{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:07:25Z","timestamp":1789556845103,"version":"build-2803163510"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["DARU J Pharm Sci"],"DOI":"10.1007\/s40199-026-00635-9","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:56:24Z","timestamp":1789556184000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of nanoemulsion-based in situ gel formulation of escitalopram oxalate for intranasal delivery in depression therapy"],"prefix":"10.1007","volume":"34","author":[{"given":"Vahid Vikram","family":"Minglani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenakshi B.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun Kumar","family":"Upadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"635_CR1","doi-asserted-by":"crossref","unstructured":"Jiang Y, Zou D, Li Y, Gu S, Dong J, Ma X, Xu S, Wang F, Huang JH. Monoamine neurotransmitters control basic emotions and affect major depressive disorders. Pharmaceuticals. 2022;15(10):1203.","DOI":"10.3390\/ph15101203"},{"key":"635_CR2","unstructured":"World Health Organization. Suicide worldwide in 2021: global health estimates. World Health Organization; 2025."},{"key":"635_CR3","doi-asserted-by":"crossref","unstructured":"Bremshey S, Gro\u00df J, Renken K, Masseck OA. The role of serotonin in depression\u2014A historical roundup and future directions. Journal of Neurochemistry. 2024;168(9):1751\u201379.","DOI":"10.1111\/jnc.16097"},{"key":"635_CR4","doi-asserted-by":"crossref","unstructured":"Schroder HS, Duda JM, Christensen K, Beard C, Bj\u00f6rgvinsson T. Stressors and chemical imbalances: Beliefs about the causes of depression in an acute psychiatric treatment sample. Journal of Affective Disorders. 2020;276:537\u201345.","DOI":"10.1016\/j.jad.2020.07.061"},{"key":"635_CR5","doi-asserted-by":"crossref","unstructured":"Albert KM, Newhouse PA. Estrogen, stress, and depression: cognitive and biological interactions. Annual review of clinical psychology. 2019;15(1):399\u2013423.","DOI":"10.1146\/annurev-clinpsy-050718-095557"},{"key":"635_CR6","doi-asserted-by":"crossref","unstructured":"Militaru AM, Trifu S, Trifu AD, Minca DG. Adverse Childhood Events, Resilience, and Psychopathology. Medicina. 2025;61(12):2138.","DOI":"10.3390\/medicina61122138"},{"key":"635_CR7","doi-asserted-by":"crossref","unstructured":"Gautam M, Tripathi A, Deshmukh D, Gaur M. Cognitive behavioral therapy for depression. Indian journal of psychiatry. 2020;62(Suppl 2):S223.","DOI":"10.4103\/psychiatry.IndianJPsychiatry_772_19"},{"key":"635_CR8","doi-asserted-by":"crossref","unstructured":"Rodoshi ZN, Shibu S, Omer O, Tallal H, Gondal MZ, Shahid Z, Azam A, Abbas N, Omer Sr O, TALLAL H. Comparative efficacy of selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) in the management of post-stroke depression: a systematic review of randomized controlled trials. Cureus. 2025;17(5).","DOI":"10.7759\/cureus.84784"},{"key":"635_CR9","doi-asserted-by":"crossref","unstructured":"Sharma A, Alam MA, Kaur A, Sharma S, Yadav S. Psychopharmacological treatment of depression and anxiety and their different drug delivery targets. Current Psychiatry Research and Reviews Formerly: Current Psychiatry Reviews. 2024;20(4):297\u2013322.","DOI":"10.2174\/2666082219666230822140902"},{"key":"635_CR10","doi-asserted-by":"crossref","unstructured":"Kirino E. Escitalopram for the management of major depressive disorder: a review of its efficacy, safety, and patient acceptability. Patient preference and adherence. 2012;853\u201361.","DOI":"10.2147\/PPA.S22495"},{"key":"635_CR11","doi-asserted-by":"crossref","unstructured":"Deorankar P, Minglani VV, Prajapati BG, Patel MB. A Review on Nanotechnology based In Situ Gelling System as a Reliable Weapon for Targeting Alzheimer\u2019s Disease via Intranasal Route. CNS & Neurological Disorders-Drug Targets. 