{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:35:55Z","timestamp":1788838555840,"version":"build-2803163510"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","award":["CVZ_APQ-03548-16"],"award-info":[{"award-number":["CVZ_APQ-03548-16"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["405822\/2016-2"],"award-info":[{"award-number":["405822\/2016-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["DARU J Pharm Sci"],"DOI":"10.1007\/s40199-020-00383-4","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T19:03:01Z","timestamp":1611082981000},"page":"61-71","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of the potential environmental risk from the destination of medicines: an epidemiological and toxicological study"],"prefix":"10.1007","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-8160","authenticated-orcid":false,"given":"Mariana A. R.","family":"Salgado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-4743","authenticated-orcid":false,"given":"Mariana R.","family":"Salvador","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-0415","authenticated-orcid":false,"given":"Andr\u00e9 O.","family":"Baldoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1779-5036","authenticated-orcid":false,"given":"Ralph G.","family":"Thom\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-8522","authenticated-orcid":false,"given":"H\u00e9lio Batista","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"383_CR1","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1016\/j.chemosphere.2018.06.046","volume":"209","author":"JCV Sposito","year":"2018","unstructured":"Sposito JCV, Montagner CC, Casado M, Navarro-Mart\u00edn L, Jut SJC, Pi\u00f1a B, et al. Emerging contaminants in Brazilian rivers: occurrence and effects on gene expression in zebrafish (Danio rerio) embryos. Chemosphere. 2018;209:696\u2013704.","journal-title":"Chemosphere"},{"key":"383_CR2","first-page":"132","volume":"41","author":"AS Silva","year":"2017","unstructured":"Silva AS, Maciel GA, Wanderley LSL, Wanderley AG. Drug use indicators in primary health care: a systematic review. Rev Panam Salud Publica. 2017;41:132\u201343.","journal-title":"Rev Panam Salud Publica"},{"key":"383_CR3","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.envint.2019.01.011","volume":"124","author":"M Bilal","year":"2019","unstructured":"Bilal M, Adeel M, Rasheed T, Zhao Y, Iqbal HMN. Emerging contaminants of high concern and their enzyme-assisted biodegradation \u2013 a review. Environ Int. 2019;124:336\u201353.","journal-title":"Environ Int"},{"key":"383_CR4","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.envint.2018.11.038","volume":"122","author":"T Rasheed","year":"2019","unstructured":"Rasheed T, Bilal M, Nabeel F, Adeel M, Iqbal HMN. Environmentally-related contaminants of high concern: potential sources and analytical modalities for detection, quantification, and treatment. Environ Int. 2019;122:52\u201366.","journal-title":"Environ Int"},{"key":"383_CR5","doi-asserted-by":"crossref","unstructured":"Lofrano G, Libralato G, Meric S, Vaiano V, Sacco O, Venditto V, Guida M, Carotenuto M. Occurrence and potential risks of emerging contaminants in water. In Visible light active structured photocatalysts for the removal of emerging contaminants. Elsevier; 2020. pp. 1\u201325.","DOI":"10.1016\/B978-0-12-818334-2.00001-8"},{"issue":"4","key":"383_CR6","doi-asserted-by":"publisher","first-page":"825","DOI":"10.2166\/wst.2011.120","volume":"63","author":"NGFM van der Aa","year":"2011","unstructured":"van der Aa NGFM, Kommer GJ, van Montfoort JE, Versteegh JFM. Demographic projections of future pharmaceutical consumption in the Netherlands. Water Sci Technol. 