{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:59:53Z","timestamp":1790827193054,"version":"4.1.0"},"reference-count":115,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100014823","name":"Direktorat Riset dan Pengabdian Masyarakat","doi-asserted-by":"publisher","award":["Penelitian Fundamental Reguler under contract numbers: 3132\/UN1\/DITLIT\/Dit-Lit\/PT dated March 01, 2023, and 2616\/UN1\/DITLIT\/PT dated March 01, 2024."],"award-info":[{"award-number":["Penelitian Fundamental Reguler under contract numbers: 3132\/UN1\/DITLIT\/Dit-Lit\/PT dated March 01, 2023, and 2616\/UN1\/DITLIT\/PT dated March 01, 2024."]}],"id":[{"id":"10.13039\/501100014823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["In Silico Pharmacol."],"DOI":"10.1007\/s40203-026-00753-x","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:22:55Z","timestamp":1790824975000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bioinformatics-based identification of capsaicin target genes associated with trastuzumab resistance in HER2-positive breast cancer: in silico and qRT-PCR validation studies"],"prefix":"10.1007","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5851-3691","authenticated-orcid":false,"given":"Adam","family":"Hermawan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dyaningtyas Dewi Pamungkas","family":"Putri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dini","family":"Maharani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul","family":"Fatimah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Made Rhamandana","family":"Putra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Intan Ayu","family":"Lestari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Djerico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Hana","family":"Widyardhita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasita Rachma","family":"Widayanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"753_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12131809","author":"L Agnello","year":"2023","unstructured":"Agnello L, d\u2019Argenio A, Caliendo A, Nilo R, Zannetti A, Fedele M et al (2023) Tissue inhibitor of metalloproteinases-1 overexpression mediates chemoresistance in triple-negative breast cancer cells. Cells. https:\/\/doi.org\/10.3390\/cells12131809","journal-title":"Cells"},{"issue":"10","key":"753_CR2","doi-asserted-by":"publisher","first-page":"16452","DOI":"10.1002\/jcb.28800","volume":"120","author":"N Akhter","year":"2019","unstructured":"Akhter N, Alzahrani FA, Dar SA, Wahid M, Sattar RSA, Hussain S et al (2019) AA genotype of cyclin D1 G870A polymorphism increases breast cancer risk: findings of a case-control study and meta-analysis. J Cell Biochem 120(10):16452\u201316466. https:\/\/doi.org\/10.1002\/jcb.28800","journal-title":"J Cell Biochem"},{"key":"753_CR3","doi-asserted-by":"crossref","unstructured":"Ali Z, Hermawan A (2022) Bioinformatics analysis uncovers the importance of rtk-ras-pi3k\/akt regulation by borneol in overcoming breast cancer resistance to Tamoxifen. Indonesian J Pharmacy\/Majalah Farmasi Indonesia 33(1)","DOI":"10.22146\/ijp.2346"},{"key":"753_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1201\/9780203710036-2","volume-title":"The FOS and JUN families of transcription factors","author":"P Angel","year":"2017","unstructured":"Angel P, Herrlich P (2017) General structure of AP-1 subunits and characteristics of the Jun proteins. The FOS and JUN families of transcription factors. CRC Press, pp 3\u201314"},{"issue":"8","key":"753_CR5","first-page":"2993","volume":"29","author":"RB Badisa","year":"2009","unstructured":"Badisa RB, Darling-Reed SF, Joseph P, Cooperwood JS, Latinwo LM, Goodman CB (2009) Selective cytotoxic activities of two novel synthetic drugs on human breast carcinoma MCF-7 cells. Anticancer Res 29(8):2993\u20132996","journal-title":"Anticancer Res"},{"issue":"5","key":"753_CR6","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.3390\/ijms19051269","volume":"19","author":"SL Barratt","year":"2018","unstructured":"Barratt SL, Flower VA, Pauling JD, Millar AB (2018) VEGF (vascular endothelial growth factor) and fibrotic lung disease. Int J Mol Sci 19(5):1269","journal-title":"Int J Mol Sci"},{"issue":"6","key":"753_CR7","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1007\/s13277-013-0969-7","volume":"34","author":"C Bjerre","year":"2013","unstructured":"Bjerre C, Vinther L, Belling KC, W\u00fcrtz S\u00d8, Yadav R, Lademann U et al (2013) TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression. Tumour Biol 34(6):3839\u20133851. https:\/\/doi.org\/10.1007\/s13277-013-0969-7","journal-title":"Tumour Biol"},{"issue":"8","key":"753_CR8","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.3390\/life14081040","volume":"14","author":"AB Boz Er","year":"2024","unstructured":"Boz Er AB, Er I (2024) PAI1 regulates cell morphology and migration markers in trastuzumab-resistant HER2-positive breast cancer cells. Life (Basel) 14(8):1040. https:\/\/doi.org\/10.3390\/life14081040","journal-title":"Life (Basel)"},{"issue":"3","key":"753_CR9","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1002\/JLB.2MR0220-549R","volume":"108","author":"TM Bui","year":"2020","unstructured":"Bui TM, Wiesolek HL, Sumagin R (2020) ICAM-1: a master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis. J Leukoc Biol 108(3):787\u2013799","journal-title":"J Leukoc Biol"},{"issue":"24","key":"753_CR10","doi-asserted-by":"publisher","first-page":"9739","DOI":"10.3390\/ijms21249739","volume":"21","author":"GA Cabral-Pacheco","year":"2020","unstructured":"Cabral-Pacheco GA, Garza-Veloz I, Castruita-De la Rosa C, Ramirez-Acu\u00f1a JM, Perez-Romero BA, Guerrero-Rodriguez JF et al (2020) The roles of matrix metalloproteinases and their inhibitors in human diseases. Int J Mol Sci 21(24):9739","journal-title":"Int J Mol Sci"},{"issue":"5","key":"753_CR11","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1093\/carcin\/bgr025","volume":"32","author":"S Caprodossi","year":"2011","unstructured":"Caprodossi S, Amantini C, Nabissi M, Morelli MB, Farfariello V, Santoni M et al (2011) Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis 32(5):686\u2013694. https:\/\/doi.org\/10.1093\/carcin\/bgr025","journal-title":"Carcinogenesis"},{"issue":"5","key":"753_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.Cd-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA et al (2012) The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov 2(5):401\u2013404. https:\/\/doi.org\/10.1158\/2159-8290.Cd-12-0095","journal-title":"Cancer Discov"},{"issue":"10","key":"753_CR13","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1177\/0960327110396530","volume":"30","author":"HC Chang","year":"2011","unstructured":"Chang HC, Chen ST, Chien SY, Kuo SJ, Tsai HT, Chen DR (2011) Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunction. Hum Exp Toxicol 30(10):1657\u20131665. https:\/\/doi.org\/10.1177\/0960327110396530","journal-title":"Hum Exp Toxicol"},{"issue":"3","key":"753_CR14","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1152\/physrev.00030.2015","volume":"96","author":"J Chen","year":"2016","unstructured":"Chen J, Zeng F, Forrester SJ, Eguchi S, Zhang M-Z, Harris RC (2016) Expression and function of the epidermal growth factor receptor in physiology and disease. Physiol Rev 96(3):1025\u20131069","journal-title":"Physiol Rev"},{"issue":"3","key":"753_CR15","first-page":"422","volume":"8","author":"Y-C Chien","year":"2018","unstructured":"Chien Y-C, Liu L-C, Ye H-Y, Wu J-Y, Yu Y-L (2018) EZH2 promotes migration and invasion of triple-negative breast cancer cells via regulating TIMP2-MMP-2\/-9 pathway. Am J Cancer Res 8(3):422","journal-title":"Am J Cancer Res"},{"key":"753_CR16","doi-asserted-by":"publisher","unstructured":"Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY (2014) cytoHubba: identifying hub objects and sub-networks from complex interactome. BMC Syst Biol 4(Suppl 4):S11 https:\/\/doi.org\/10.1186\/1752-0509-8-s4-s11","DOI":"10.1186\/1752-0509-8-s4-s11"},{"key":"753_CR17","doi-asserted-by":"crossref","unstructured":"Cianfrocca R, Tocci P, Spinella F, Di Castro V, Bagnato A, Rosan\u00f2 L (2012) The endothelin a receptor and epidermal growth factor receptor signaling converge on \u03b2-catenin to promote ovarian cancer metastasis. Life Sci 13\u201314(ed2012): 550\u20136","DOI":"10.1016\/j.lfs.2012.03.023"},{"issue":"5","key":"753_CR18","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1002\/path.5225","volume":"247","author":"GA Conlon","year":"2019","unstructured":"Conlon GA, Murray GI (2019) Recent advances in understanding the roles of matrix metalloproteinases in tumour invasion and metastasis. J Pathol 247(5):629\u2013640","journal-title":"J Pathol"},{"key":"753_CR19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1201\/9781351075442-3","volume-title":"Peptides and protein phosphorylation","author":"JA Cooper","year":"2018","unstructured":"Cooper JA (2018) The src family of protein-tyrosine kinases. Peptides and protein phosphorylation. CRC Press, pp 85\u2013113"},{"issue":"11","key":"753_CR20","doi-asserted-by":"publisher","first-page":"11107","DOI":"10.1007\/s13277-014-2401-3","volume":"35","author":"MRP da Rosa","year":"2014","unstructured":"da Rosa MRP, Falc\u00e3o ASC, Fuzii HT, da Silva Kataoka MS, Ribeiro AL, Boccardo E et al (2014) EGFR signaling downstream of EGF regulates migration, invasion, and MMP secretion of immortalized cells derived from human ameloblastoma. Tumor Biology 35(11):11107\u201311120","journal-title":"Tumor Biology"},{"issue":"W1","key":"753_CR21","doi-asserted-by":"publisher","first-page":"W357","DOI":"10.1093\/nar\/gkz382","volume":"47","author":"A Daina","year":"2019","unstructured":"Daina A, Michielin O, Zoete V (2019) SwisstarGetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res 47(W1):W357\u2013W364. https:\/\/doi.org\/10.1093\/nar\/gkz382","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"753_CR22","doi-asserted-by":"publisher","first-page":"D1257","DOI":"10.1093\/nar\/gkac833","volume":"51","author":"AP Davis","year":"2023","unstructured":"Davis AP, Wiegers TC, Johnson RJ, Sciaky D, Wiegers J, Mattingly CJ (2023) Comparative toxicogenomics database (CTD): update 2023. Nucleic Acids Res 51(D1):D1257\u2013D1262","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"753_CR23","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1007\/s13277-013-0659-5","volume":"34","author":"X Deng","year":"2013","unstructured":"Deng X, Fogh L, Lademann U, Jensen V, Stenvang J, Yang H et al (2013) TIMP-1 overexpression does not affect sensitivity to HER2-targeting drugs in the HER2-gene-amplified SK-BR-3 human breast cancer cell line. Tumour Biol 34(2):1161\u20131170. https:\/\/doi.org\/10.1007\/s13277-013-0659-5","journal-title":"Tumour Biol"},{"issue":"3","key":"753_CR24","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s10549-009-0592-x","volume":"122","author":"R Dua","year":"2010","unstructured":"Dua R, Zhang J, Nhonthachit P, Penuel E, Petropoulos C, Parry G (2010) EGFR over-expression and activation in high HER2, ER negative breast cancer cell line induces trastuzumab resistance. Breast Cancer Res Treat 122(3):685\u2013697. https:\/\/doi.org\/10.1007\/s10549-009-0592-x","journal-title":"Breast Cancer Res Treat"},{"issue":"6","key":"753_CR25","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.3390\/cancers15061738","volume":"15","author":"I Essadi","year":"2023","unstructured":"Essadi I, Benbrahim Z, Kaakoua M, Reverdy T, Corbaux P, Freyer G (2023) HER2-positive metastatic breast cancer: available treatments and current developments. Cancers (Basel) 15(6):1738","journal-title":"Cancers (Basel)"},{"key":"753_CR26","doi-asserted-by":"publisher","DOI":"10.4238\/gmr16037446","author":"Z Fang","year":"2017","unstructured":"Fang Z, Li M, Ma Z, Tu G (2017) Association of endothelin-1 gene polymorphisms with essential hypertension in a Chinese population. Genetics Mol Res. https:\/\/doi.org\/10.4238\/gmr16037446","journal-title":"Genetics Mol Res"},{"issue":"11","key":"753_CR27","doi-asserted-by":"publisher","first-page":"3140","DOI":"10.1002\/ijc.32369","volume":"145","author":"JT Fekete","year":"2019","unstructured":"Fekete JT, Gy\u0151rffy B (2019) ROCplot.org: validating predictive biomarkers of chemotherapy\/hormonal therapy\/anti-HER2 therapy using transcriptomic data of 3,104 breast cancer patients. Int J Cancer 145(11):3140\u20133151. https:\/\/doi.org\/10.1002\/ijc.32369","journal-title":"Int J Cancer"},{"issue":"1","key":"753_CR28","doi-asserted-by":"publisher","first-page":"17884","DOI":"10.1038\/s41598-024-68938-y","volume":"14","author":"M