{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:39:34Z","timestamp":1792460374137,"version":"4.5.0"},"reference-count":106,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000839","name":"University of Reading","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000839","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Diabetes Metab Disord"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Given that the relationship between vitamin D status and metabolic diseases such as obesity and type 2 diabetes (T2D) remains unclear, this review will focus on the genetic associations, which are less prone to confounding, between vitamin D-related single nucleotide polymorphisms (SNPs) and metabolic diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search of relevant articles was performed on PubMed up to December 2019. Those articles that had examined the association of vitamin D-related SNPs with obesity and\/or T2D were included. Two reviewers independently evaluated the eligibility for the inclusion criteria and extracted the data. In total, 73 articles were included in this review.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There is a lack of research focusing on the association of vitamin D synthesis-related genes with obesity and T2D; however, the limited available research, although inconsistent, is suggestive of a protective effect on T2D risk. While there are several studies that investigated the vitamin D metabolism-related SNPs, the research focusing on vitamin D activation, catabolism and transport genes is limited. Studies on\n                      <jats:italic>CYP27B1<\/jats:italic>\n                      ,\n                      <jats:italic>CYP24A1<\/jats:italic>\n                      and\n                      <jats:italic>GC<\/jats:italic>\n                      genes demonstrated a lack of association with obesity and T2D in Europeans; however, significant associations with T2D were found in South Asians.\n                      <jats:italic>VDR<\/jats:italic>\n                      gene SNPs have been extensively researched; in particular, the focus has been mainly on BsmI (rs1544410), TaqI (rs731236), ApaI (rs7975232) and FokI (rs2228570) SNPs. Even though the association between\n                      <jats:italic>VDR<\/jats:italic>\n                      SNPs and metabolic diseases remain inconsistent, some positive associations showing potential effects on obesity and T2D in specific ethnic groups were identified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, this literature review suggests that ethnic-specific genetic associations are involved. Further research utilizing large studies is necessary to better understand these ethnic-specific genetic associations between vitamin D deficiency and metabolic diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s40200-020-00561-w","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T05:02:46Z","timestamp":1592370166000},"page":"1701-1729","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Vitamin D pathway-related gene polymorphisms and their association with metabolic diseases: A literature review"],"prefix":"10.1007","volume":"19","author":[{"given":"Buthaina E.","family":"Alathari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aji A.","family":"Sabta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinnappan A.","family":"Kalpana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karani Santhanakrishnan","family":"Vimaleswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"561_CR1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/cphy.c140071","volume":"6","author":"SJ Khundmiri","year":"2016","unstructured":"Khundmiri SJ, Murray RD, Lederer E, PTH, Vitamin D. Compr Physiol. 2016;6:561\u2013601.","journal-title":"Compr Physiol"},{"key":"561_CR2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1080\/09674845.2013.11669951","volume":"70","author":"S Basit","year":"2013","unstructured":"Basit S. Vitamin D in health and disease: a literature review. Br J Biomed Sci. 2013;70:161\u201372.","journal-title":"Br J Biomed Sci"},{"key":"561_CR3","doi-asserted-by":"crossref","first-page":"F8","DOI":"10.1152\/ajprenal.00336.2004","volume":"289","author":"AS Dusso","year":"2005","unstructured":"Dusso AS, Brown AJ, Slatopolsky E, Vitamin D. Am J Physiol Renal Physiol. 2005;289:F8\u201328.","journal-title":"Am J Physiol Renal Physiol"},{"key":"561_CR4","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrcardio.2016.73","volume":"13","author":"S Pilz","year":"2016","unstructured":"Pilz S, Verheyen N, Grubler MR, Tomaschitz A, Marz W. Vitamin D and cardiovascular disease prevention. Nat Rev Cardiol. 2016;13:404\u201317.","journal-title":"Nat Rev Cardiol"},{"key":"561_CR5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S2213-8587(13)70165-7","volume":"2","author":"P Autier","year":"2014","unstructured":"Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014;2:76\u201389.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"561_CR6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00223-012-9660-z","volume":"92","author":"Z Dastani","year":"2013","unstructured":"Dastani Z, Li R, Richards B. Genetic regulation of vitamin D levels. Calcif Tissue Int. 2013;92:106\u201317.","journal-title":"Calcif Tissue Int"},{"key":"561_CR7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2340\/00015555-0980","volume":"91","author":"WG Tsiaras","year":"2011","unstructured":"Tsiaras WG, Weinstock MA. Factors influencing vitamin D status. Acta Derm Venereol. 