2011;63(4):825\u201331.","journal-title":"Water Sci Technol"},{"issue":"2","key":"383_CR7","first-page":"203","volume":"30","author":"CS Bueno","year":"2009","unstructured":"Bueno CS, Weber D, Oliveira KR. Home pharmacy and drug disposal in the Luiz Fogliatto neighborhood from municipality of Iju\u00ed - RS. J Appl Basic Pharm Sci. 2009;30(2):203\u201310.","journal-title":"J Appl Basic Pharm Sci"},{"issue":"6","key":"383_CR8","first-page":"1857","volume":"2","author":"MS Rodrigues","year":"2018","unstructured":"Rodrigues MS, M\u00f4nica F, Freitas MD, Dalb\u00f3 S. Dispose of household medicines and its environmental impact: analysis of a community understanding. Braz Appl Sci Rev. 2018;2(6):1857\u201368.","journal-title":"Braz Appl Sci Rev"},{"issue":"3","key":"383_CR9","first-page":"34","volume":"4","author":"LSV Alvarenga","year":"2010","unstructured":"Alvarenga LSV, Nicoletti MA. Domestic discarding of medicines and some considerations about the current environment impact. Rev Saude Publica. 2010;4(3):34\u20139.","journal-title":"Rev Saude Publica"},{"issue":"4","key":"383_CR10","first-page":"17","volume":"4","author":"KV Vaz","year":"2011","unstructured":"Vaz KV, Freitas MM, Cirqueira JZ. Investigation about ways of discarding expired medicines. Cenarium Pharmaceutico. 2011;4(4):17\u201320.","journal-title":"Cenarium Pharmaceutico"},{"issue":"3","key":"383_CR11","first-page":"117","volume":"12","author":"D Schwingel","year":"2015","unstructured":"Schwingel D, De Souza J, Simonetti E, Rigo MPM, Ely LS, De Castro LC, et al. Home pharmacy versus rational medicine use. Rev Caderno Pedagogico. 2015;12(3):117\u201330.","journal-title":"Rev Caderno Pedagogico"},{"key":"383_CR12","unstructured":"Ueda J, Tavernaro R, Marostega V, Pavan W. Environmental impact of drugs disposal and study of population awareness about the problem. Rev Bras Cienc Amb. 2009;5(9)."},{"key":"383_CR13","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.scitotenv.2019.03.334","volume":"671","author":"GR Quadra","year":"2019","unstructured":"Quadra GR, Silva PSA, Parana\u00edba JR, Josu\u00e9 IIP, Souza H, Costa R, et al. Investigation of medicines consumption and disposal in Brazil: a study case in a developing country. Sci Total Environ. 2019;671:505\u20139.","journal-title":"Sci Total Environ"},{"issue":"1","key":"383_CR14","first-page":"5","volume":"16","author":"EH Lenhardt","year":"2014","unstructured":"Lenhardt EH, S\u00f3lis LJB, Cintra EVCS, Botelho EHLO. Drug disposal at Grande Terceiro neighborhood, Cuiab\u00e1-MT. UNOPAR Cient Cienc Biol Saude. 2014;16(1):5\u20138.","journal-title":"UNOPAR Cient Cienc Biol Saude"},{"issue":"1","key":"383_CR15","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.fsi.2014.07.009","volume":"40","author":"JLC Ribas","year":"2014","unstructured":"Ribas JLC, Silva CA, Andrade L, Galvan GL, Cestari MM, Trindade ES, et al. Effects of anti-inflammatory drugs in primary kidney cell culture of a freshwater fish. Fish Shellfish Immunol. 2014;40(1):296\u2013303.","journal-title":"Fish Shellfish Immunol."},{"issue":"1","key":"383_CR16","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1590\/S0100-40422014000100023","volume":"37","author":"VJ Gaffney","year":"2014","unstructured":"Gaffney VJ, Cardoso VV, Rodrigues A, Ferreira E, Benoliel MJ, Almeida CMM. Analysis of pharmaceutical compounds in water by SPE-UPLC-ESI-MS\/MS. Quim Nova. 2014;37(1):138\u201349.","journal-title":"Quim Nova"},{"issue":"1\u20133","key":"383_CR17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jhazmat.2009.10.100","volume":"175","author":"LH Santos","year":"2010","unstructured":"Santos LH, Araujo AN, Fachini A, Pena A, Delerue-Matos C, Montenegro MC. Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater. 2010;175(1\u20133):45\u201395.","journal-title":"J Hazard Mater"},{"issue":"6","key":"383_CR18","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1016\/j.ecolind.2010.03.018","volume":"10","author":"V Hermoso","year":"2010","unstructured":"Hermoso V, Clavero M, Blanco-Garrido F, Prenda J. Assessing the ecological status in species-poor systems: a fish-based index for Mediterranean Rivers (Guadiana River, SW Spain). Ecol Indic. 2010;10(6):1152\u201361.","journal-title":"Ecol Indic"},{"key":"383_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.fsi.2017.07.001","volume":"68","author":"CF Sales","year":"2017","unstructured":"Sales CF, Santos KPE, Rizzo E, Ribeiro RIMA, Santos HB, Thom\u00e9 RG. Proliferation, survival and cell death in fish gills remodeling: from injury to recovery. Fish Shellfish Immunol. 2017;68:10\u20138.","journal-title":"Fish Shellfish Immunol"},{"issue":"5","key":"383_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22289","volume":"33","author":"Q Shi","year":"2019","unstructured":"Shi Q, Zhuang Y, Hu T, Lu C, Wang X, Huang H, et al. Developmental toxicity of triclocarban in zebrafish (Danio rerio) embryos. J Biochem Mol Toxicol. 2019;33(5):e22289.","journal-title":"J Biochem Mol Toxicol"},{"key":"383_CR21","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.ecoenv.2019.01.041","volume":"171","author":"TB Gomes","year":"2019","unstructured":"Gomes TB, Fernandes S, Junior S, Saint\u2019pierre TD, Correia FV, Hauser-Davis RA, et al. Sublethal psychotropic pharmaceutical effects on the model organism Danio rerio: oxidative stress and metal dishomeostasis. Ecotoxicol Environ Saf. 2019;171:781\u20139.","journal-title":"Ecotoxicol Environ Saf"},{"key":"383_CR22","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.envpol.2018.02.011","volume":"237","author":"LBD De Lima","year":"2018","unstructured":"De Lima LBD, de Morais PB, de Andrade RLT, Mattos LV, Moron SE. Use of biomarkers to evaluate the ecological risk of xenobiotics associated with agriculture. Environ Pollut. 2018;237:611\u201324.","journal-title":"Environ Pollut"},{"key":"383_CR23","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1590\/S1413-81232013000600024","volume":"18","author":"R Guimar\u00e3es","year":"2013","unstructured":"Guimar\u00e3es R. Translational research: an interpretation. Cien Saude Coletiva. 2013;18:1731\u201344.","journal-title":"Cien Saude Coletiva"},{"key":"383_CR24","doi-asserted-by":"publisher","first-page":"eAO5066","DOI":"10.31744\/einstein_journal\/2020AO5066","volume":"18","author":"MR Fernandes","year":"2020","unstructured":"Fernandes MR, Figueiredo RC, Silva LGR, Rocha RS, Baldoni AO. Storage and disposal of expired medicines in home pharmacies: emerging public health problems. Einstein (S\u00e3o Paulo). 2020;18:eAO5066.","journal-title":"Einstein (S\u00e3o Paulo)"},{"key":"383_CR25","unstructured":"Population of Divinopolis City from IBGE 2019. https:\/\/cidades.ibge.gov.br\/brasil\/mg\/divinopolis\/panorama. Accessed 18 Aug 2020."},{"issue":"1\u20132","key":"383_CR26","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/biomet\/35.1-2.191","volume":"35","author":"DJ Finney","year":"1948","unstructured":"Finney DJ, Stevens WL. A table for the calculation of working probits and weights in probit analysis. Biometrika. 1948;35(1\u20132):191\u2013201.","journal-title":"Biometrika."