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Understanding the underlying pathogenesis is crucial for the development of new remedies. Resveratrol controls obesity and glycemic disorders in patients with MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to evaluate the effect of resveratrol and dulaglutide on adipose tissues and liver in rats with MS, declaring their possible mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Rats allocated as Control, MS (induced by a high fat\/ high sucrose diet for eight weeks), MS\u2009+\u2009Resveratrol (30\u00a0mg\/kg\/day orally), and MS\u2009+\u2009Dulaglutide (0.6\u00a0mg\/kg twice weekly SC); drugs administration was in the last four weeks. Serum biochemical measurements were done. Liver and visceral fat were processed for biochemistry, histopathology, and immunohistochemistry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MS results demonstrated significantly increased systolic and diastolic blood pressure, anthropometric measurements, serum levels of alanine aminotransferase (ALT), glycemic indices, and lipids with decreased HDL-C. Tissue levels of leptin, malondialdehyde (MDA), and TNF-\u03b1 reactivity significantly increased. Expression of adiponectin, PPAR\u03b3, and insulin growth factor-1 (IGF-1) decreased. Also, Western blotting mRNA gene expression of liver SIRT-1 was down-regulated. Resveratrol and dulaglutide significantly and effectively reversed MS complexity, ameliorating all findings, particularly NAFLD and adiposity-induced inflammation.\u00a0Resveratrol significantly appears superior to dulaglutide regarding the effects on hemodynamics, lipids, adipokines, IGF-1 levels, and adipocyte size. Parallel, dulaglutide has more influence on glycemic control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Protective effects of the drugs may be through correlations between SIRT-1\/adipokines\/IGF-1 and PPAR\u03b3, improving the cross-talk between insulin resistance, obesity markers, liver dysfunction, and TNF-\u03b1. Promising multi-beneficial therapies of resveratrol or dulaglutide in MS are recommended clinically for this purpose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                    <jats:p>Showing the Experimental Design<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40199-023-00458-y","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T13:03:16Z","timestamp":1680094996000},"page":"13-27","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Resveratrol and Dulaglutide ameliorate adiposity and liver dysfunction in rats with diet-induced metabolic syndrome: Role of SIRT-1 \/ adipokines \/ PPAR\u03b3 and IGF-1"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-5731","authenticated-orcid":false,"given":"Hanan Abdel Moneam A.","family":"Shamardl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9331-7116","authenticated-orcid":false,"given":"Noha A.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7124-2758","authenticated-orcid":false,"given":"Dina H.","family":"Merzeban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-6753","authenticated-orcid":false,"given":"Azza M.","family":"Elamir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab M.","family":"Golam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa M.","family":"Elsayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"issue":"1","key":"458_CR1","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1139\/h06-095","volume":"32","author":"S Desroches","year":"2007","unstructured":"Desroches S, Lamarche B. 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