2011;91:115\u201324.","journal-title":"Acta Derm Venereol"},{"key":"561_CR8","doi-asserted-by":"crossref","unstructured":"Holick MF High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006, 81, 353\u2013373.","DOI":"10.4065\/81.3.353"},{"key":"561_CR9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1146\/annurev-med-051214-025146","volume":"67","author":"TJ Wang","year":"2016","unstructured":"Wang TJ. Vitamin D and Cardiovascular Disease. Annu Rev Med. 2016;67:261\u201372.","journal-title":"Annu Rev Med"},{"issue":"Suppl 2","key":"561_CR10","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/ajcn\/88.2.491S","volume":"88","author":"AW Norman","year":"2008","unstructured":"Norman AW. From vitamin D to hormone D: fundamentals of the vitamin D endocrine system essential for good health. Am J Clin Nutr. 2008;88(Suppl 2):491\u20139.","journal-title":"Am J Clin Nutr"},{"key":"561_CR11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bone.2018.10.006","volume":"126","author":"X Jiang","year":"2019","unstructured":"Jiang X, Kiel DP, Kraft P. The genetics of vitamin D. Bone. 2019;126:59\u201377.","journal-title":"Bone"},{"key":"561_CR12","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1002\/jcp.26216","volume":"233","author":"A Bahrami","year":"2018","unstructured":"Bahrami A, Sadeghnia HR, Tabatabaeizadeh SA, Bahrami-Taghanaki H, Behboodi N, Esmaeili H, Ferns GA, Mobarhan MG, Avan A. Genetic and epigenetic factors influencing vitamin D status. J Cell Physiol. 2018;233:4033\u201343.","journal-title":"J Cell Physiol"},{"key":"561_CR13","doi-asserted-by":"crossref","unstructured":"Erkus E, Aktas G, Kocak MZ, Duman TT, Atak BM, Savli H. Diabetic regulation of subjects with type 2 diabetes mellitus is associated with serum vitamin D levels. Rev Assoc Med Bras (1992). 2019;65:51\u201355.","DOI":"10.1590\/1806-9282.65.1.51"},{"key":"561_CR14","doi-asserted-by":"crossref","unstructured":"Mathieu SV, Fischer K, Dawson-Hughes B, Freystaetter G, Beuschlein F, Schietzel S, Egli A; Bischoff-Ferrari H. A. Association between 25-Hydroxyvitamin D Status and Components of Body Composition and Glucose Metabolism in Older Men and Women. Nutrients. 2018;10.","DOI":"10.3390\/nu10121826"},{"key":"561_CR15","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/07315724.2018.1538828","volume":"38","author":"A Pantovic","year":"2019","unstructured":"Pantovic A, Zec M, Zekovic M, Obrenovic R, Stankovic S, Glibetic M. Vitamin D Is Inversely Related to Obesity: Cross-Sectional Study in a Small Cohort of Serbian Adults. J Am Coll Nutr. 2019;38:405\u201314.","journal-title":"J Am Coll Nutr"},{"key":"561_CR16","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1210\/jc.2018-01522","volume":"104","author":"JS Zheng","year":"2019","unstructured":"Zheng JS, Imamura F, Sharp SJ, van der Schouw YT, Sluijs I, Gundersen TE, Ardanaz E, Boeing H, Bonet C, Gomez JH, et al. Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study. J Clin Endocrinol Metab. 2019;104:1293\u2013303.","journal-title":"J Clin Endocrinol Metab"},{"key":"561_CR17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2148-13-144","volume":"13","author":"V Kuan","year":"2013","unstructured":"Kuan V, Martineau AR, Griffiths CJ, Hypponen E, Walton R. DHCR7 mutations linked to higher vitamin D status allowed early human migration to northern latitudes. BMC Evol Biol. 2013;13:144\u201353.","journal-title":"BMC Evol Biol"},{"key":"561_CR18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.plipres.2016.09.003","volume":"64","author":"AV Prabhu","year":"2016","unstructured":"Prabhu AV, Luu W, Li D, Sharpe LJ, Brown AJ. DHCR7: A vital enzyme switch between cholesterol and vitamin D production. Prog Lipid Res. 2016;64:138\u201351.","journal-title":"Prog Lipid Res"},{"key":"561_CR19","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jsbmb.2016.08.004","volume":"165","author":"MA Abbas","year":"2017","unstructured":"Abbas MA. Physiological functions of Vitamin D in adipose tissue. J Steroid Biochem Mol Biol. 2017;165:369\u201381.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"561_CR20","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/ijo.2011.246","volume":"36","author":"T Dorjgochoo","year":"2012","unstructured":"Dorjgochoo T, Shi J, Gao YT, Long J, Delahanty R, Xiang YB, Cai Q, Shu XO. Genetic variants in vitamin D metabolism-related genes and body mass index: analysis of genome-wide scan data of approximately 7000 Chinese women. Int J Obes (Lond). 2012;36:1252\u20135.","journal-title":"Int J Obes (Lond)"},{"key":"561_CR21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1472-6823-13-36","volume":"13","author":"L Foucan","year":"2013","unstructured":"Foucan L, Velayoudom-Cephise FL, Larifla L, Armand C, Deloumeaux J, Fagour C, Plumasseau J, Portlis ML, Liu L, Bonnet F, et al. Polymorphisms in GC and NADSYN1 Genes are associated with vitamin D status and metabolic profile in Non-diabetic adults. BMC Endocr Disord. 2013;13:36\u201343.","journal-title":"BMC Endocr Disord"},{"key":"561_CR22","doi-asserted-by":"crossref","first-page":"e1001383","DOI":"10.1371\/journal.pmed.1001383","volume":"10","author":"KS Vimaleswaran","year":"2013","unstructured":"Vimaleswaran KS, Berry DJ, Lu C, Tikkanen E, Pilz S, Hiraki LT, Cooper JD, Dastani Z, Li R, Houston DK, et al. Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med. 2013;10:e1001383.","journal-title":"PLoS Med"},{"key":"561_CR23","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/ijo.2013.6","volume":"37","author":"KS Vimaleswaran","year":"2013","unstructured":"Vimaleswaran KS, Cavadino A, Berry DJ, Whittaker JC, Power C, Jarvelin MR, Hypponen E. Genetic association analysis of vitamin D pathway with obesity traits. Int J Obes (Lond). 2013;37:1399\u2013406.","journal-title":"Int J Obes (Lond)"},{"key":"561_CR24","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S2213-8587(13)70200-6","volume":"2","author":"S Afzal","year":"2014","unstructured":"Afzal S, Brondum-Jacobsen P, Bojesen SE, Nordestgaard BG. Vitamin D concentration, obesity, and risk of diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol. 2014;2:298\u2013306.