},{"issue":"2","key":"383_CR27","first-page":"179","volume":"32","author":"C Chakraborty","year":"2011","unstructured":"Chakraborty C, Hsu CH, Wen ZH, Lin CS, Agoramoorthy G. Effect of caffeine, norfloxacin and nimesulide on heartbeat and VEGF expression of Zebrafish larvae. J Environ Biol. 2011;32(2):179\u201383.","journal-title":"J Environ Biol"},{"issue":"1","key":"383_CR28","first-page":"81","volume":"54","author":"JL Strykowski","year":"2015","unstructured":"Strykowski JL, Schech JM. Effectiveness of recommended euthanasia methods in larval zebrafish (Danio rerio). J Am Assoc Lab Anim Sci. 2015;54(1):81\u20134.","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"383_CR29","unstructured":"Organization for Economic Cooperation and Development (OECD). Test No. 236: Fish Embryo Acute Toxicity (FET) Test. In: OECD Guidelines for the Testing of Chemicals, Section 2: Biotic Effects. Paris: OECD Publishing; 2013. pp.1\u201322."},{"issue":"3","key":"383_CR30","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/etc.4351","volume":"38","author":"JM Rawlings","year":"2019","unstructured":"Rawlings JM, Belanger SE, Connors KA, Carr GJ. Fish embryo tests and acute fish toxicity tests are interchangeable in the application of the threshold approach. Environ Toxicol Chem. 2019;38(3):671\u201381.","journal-title":"Environ Toxicol Chem"},{"key":"383_CR31","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.chemosphere.2018.09.013","volume":"213","author":"B Rangasamy","year":"2018","unstructured":"Rangasamy B, Hemalatha D, Shobana C, Nataraj B, Ramesh M. Developmental toxicity and biological responses of zebrafish (Danio rerio) exposed to anti-inflammatory drug ketoprofen. Chemosphere. 2018;213:423\u201333.","journal-title":"Chemosphere."},{"issue":"1","key":"383_CR32","first-page":"27","volume":"9","author":"R Gitawati","year":"2014","unstructured":"Gitawati R. Pattern of household drug storage. Kesmas: Natl Public Health J. 2014;9(1):27\u201331.","journal-title":"Kesmas: Natl Public Health J"},{"issue":"3","key":"383_CR33","first-page":"526","volume":"39","author":"AM Mobrad","year":"2020","unstructured":"Mobrad AM, Ahmad F, Saleh SA, Rammah AAAA, Syed W, Samreen S. Unused and expired medicines: investigating the knowledge and practice of general community. Lat Am J Pharm. 2020;39(3):526\u201331.","journal-title":"Lat Am J Pharm"},{"key":"383_CR34","doi-asserted-by":"publisher","first-page":"95","DOI":"10.11606\/S1518-8787.2017051000053","volume":"51","author":"RR Martins","year":"2017","unstructured":"Martins RR, Farias AD, Oliveira YMDC, Diniz RS, Oliveira AG. Prevalence and risk factors of inadequate medicine home storage: a community-based study. Rev Saude Publica. 2017;51:95\u2013102.","journal-title":"Rev Saude Publica"},{"issue":"4","key":"383_CR35","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1345\/aph.1K533","volume":"42","author":"L De Bolle","year":"2008","unstructured":"De Bolle L, Mehuys E, Adriaens E, Remon JP, Van Bortel L, Christiaens T. Home medication cabinets and self-medication: a source of potential health threats? Ann Pharmacother. 2008;42(4):572\u20139.","journal-title":"Ann Pharmacother"},{"issue":"2","key":"383_CR36","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1590\/1413-81232020252.10882018","volume":"25","author":"VM Constantino","year":"2020","unstructured":"Constantino VM, Fregonesi BM, Tonani KADA, Zagui GS, Toninato APC, Nonose ERDS, et al. Storage and disposal of pharmaceuticals at home: a systematic review. Cien Saude Coletiva. 2020;25(2):585\u201394.","journal-title":"Cien Saude Coletiva"},{"issue":"42","key":"383_CR37","first-page":"1","volume":"10","author":"D Cameli","year":"2012","unstructured":"Cameli D, Francis M, Francois VE, Medder NR, Von Eden L, Truglio-Londrigan M. A systematic review of medication reconciliation strategies to reduce medication errors in community dwelling older adults. JBI Evid Synth. 