{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T16:29:12Z","timestamp":1744648152836,"version":"3.37.3"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T00:00:00Z","timestamp":1576022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005788","name":"Medical University of Vienna","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005788","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychiatr"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Obsessive\u2013compulsive disorder (OCD) is characterized by repetitive, persistent and unwanted thoughts and ritualistic, repetitive behaviors. The pathophysiology of OCD involves many distinct cortical and subcortical regions and it has been reported that OCD may occur as a\u00a0consequence of traumatic brain injury, infections and tumors as well as cerebrovascular insult such as cerebral venous sinus thrombosis (CVST). We here describe the case of a\u00a036-year-old woman who developed OCD at the age of 13\u00a0with almost complete remission of the symptoms after a\u00a01 year-long treatment. Interestingly, after suffering CVST at the superior sagittal sinus at the age of\u00a033, she experienced a\u00a0relapse of OCD. The patient was successfully treated with Sertraline and Clomipramine. Previous studies revealed cases of OCD following different cerebrovascular accidents, i.e. predominantly arterial stroke. However, the present case is the first to describe OCD after venous thrombosis. Based on our clinical experience, the most effective treatment of OCD after CVST represents the combination of the selective serotonin reuptake inhibitor Sertraline and the tricyclic antidepressant Clomipramine.<\/jats:p>","DOI":"10.1007\/s40211-019-00327-8","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T14:06:52Z","timestamp":1576073212000},"page":"27-29","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relapse of obsessive\u2013compulsive disorder after cerebral venous sinus thrombosis: a case report","Rezidiv einer Zwangsst\u00f6rung nach zerebraler Sinusvenenthrombose: eine Kasuistik"],"prefix":"10.1007","volume":"34","author":[{"given":"Vid","family":"Veliki\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Wippel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion","family":"Freidl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,12,11]]},"reference":[{"issue":"3","key":"327_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.psc.2014.06.004","volume":"37","author":"WK Goodman","year":"2014","unstructured":"Goodman\u00a0WK, Grice\u00a0DE, Lapidus\u00a0KA, Coffey\u00a0BJ. Obsessive-compulsive disorder. Psychiatr Clin North Am. 2014;37(3):257\u201367.","journal-title":"Psychiatr Clin North Am"},{"key":"327_CR2","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1176\/appi.focus.130219","volume":"13","author":"BO Olatunji","year":"2015","unstructured":"Olatunji\u00a0BO, Davis\u00a0ML, Powers\u00a0MB, Smits\u00a0JA. Cognitive-behavioral therapy for obsessive-compulsive disorder: a meta-analysis of treatment outcome and moderators. Focus. 2015;13:222\u201331.","journal-title":"Focus"},{"key":"327_CR3","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","volume":"46","author":"WK Goodman","year":"1989","unstructured":"Goodman\u00a0WK. The yale-brown obsessive compulsive scale. Arch Gen Psychiatry. 1989;46:1006\u201311.","journal-title":"Arch Gen Psychiatry"},{"issue":"3","key":"327_CR4","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00115-010-2963-2","volume":"82","author":"A Kordon","year":"2011","unstructured":"Kordon\u00a0A, Zurowski\u00a0B, Wahl\u00a0K, Hohagen\u00a0F. Evidence-based pharmacotherapy and other somatic treatment approaches for obsessive-compulsive disorder: state of the art. Nervenarzt. 2011;82(3):319\u201320.","journal-title":"Nervenarzt"},{"key":"327_CR5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jagp.2015.06.003","volume":"24","author":"TB Cumming","year":"2016","unstructured":"Cumming\u00a0TB, Blomstrand\u00a0C, Skoog\u00a0I, Linden\u00a0T. The high prevalence of anxiety disorders after stroke. Am J Geriatr Psychiatry. 2016;24:154\u201360.","journal-title":"Am J Geriatr Psychiatry"},{"key":"327_CR6","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1056\/NEJM200507213530319","volume":"353","author":"J Stam","year":"2005","unstructured":"Stam\u00a0J. Thrombosis of the cerebral veins and sinuses. N\u00a0Engl J Med. 2005;353:314\u20135.","journal-title":"N Engl J Med"},{"key":"327_CR7","doi-asserted-by":"publisher","first-page":"698","DOI":"10.5535\/arm.2014.38.5.698","volume":"38","author":"Y Choe","year":"2014","unstructured":"Choe\u00a0Y, Lee\u00a0J\u2011B, Kim\u00a0Y\u2011J, Choi\u00a0I\u2011S. Cerebral venous sinus thrombosis and venous hemorrhagic infarction in a\u00a0young woman. Ann Rehabil Med. 2014;38:698\u2013701.","journal-title":"Ann Rehabil Med"},{"key":"327_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.12.034","author":"R Akaho","year":"2019","unstructured":"Akaho\u00a0R, Deguchi\u00a0I, Kigawa\u00a0H, Nishimura\u00a0K. Obsessive-compulsive disorder following cerebrovascular accident: a case report and literature review. J\u00a0Stroke Cerebrovasc Dis. 2019; https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2018.12.034.","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"327_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.4088\/JCP.v67n0214","volume":"67","author":"HB Simpson","year":"2006","unstructured":"Simpson\u00a0HB, Huppert\u00a0JD, Petkova\u00a0E, Foa\u00a0EB, Liebowitz\u00a0MR. Response versus remission in obsessive- compulsive disorder. J\u00a0Clin Psychiatry. 2006;67:269\u201376.","journal-title":"J Clin Psychiatry"},{"key":"327_CR10","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11920-012-0268-9","volume":"14","author":"DJ Stein","year":"2012","unstructured":"Stein\u00a0DJ, Koen\u00a0N, Fineberg\u00a0N, Fontenelle\u00a0LF, Matsunaga\u00a0H, Osser\u00a0D, et al. A 2012 evidence-based algorithm for the pharmacotherapy for obsessive-compulsive disorder. Curr Psychiatry Rep. 2012;14:211\u20139.","journal-title":"Curr Psychiatry Rep"}],"container-title":["neuropsychiatrie"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40211-019-00327-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40211-019-00327-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40211-019-00327-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T01:24:37Z","timestamp":1607563477000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40211-019-00327-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,11]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["327"],"URL":"https:\/\/doi.org\/10.1007\/s40211-019-00327-8","relation":{},"ISSN":["0948-6259","2194-1327"],"issn-type":[{"type":"print","value":"0948-6259"},{"type":"electronic","value":"2194-1327"}],"subject":[],"published":{"date-parts":[[2019,12,11]]},"assertion":[{"value":"24 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical guidelines"}},{"value":"V.\u00a0Veliki\u0107, A.\u00a0Wippel, and M.\u00a0Freidl declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"For this work no experiments on human or animals were conducted and this publication was authored according Good Scientific Practice ethics in science and research guidelines of the Medical University of Vienna. Written permission for publication of this case report was obtained from the patient. A copy of the written consent is available for review by the editor of this journal.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}