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"561_CR25","doi-asserted-by":"crossref","first-page":"34911","DOI":"10.18632\/oncotarget.26178","volume":"9","author":"L Bertoccini","year":"2018","unstructured":"Bertoccini L, Bailetti D, Buzzetti R, Cavallo MG, Copetti M, Cossu E, D\u2019Angelo P, De Cosmo S, Di Mauro L, Leonetti F, et al. Variability in genes regulating vitamin D metabolism is associated with vitamin D levels in type 2 diabetes. Oncotarget. 2018;9:34911\u20138.","journal-title":"Oncotarget"},{"key":"561_CR26","doi-asserted-by":"crossref","first-page":"e1002566","DOI":"10.1371\/journal.pmed.1002566","volume":"15","author":"L Lu","year":"2018","unstructured":"Lu L, Bennett DA, Millwood IY, Parish S, McCarthy MI, Mahajan A, Lin X, Bragg F, Guo Y, Holmes MV, et al. Association of vitamin D with risk of type 2 diabetes: A Mendelian randomisation study in European and Chinese adults. PLoS Med. 2018;15:e1002566.","journal-title":"PLoS Med"},{"key":"561_CR27","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.gene.2018.08.006","volume":"678","author":"Y Wang","year":"2018","unstructured":"Wang Y, Yu F, Yu S, Zhang D, Wang J, Han H, Sun H, Xue Y, Ba Y, Wang C, et al. Triangular relationship between CYP2R1 gene polymorphism, serum 25(OH)D3 levels and T2DM in a Chinese rural population. Gene. 2018;678:172\u20136.","journal-title":"Gene"},{"key":"561_CR28","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s10654-013-9844-5","volume":"28","author":"B Buijsse","year":"2013","unstructured":"Buijsse B, Boeing H, Hirche F, Weikert C, Schulze MB, Gottschald M, K\u00fchn T, Katzke VA, Teucher B, Dierkes J, et al. Plasma 25-hydroxyvitamin D and its genetic determinants in relation to incident type 2 diabetes: a prospective case-cohort study. Eur J Epidemiol. 2013;28:743\u201352.","journal-title":"Eur J Epidemiol"},{"key":"561_CR29","doi-asserted-by":"crossref","first-page":"e37295","DOI":"10.1371\/journal.pone.0037295","volume":"7","author":"R Jorde","year":"2012","unstructured":"Jorde R, Schirmer H, Wilsgaard T, Joakimsen RM, Mathiesen EB, Njolstad I, Lochen ML, Figenschau Y, Berg JP, Svartberg J, et al. Polymorphisms related to the serum 25-hydroxyvitamin D level and risk of myocardial infarction, diabetes, cancer and mortality. The Tromso Study. PLoS One. 2012;7:e37295.","journal-title":"PLoS One"},{"key":"561_CR30","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.ecl.2017.07.011","volume":"46","author":"G Jones","year":"2017","unstructured":"Jones G, Kottler ML, Schlingmann KP. Genetic Diseases of Vitamin D Metabolizing Enzymes. Endocrinol Metab Clin North Am. 2017;46:1095\u2013117.","journal-title":"Endocrinol Metab Clin North Am"},{"key":"561_CR31","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1017\/S0029665115004164","volume":"75","author":"JF Landrier","year":"2016","unstructured":"Landrier JF, Karkeni E, Marcotorchino J, Bonnet L, Tourniaire F. Vitamin D modulates adipose tissue biology: possible consequences for obesity? Proc Nutr Soc. 2016;75:38\u201346.","journal-title":"Proc Nutr Soc"},{"key":"561_CR32","doi-asserted-by":"crossref","first-page":"E1343","DOI":"10.1210\/jc.2014-4387","volume":"100","author":"A Molin","year":"2015","unstructured":"Molin A, Coudray N, Richard N, Kottler M-L, Deschenes G, Kesler-Roussey G, Tiulpakov A, Baudoin R, Jones G, Kaufmann M, et al. CYP24A1 Mutations in a Cohort of Hypercalcemic Patients: Evidence for a Recessive Trait. J Clin Endocrinol Metab. 2015;100:E1343\u201352.","journal-title":"J Clin Endocrinol Metab"},{"key":"561_CR33","doi-asserted-by":"crossref","first-page":"649","DOI":"10.2215\/CJN.05360512","volume":"8","author":"G Nesterova","year":"2013","unstructured":"Nesterova G, Malicdan MC, Yasuda K, Sakaki T, Vilboux T, Ciccone C, Horst R, Huang Y, Golas G, Introne W, et al. 1,25-(OH)2D-24 Hydroxylase (CYP24A1) Deficiency as a Cause of Nephrolithiasis. Clin J Am Soc Nephrol. 2013;8:649\u201357.","journal-title":"Clin J Am Soc Nephrol"},{"key":"561_CR34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.3389\/fendo.2019.00317","volume":"10","author":"DD Bikle","year":"2019","unstructured":"Bikle DD, Schwartz J, Vitamin DB, Protein. Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions. Front Endocrinol. 2019;10:317\u20137.","journal-title":"Front Endocrinol"},{"key":"561_CR35","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4158\/EP161604.RA","volume":"23","author":"NK Jassil","year":"2017","unstructured":"Jassil NK, Sharma A, Bikle D, Wang X. Vitamin D binding protein and 25-hydroxyvitamin D levels: emerging clinical applications. Endocr Pract. 2017;23:605\u201313.","journal-title":"Endocr Pract"},{"key":"561_CR36","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/sj.ijo.0803583","volume":"31","author":"H Jiang","year":"2007","unstructured":"Jiang H, Xiong DH, Guo YF, Shen H, Xiao P, Yang F, Chen Y, Zhang F, Recker RR, Deng H. W. Association analysis of vitamin D-binding protein gene polymorphisms with variations of obesity-related traits in Caucasian nuclear families. Int J Obes (Lond). 2007;31:1319\u201324.","journal-title":"Int J Obes (Lond)"},{"key":"561_CR37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1139\/apnm-2015-0284","volume":"41","author":"N Almesri","year":"2016","unstructured":"Almesri N, Das NS, Ali ME, Gumaa K, Giha HA. Independent associations of polymorphisms in vitamin D binding protein (GC) and vitamin D receptor (VDR) genes with obesity and plasma 25OHD3 levels demonstrate sex dimorphism. Appl Physiol Nutr Metab. 