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Neurobiologische Befunde unterlegen eine Beziehung zwischen insomnischen Symptomen und Suizidalit\u00e4t, u.\u202fa. durch eine serotonerge Dysfunktion sowie eine besonders beeintr\u00e4chtigte circadiane Rhythmik mit konsekutiver Hypofrontalit\u00e4t, beeintr\u00e4chtigter Probleml\u00f6sef\u00e4higkeit und verminderter Impulskontrolle. Im Rahmen der Suizidpr\u00e4vention muss bei Patienten mit kombinierten insomnischen und depressiven Symptomen nachdr\u00fccklich nach weiteren Risikofaktoren f\u00fcr Suizidalit\u00e4t gesucht werden, u.\u202fa. soziale Isolation, n\u00e4chtliche Gr\u00fcbelneigung, komorbide psychische Erkrankungen, Zugang zu potenziell toxischen Pharmaka oder Waffen.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Schlussfolgerung<\/jats:title>\n                <jats:p>Besonders bei Patienten mit weiteren Suizid-Risikofaktoren m\u00fcssen insomnische Symptome fr\u00fchzeitig konsequent behandelt werden. In der Pharmakotherapie sind f\u00fcr Patienten mit insomnischen Symptomen und Suizidalit\u00e4t schlaff\u00f6rdernde Antidepressiva mit niedriger Toxizit\u00e4t und Antipsychotika vorzuziehen. Eine an den circadianen Rhythmus angepasste multimodale antiinsomnische und antidepressive Therapie k\u00f6nnte die Zusammenh\u00e4nge zwischen depressiv-suizidalen und insomnischen Symptomen g\u00fcnstig beeinflussen.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s40211-023-00466-z","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T13:03:25Z","timestamp":1683896605000},"page":"53-61","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Insomnische Symptome und Suizidalit\u00e4t\u00a0\u2013 Zusammenh\u00e4nge und Management","Insomniac symptoms and suicidality\u2014link and management"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8947-6088","authenticated-orcid":false,"given":"Dirk","family":"Schwerth\u00f6ffer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"F\u00f6rstl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"466_CR1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.copsyc.2019.12.002","volume":"34","author":"LD Asarnow","year":"2020","unstructured":"Asarnow\u00a0LD. 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