Ferrell","year":"2024","unstructured":"Ferrell M, Guven DC, Gomez CG, Nasrollahi E, Giza R, Cheng S et al (2024) Investigating the WNT and TGF-beta pathways alterations and tumor mutant burden in young-onset colorectal cancer. Sci Rep 14(1):17884. https:\/\/doi.org\/10.1038\/s41598-024-68938-y","journal-title":"Sci Rep"},{"issue":"3","key":"753_CR29","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1002\/ijc.25076","volume":"127","author":"J Fischgr\u00e4be","year":"2010","unstructured":"Fischgr\u00e4be J, G\u00f6tte M, Michels K, Kiesel L, W\u00fclfing P (2010) Targeting endothelin A receptor enhances anti-proliferative and anti-invasive effects of the HER2 antibody trastuzumab in HER2-overexpressing breast cancer cells. Int J Cancer 127(3):696\u2013706. https:\/\/doi.org\/10.1002\/ijc.25076","journal-title":"Int J Cancer"},{"issue":"3","key":"753_CR30","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.biopha.2011.02.004","volume":"65","author":"ZY Fu","year":"2011","unstructured":"Fu ZY, Lv JH, Ma CY, Yang DP, Wang T (2011) Tissue inhibitor of metalloproteinase-1 decreased chemosensitivity of MDA-435 breast cancer cells to chemotherapeutic drugs through the PI3K\/AKT\/NF-k{cyrillic}B pathway. Biomed Pharmacother 65(3):163\u2013167. https:\/\/doi.org\/10.1016\/j.biopha.2011.02.004","journal-title":"Biomed Pharmacother"},{"issue":"11","key":"753_CR31","doi-asserted-by":"publisher","first-page":"4833","DOI":"10.21873\/anticanres.17309","volume":"44","author":"CK Fu","year":"2024","unstructured":"Fu CK, Lee HT, Chen JC, Yang MD, Cheng HC, Mong MC et al (2024) Contributions of tissue inhibitor of metalloproteinase-1 genotypes to the risk of metastasis in gastric cancer. Anticancer Res 44(11):4833\u20134841. https:\/\/doi.org\/10.21873\/anticanres.17309","journal-title":"Anticancer Res"},{"issue":"269","key":"753_CR32","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO et al (2013) Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 6(269):pl1. https:\/\/doi.org\/10.1126\/scisignal.2004088","journal-title":"Sci Signal"},{"issue":"8","key":"753_CR33","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","volume":"36","author":"SX Ge","year":"2020","unstructured":"Ge SX, Jung D, Yao R (2020) ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics 36(8):2628\u20132629","journal-title":"Bioinformatics"},{"key":"753_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1200\/edbk_351222","volume":"42","author":"M Gion","year":"2022","unstructured":"Gion M, Trapani D, Cort\u00e9s A, Valenza C, Lin N, Cort\u00e9s J et al (2022) Systemic therapy for HER2-positive metastatic breast cancer: moving into a new era. Am Soc Clin Oncol Educ Book 42:1\u201311. https:\/\/doi.org\/10.1200\/edbk_351222","journal-title":"Am Soc Clin Oncol Educ Book"},{"issue":"10","key":"753_CR35","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1093\/carcin\/bgn154","volume":"29","author":"AK Golembesky","year":"2008","unstructured":"Golembesky AK, Gammon MD, North KE, Bensen JT, Schroeder JC, Teitelbaum SL et al (2008) Peroxisome proliferator-activated receptor-alpha (PPARA) genetic polymorphisms and breast cancer risk: a Long Island ancillary study. Carcinogenesis 29(10):1944\u20131949. https:\/\/doi.org\/10.1093\/carcin\/bgn154","journal-title":"Carcinogenesis"},{"key":"753_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810172","author":"BM Guti\u00e9rrez-Zepeda","year":"2024","unstructured":"Guti\u00e9rrez-Zepeda BM, G\u00f3mez-Del Toro MM, Ortiz-Soto DJ, Becerra-Loaiza DS, Quiroz-Bola\u00f1os AF, Topete A et al (2024) The VEGFA rs3025039 variant is a risk factor for breast cancer in Mexican women. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms251810172","journal-title":"Int J Mol Sci"},{"key":"753_CR37","doi-asserted-by":"publisher","first-page":"4101","DOI":"10.1016\/j.csbj.2021.07.014","volume":"19","author":"B Gy\u0151rffy","year":"2021","unstructured":"Gy\u0151rffy B (2021) Survival analysis across the entire transcriptome identifies biomarkers with the highest prognostic power in breast cancer. Comput Struct Biotechnol J 19:4101\u20134109. https:\/\/doi.org\/10.1016\/j.csbj.2021.07.014","journal-title":"Comput Struct Biotechnol J"},{"issue":"2","key":"753_CR38","doi-asserted-by":"publisher","first-page":"403","DOI":"10.4161\/mabs.27443","volume":"6","author":"S Han","year":"2014","unstructured":"Han S, Meng Y, Tong Q, Li G, Zhang X, Chen Y et al (2014) The ErbB2-targeting antibody trastuzumab and the small-molecule SRC inhibitor saracatinib synergistically inhibit ErbB2-overexpressing gastric cancer. Mabs 6(2):403\u2013408. https:\/\/doi.org\/10.4161\/mabs.27443","journal-title":"Mabs"},{"issue":"3","key":"753_CR39","doi-asserted-by":"publisher","first-page":"511","DOI":"10.3390\/biomedicines12030511","volume":"12","author":"M Harrison","year":"2024","unstructured":"Harrison M, Zinovkin D, Pranjol MZI (2024) Endothelin-1 and its role in cancer and potential therapeutic opportunities. Biomedicines 12(3):511. https:\/\/doi.org\/10.3390\/biomedicines12030511","journal-title":"Biomedicines"},{"issue":"3","key":"753_CR40","first-page":"229","volume":"1","author":"ES Henson","year":"2007","unstructured":"Henson ES, Johnston JB, Los M, Gibson SB (2007) Clinical activities of the epidermal growth factor receptor family inhibitors in breast cancer. Biologics: Targets Therapy 1(3):229\u2013239","journal-title":"Biologics: Targets Therapy"},{"issue":"2","key":"753_CR41","first-page":"198","volume":"12","author":"A Hermawan","year":"2021","unstructured":"Hermawan A, Putri H (2021) Bioinformatics analysis of TIMP1, HK2 and IGFBP7 as potential biomarkers and therapeutic targets of paclitaxel resistance in breast cancer. Middle East J Cancer 12(2):198\u2013207","journal-title":"Middle East J Cancer"},{"issue":"2","key":"753_CR42","doi-asserted-by":"publisher","first-page":"e24356","DOI":"10.1016\/j.heliyon.2024.e24356","volume":"10","author":"A Hermawan","year":"2024","unstructured":"Hermawan A, Putri H, Fatimah N, Prasetio HH (2024a) Transcriptomics analysis reveals distinct mechanism of breast cancer stem cells regulation in mammospheres from MCF-7 and T47D cells. Heliyon 10(2):e24356. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e24356","journal-title":"Heliyon"},{"issue":"7","key":"753_CR43","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1080\/01635581.2024.2348217","volume":"76","author":"A Hermawan","year":"2024","unstructured":"Hermawan A, Ikawati M, Putri DDP, Fatimah N, Prasetio HH (2024b) Nobiletin inhibits breast cancer stem cell by regulating the cell cycle: a comprehensive bioinformatics analysis and in vitro experiments. Nutr Cancer 76(7):638\u2013655. https:\/\/doi.org\/10.1080\/01635581.2024.2348217","journal-title":"Nutr Cancer"},{"key":"753_CR44","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02116-y","author":"A Hermawan","year":"2025","unstructured":"Hermawan A, Hanif N, Putri DDP, Fatimah N, Prasetio HH (2025a) Citrus flavonoids for overcoming breast cancer resistance to methotrexate: identification of potential targets of nobiletin and sinensetin. Discov Oncol. https:\/\/doi.org\/10.1007\/s12672-025-02116-y","journal-title":"Discov Oncol"},{"key":"753_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2025.109809","author":"A Hermawan","year":"2025","unstructured":"Hermawan A, Pamungkas Putri DD, Fatimah N, Rhamandana Putra IM, Lestari IA (2025b) \u03b1-chaconine increases the sensitivity of HER2+ breast cancer cells to trastuzumab by targeting acetylcholinesterase. Comput Biol Med. https:\/\/doi.org\/10.1016\/j.compbiomed.2025.109809","journal-title":"Comput Biol Med"},{"key":"753_CR46","doi-asserted-by":"publisher","first-page":"116528","DOI":"10.1016\/j.jpba.2024.116528","volume":"253","author":"A Hermawan","year":"2025","unstructured":"Hermawan A, Windarsih A, Putri DDP, Fatimah N (2025c) LC-HRMS-based global metabolomics profiling unravels the distinct metabolic signature of lapatinib-resistant and trastuzumab-resistant HER2+ breast cancer cells. J Pharm Biomed Anal 253:116528. https:\/\/doi.org\/10.1016\/j.jpba.2024.116528","journal-title":"J Pharm Biomed Anal"},{"issue":"9","key":"753_CR47","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1136\/thorax.58.9.778","volume":"58","author":"M Hetzel","year":"2003","unstructured":"Hetzel M, Walcher D, Gr\u00fcb M, Bach H, Hombach V, Marx N (2003) Inhibition of MMP-9 expression by PPAR\u03b3 activators in human bronchial epithelial cells. Thorax 58(9):778\u2013783","journal-title":"Thorax"},{"issue":"24","key":"753_CR48","doi-asserted-by":"publisher","first-page":"38161","DOI":"10.18632\/oncotarget.16975","volume":"8","author":"J Hu","year":"2017","unstructured":"Hu J, Luo H, Jiang Y, Chen P (2017) Dietary capsaicin and antibiotics act synergistically to reduce non-alcoholic fatty liver disease induced by high fat diet in mice. Oncotarget 8(24):38161\u201338175. https:\/\/doi.org\/10.18632\/oncotarget.16975","journal-title":"Oncotarget"},{"issue":"3","key":"753_CR49","doi-asserted-by":"publisher","first-page":"107","DOI":"10.3892\/ol.2023.13693","volume":"25","author":"Z Hu","year":"2023","unstructured":"Hu Z, Liu Y, Liu M, Zhang Y, Wang C (2023) Roles of TGF-\u03b2 signalling pathway-related lncRNAs in cancer. Oncol Lett 25(3):107","journal-title":"Oncol Lett"},{"issue":"1","key":"753_CR50","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1186\/s12964-025-02356-z","volume":"23","author":"Q Hu","year":"2025","unstructured":"Hu Q, Chen Q, Yang W, Ren A, Tan J, Huang T (2025) GPX3 promotes cisplatin resistance in TNBC by manipulating ROS-TGFB1-ZEB2. Cell Commun Signal 23(1):355. https:\/\/doi.org\/10.1186\/s12964-025-02356-z","journal-title":"Cell Commun Signal"},{"issue":"4","key":"753_CR51","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1007\/s12031-016-0775-y","volume":"59","author":"D Huang","year":"2016","unstructured":"Huang D, Zhao Q, Liu H, Guo Y, Xu H (2016) PPAR-\u03b1 agonist WY-14643 inhibits LPS-induced inflammation in synovial fibroblasts via NF-kB pathway. J Mol Neurosci 59(4):544\u2013553","journal-title":"J Mol Neurosci"},{"issue":"4","key":"753_CR52","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1002\/mnfr.201000292","volume":"55","author":"YP Hwang","year":"2011","unstructured":"Hwang YP, Yun HJ, Choi JH, Han EH, Kim HG, Song GY et al (2011) Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK\/Akt, PKC\/Raf\/ERK, p38 MAPK, and AP-1 signaling. Mol Nutr Food Res 55(4):594\u2013605. https:\/\/doi.org\/10.1002\/mnfr.201000292","journal-title":"Mol Nutr Food Res"},{"key":"753_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4137\/sti.S30306","volume":"4","author":"K Inoue","year":"2015","unstructured":"Inoue K, Fry EA (2015) Aberrant expression of cyclin D1 in cancer. Sign Transduct Insights 4:1\u201313. https:\/\/doi.org\/10.4137\/sti.S30306","journal-title":"Sign Transduct Insights"},{"key":"753_CR54","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/978-981-15-2361-8_14","volume-title":"Plant-derived bioactives: chemistry and mode of action","author":"R Jaganathan","year":"2020","unstructured":"Jaganathan R, Purushotham B, Radhakrishnan N, Swamy MK (2020) Capsaicin and its potential anticancer mechanisms of action. Plant-derived bioactives: chemistry and mode of action. Springer, pp 301\u2013321"},{"key":"753_CR55","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.895729","author":"SA Jeffreys","year":"2022","unstructured":"Jeffreys SA, Becker TM, Khan S, Soon P, Neubauer H, de Souza P et al (2022) Prognostic and predictive value of CCND1\/cyclin D1 amplification in breast cancer with a focus on postmenopausal patients: a systematic review and meta-analysis. Front Endocrinol. https:\/\/doi.org\/10.3389\/fendo.2022.895729","journal-title":"Front Endocrinol"},{"key":"753_CR56","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02150-4","author":"JH Kang","year":"2024","unstructured":"Kang JH, Uddin N, Kim S, Zhao Y, Yoo KC, Kim MJ et al (2024) Tumor-intrinsic role of ICAM-1 in driving metastatic progression of triple-negative breast cancer through direct interaction with EGFR. Mol Cancer. https:\/\/doi.org\/10.1186\/s12943-024-02150-4","journal-title":"Mol Cancer"},{"key":"753_CR57","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.biochi.2016.12.019","volume":"136","author":"S Kersten","year":"2017","unstructured":"Kersten S, Stienstra R (2017) The role and regulation of the peroxisome proliferator activated receptor alpha in human liver. Biochimie 136:75\u201384","journal-title":"Biochimie"},{"issue":"D1","key":"753_CR58","doi-asserted-by":"publisher","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","volume":"51","author":"S Kim","year":"2023","unstructured":"Kim