2016;41:345\u201353.","journal-title":"Appl Physiol Nutr Metab"},{"key":"561_CR38","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1262-3636(07)70017-4","volume":"29","author":"MT Malecki","year":"2003","unstructured":"Malecki MT, Klupa T, Wolkow P, Bochenski J, Wanic K, Sieradzki J. Association study of the vitamin D: 1alpha-hydroxylase (CYP1alpha) gene and type 2 diabetes mellitus in a Polish population. Diabetes Metab. 2003;29:119\u201324.","journal-title":"Diabetes Metab"},{"key":"561_CR39","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/s41598-018-19838-5","volume":"8","author":"S Yu","year":"2018","unstructured":"Yu S, Li X, Wang Y, Mao Z, Wang C, Ba Y, Li W. Maternal transmission disequilibrium of rs2248359 in type 2 diabetes mellitus families and its association with vitamin D level in offspring. Sci Rep. 2018;8:1345\u201352.","journal-title":"Sci Rep"},{"key":"561_CR40","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.jdiacomp.2018.01.004","volume":"32","author":"S Yu","year":"2018","unstructured":"Yu S, Li X, Wang Y, Mao Z, Wang C, Ba Y, Li W. Transmission disequilibrium of rs4809957 in type 2 diabetes mellitus families and its association with vitamin D deficiency: A family-based case-control study. J Diabetes Complications. 2018;32:406\u201310.","journal-title":"J Diabetes Complications"},{"key":"561_CR41","first-page":"1658","volume":"67","author":"K Iqbal","year":"2017","unstructured":"Iqbal K, Islam N, Azam I, Asghar A, Mehboobali N, Iqbal MP. Association of Vitamin D binding protein polymorphism with risk of type 2 diabetes mellitus in a Pakistani urban population: A case control study. J Pak Med Assoc. 2017;67:1658\u201363.","journal-title":"J Pak Med Assoc"},{"key":"561_CR42","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.gene.2017.09.008","volume":"636","author":"MM Rahman","year":"2017","unstructured":"Rahman MM, Hosen MB, Faruk MO, Hasan MM, Kabir Y, Howlader M. Z. H. Association of vitamin D and vitamin D binding protein (DBP) gene polymorphism with susceptibility of type 2 diabetes mellitus in Bangladesh. Gene. 2017;636:42\u20137.","journal-title":"Gene"},{"key":"561_CR43","doi-asserted-by":"crossref","first-page":"e005617","DOI":"10.1136\/bmjopen-2014-005617","volume":"4","author":"G Wang","year":"2014","unstructured":"Wang G, Li Y, Li L, Yu F, Cui L, Ba Y, Li W, Wang C. Association of the vitamin D binding protein polymorphisms with the risk of type 2 diabetes mellitus: a meta-analysis. BMJ Open. 2014;4:e005617.","journal-title":"BMJ Open"},{"key":"561_CR44","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0168-8227(02)00020-7","volume":"57","author":"MT Malecki","year":"2002","unstructured":"Malecki MT, Klupa T, Wanic K, Cyganek K, Frey J, Sieradzki J. Vitamin D binding protein gene and genetic susceptibility to type 2 diabetes mellitus in a Polish population. Diabetes Res Clin Pract. 2002;57:99\u2013104.","journal-title":"Diabetes Res Clin Pract"},{"key":"561_CR45","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1463-1326.2007.00710.x","volume":"10","author":"X Palomer","year":"2008","unstructured":"Palomer X, Gonzalez-Clemente JM, Blanco-Vaca F, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab. 2008;10:185\u201397.","journal-title":"Diabetes Obes Metab"},{"key":"561_CR46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2009.09.005","volume":"79","author":"FC Campbell","year":"2010","unstructured":"Campbell FC, Xu H, El-Tanani M, Crowe P, Bingham V. The yin and yang of vitamin D receptor (VDR) signaling in neoplastic progression: operational networks and tissue-specific growth control. Biochem Pharmacol. 2010;79:1\u20139.","journal-title":"Biochem Pharmacol"},{"key":"561_CR47","first-page":"29","volume":"38","author":"P Nezbedova","year":"2004","unstructured":"Nezbedova P, Brtko J. 1alpha,25-dihydroxyvitamin D3 inducible transcription factor and its role in the vitamin D action. Endocr Regul. 2004;38:29\u201338.","journal-title":"Endocr Regul"},{"key":"561_CR48","unstructured":"Bikle D, Vitamin D. Production, Metabolism, and Mechanisms of Action. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, Dungan K, Grossman A et al, editors Endotext. South Dartmouth (MA): MDText.com, Inc.; 2000. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK278935\/."},{"key":"561_CR49","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1262-3636(07)70200-8","volume":"31","author":"AF Reis","year":"2005","unstructured":"Reis AF, Hauache OM, Velho G. Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. A review of evidence. Diabetes Metab. 2005;31:318\u201325.","journal-title":"Diabetes Metab"},{"key":"561_CR50","doi-asserted-by":"crossref","first-page":"e0178695","DOI":"10.1371\/journal.pone.0178695","volume":"12","author":"R Rahmadhani","year":"2017","unstructured":"Rahmadhani R, Zaharan NL, Mohamed Z, Moy FM, Jalaludin MY. The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country. PLoS One. 2017;12:e0178695.","journal-title":"PLoS One"},{"key":"561_CR51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000490669","volume":"73","author":"FJ Ruiz-Ojeda","year":"2018","unstructured":"Ruiz-Ojeda FJ, Anguita-Ruiz A, Leis R, Aguilera CM. Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship. Ann Nutr Metab. 