2025;24(8):594\u2013609.","DOI":"10.2174\/0118715273335978250127070434"},{"key":"635_CR12","doi-asserted-by":"crossref","unstructured":"Nair AB, Chaudhary S, Jacob S, Patel D, Shinu P, Shah H, Chaudhary A, Aldhubiab B, Almuqbil RM, Alnaim AS, Alqattan F. Intranasal administration of dolutegravir-loaded nanoemulsion-based in situ gel for enhanced bioavailability and direct brain targeting. Gels. 2023;9(2):130.","DOI":"10.3390\/gels9020130"},{"key":"635_CR13","doi-asserted-by":"crossref","unstructured":"Gadhave D, Quadros M, Ugale AR, Goyal M, Gupta V. A Nanoemulgel for Nose-to-Brain delivery of Quetiapine\u2013QbD-Enabled formulation development & in-vitro characterization. International journal of pharmaceutics. 2023;648:123566.","DOI":"10.1016\/j.ijpharm.2023.123566"},{"key":"635_CR14","doi-asserted-by":"crossref","unstructured":"Khot S, Mahajan U, Jadhav A, Vaishampayan P, Bagul U, Gadhave D, Gorain B, Kokare C. Nose-to-brain delivery of sorafenib-loaded lipid-based poloxamer-carrageenan nanoemulgel: Formulation and therapeutic investigation in glioblastoma-induced orthotopic rat model. International Journal of Biological Macromolecules. 2025;309:142861.","DOI":"10.1016\/j.ijbiomac.2025.142861"},{"key":"635_CR15","doi-asserted-by":"crossref","unstructured":"Bahadur S, Pardhi DM, Rautio J, Rosenholm JM, Pathak K. Intranasal nanoemulsions for direct nose-to-brain delivery of actives for CNS disorders. Pharmaceutics. 2020;12(12):1230.","DOI":"10.3390\/pharmaceutics12121230"},{"key":"635_CR16","doi-asserted-by":"crossref","unstructured":"Lotfi M, Nakhlband A, Doustmihan A, Omidi Y, Fathi M, Adibkia K. Formulation and evaluation of in-situ forming poloxamer-based hydrogel containing thiolated chitosan nanoparticles as intranasal galantamine delivery system. International 989 Journal of Biological Macromolecules. 2025;320:145647.","DOI":"10.1016\/j.ijbiomac.2025.145647"},{"key":"635_CR17","doi-asserted-by":"crossref","unstructured":"Jawad M, Shafique U, ud Din F, Butt A, Khan S, Khan GM, Alamri AH, Lahiq AA, Alsharif ST, Almerai KS. Nose to brain delivery of escitalopram-loaded nano-structured lipid carriers thermosensitive gel: formulation, physiochemical, pharmacokinetic and pharmacodynamics evaluation. Journal of Drug Delivery Science and Technology. 2024;97:105800.","DOI":"10.1016\/j.jddst.2024.105800"},{"key":"635_CR18","doi-asserted-by":"crossref","unstructured":"Mujtaba MA, Rashid MA, Godbole MD, Alhamhoom Y, Shende DS, Alshehri S, Akbar MJ, Kaleem M, Mahajan UN, Shahzad N. Escitalopram oxalate-loaded chitosan nanoparticle in situ gel formulation intended for direct nose-to-brain delivery: in vitro, ex vivo, and in vivo pharmacokinetic evaluation. Frontiers in Pharmacology. 2025;16:1577331.","DOI":"10.3389\/fphar.2025.1577331"},{"key":"635_CR19","doi-asserted-by":"crossref","unstructured":"Ghareeb MM, Mohammed MS. Topical nanoemulsion-based gel of isoconazole nitrate. Al Mustansiriyah Journal of Pharmaceutical Sciences. 2023;23(4):378\u201396.","DOI":"10.32947\/ajps.v23i4.1093"},{"key":"635_CR20","doi-asserted-by":"crossref","unstructured":"Paliwal H, Prajapati BG. Development and in vitro characterization of a voriconazole loaded nanoemulsion for potential intranasal drug delivery. Bionanoscience. 