S, Chen J, Cheng T, Gindulyte A, He J, He S et al (2023) PubChem 2023 update. Nucleic Acids Res 51(D1):D1373\u2013D1380","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"753_CR59","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/s41591-025-03502-3","volume":"31","author":"J Kim","year":"2025","unstructured":"Kim J, Harper A, McCormack V, Sung H, Houssami N, Morgan E et al (2025) Global patterns and trends in breast cancer incidence and mortality across 185 countries. Nat Med 31(4):1154\u20131162. https:\/\/doi.org\/10.1038\/s41591-025-03502-3","journal-title":"Nat Med"},{"issue":"1","key":"753_CR60","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.pharmthera.2011.03.012","volume":"131","author":"AK Larsen","year":"2011","unstructured":"Larsen AK, Ouaret D, El Ouadrani K, Petitprez A (2011) Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis. Pharmacol Ther 131(1):80\u201390. https:\/\/doi.org\/10.1016\/j.pharmthera.2011.03.012","journal-title":"Pharmacol Ther"},{"key":"753_CR61","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0132-3","author":"P Lavaud","year":"2014","unstructured":"Lavaud P, Andre F (2014) Strategies to overcome trastuzumab resistance in HER2-overexpressing breast cancers: Focus on new data from clinical trials. BMC Med. https:\/\/doi.org\/10.1186\/s12916-014-0132-3","journal-title":"BMC Med"},{"issue":"1","key":"753_CR62","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2022.5461","volume":"62","author":"Y-J Lee","year":"2023","unstructured":"Lee Y-J, Jung E, Choi J, Hwang J-S, Jeong E-J, Roh Y et al (2023) The EDN1\/EDNRA\/\u03b2\u2011arrestin axis promotes colorectal cancer progression by regulating STAT3 phosphorylation. Int J Oncol 62(1):13. https:\/\/doi.org\/10.3892\/ijo.2022.5461","journal-title":"Int J Oncol"},{"issue":"1","key":"753_CR63","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12935-024-03485-0","volume":"24","author":"Z Li","year":"2024","unstructured":"Li Z, Zhao Q, Liu X, Zhou X, Wang Y, Zhao M et al (2024) Capsaicin combined with cisplatin inhibits TGF-\u03b21-induced EMT and TSCC cells migration via the Claudin-1\/PI3K\/AKT\/mTOR signaling pathway. Cancer Cell Int 24(1):300. https:\/\/doi.org\/10.1186\/s12935-024-03485-0","journal-title":"Cancer Cell Int"},{"issue":"7","key":"753_CR64","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.3390\/ijms18071343","volume":"18","author":"Y-T Lin","year":"2017","unstructured":"Lin Y-T, Wang H-C, Hsu Y-C, Cho C-L, Yang M-Y, Chien C-Y (2017) Capsaicin induces autophagy and apoptosis in human nasopharyngeal carcinoma cells by downregulating the PI3K\/AKT\/mTOR pathway. Int J Mol Sci 18(7):1343","journal-title":"Int J Mol Sci"},{"issue":"5","key":"753_CR65","doi-asserted-by":"publisher","first-page":"110914","DOI":"10.1016\/j.ygeno.2024.110914","volume":"116","author":"X Lin","year":"2024","unstructured":"Lin X, Zhao R, Bin Y, Huo R, Xue G, Wu J (2024) TIMP1 promotes thyroid cancer cell progression through macrophage phenotypic polarization via the PI3K\/AKT signaling pathway. Genomics 116(5):110914. https:\/\/doi.org\/10.1016\/j.ygeno.2024.110914","journal-title":"Genomics"},{"key":"753_CR66","doi-asserted-by":"publisher","first-page":"114095","DOI":"10.1016\/j.bcp.2020.114095","volume":"178","author":"B Liu","year":"2020","unstructured":"Liu B, Chen D, Chen S, Saber A, Haisma H (2020) Transcriptional activation of cyclin D1 via HER2\/HER3 contributes to EGFR-TKI resistance in lung cancer. Biochem Pharmacol 178:114095","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"753_CR67","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1186\/s12879-024-10000-3","volume":"24","author":"Z Liu","year":"2024","unstructured":"Liu Z, Petinrin OO, Chen N, Toseef M, Liu F, Zhu Z et al (2024) Identification and evaluation of candidate COVID-19 critical genes and medicinal drugs related to plasma cells. BMC Infect Dis 24(1):1099. https:\/\/doi.org\/10.1186\/s12879-024-10000-3","journal-title":"BMC Infect Dis"},{"issue":"4","key":"753_CR68","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1007\/s00335-025-10166-4","volume":"36","author":"Z Liu","year":"2025","unstructured":"Liu Z, Liu F, Yao Z, Long Y, Chen N, Yu J et al (2025) Multi-omics dissection of RAD21-PON1 axis reveals metabolic-immune crosstalk and prognostic significance in hepatocellular carcinoma. Mamm Genome 36(4):1291\u20131315. https:\/\/doi.org\/10.1007\/s00335-025-10166-4","journal-title":"Mamm Genome"},{"issue":"11","key":"753_CR69","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1093\/jnci\/djad142","volume":"115","author":"K Lu","year":"2023","unstructured":"Lu K, Wang HC, Tu YC, Chang CC, Lou PJ, Chang TC et al (2023) Suppressing c-FOS expression by G-quadruplex ligands inhibits osimertinib-resistant non-small cell lung cancer. J Natl Cancer Inst 115(11):1383\u20131391. https:\/\/doi.org\/10.1093\/jnci\/djad142","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"753_CR70","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s13058-022-01596-y","volume":"24","author":"J Luo","year":"2022","unstructured":"Luo J, Zou H, Guo Y, Tong T, Ye L, Zhu C et al (2022) SRC kinase-mediated signaling pathways and targeted therapies in breast cancer. Breast Cancer Res 24(1):99","journal-title":"Breast Cancer Res"},{"issue":"14","key":"753_CR71","doi-asserted-by":"publisher","first-page":"3540","DOI":"10.3390\/cancers13143540","volume":"13","author":"H Maadi","year":"2021","unstructured":"Maadi H, Soheilifar MH, Choi W-S, Moshtaghian A, Wang Z (2021) Trastuzumab mechanism of action; 20 years of research to unravel a dilemma. Cancers (Basel) 13(14):3540","journal-title":"Cancers (Basel)"},{"key":"753_CR72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055997","author":"JJ Mansure","year":"2013","unstructured":"Mansure JJ, Nassim R, Chevalier S, Szymanski K, Rocha J, Aldousari S et al (2013) A novel mechanism of PPAR gamma induction via EGFR signalling constitutes rational for combination therapy in bladder cancer. PLoS ONE. https:\/\/doi.org\/10.1371\/journal.pone.0055997","journal-title":"PLoS ONE"},{"issue":"6","key":"753_CR73","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.3390\/cancers12061448","volume":"12","author":"S Martellucci","year":"2020","unstructured":"Martellucci S, Clementi L, Sabetta S, Mattei V, Botta L, Angelucci A (2020) Src family