2018;73:89\u201399.","journal-title":"Ann Nutr Metab"},{"key":"561_CR52","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1017\/S0007114512003285","volume":"108","author":"C Ding","year":"2012","unstructured":"Ding C, Gao D, Wilding J, Trayhurn P, Bing C. Vitamin D signalling in adipose tissue. Br J Nutr. 2012;108:1915\u201323.","journal-title":"Br J Nutr"},{"key":"561_CR53","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.gene.2014.03.044","volume":"542","author":"NM Al-Daghri","year":"2014","unstructured":"Al-Daghri NM, Al-Attas OS, Alkharfy KM, Khan N, Mohammed AK, Vinodson B, Ansari MG, Alenad A, Alokail MS. Association of VDR-gene variants with factors related to the metabolic syndrome, type 2 diabetes and vitamin D deficiency. Gene. 2014;542:129\u201333.","journal-title":"Gene"},{"key":"561_CR54","doi-asserted-by":"crossref","first-page":"e102141","DOI":"10.1371\/journal.pone.0102141","volume":"9","author":"NM Al-Daghri","year":"2014","unstructured":"Al-Daghri NM, Guerini FR, Al-Attas OS, Alokail MS, Alkharfy KM, Draz HM, Agliardi C, Costa AS, Saulle I, Mohammed AK, et al. Vitamin D receptor gene polymorphisms are associated with obesity and inflammosome activity. PLoS One. 2014;9:e102141.","journal-title":"PLoS One"},{"key":"561_CR55","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.19082\/5427","volume":"9","author":"AS Al-Hazmi","year":"2017","unstructured":"Al-Hazmi AS, Al-Mehmadi MM, Al-Bogami SM, Shami AA, Al-Askary AA, Alomery AM, Al-Shehri SS, Dahlawi H, Abdulrazag K, Ali T, et al. Vitamin D receptor gene polymorphisms as a risk factor for obesity in Saudi men. Electron Physician. 2017;9:5427\u201333.","journal-title":"Electron Physician"},{"key":"561_CR56","doi-asserted-by":"crossref","unstructured":"Binh TQ, Nakahori Y, Hien VT, Khan NC, Lam NT, Mai le B, Yamamoto S Correlations between genetic variance and adiposity measures, and gene x gene interactions for obesity in postmenopausal Vietnamese women. J Genet. 2011;90:1\u20139.","DOI":"10.1007\/s12041-011-0028-3"},{"key":"561_CR57","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.metabol.2012.03.018","volume":"61","author":"DA Ferrarezi","year":"2012","unstructured":"Ferrarezi DA, Bellili-Munoz N, Nicolau C, Cheurfa N, Guazzelli IC, Frazzatto E, Velho G, Villares S. M. Allelic variations in the vitamin D receptor gene, insulin secretion and parents\u2019 heights are independently associated with height in obese children and adolescents. Metabolism. 2012;61:1413\u201321.","journal-title":"Metabolism"},{"key":"561_CR58","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/13685530802273426","volume":"11","author":"A Filus","year":"2008","unstructured":"Filus A, Trzmiel A, Kuliczkowska-Plaksej J, Tworowska U, Jedrzejuk D, Milewicz A, Medras M. Relationship between vitamin D receptor BsmI and FokI polymorphisms and anthropometric and biochemical parameters describing metabolic syndrome. Aging Male. 2008;11:134\u20139.","journal-title":"Aging Male"},{"key":"561_CR59","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1530\/eje.0.1500323","volume":"150","author":"E Grundberg","year":"2004","unstructured":"Grundberg E, Brandstrom H, Ribom EL, Ljunggren O, Mallmin H, Kindmark A. Genetic variation in the human vitamin D receptor is associated with muscle strength, fat mass and body weight in Swedish women. Eur J Endocrinol. 2004;150:323\u20138.","journal-title":"Eur J Endocrinol"},{"issue":"Suppl 2","key":"561_CR60","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.dsx.2017.03.047","volume":"11","author":"HA Hasan","year":"2017","unstructured":"Hasan HA, AbuOdeh RO, Muda W, Mohamed H, Samsudin AR. Association of Vitamin D receptor gene polymorphisms with metabolic syndrome and its components among adult Arabs from the United Arab Emirates. Diabetes Metab Syndr. 2017;11(Suppl 2):531\u20137.","journal-title":"Diabetes Metab Syndr"},{"key":"561_CR61","first-page":"181","volume":"145","author":"WZ Ye","year":"2001","unstructured":"Ye WZ, Reis AF, Dubois-Laforgue D, Bellanne-Chantelot C, Timsit J, Velho G. Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset. Eur J Endocrinol. 2001;145:181\u20136.","journal-title":"Eur J Endocrinol"},{"key":"561_CR62","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12881-017-0454-z","volume":"18","author":"J Bienertova-Vasku","year":"2017","unstructured":"Bienertova-Vasku J, Zlamal F, Pohorala A, Mikes O, Goldbergova-Pavkova M, Novak J, Splichal Z, Pikhart H. Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population. BMC Med Genet. 2017;18:90.","journal-title":"BMC Med Genet"},{"key":"561_CR63","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gene.2017.10.029","volume":"640","author":"M Correa-Rodriguez","year":"2018","unstructured":"Correa-Rodriguez M, Carrillo-Avila JA, Schmidt-RioValle J, Gonzalez-Jimenez E, Vargas S, Martin J, Rueda-Medina B. Genetic association analysis of vitamin D receptor gene polymorphisms and obesity-related phenotypes. Gene. 2018;640:51\u20136.","journal-title":"Gene"},{"key":"561_CR64","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/09513590802302985","volume":"24","author":"U Tworowska-Bardzinska","year":"2008","unstructured":"Tworowska-Bardzinska U, Lwow F, Kubicka E, Laczmanski L, Jedzrzejuk D, Dunajska K, Milewicz A. The vitamin D receptor gene BsmI polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women. Gynecol Endocrinol. 2008;24:514\u20138.","journal-title":"Gynecol Endocrinol"},{"key":"561_CR65","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s12041-015-0541-x","volume":"94","author":"HR Fan","year":"2015","unstructured":"Fan HR, Lin LQ, Ma H, Li Y, Sun CH. Association between vitamin D receptor gene polymorphism (TaqI) and obesity in Chinese population. J Genet. 