2012;10(42):1\u201318.","journal-title":"JBI Evid Synth"},{"issue":"3","key":"383_CR38","doi-asserted-by":"publisher","first-page":"e92323","DOI":"10.1371\/journal.pone.0092323","volume":"9","author":"M Ocan","year":"2014","unstructured":"Ocan M, Bwanga F, Gs B, Bagenda D, Waako P, Ogwal-Okeng J, et al. Patterns and predictors of self-medication in Northern Uganda. PLoS One. 2014;9(3):e92323.","journal-title":"PLoS One"},{"issue":"4","key":"383_CR39","first-page":"172","volume":"2","author":"HGO Alvim","year":"2019","unstructured":"Alvim HGO, Carvalho MJP. The importance of pharmacist orientation on the correct use of medicines. Rev JRG Estud Acad. 2019;2(4):172\u20139.","journal-title":"Rev JRG Estud Acad"},{"issue":"5","key":"383_CR40","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s40266-017-0445-y","volume":"34","author":"M Locquet","year":"2017","unstructured":"Locquet M, Honvo G, Rabenda V, Van Hees T, Petermans J, Reginster JY, et al. Adverse health events related to self-medication practices among elderly: a systematic review. Drugs Aging. 2017;34(5):359\u201365.","journal-title":"Drugs Aging"},{"issue":"10","key":"383_CR41","doi-asserted-by":"publisher","first-page":"119","DOI":"10.22159\/ijpps.2016v8i10.12748","volume":"8","author":"SM Albawani","year":"2016","unstructured":"Albawani SM, Hassan YB, Abd-Aziz N, Gnanasan S. Self-medication practice among consumers in Sana\u2019a City. Int J Pharm Pharm Sci. 2016;8(10):119\u201324.","journal-title":"Int J Pharm Pharm Sci"},{"issue":"2","key":"383_CR42","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.jiph.2018.09.002","volume":"12","author":"RA Almohammed","year":"2019","unstructured":"Almohammed RA, Bird EL. Public knowledge and behaviours relating to antibiotic use in gulf cooperation council countries: a systematic review. J Infect Public Health. 2019;12(2):159\u201366.","journal-title":"J Infect Public Health"},{"key":"383_CR43","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2147\/DHPS.S25372","volume":"3","author":"N Kheir","year":"2011","unstructured":"Kheir N, El Hajj M, Wilbur K, Rm K, Yousif A. An exploratory study on medications in Qatar homes. Drug Healthc Patient Saf. 2011;3:99\u2013106.","journal-title":"Drug Healthc Patient Saf"},{"issue":"3","key":"383_CR44","first-page":"2476","volume":"4","author":"S Aditya","year":"2013","unstructured":"Aditya S, Singh H. Safe medication disposal: need to sensitize undergraduate students. Int J Pharm Life Sci. 2013;4(3):2476\u201380.","journal-title":"Int J Pharm Life Sci"},{"issue":"2","key":"383_CR45","doi-asserted-by":"publisher","first-page":"26","DOI":"10.24862\/cco.v10i2.344","volume":"10","author":"P Bertolin","year":"2016","unstructured":"Bertolin P, Kronbauer EAW, Pegoraro T. Disposal of home medicines in a municipality in the Paran\u00e1 state. Conex Cienc. 2016;10(2):26\u201339.","journal-title":"Conex Cienc"},{"issue":"3","key":"383_CR46","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1590\/S1413-41522014019000000472","volume":"19","author":"GMF Pinto","year":"2014","unstructured":"Pinto GMF, Silva KR, Pereira RFAB, Sampaio SI. Study of residential expired medicines disposal in Paul\u00ednia (SP) area, Brazil. Eng Sanit Ambient. 2014;19(3):219\u201324.","journal-title":"Eng Sanit Ambient"},{"issue":"2","key":"383_CR47","doi-asserted-by":"publisher","first-page":"9","DOI":"10.17564\/2316-3798.2015v3n2p9-18","volume":"3","author":"C Ferreira","year":"2015","unstructured":"Ferreira C, Santos MAS, Rodrigues SC. Analysis of the population's knowledge about drug disposal in Belo Horizonte - Minas Gerais. Rev Interfaces Cient Saude Ambient. 