2025;15(2):263.","DOI":"10.1007\/s12668-025-01859-w"},{"key":"635_CR21","doi-asserted-by":"crossref","unstructured":"Chong WT, Tan CP, Cheah YK, B. Lajis AF, Habi Mat Dian NL, Kanagaratnam S, Lai OM. Optimization of process parameters in preparation of tocotrienol-rich red palm oil based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology. PLoS One. 2018;13(8):e0202771.","DOI":"10.1371\/journal.pone.0202771"},{"key":"635_CR22","doi-asserted-by":"crossref","unstructured":"Gondhale-Karpe P, Bhope S, Puri M, Manwatkar S, Mahajan B. Analytical tools for the characterization of nasal spray drug products. InBiosystems, biomedical & drug delivery systems: characterization, restoration and optimization. 2024;61\u201379.","DOI":"10.1007\/978-981-97-2596-0_4"},{"key":"635_CR23","doi-asserted-by":"crossref","unstructured":"Kotta S, Aldawsari HM, Badr-Eldin SM, Nair AB, Kaleem M, Dalhat MH. Thermosensitive hydrogels loaded with resveratrol nanoemulsion: formulation optimization by central composite design and evaluation in MCF-7 human breast cancer cell lines. Gels. 2022;8(7):450.","DOI":"10.3390\/gels8070450"},{"key":"635_CR24","doi-asserted-by":"crossref","unstructured":"Huang C, Wang C, Zhang W, Yang T, Xia M, Lei X, Peng Y, Wu Y, Feng J, Li D, Zhang G. Preparation, in vitro and in vivo evaluation of nanoemulsion in situ gel for transnasal delivery of traditional Chinese medicine volatile oil from Ligusticum sinense Oliv. cv. Chaxiong. Molecules. 2022;27(21):7644.","DOI":"10.3390\/molecules27217644"},{"key":"635_CR25","doi-asserted-by":"crossref","unstructured":"Trivedi R, Minglani VV, El-Gazzar AM, Batiha GE, Mahmoud MH, Patel M, Patel M. Optimization of pramipexole-loaded in situ thermosensitive intranasal gel for Parkinson\u2019s disease. Pharmaceuticals. 2024;17(2):172.","DOI":"10.3390\/ph17020172"},{"key":"635_CR26","doi-asserted-by":"crossref","unstructured":"Ahmad N, Ansari K, Alamoudi MK, Haque A, Ullah Z, Khalid MS, Ahmad S. A novel mucoadhesive paliperidone-nanoemulsion developed using the ultrasonication method in the treatment of schizophrenia. RSC advances. 2024;14(33):23952\u201372.","DOI":"10.1039\/D4RA04624B"},{"key":"635_CR27","doi-asserted-by":"crossref","unstructured":"Sheng L, Wei Y, Pi C, Cheng J, Su Z, Wang Y, Chen T, Wen J, Wei Y, Ma J, Tang J. Preparation and evaluation of curcumin derivatives nanoemulsion based on turmeric extract and its antidepressant effect. International journal of nanomedicine. 2023;7965\u201383.","DOI":"10.2147\/IJN.S430769"},{"key":"635_CR28","doi-asserted-by":"crossref","unstructured":"Pires PC, Peixoto D, Teixeira I, Rodrigues M, Alves G, Santos AO. Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin for intranasal administration: Formulation development and in vitro characterization. European Journal of Pharmaceutical Sciences. 2020;141:105099.","DOI":"10.1016\/j.ejps.2019.105099"},{"key":"635_CR29","doi-asserted-by":"crossref","unstructured":"Jacob S, Kather FS, Satyam SM, Boddu SH, Assaf F, Allam TH, Nair AB. Injectable in situ thermoreversible gel depot system of Lidocaine nanoemulsion for prolonged anesthetic activity in dental and operative procedures. Pharmaceutics. 2025;17(10):1355.","DOI":"10.3390\/pharmaceutics17101355"},{"key":"635_CR30","doi-asserted-by":"crossref","unstructured":"Prajapati B, Modi C, Patel U, Kendre P. Nanoemulsion based in-situ gel for ocular delivery of brimonidine tartrate. Current Drug Therapy. 2024;19(3):336\u201345.","DOI":"10.2174\/1574885518666230626164030"},{"key":"635_CR31","doi-asserted-by":"crossref","unstructured":"Vijaya Rani KR, Rajan S, Bhupathyraaj M, Priya RK, Halligudi N, Al-Ghazali MA, Sridhar SB, Shareef J, Thomas S, Desai SM, Pol PD. The effect of polymers on drug release kinetics in nanoemulsion in situ gel formulation. Polymers. 2022;14(3):427.","DOI":"10.3390\/polym14030427"},{"key":"635_CR32","unstructured":"United States Pharmacopeia. <601> Nasal sprays and aerosols\u2014performance tests. In: USP\u2013NF 2024 (USP 47\u2013NF 42). Rockville (MD): USP Convention. 2024."