2015;94:473\u20138.","journal-title":"J Genet"},{"key":"561_CR66","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1038\/aps.2009.169","volume":"30","author":"JM Gu","year":"2009","unstructured":"Gu JM, Xiao WJ, He JW, Zhang H, Hu WW, Hu YQ, Li M, Liu YJ, Fu WZ, Yu JB, et al. Association between VDR and ESR1 gene polymorphisms with bone and obesity phenotypes in Chinese male nuclear families. Acta Pharmacol Sin. 2009;30:1634\u201342.","journal-title":"Acta Pharmacol Sin"},{"key":"561_CR67","doi-asserted-by":"crossref","first-page":"329","DOI":"10.5603\/EP.2015.0042","volume":"66","author":"EA Rivera-Leon","year":"2015","unstructured":"Rivera-Leon EA, Palmeros-Sanchez B, Llamas-Covarrubias IM, Fernandez S, Armendariz-Borunda J, Gonzalez-Hita M, Bastidas-Ramirez BE, Zepeda-Moreno A, Sanchez-Enriquez S. Vitamin-D receptor gene polymorphisms (TaqI and ApaI) and circulating osteocalcin in type 2 diabetic patients and healthy subjects. Endokrynol Pol. 2015;66:329\u201333.","journal-title":"Endokrynol Pol"},{"key":"561_CR68","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/abbs\/37.1.61","volume":"37","author":"H Xu","year":"2005","unstructured":"Xu H, Xiong DH, Xu FH, Zhang YY, Lei SF, Deng HW. Association between VDR ApaI polymorphism and hip bone mineral density can be modified by body mass index: a study on postmenopausal Chinese women. Acta Biochim Biophys Sin (Shanghai). 2005;37:61\u20137.","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"561_CR69","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12944-019-1027-2","volume":"18","author":"F Shen","year":"2019","unstructured":"Shen F, Wang Y, Sun H, Zhang D, Yu F, Yu S, Han H, Wang J, Ba Y, Wang C, et al. Vitamin D receptor gene polymorphisms are associated with triceps skin fold thickness and body fat percentage but not with body mass index or waist circumference in Han Chinese. Lipids Health Dis. 2019;18:97.","journal-title":"Lipids Health Dis"},{"key":"561_CR70","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.gene.2012.10.044","volume":"512","author":"Y Vasilopoulos","year":"2012","unstructured":"Vasilopoulos Y, Sarafidou T, Kotsa K, Papadimitriou M, Goutzelas Y, Stamatis C, Bagiatis V, Tsekmekidou X, Yovos JG. Mamuris Z. VDR TaqI is associated with obesity in the Greek population. Gene. 2012;512:237\u20139.","journal-title":"Gene"},{"key":"561_CR71","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/gerona\/59.1.B10","volume":"59","author":"SM Roth","year":"2004","unstructured":"Roth SM, Zmuda JM, Cauley JA, Shea PR, Ferrell RE. Vitamin D receptor genotype is associated with fat-free mass and sarcopenia in elderly men. J Gerontol A Biol Sci Med Sci. 2004;59:10\u20135.","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"561_CR72","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3945\/ajcn.2010.29986","volume":"93","author":"HM Ochs-Balcom","year":"2011","unstructured":"Ochs-Balcom HM, Chennamaneni R, Millen AE, Shields PG, Marian C, Trevisan M, Freudenheim JL. Vitamin D receptor gene polymorphisms are associated with adiposity phenotypes. Am J Clin Nutr. 2011;93:5\u201310.","journal-title":"Am J Clin Nutr"},{"key":"561_CR73","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.diabet.2014.01.003","volume":"40","author":"KS Vimaleswaran","year":"2014","unstructured":"Vimaleswaran KS, Power C, Hypponen E. Interaction between vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D concentrations on metabolic and cardiovascular disease outcomes. Diabetes Metab. 2014;40:386\u20139.","journal-title":"Diabetes Metab"},{"key":"561_CR74","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.4049\/jimmunol.1101954","volume":"188","author":"NM Al-Daghri","year":"2012","unstructured":"Al-Daghri NM, Al-Attas O, Alokail MS, Alkharfy KM, Draz HM, Agliardi C, Mohammed AK, Guerini FR, Clerici M. Vitamin D receptor gene polymorphisms and HLA DRB1*04 cosegregation in Saudi type 2 diabetes patients. J Immunol. 2012;188:1325\u201332.","journal-title":"J Immunol"},{"key":"561_CR75","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jcjd.2017.06.003","volume":"42","author":"R Malik","year":"2018","unstructured":"Malik R, Farooq R, Mehta P, Ishaq S, Din I, Shah P, Majid S. Association of Vitamin D Receptor Gene Polymorphism in Adults With Type 2 Diabetes in the Kashmir Valley. Can J Diabetes. 2018;42:251\u20136.","journal-title":"Can J Diabetes"},{"key":"561_CR76","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.4238\/vol9-4gmr883","volume":"9","author":"PN Mukhopadhyaya","year":"2010","unstructured":"Mukhopadhyaya PN, Acharya A, Chavan Y, Purohit SS, Mutha A. Metagenomic study of single-nucleotide polymorphism within candidate genes associated with type 2 diabetes in an Indian population. Genet Mol Res. 2010;9:2060\u20138.","journal-title":"Genet Mol Res"},{"key":"561_CR77","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1046\/j.1464-5491.2001.00585.x","volume":"18","author":"JR Ortlepp","year":"2001","unstructured":"Ortlepp JR, Lauscher J, Hoffmann R, Hanrath P, Joost HG. The vitamin D receptor gene variant is associated with the prevalence of type 2 diabetes mellitus and coronary artery disease. Diabet Med. 2001;18:842\u20135.","journal-title":"Diabet Med"},{"key":"561_CR78","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jsbmb.2017.03.012","volume":"175","author":"HA Safar","year":"2018","unstructured":"Safar HA, Chehadeh SEH, Abdel-Wareth L, Haq A, Jelinek HF, ElGhazali G, Anouti FA. Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus. J Steroid Biochem Mol Biol. 2018;175:119\u201324.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"561_CR79","doi-asserted-by":"crossref","first-page":"9588","DOI":"10.4238\/2014.November.14.2","volume":"13","author":"JR Xu","year":"2014","unstructured":"Xu JR, Yang Y, Liu XM, Wang YJ. Association of VDR polymorphisms with type 2 diabetes mellitus in Chinese Han and Hui populations. Genet Mol Res. 2014;13:9588\u201398.","journal-title":"Genet Mol Res"},{"key":"561_CR80","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.gene.2011.12.049","volume":"495","author":"H Zhang","year":"2012","unstructured":"Zhang H, Wang J, Yi B, Zhao Y, Liu Y, Zhang K, Cai X, Sun J, Huang L. Liao Q. BsmI polymorphisms in vitamin D receptor gene are associated with diabetic nephropathy in type 2 diabetes in the Han Chinese population. Gene. 2012;495:183\u20138.","journal-title":"Gene"},{"key":"561_CR81","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41387-018-0038-9","volume":"8","author":"B Angel","year":"2018","unstructured":"Angel B, Lera L, Marquez C, Albala C. The association of VDR polymorphisms and type 2 diabetes in older people living in community in Santiago de Chile. Nutr Diabetes. 