(2):91\u20136.","journal-title":"Eur Cytokine Netw"},{"issue":"3","key":"344_CR85","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.etap.2013.07.009","volume":"36","author":"MD Costa","year":"2013","unstructured":"Costa MD, de Freitas ML, Dalmolin L, Oliveira LP, Fleck MA, Pagliarini P, et al. Diphenyl diselenide prevents hepatic alterations induced by paraquat in rats. Environ Toxicol Pharmacol. 2013;36(3):750\u20138.","journal-title":"Environ Toxicol Pharmacol"},{"issue":"2","key":"344_CR86","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.intimp.2015.09.003","volume":"29","author":"Q Shi","year":"2015","unstructured":"Shi Q, Song X, Fu J, Su C, Xia X, Song E, et al. Artificial sweetener neohesperidin dihydrochalcone showed antioxidative, anti-inflammatory and anti-apoptosis effects against paraquat-induced liver injury in mice. Int Immunopharmacol. 2015;29(2):722\u20139.","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"344_CR87","doi-asserted-by":"crossref","first-page":"3330","DOI":"10.1021\/jf904549s","volume":"58","author":"MC Chen","year":"2010","unstructured":"Chen MC, Ye YY, Ji G, Liu JW. Hesperidin upregulates heme oxygenase-1 to attenuate hydrogen peroxide-induced cell damage in hepatic L02 cells. J Agric Food Chem. 2010;58(6):3330\u20135.","journal-title":"J Agric Food Chem"},{"key":"344_CR88","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.lfs.2017.07.026","volume":"185","author":"RA Zaghloul","year":"2017","unstructured":"Zaghloul RA, Elsherbiny NM, Kenawy HI, El-Karef A, Eissa LA, El-Shishtawy MM. Hepatoprotective effect of hesperidin in hepatocellular carcinoma: involvement of Wnt signaling pathways. Life Sci. 2017;185:114\u201325.","journal-title":"Life Sci"},{"issue":"2\u20133","key":"344_CR89","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejphar.2011.02.031","volume":"658","author":"KB Kalpana","year":"2011","unstructured":"Kalpana KB, Devipriya N, Srinivasan M, Vishwanathan P, Thayalan K, Menon VP. Evaluating the radioprotective effect of hesperidin in the liver of Swiss albino mice. Eur J Pharmacol. 2011;658(2\u20133):206\u201312.","journal-title":"Eur J Pharmacol"},{"issue":"1\u20133","key":"344_CR90","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejphar.2008.03.052","volume":"587","author":"K Pradeep","year":"2008","unstructured":"Pradeep K, Park SH, Ko KC. Hesperidin a flavanoglycone protects against gamma-irradiation induced hepatocellular damage and oxidative stress in Sprague-Dawley rats. Eur J Pharmacol. 2008;587(1\u20133):273\u201380.","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"344_CR91","first-page":"165","volume":"1","author":"S Park","year":"2010","unstructured":"Park S, Pradeep K, Choi M, Ko K, Park H. Hesperidin and curdlan treatment ameliorates \u03b3-radiation induced cellular damage and oxidative stress in the liver of Sprague-Dawley rats. Res J Pharm, Biol Chem Sci. 2010;1(3):165\u201377.","journal-title":"Res J Pharm, Biol Chem Sci"}],"container-title":["DARU Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40199-020-00344-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40199-020-00344-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40199-020-00344-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T15:57:13Z","timestamp":1696003033000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40199-020-00344-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,10]]},"references-count":91,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["344"],"URL":"https:\/\/doi.org\/10.1007\/s40199-020-00344-x","relation":{},"ISSN":["2008-2231"],"issn-type":[{"value":"2008-2231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,10]]},"assertion":[{"value":"10 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No potential conflict of interest was reported by the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}