kinases as therapeutic targets in advanced solid tumors: what we have learned so far. Cancers 12(6):1448","journal-title":"Cancers"},{"key":"753_CR74","first-page":"1","volume-title":"Encyclopedia of signaling molecules","author":"S Mukhopadhyay","year":"2016","unstructured":"Mukhopadhyay S, Khaket TP, Mukherjee TK (2016) Intercellular adhesion molecule 1. Encyclopedia of signaling molecules. Springer, pp 1\u20137"},{"issue":"1","key":"753_CR75","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.mehy.2007.01.092","volume":"70","author":"S Namazi","year":"2008","unstructured":"Namazi S, Rouhani Fard SA, Abedtash H (2008) Role of endothelin-1 in tamoxifen resistance: mechanism for a new possible treatment strategy in breast cancer. Med Hypotheses 70(1):109\u2013111. https:\/\/doi.org\/10.1016\/j.mehy.2007.01.092","journal-title":"Med Hypotheses"},{"issue":"6","key":"753_CR76","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1158\/0008-5472.CAN-08-1056","volume":"69","author":"M Narayan","year":"2009","unstructured":"Narayan M, Wilken JA, Harris LN, Baron AT, Kimbler KD, Maihle NJ (2009) Trastuzumab-induced HER reprogramming in \u201cresistant\u201d breast carcinoma cells. Cancer Res 69(6):2191\u20132194. https:\/\/doi.org\/10.1158\/0008-5472.CAN-08-1056","journal-title":"Cancer Res"},{"issue":"3 Suppl 11","key":"753_CR77","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1053\/sonc.2002.34053","volume":"29","author":"MD Pegram","year":"2002","unstructured":"Pegram MD, Reese DM (2002) Combined biological therapy of breast cancer using monoclonal antibodies directed against HER2\/ protein and vascular endothelial growth factor. Semin Oncol 29(3 Suppl 11):29\u201337. https:\/\/doi.org\/10.1053\/sonc.2002.34053","journal-title":"Semin Oncol"},{"issue":"4","key":"753_CR78","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1634\/theoncologist.2008-0276","volume":"14","author":"NA Pennell","year":"2009","unstructured":"Pennell NA, Lynch TJ Jr. (2009) Combined inhibition of the VEGFR and EGFR signaling pathways in the treatment of NSCLC. Oncologist 14(4):399\u2013411. https:\/\/doi.org\/10.1634\/theoncologist.2008-0276","journal-title":"Oncologist"},{"issue":"4","key":"753_CR79","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S1470-2045(12)70049-9","volume":"13","author":"J-Y Pierga","year":"2012","unstructured":"Pierga J-Y, Petit T, Delozier T, Ferrero J-M, Campone M, Gligorov J et al (2012) Neoadjuvant bevacizumab, trastuzumab, and chemotherapy for primary inflammatory HER2-positive breast cancer (BEVERLY-2): an open-label, single-arm phase 2 study. Lancet Oncol 13(4):375\u2013384. https:\/\/doi.org\/10.1016\/S1470-2045(12)70049-9","journal-title":"Lancet Oncol"},{"issue":"1","key":"753_CR80","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3390\/molecules26010094","volume":"26","author":"GDA Popescu","year":"2020","unstructured":"Popescu GDA, Scheau C, Badarau IA, Dumitrache M-D, Caruntu A, Scheau A-E et al (2020) The effects of capsaicin on gastrointestinal cancers. Molecules 26(1):94","journal-title":"Molecules"},{"issue":"19","key":"753_CR81","doi-asserted-by":"publisher","first-page":"4224","DOI":"10.1158\/0008-5472.CAN-20-0141","volume":"80","author":"I Pulido","year":"2020","unstructured":"Pulido I, Ollosi S, Aparisi S, Becker JH, Aliena-Valero A, Benet M et al (2020) Endothelin-1-mediated drug resistance in EGFR-mutant non-small cell lung carcinoma. Cancer Res 80(19):4224\u20134232. https:\/\/doi.org\/10.1158\/0008-5472.CAN-20-0141","journal-title":"Cancer Res"},{"issue":"14","key":"753_CR82","doi-asserted-by":"publisher","first-page":"16019","DOI":"10.1021\/acsami.0c23137","volume":"13","author":"C Qi","year":"2021","unstructured":"Qi C, Wang D, Gong X, Zhou Q, Yue X, Li C et al (2021) Co-delivery of curcumin and capsaicin by dual-targeting liposomes for inhibition of aHSC-induced drug resistance and metastasis. ACS Appl Mater Interfaces 13(14):16019\u201316035. https:\/\/doi.org\/10.1021\/acsami.0c23137","journal-title":"ACS Appl Mater Interfaces"},{"key":"753_CR83","doi-asserted-by":"publisher","first-page":"114420","DOI":"10.1016\/j.biopha.2023.114420","volume":"161","author":"Z Qian","year":"2023","unstructured":"Qian Z, Chen L, Liu J, Jiang Y, Zhang Y (2023) The emerging role of PPAR-alpha in breast cancer. Biomed Pharmacother 161:114420. https:\/\/doi.org\/10.1016\/j.biopha.2023.114420","journal-title":"Biomed Pharmacother"},{"key":"753_CR84","doi-asserted-by":"publisher","first-page":"544","DOI":"10.3389\/fonc.2019.00544","volume":"9","author":"AC Racca","year":"2019","unstructured":"Racca AC, Prucca CG, Caputto BL (2019) Fra-1 and c-Fos N-terminal deletion mutants impair breast tumor cell proliferation by blocking lipid synthesis activation. Front Oncol 9:544","journal-title":"Front Oncol"},{"issue":"3","key":"753_CR85","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s10549-021-06342-0","volume":"189","author":"S Reid","year":"2021","unstructured":"Reid S, Haddad D, Tezak A, Weidner A, Wang X, Mautz B et al (2021) Impact of molecular subtype and race on HR+, HER2\u2212 breast cancer survival. Breast Cancer Res Treat 189(3):845\u2013852","journal-title":"Breast Cancer Res Treat"},{"issue":"16","key":"753_CR86","doi-asserted-by":"publisher","first-page":"4909","DOI":"10.1158\/1078-0432.CCR-07-0701","volume":"13","author":"CA Ritter","year":"2007","unstructured":"Ritter CA, Perez-Torres M, Rinehart C, Guix M, Dugger T, Engelman JA et al (2007) Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network. Clin Cancer Res 13(16):4909\u20134919. https:\/\/doi.org\/10.1158\/1078-0432.CCR-07-0701","journal-title":"Clin Cancer Res"},{"issue":"24","key":"753_CR87","doi-asserted-by":"publisher","first-page":"7453","DOI":"10.1158\/0008-5472.CAN-13-3133","volume":"74","author":"L Rosan\u00f2","year":"2014","unstructured":"Rosan\u00f2 L, Cianfrocca R, Tocci P, Spinella F, Di Castro V, Caprara V et al (2014) Endothelin a receptor\/\u03b2-arrestin signaling to the Wnt pathway renders ovarian cancer cells resistant to chemotherapy. Cancer Res 74(24):7453\u20137464. https:\/\/doi.org\/10.1158\/0008-5472.CAN-13-3133","journal-title":"Cancer Res"},{"issue":"11","key":"753_CR88","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1158\/1535-7163.MCT-19-0455","volume":"18","author":"A Sampera","year":"2019","unstructured":"Sampera