2018;8:31.","journal-title":"Nutr Diabetes"},{"key":"561_CR82","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4103\/0019-5359.53164","volume":"63","author":"HK Bid","year":"2009","unstructured":"Bid HK, Konwar R, Aggarwal CG, Gautam S, Saxena M, Nayak VL, Banerjee M, Vitamin D. receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus: a North Indian study. Indian J Med Sci. 2009;63:187\u201394.","journal-title":"Indian J Med Sci"},{"key":"561_CR83","first-page":"25","volume":"15","author":"HIE Gendy","year":"2019","unstructured":"Gendy HIE, Sadik NA, Helmy MY, Rashed LA. Vitamin D receptor gene polymorphisms and 25(OH) vitamin D: Lack of association to glycemic control and metabolic parameters in type 2 diabetic Egyptian patients. J Clin Transl Endocrinol. 2019;15:25\u20139.","journal-title":"J Clin Transl Endocrinol"},{"key":"561_CR84","doi-asserted-by":"crossref","first-page":"688","DOI":"10.2337\/diabetes.47.4.688","volume":"47","author":"GA Hitman","year":"1998","unstructured":"Hitman GA, Mannan N, McDermott MF, Aganna E, Ogunkolade BW, Hales CN, Boucher BJ. Vitamin D receptor gene polymorphisms influence insulin secretion in Bangladeshi Asians. Diabetes. 1998;47:688\u201390.","journal-title":"Diabetes"},{"key":"561_CR85","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.mgene.2014.07.002","volume":"2","author":"AM Mackawy","year":"2014","unstructured":"Mackawy AM, Badawi ME. Association of vitamin D and vitamin D receptor gene polymorphisms with chronic inflammation, insulin resistance and metabolic syndrome components in type 2 diabetic Egyptian patients. Meta Gene. 2014;2:540\u201356.","journal-title":"Meta Gene"},{"key":"561_CR86","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1055\/s-2003-44711","volume":"111","author":"MT Malecki","year":"2003","unstructured":"Malecki MT, Frey J, Moczulski D, Klupa T, Kozek E, Sieradzki J. Vitamin D receptor gene polymorphisms and association with type 2 diabetes mellitus in a Polish population. Exp Clin Endocrinol Diabetes. 2003;111:505\u20139.","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"561_CR87","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1053\/meta.2002.29969","volume":"51","author":"JY Oh","year":"2002","unstructured":"Oh JY, Barrett-Connor E. Association between vitamin D receptor polymorphism and type 2 diabetes or metabolic syndrome in community-dwelling older adults: the Rancho Bernardo Study. Metabolism. 2002;51:356\u20139.","journal-title":"Metabolism"},{"key":"561_CR88","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4103\/ijem.IJEM_213_17","volume":"22","author":"D Sarma","year":"2018","unstructured":"Sarma D, Chauhan VS, Saikia KK, Sarma P, Nath S. Prevalence Pattern of Key Polymorphisms in the Vitamin D Receptor gene among Patients of Type 2 Diabetes Mellitus in Northeast India. Indian J Endocrinol Metab. 2018;22:229\u201335.","journal-title":"Indian J Endocrinol Metab"},{"key":"561_CR89","first-page":"465","volume":"6","author":"DB Shah","year":"2015","unstructured":"Shah DB, D Doshi D, Singh K, Patel R. Investigation of the VDR Gene Polymorphism in Unrelated Gujarati Group with and without Diabetic Mellitus Type-2. Res J Pharm Biol Chem Sci. 2015;6:465\u20138.","journal-title":"Res J Pharm Biol Chem Sci"},{"key":"561_CR90","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1530\/eje.0.1440385","volume":"144","author":"G Speer","year":"2001","unstructured":"Speer G, Cseh K, Winkler G, Vargha P, Braun E, Takacs I, Lakatos P. Vitamin D and estrogen receptor gene polymorphisms in type 2 diabetes mellitus and in android type obesity. Eur J Endocrinol. 2001;144:385\u20139.","journal-title":"Eur J Endocrinol"},{"key":"561_CR91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000339021","volume":"36","author":"M Vedralova","year":"2012","unstructured":"Vedralova M, Kotrbova-Kozak A, Zeleznikova V, Zoubkova H, Rychlik I, Cerna M. Polymorphisms in the vitamin D receptor gene and parathyroid hormone gene in the development and progression of diabetes mellitus and its chronic complications, diabetic nephropathy and non-diabetic renal disease. Kidney Blood Press Res. 2012;36:1\u20139.","journal-title":"Kidney Blood Press Res"},{"key":"561_CR92","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/1753-0407.12413","volume":"9","author":"F Yu","year":"2017","unstructured":"Yu F, Wang C, Wang L, Jiang H, Ba Y, Cui L, Wang Y, Yu S, Li W. Study and evaluation the impact of vitamin D receptor variants on the risk of type 2 diabetes mellitus in Han Chinese. J Diabetes. 2017;9:275\u201384.","journal-title":"J Diabetes"},{"key":"561_CR93","doi-asserted-by":"crossref","first-page":"e0145359","DOI":"10.1371\/journal.pone.0145359","volume":"10","author":"I Zostautiene","year":"2015","unstructured":"Zostautiene I, Jorde R, Schirmer H, Mathiesen EB, Njolstad I, Lochen ML, Wilsgaard T, Joakimsen RM, Kamycheva E. Genetic Variations in the Vitamin D Receptor Predict Type 2 Diabetes and Myocardial Infarction in a Community-Based Population: The Tromso Study. PLoS One. 2015;10:e0145359.","journal-title":"PLoS One"},{"key":"561_CR94","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.arcmed.2013.02.002","volume":"44","author":"L Li","year":"2013","unstructured":"Li L, Wu B, Liu JY, Yang LB. Vitamin D receptor gene polymorphisms and type 2 diabetes: a meta-analysis. Arch Med Res. 2013;44:235\u201341.","journal-title":"Arch Med Res"},{"key":"561_CR95","doi-asserted-by":"crossref","first-page":"9405","DOI":"10.1007\/s11033-012-1805-7","volume":"39","author":"Q