},{"key":"635_CR33","doi-asserted-by":"crossref","unstructured":"Shaghlil L, Al-Ebini Y, Shawabkeh MJ, Adam F, Saxena KK, Alshishani A, Harun SW. Advances in Intranasal CNS Targeting: Integrating Formulations, Devices, Computational Fluid Dynamics, and 3D Printing. Pharmaceutics. 2026;18(7):902.","DOI":"10.3390\/pharmaceutics18070902"},{"key":"635_CR34","doi-asserted-by":"crossref","unstructured":"Corazza E, Di Cagno MP, Bauer-Brandl A, Abruzzo A, Cerchiara T, Bigucci 1050 F, Luppi B. Drug delivery to the brain: In situ gelling formulation enhances carbamazepine diffusion through nasal mucosa models with mucin. European Journal of Pharmaceutical Sciences. 2022;179:106294.","DOI":"10.1016\/j.ejps.2022.106294"},{"key":"635_CR35","doi-asserted-by":"crossref","unstructured":"Das S, Sarkar M, Bagchi A, Bahadur S. Intranasal nanoemulsion for targeted medication delivery to the brain: a novel approach to treat psychotic disorder. Drug Delivery and Translational Research. 2026;1\u201325.","DOI":"10.1007\/s13346-026-02054-4"},{"key":"635_CR36","doi-asserted-by":"crossref","unstructured":"Lin L, Chen Q, Dai Y, Xia Y. Self-nanoemulsifying drug delivery system for enhanced bioavailability of madecassic acid: in vitro and in vivo evaluation. International journal of nanomedicine. 2023;2345\u201358.","DOI":"10.2147\/IJN.S408115"},{"key":"635_CR37","doi-asserted-by":"crossref","unstructured":"Sita VG, Vavia P. Bromocriptine nanoemulsion-loaded transdermal gel: optimization using factorial design, in vitro and in vivo evaluation. AAPS PharmSciTech. 2020;21(3):80.","DOI":"10.1208\/s12249-020-1620-8"},{"key":"635_CR38","doi-asserted-by":"crossref","unstructured":"Vaz G, Clementino A, Mitsou E, Ferrari E, Buttini F, Sissa C, Xenakis A, Sonvico F, Dora CL. In vitro evaluation of curcumin-and quercetin-loaded nanoemulsions for intranasal administration: effect of surface charge and viscosity. Pharmaceutics. 2022;14(1):194.","DOI":"10.3390\/pharmaceutics14010194"},{"key":"635_CR39","doi-asserted-by":"crossref","unstructured":"Mallick A, Gupta A, Hussain A, Aparajay P, Singh S, Singh SK, Dev A. Intranasal delivery of gabapentin loaded optimized nanoemulsion for augmented permeation. Journal of Drug Delivery Science and Technology. 2020;56:101606.","DOI":"10.1016\/j.jddst.2020.101606"},{"key":"635_CR40","doi-asserted-by":"crossref","unstructured":"Kapoor DU, Kukkar RR, Gaur M, Prajapati BG, Malviya R. The potential of quality target product profile in the optimization of nanoemulsions. Current Nanomedicine. 2025;15(1):4\u201317.","DOI":"10.2174\/0124681873280769231217084737"},{"key":"635_CR41","doi-asserted-by":"crossref","unstructured":"Krishnamoorthy NK, Roohi TF, Peddha MS, Kinattingal N, Wani SU, Krishna KL, Shakeel F, Mehdi S. Evaluation of antidepressant activity of capsaicin nanoemulsion in nicotine withdrawal-induced depression in mice. Brain Sciences. 2023;13(12):1668.","DOI":"10.3390\/brainsci13121668"},{"key":"635_CR42","doi-asserted-by":"crossref","unstructured":"Elkomy MH, Abo El-Ela FI, Zaki RM, Alsaidan OA, Elmowafy M, Zafar A, Shalaby K, Abdelgawad MA, Omar HA, Salama R, Eid HM. Intranasal nanotransferosomal gel for quercetin brain targeting: II. Antidepressant effect in an experimental animal model. Pharmaceutics. 2023;15(8):2095.","DOI":"10.3390\/pharmaceutics15082095"},{"key":"635_CR43","doi-asserted-by":"crossref","unstructured":"Ladel S, Schlossbauer P, Flamm J, Luksch H, Mizaikoff B, Schindowski 1081 K. Improved in vitro model for intranasal mucosal drug delivery: primary olfactory and respiratory epithelial cells compared with the permanent nasal cell line RPMI 2650. Pharmaceutics. 