A, S\u00e1nchez-Mart\u00edn FJ, Arp\u00ed O, Visa L, Iglesias M, Men\u00e9ndez S et al (2019) HER-family ligands promote acquired resistance to trastuzumab in gastric cancer. Mol Cancer Ther 18(11):2135\u20132145. https:\/\/doi.org\/10.1158\/1535-7163.MCT-19-0455","journal-title":"Mol Cancer Ther"},{"issue":"3","key":"753_CR89","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.3390\/ijms24032026","volume":"24","author":"C Sarkar","year":"2023","unstructured":"Sarkar C, Das B, Rawat VS, Wahlang JB, Nongpiur A, Tiewsoh I et al (2023) Artificial intelligence and machine learning technology driven modern drug discovery and development. Int J Mol Sci 24(3):2026","journal-title":"Int J Mol Sci"},{"issue":"11","key":"753_CR90","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13(11):2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303","journal-title":"Genome Res"},{"issue":"2 Pt 2","key":"753_CR91","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.gene.2015.09.019","volume":"575","author":"EA Sharieh","year":"2016","unstructured":"Sharieh EA, Awidi AS, Ahram M, Zihlif MA (2016) Alteration of gene expression in MDA-MB-453 breast cancer cell line in response to continuous exposure to Trastuzumab. Gene 575(2 Pt 2):415\u2013420. https:\/\/doi.org\/10.1016\/j.gene.2015.09.019","journal-title":"Gene"},{"issue":"12","key":"753_CR92","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1177\/1947601911423031","volume":"2","author":"M Shibuya","year":"2011","unstructured":"Shibuya M (2011) Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti-and pro-angiogenic therapies. Genes Cancer 2(12):1097\u20131105","journal-title":"Genes Cancer"},{"issue":"5","key":"753_CR93","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.3892\/or.2017.5998","volume":"38","author":"F Su","year":"2017","unstructured":"Su F, Geng J, Li X, Qiao C, Luo L, Feng J et al (2017) SP1 promotes tumor angiogenesis and invasion by activating VEGF expression in an acquired trastuzumab\u2011resistant ovarian cancer model. Oncol Rep 38(5):2677\u20132684. https:\/\/doi.org\/10.3892\/or.2017.5998","journal-title":"Oncol Rep"},{"issue":"10","key":"753_CR94","doi-asserted-by":"publisher","first-page":"7659","DOI":"10.1007\/s00210-024-03092-w","volume":"397","author":"H Sun","year":"2024","unstructured":"Sun H, Wang Z, Tu B, Shao Z, Li Y, Han D et al (2024) Capsaicin reduces blood glucose and prevents prostate growth by regulating androgen, RAGE\/IGF-1\/Akt, TGF-\u03b2\/Smad signalling pathway and reversing epithelial-mesenchymal transition in streptozotocin-induced diabetic mice. Naunyn Schmiedebergs Arch Pharmacol 397(10):7659\u20137671. https:\/\/doi.org\/10.1007\/s00210-024-03092-w","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"753_CR95","doi-asserted-by":"publisher","unstructured":"Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, et al (2015) STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res 43(Database issue):D447\u201352 https:\/\/doi.org\/10.1093\/nar\/gku1003","DOI":"10.1093\/nar\/gku1003"},{"issue":"13-14","key":"753_CR96","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1016\/j.clinbiochem.2009.06.022","volume":"42","author":"FM Taha","year":"2009","unstructured":"Taha FM, Zeeneldin AA, Helal AM, Gaber AA, Sallam YA, Ramadan H et al (2009) Prognostic value of serum vascular endothelial growth factor in Egyptian females with metastatic triple negative breast cancer. Clin Biochem 42(13\u201314):1420\u20131426. https:\/\/doi.org\/10.1016\/j.clinbiochem.2009.06.022","journal-title":"Clin Biochem"},{"issue":"17","key":"753_CR97","doi-asserted-by":"publisher","first-page":"e70045","DOI":"10.1096\/fj.202401427R","volume":"38","author":"Z Tang","year":"2024","unstructured":"Tang Z, Zhang D, Yao C, Jiang M, Wang C, Chen Z et al (2024) TIPE2 inhibits the migration and invasion of epithelial ovarian cancer cells by targeting Smad2 to reverse TGF-\u03b21-induced EMT. FASEB J 38(17):e70045. https:\/\/doi.org\/10.1096\/fj.202401427R","journal-title":"FASEB J"},{"issue":"2","key":"753_CR98","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1080\/15384101.2019.1706903","volume":"19","author":"G Tchakarska","year":"2020","unstructured":"Tchakarska G, Sola B (2020) The double dealing of cyclin D1. Cell Cycle 19(2):163\u2013178","journal-title":"Cell Cycle"},{"issue":"2","key":"753_CR99","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/onc.2009.335","volume":"29","author":"NH Thoennissen","year":"2010","unstructured":"Thoennissen NH, O\u2019Kelly J, Lu D, Iwanski GB, La DT, Abbassi S et al (2010) Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and-negative breast cancer cells by modulating the EGFR\/HER-2 pathway. Oncogene 29(2):285\u2013296. https:\/\/doi.org\/10.1038\/onc.2009.335","journal-title":"Oncogene"},{"key":"753_CR100","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25168865","author":"JM Tinajero-Rodr\u00edguez","year":"2024","unstructured":"Tinajero-Rodr\u00edguez JM, Ram\u00edrez-Vidal L, Becerril-Rico J, Alvarado-Ortiz E, Romero-Rodr\u00edguez DP, L\u00f3pez-Casillas F et al (2024) ICAM1 (CD54) contributes to the metastatic capacity of gastric cancer stem cells. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25168865","journal-title":"Int J Mol Sci"},{"issue":"1","key":"753_CR101","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12929-025-01119-9","volume":"32","author":"C Tito","year":"2025","unstructured":"Tito C, Masciarelli S, Colotti G, Fazi F (2025) EGF receptor in organ development, tissue homeostasis and regeneration. J Biomed Sci 32(1):24. https:\/\/doi.org\/10.1186\/s12929-025-01119-9","journal-title":"J Biomed Sci"},{"issue":"5","key":"753_CR102","first-page":"531","volume":"24","author":"E Vairaktaris","year":"2009","unstructured":"Vairaktaris E, Goutzanis L, Yapijakis C, Vassiliou S, Spyridonidou S, Vylliotis A et al (2009) Diabetes enhances the expression of H-ras and suppresses the expression of EGFR leading to increased cell proliferation. Histol Histopathol 24(5):531\u2013539","journal-title":"Histol Histopathol"},{"issue":"W1","key":"753_CR103","doi-asserted-by":"publisher","first-page":"W130","DOI":"10.1093\/nar\/gkx356","volume":"45","author":"J Wang","year":"2017","unstructured":"Wang J, Vasaikar S, Shi Z, Greer M, Zhang B (2017a) WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit. Nucleic