Wang","year":"2012","unstructured":"Wang Q, Xi B, Reilly KH, Liu M, Fu M. Quantitative assessment of the associations between four polymorphisms (FokI, ApaI, BsmI, TaqI) of vitamin D receptor gene and risk of diabetes mellitus. Mol Biol Rep. 2012;39:9405\u201314.","journal-title":"Mol Biol Rep"},{"key":"561_CR96","first-page":"614","volume":"25","author":"F Yu","year":"2016","unstructured":"Yu F, Cui LL, Li X, Wang CJ, Ba Y, Wang L, Li J, Li C, Dai LP, Li WJ. The genetic polymorphisms in vitamin D receptor and the risk of type 2 diabetes mellitus: an updated meta-analysis. Asia Pac J Clin Nutr. 2016;25:614\u201324.","journal-title":"Asia Pac J Clin Nutr"},{"key":"561_CR97","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3109\/10799893.2014.919592","volume":"34","author":"B Zhu","year":"2014","unstructured":"Zhu B, Zhao HL, Ou C, Huang LS, Li PZ, Lao M. Association of vitamin D receptor BsmI gene polymorphism with the risk of type 2 diabetes mellitus. J Recept Signal Transduct Res. 2014;34:458\u201362.","journal-title":"J Recept Signal Transduct Res"},{"key":"561_CR98","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jdiacomp.2008.12.002","volume":"24","author":"F Dilmec","year":"2010","unstructured":"Dilmec F, Uzer E, Akkafa F, Kose E, van Kuilenburg AB. Detection of VDR gene ApaI and TaqI polymorphisms in patients with type 2 diabetes mellitus using PCR-RFLP method in a Turkish population. J Diabetes Complications. 2010;24:186\u201391.","journal-title":"J Diabetes Complications"},{"key":"561_CR99","first-page":"150","volume":"25","author":"S Boullu-Sanchis","year":"1999","unstructured":"Boullu-Sanchis S, Lepretre F, Hedelin G, Donnet JP, Schaffer P, Froguel P, Pinget M. Type 2 diabetes mellitus: association study of five candidate genes in an Indian population of Guadeloupe, genetic contribution of FABP2 polymorphism. Diabetes Metab. 1999;25:150\u20136.","journal-title":"Diabetes Metab"},{"key":"561_CR100","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1309\/LMW788XEEYVVLBUV","volume":"42","author":"R Nosratabadi","year":"2011","unstructured":"Nosratabadi R, Arababadi MK, Salehabad VA. Vitamin D Receptor Polymorphisms in Type 2 Diabetes in Southeastern Iranian Patients. Lab Medicine. 2011;42:32\u20134.","journal-title":"Lab Medicine"},{"key":"561_CR101","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2147\/TACG.S101410","volume":"9","author":"J Maia","year":"2016","unstructured":"Maia J, da Silva AS, do Carmo RF, de Mendonca TF, Griz LH, Moura P, Bandeira F. The association between vitamin D receptor gene polymorphisms (TaqI and FokI), Type 2 diabetes, and micro-\/macrovascular complications in postmenopausal women. Appl Clin Genet. 2016;9:131\u20136.","journal-title":"Appl Clin Genet"},{"key":"561_CR102","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4238\/2012.March.14.1","volume":"11","author":"HC Vural","year":"2012","unstructured":"Vural HC, Maltas E. RT-qPCR assay on the vitamin D receptor gene in type 2 diabetes and hypertension patients in Turkey. Genet Mol Res. 2012;11:582\u201390.","journal-title":"Genet Mol Res"},{"key":"561_CR103","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/07435800.2017.1305965","volume":"42","author":"L Bertoccini","year":"2017","unstructured":"Bertoccini L, Sentinelli F, Leonetti F, Bailetti D, Capoccia D, Cimini FA, Barchetta I, Incani M, Lenzi A, Cossu E, et al. The vitamin D receptor functional variant rs2228570 (C > T) does not associate with type 2 diabetes mellitus. Endocr Res. 2017;42:331\u20135.","journal-title":"Endocr Res"},{"key":"561_CR104","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.arcmed.2015.09.006","volume":"46","author":"J Jia","year":"2015","unstructured":"Jia J, Ding H, Yang K, Mao L, Zhao H, Zhan Y, Shen C. Vitamin D Receptor Genetic Polymorphism Is Significantly Associated with Risk of Type 2 Diabetes Mellitus in Chinese Han Population. Arch Med Res. 2015;46:572\u20139.","journal-title":"Arch Med Res"},{"key":"561_CR105","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.numecd.2016.02.004","volume":"26","author":"F Sentinelli","year":"2016","unstructured":"Sentinelli F, Bertoccini L, Barchetta I, Capoccia D, Incani M, Pani MG, Loche S, Angelico F, Arca M, Morini S, et al. The vitamin D receptor (VDR) gene rs11568820 variant is associated with type 2 diabetes and impaired insulin secretion in Italian adult subjects, and associates with increased cardio-metabolic risk in children. Nutr Metab Cardiovasc Dis. 2016;26:407\u201313.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"561_CR106","first-page":"58","volume":"32","author":"H Han","year":"2019","unstructured":"Han H, Zhao MX, Wang Y, Wang J, Ren BN, Ge HN, Wang T, Sun BB, Ba Y, Li WJ. Significant Polymorphisms of Vitamin D Receptor Gene (rs2189480 and rs3847987) Related to the Risk of Type 2 Diabetes in Henan Rural Area. Biomed Environ Sci. 2019;32:58\u201362.","journal-title":"Biomed Environ Sci"}],"container-title":["Journal of Diabetes &amp; Metabolic Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40200-020-00561-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40200-020-00561-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40200-020-00561-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T19:55:31Z","timestamp":1623786931000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40200-020-00561-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,16]]},"references-count":106,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["561"],"URL":"https:\/\/doi.org\/10.1007\/s40200-020-00561-w","relation":{},"ISSN":["2251-6581"],"issn-type":[{"value":"2251-6581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,16]]},"assertion":[{"value":"16 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}