2015;3(2):9\u201318.","journal-title":"Rev Interfaces Cient Saude Ambient"},{"key":"383_CR48","doi-asserted-by":"publisher","first-page":"3283","DOI":"10.1590\/S1413-81232010000800034","volume":"15","author":"E Falqueto","year":"2010","unstructured":"Falqueto E, Kligerman DC, Assump\u00e7\u00e3o RF. How to do the correct discard of medicine residues? Cien Saude Colet. 2010;15:3283\u201393.","journal-title":"Cien Saude Colet"},{"issue":"1","key":"383_CR49","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.envint.2010.10.002","volume":"37","author":"AYC Tong","year":"2011","unstructured":"Tong AYC, Peake BM, Braund R. Disposal practices for unused medications around the world. Environ Int. 2011;37(1):292\u20138.","journal-title":"Environ Int"},{"issue":"4","key":"383_CR50","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1590\/1809-4422asoc0295r1v2042017","volume":"20","author":"HMP Ramos","year":"2017","unstructured":"Ramos HMP, Cruvinel VRN, Meiners MMMA, Queiroz CA, Galato D. Medication disposal: a reflection about possible sanitary and environmental risks. Ambient Soc. 2017;20(4):145\u201368.","journal-title":"Ambient Soc"},{"issue":"5","key":"383_CR51","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1590\/S0100-40422009000500040","volume":"32","author":"TS Moreira","year":"2009","unstructured":"Moreira TS, Cid YP, Pierre MBR, Sousa VP, Kummerle AE, Fraga CAM. Extraction and purification of selectives ciclooxigenase-2 nonsteroidal antiinflammatory drugs. Quim Nova. 2009;32(5):1324\u20138.","journal-title":"Quim Nova"},{"key":"383_CR52","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ejphar.2019.01.044","volume":"848","author":"E Caiazzo","year":"2019","unstructured":"Caiazzo E, Ialenti A, Cicala C. The relatively selective cyclooxygenase-2 inhibitor nimesulide: What\u2019s going on? Eur J Pharmacol. 2019;848:105\u201311.","journal-title":"Eur J Pharmacol"},{"key":"383_CR53","volume-title":"The world medicines situation 2011 - Rational use of medicines","author":"K Holloway","year":"2011","unstructured":"Holloway K, Van Dijk L. The world medicines situation 2011 - Rational use of medicines. Geneva: (WHO\/EMP\/MIE\/2011.2.2); 2011."},{"issue":"1","key":"383_CR54","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209264","volume":"14","author":"J Kwon","year":"2019","unstructured":"Kwon J, Kim S, Yoo H, Lee E. Nimesulide-induced hepatotoxicity: a systematic review and meta-analysis. PLoS One. 2019;14(1):e0209264.","journal-title":"PLoS One"},{"issue":"1","key":"383_CR55","first-page":"103","volume":"36","author":"JT Hamm","year":"2019","unstructured":"Hamm JT, Ceger P, Allen D, Stout M, Maull EA, Baker G, et al. Characterizing sources of variability in zebrafish embryo screening protocols. ALTEX Altern Anim Ex. 2019;36(1):103\u201320.","journal-title":"ALTEX Altern Anim Ex"},{"issue":"18","key":"383_CR56","doi-asserted-by":"publisher","first-page":"18832","DOI":"10.1007\/s11356-016-7092-4","volume":"23","author":"Q Li","year":"2016","unstructured":"Li Q, Wang P, Chen L, Gao H, Wu L. Acute toxicity and histopathological effects of naproxen in zebrafish (Danio rerio) early life stages. Environ Sci Pollut Res. 2016;23(18):18832\u201341.","journal-title":"Environ Sci Pollut Res"},{"key":"383_CR57","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.scitotenv.2019.01.300","volume":"664","author":"S Zhou","year":"2019","unstructured":"Zhou S, Chen Q, Di Paolo C, Shao Y, Hollert H, Seiler TB. Behavioral profile alterations in zebrafish larvae exposed to environmentally relevant concentrations of eight priority pharmaceuticals. Sci Total Environ. 