2019;11(8):367.","DOI":"10.3390\/pharmaceutics11080367"},{"key":"635_CR44","doi-asserted-by":"crossref","unstructured":"Haasbroek\u2010Pheiffer A, Van Niekerk S, Van der Kooy F, Cloete T, Steenekamp J, Hamman J. In vitro and ex vivo experimental models for evaluation of intranasal systemic drug delivery as well as direct nose\u2010to\u2010brain drug delivery. Biopharmaceutics & drug disposition. 2023;44(1):94\u2013112.","DOI":"10.1002\/bdd.2348"},{"key":"635_CR45","doi-asserted-by":"crossref","unstructured":"Khan MF, Ahmad N, Ansari K, Ullah Z, Ibrahim HO, Alyami HM, Alqahtani AJ, Ahmad S. A dual nanoapproach for the treatment of depression and sleep via a novel optimized eugenol-mucoadhesive nanoemulsion. ACS omega. 2025;10(16):16815\u201340.","DOI":"10.1021\/acsomega.5c00783"},{"key":"635_CR46","doi-asserted-by":"crossref","unstructured":"Md S, Alhakamy NA, Aldawsari HM, Husain M, Kotta S, Abdullah ST, A. Fahmy U, Alfaleh MA, Asfour HZ. Formulation design, statistical optimization, and in vitro evaluation of a naringenin nanoemulsion to enhance apoptotic activity in A549 lung cancer cells. Pharmaceuticals. 2020;13(7):152.","DOI":"10.3390\/ph13070152"},{"key":"635_CR47","doi-asserted-by":"crossref","unstructured":"Preeti, Sambhakar S, Malik R, Bhatia S, Al Harrasi A, Rani C, Saharan R, Kumar S, Geeta, Sehrawat R. Nanoemulsion: an emerging novel technology for improving the bioavailability of drugs. Scientifica. 2023;2023(1):6640103.","DOI":"10.1155\/2023\/6640103"},{"key":"635_CR48","doi-asserted-by":"crossref","unstructured":"Daud IS, Ab Rashid NK, Palmer J, Flint S. Characterization, antibacterial activity, and stability of supercritical fluid extracted lemongrass nanoemulsion on Bacillus cereus. Food Bioscience. 2025;68:106526.","DOI":"10.1016\/j.fbio.2025.106526"},{"key":"635_CR49","doi-asserted-by":"crossref","unstructured":"Bahloul B, Ben Bnina E, Dridi D, Bouhamed A, Castillo Henr\u00edquez L, Flamini G, Vega-Baudrit JR. Development and investigation of a nanoemulgel formulated from Tunisian Opuntia ficus-indica L. seed oil for enhanced wound healing activity. Gels. 2024;10(9):582.","DOI":"10.3390\/gels10090582"},{"key":"635_CR50","doi-asserted-by":"crossref","unstructured":"Nguyen TT, Maeng HJ. Pharmacokinetics and pharmacodynamics of intranasal solid1107 lipid nanoparticles and nanostructured lipid carriers for nose-to-brain delivery. Pharmaceutics. 2022;14(3):572.","DOI":"10.3390\/pharmaceutics14030572"},{"key":"635_CR51","doi-asserted-by":"crossref","unstructured":"Silva S, Fonseca C, Bicker J, Falc\u00e3o A, Fortuna A. Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression. European Journal of Pharmaceutics and Biopharmaceutics. 2024;194:118\u201330.","DOI":"10.1016\/j.ejpb.2023.12.002"},{"key":"635_CR52","doi-asserted-by":"crossref","unstructured":"Rana I, Khan N, Ansari MM, Shah FA, ud Din F, Sarwar S, Imran M, Qureshi OS, Choi HI, Lee CH, Kim JK. Solid lipid nanoparticles-mediated enhanced antidepressant activity of duloxetine in lipopolysaccharide-induced depressive model. Colloids and Surfaces B: Biointerfaces. 2020;194:111209.","DOI":"10.1016\/j.colsurfb.2020.111209"}],"container-title":["DARU Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40199-026-00635-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40199-026-00635-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40199-026-00635-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T10:56:52Z","timestamp":1789556212000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40199-026-00635-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["635"],"URL":"https:\/\/doi.org\/10.1007\/s40199-026-00635-9","relation":{},"ISSN":["2008-2231"],"issn-type":[{"value":"2008-2231","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"assertion":[{"value":"23 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"77"}}