Acids Res 45(W1):W130\u2013W137. https:\/\/doi.org\/10.1093\/nar\/gkx356","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"753_CR104","doi-asserted-by":"publisher","first-page":"e0180558","DOI":"10.1371\/journal.pone.0180558","volume":"12","author":"Q Wang","year":"2017","unstructured":"Wang Q, Liu H, Wang Q, Zhou F, Liu Y, Zhang Y et al (2017b) Involvement of c-Fos in cell proliferation, migration, and invasion in osteosarcoma cells accompanied by altered expression of Wnt2 and Fzd9. PLoS ONE 12(6):e0180558","journal-title":"PLoS ONE"},{"issue":"12","key":"753_CR105","doi-asserted-by":"publisher","first-page":"3949","DOI":"10.31557\/apjcp.2021.22.12.3949","volume":"22","author":"MA Wibowo","year":"2021","unstructured":"Wibowo MA, Nugroho EP, Hermawan A (2021) Genomic understanding reveals the important role of FGFR2 as paeoniflorin target for circumventing breast cancer resistance to tamoxifen. Asian Pac J Cancer Prev 22(12):3949\u20133958. https:\/\/doi.org\/10.31557\/apjcp.2021.22.12.3949","journal-title":"Asian Pac J Cancer Prev"},{"issue":"13","key":"753_CR106","doi-asserted-by":"publisher","first-page":"5475","DOI":"10.1158\/0008-5472.CAN-10-0176","volume":"70","author":"Y Wu","year":"2010","unstructured":"Wu Y, Shang X, Sarkissyan M, Slamon D, Vadgama JV (2010) FOXO1A is a target for HER2-overexpressing breast tumors. Cancer Res 70(13):5475\u20135485. https:\/\/doi.org\/10.1158\/0008-5472.CAN-10-0176","journal-title":"Cancer Res"},{"issue":"2","key":"753_CR107","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.ceca.2014.04.006","volume":"56","author":"TTL Wu","year":"2014","unstructured":"Wu TTL, Peters AA, Tan PT, Roberts-Thomson SJ, Monteith GR (2014) Consequences of activating the calcium-permeable ion channel TRPV1 in breast cancer cells with regulated TRPV1 expression. Cell Calcium 56(2):59\u201367. https:\/\/doi.org\/10.1016\/j.ceca.2014.04.006","journal-title":"Cell Calcium"},{"key":"753_CR108","doi-asserted-by":"publisher","first-page":"2577","DOI":"10.2147\/OTT.S82225","volume":"8","author":"Y Wu","year":"2015","unstructured":"Wu Y, Li R, Zhang J, Wang G, Liu B, Huang X et al (2015) Protein tyrosine phosphatase SHP-1 sensitizes EGFR\/HER-2 positive breast cancer cells to trastuzumab through modulating phosphorylation of EGFR and HER-2. Onco Targets Ther 8:2577\u20132587. https:\/\/doi.org\/10.2147\/OTT.S82225","journal-title":"Onco Targets Ther"},{"issue":"6","key":"753_CR109","doi-asserted-by":"publisher","first-page":"4868","DOI":"10.3892\/mmr.2020.11585","volume":"22","author":"D Wu","year":"2020","unstructured":"Wu D, Jia H, Zhang Z, Li S (2020) Capsaicin suppresses breast cancer cell viability by regulating the CDK8\/PI3K\/Akt\/Wnt\/\u03b2\u2011catenin signaling pathway. Mol Med Rep 22(6):4868\u20134876","journal-title":"Mol Med Rep"},{"issue":"6","key":"753_CR110","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.7150\/ijbs.99275","volume":"21","author":"M Xiong","year":"2025","unstructured":"Xiong M, Liu D, Wang X, Ren H, Chi W, Xiu B et al (2025) PPARG activation of fatty acid metabolism drives resistance to anti-HER2 therapies in HER2-positive breast cancer. Int J Biol Sci 21(6):2396\u20132414. https:\/\/doi.org\/10.7150\/ijbs.99275","journal-title":"Int J Biol Sci"},{"issue":"2","key":"753_CR111","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S1875-5364(25)60823-5","volume":"23","author":"Z Yang","year":"2025","unstructured":"Yang Z, Guo H, Zhang P, Liu K, Ba J, Bai X et al (2025) Capsaicin (CAP) exerts a protective effect against ethanol-induced oxidative gastric mucosal injury by modulating the chemokine receptor 4 (CCR4)\/Src\/p47phox signaling pathway both in vitro and in vivo. Chin J Nat Med 23(2):191\u2013202. https:\/\/doi.org\/10.1016\/S1875-5364(25)60823-5","journal-title":"Chin J Nat Med"},{"key":"753_CR112","doi-asserted-by":"publisher","unstructured":"Yu H, Chen J, Wang F, Jia D, Bi S, Mao Y, et al (2025) Capsaicin alleviates autophagy-lysosomal dysfunction via PPARA-mediated V-ATPase subunit ATP6V0E1 signaling in 3xTg-AD mice. Adv Sci (Weinh) e02707):e02707 https:\/\/doi.org\/10.1002\/advs.202502707","DOI":"10.1002\/advs.202502707"},{"issue":"D1","key":"753_CR113","doi-asserted-by":"publisher","first-page":"D1180","DOI":"10.1093\/nar\/gkad1004","volume":"52","author":"B Zdrazil","year":"2023","unstructured":"Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S et al (2023) The ChEMBL database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res 52(D1):D1180\u2013D1192. https:\/\/doi.org\/10.1093\/nar\/gkad1004","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"753_CR114","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nm.2309","volume":"17","author":"S Zhang","year":"2011","unstructured":"Zhang S, Huang W-C, Li P, Guo H, Poh S-B, Brady SW et al (2011) Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med 17(4):461\u2013469. https:\/\/doi.org\/10.1038\/nm.2309","journal-title":"Nat Med"},{"issue":"1","key":"753_CR115","first-page":"97","volume":"6","author":"N Zhang","year":"2016","unstructured":"Zhang N, Fu JN, Chou TC (2016) Synergistic combination of microtubule targeting anticancer fludelone with cytoprotective panaxytriol derived from panax ginseng against MX-1 cells in vitro: experimental design and data analysis using the combination index method. Am J Cancer Res 6(1):97\u2013104","journal-title":"Am J Cancer Res"}],"container-title":["In Silico Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40203-026-00753-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40203-026-00753-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40203-026-00753-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:23:07Z","timestamp":1790824987000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40203-026-00753-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":115,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["753"],"URL":"https:\/\/doi.org\/10.1007\/s40203-026-00753-x","relation":{},"ISSN":["2193-9616"],"issn-type":[{"value":"2193-9616","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"4 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no conflict of interest.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable. This research does not involving human participants and\/or animals.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"253"}}