2019;664:89\u201398.","journal-title":"Sci Total Environ"},{"issue":"1","key":"383_CR58","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.ydbio.2005.03.014","volume":"282","author":"Y Cha","year":"2005","unstructured":"Cha Y, Kim S, Solnica-Krezel L, DuBois RN. Cyclooxygenase-1 signaling is required for vascular tube formation during development. Dev Biol. 2005;282(1):274\u201383.","journal-title":"Dev Biol"},{"issue":"3","key":"383_CR59","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1016\/j.etap.2009.01.002","volume":"27","author":"A David","year":"2009","unstructured":"David A, Pancharatna K. Developmental anomalies induced by a non-selective COX inhibitor (ibuprofen) in zebrafish (Danio rerio). Environ Toxicol Pharmacol. 2009;27(3):390\u20135.","journal-title":"Environ Toxicol Pharmacol"},{"key":"383_CR60","first-page":"1086702","volume":"229","author":"K Nowakowska","year":"2020","unstructured":"Nowakowska K, Giebu\u0142towicz J, Kamaszewski M, Adamski A, Szudrowicz H, Ostaszewska T, et al. Acute exposure of zebrafish (Danio rerio) larvae to environmental concentrations of selected antidepressants: bioaccumulation, physiological and histological changes. Comp Biochem Phys C Toxicol Pharmacol. 2020;229:1086702.","journal-title":"Comp Biochem Phys C Toxicol Pharmacol"},{"issue":"6","key":"383_CR61","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S1084952102001040","volume":"13","author":"NS Glickman","year":"2002","unstructured":"Glickman NS, Yelon D. Cardiac development in zebrafish: coordination of form and function. Semin Cell Dev Biol. 2002;13(6):507\u201313.","journal-title":"Semin Cell Dev Biol"},{"issue":"1","key":"383_CR62","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1472-6750-8-21","volume":"8","author":"MA Denvir","year":"2008","unstructured":"Denvir MA, Tucker CS, Mullins JJ. Systolic and diastolic ventricular function in zebrafish embryos: influence of norepenephrine, MS-222 and temperature. BMC Biotechnol. 2008;8(1):21\u20139.","journal-title":"BMC Biotechnol"},{"issue":"2","key":"383_CR63","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1517\/17425255.2.2.231","volume":"2","author":"AL Rubinstein","year":"2006","unstructured":"Rubinstein AL. 2006. Zebrafish assays for drug toxicity screening. Expert Opin Drug Met Toxicol. 2006;2(2):231\u201340.","journal-title":"Expert Opin Drug Met Toxicol"},{"issue":"3","key":"383_CR64","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.taap.2007.11.016","volume":"228","author":"D Rald\u00faa","year":"2008","unstructured":"Rald\u00faa D, Andr\u00e9 M, Babin PJ. Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish. Toxicol Appl Pharmacol. 2008;228(3):301\u201314.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"383_CR65","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.cbpa.2006.09.014","volume":"146","author":"IF Kodde","year":"2007","unstructured":"Kodde IF, van der Stok J, Smolenski RT, de Jong JW. Metabolic and genetic regulation of cardiac energy substrate preference. Comp Biochem Phys A Physiol. 2007;146(1):26\u201339.","journal-title":"Comp Biochem Phys A Physiol"},{"issue":"10","key":"383_CR66","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1897\/07-369.1","volume":"27","author":"R Adema-Hannes","year":"2008","unstructured":"Adema-Hannes R, Shenker J. Acute lethal and teratogenic effects of tributyltin chloride and copper chloride on mahi mahi (Coryphaena hippurus) eggs and larvae. Environ Toxicol Chem. 2008;27(10):2131\u20135.","journal-title":"Environ Toxicol Chem"},{"issue":"1","key":"383_CR67","first-page":"909","volume":"24","author":"C Chang","year":"2014","unstructured":"Chang C, Wu SL, Zhao XD, Zhao CT, Li YH. Developmental toxicity of doxorubicin hydrochloride in embryo-larval stages of Zebrafish. Biomed Mater Eng. 2014;24(1):909\u201316.","journal-title":"Biomed Mater Eng"},{"issue":"4","key":"383_CR68","doi-asserted-by":"publisher","first-page":"351","DOI":"10.4142\/jvs.2008.9.4.351","volume":"9","author":"SH Seok","year":"2008","unstructured":"Seok SH, Baek MW, Lee HY, Kim DJ, Na YR, Noh KJ, et al. In vivo alternative testing with zebrafish in ecotoxicology. J Vet Sci. 2008;9(4):351\u20137.","journal-title":"J Vet Sci"},{"key":"383_CR69","doi-asserted-by":"crossref","unstructured":"Lei M, Zhang L, Lei J, Zong L, Li J, Wu Z, et al. Overview of emerging contaminants and associated human health effects. Biomed Res Int. 2015;404796.","DOI":"10.1155\/2015\/404796"},{"key":"383_CR70","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.marenvres.2013.10.008","volume":"96","author":"J Beyer","year":"2014","unstructured":"Beyer J, Petersen K, Song Y, Ruus A, Grung M, Bakke T, et al. Environmental risk assessment of combined effects in aquatic ecotoxicology: a discussion paper. Mar Environ Res. 2014;96:81\u201391.","journal-title":"Mar Environ Res"},{"issue":"2","key":"383_CR71","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1586\/ecp.11.6","volume":"4","author":"CG Daughton","year":"2011","unstructured":"Daughton CG, Ruhoy IS. Green pharmacy and pharmEcovigilance: prescribing and the planet. Expert Rev Clin Pharmacol. 2011;4(2):211\u201332.","journal-title":"Expert Rev Clin Pharmacol"},{"issue":"4","key":"383_CR72","first-page":"174","volume":"13","author":"R Marques","year":"2018","unstructured":"Marques R, Xavier CR. Socio-environmental responsibility from the use and disposal of medicines. Braz J Environ Educ. 2018;13(4):174\u201389.","journal-title":"Braz J Environ Educ"},{"key":"383_CR73","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.cbpc.2017.06.004","volume":"200","author":"JS Jackson","year":"2017","unstructured":"Jackson JS, Kennedy CJ. Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug\/multixenobiotic resistance (MDR\/MXR) functional activity in the model teleost, Danio rerio (zebrafish). Comp Biochem Phys C Toxicol Pharmacol. 2017;200:34\u201341.","journal-title":"Comp Biochem Phys C Toxicol Pharmacol"},{"issue":"1","key":"383_CR74","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/s40199-017-0176-y","volume":"25","author":"NN Koopaei","year":"2017","unstructured":"Koopaei NN, Abdollahi M. Health risks associated with the pharmaceuticals in wastewater. DARU J Pharm Sci. 2017;25(1):9.","journal-title":"DARU J Pharm Sci"},{"issue":"6","key":"383_CR75","first-page":"639","volume":"56","author":"M Florea","year":"2008","unstructured":"Florea M, Monciu CM, Andritoiu ML, Bacanu LG. Spectrophotometric determination of nimesulide through ion-pair complex formation with hexadecyltrimethylammonium bromide. Farmacia. 2008;56(6):639\u201346.","journal-title":"Farmacia."}],"container-title":["DARU Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40199-020-00383-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40199-020-00383-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40199-020-00383-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T17:11:02Z","timestamp":1710781862000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40199-020-00383-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["383"],"URL":"https:\/\/doi.org\/10.1007\/s40199-020-00383-4","relation":{},"ISSN":["2008-2231"],"issn-type":[{"value":"2008-2231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,19]]},"assertion":[{"value":"12 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}