{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:05:15Z","timestamp":1780466715660,"version":"3.54.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/deed.de"}],"funder":[{"DOI":"10.13039\/501100001734","name":"Copenhagen University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001734","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neuropsychiatr"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Severe mental disorders, particularly schizophrenia and related disorders, remain among the most disabling and costly health conditions worldwide. Despite advances in pharmacological and psychosocial treatments, recovery rates remain low. Early intervention has emerged as a\u00a0key strategy to improve outcomes. Reducing the duration of untreated psychosis (DUP) and providing specialized early intervention services\u2014such as Denmark\u2019s OPUS, the UK\u2019s LEO, and the US Recovery After an Initial Schizophrenia Episode (RAISE) trial\u2014have shown significant benefits in symptom reduction, functioning, and cost-effectiveness. Assertive Community Treatment (ACT), Individual Placement and Support (IPS), and Housing First programs further enhance recovery for individuals with complex needs, including comorbid substance use and homelessness. Innovative therapies, such as avatar-based treatment for persistent hallucinations, show promise in treatment-resistant cases. Children of parents with severe mental illness are at elevated risk and offer a\u00a0unique opportunity for prevention. The Danish High Risk and Resilience Study (VIA\u00a07), which follows high-risk children from age 7\u00a0to\u00a019, exemplifies how longitudinal research can identify early modifiable risk factors and inform timely interventions. To improve long-term outcomes, services must be coordinated, person-centered, and recovery-oriented\u2014delivering care that is accessible, humane, and tailored to the individual\u2019s stage of illness and life circumstances.<\/jats:p>","DOI":"10.1007\/s40211-025-00539-1","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:17:24Z","timestamp":1756282644000},"page":"61-66","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Services to improve outcomes in severe mental disorders","Dienstleistungen zur Outcome-Verbesserung f\u00fcr Menschen mit schweren psychischen Erkrankungen"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4895-7023","authenticated-orcid":false,"given":"Merete","family":"Nordentoft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,27]]},"reference":[{"issue":"10211","key":"539_CR1","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1016\/S0140-6736(19)32316-5","volume":"394","author":"O Plana-Ripoll","year":"2019","unstructured":"Plana-Ripoll\u00a0O, Pedersen\u00a0CB, Agerbo\u00a0E, Holtz\u00a0Y, Erlangsen\u00a0A, Canudas-Romo\u00a0V, et\u00a0al. A\u00a0comprehensive analysis of mortality-related health metrics associated with mental disorders: a\u00a0nationwide, register-based cohort study. Lancet. 2019;394(10211):1827\u201335.","journal-title":"Lancet"},{"issue":"2","key":"539_CR2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1093\/schbul\/sbac103","volume":"49","author":"HG Hansen","year":"2023","unstructured":"Hansen\u00a0HG, Speyer\u00a0H, Starzer\u00a0M, Albert\u00a0N, Hjorthoj\u00a0C, Eplov\u00a0LF, Nordentoft\u00a0M. Clinical recovery among individuals with a\u00a0first-episode schizophrenia an updated systematic review and meta-analysis. Schizophr Bull. 2023;49(2):297\u2013308.","journal-title":"Schizophr Bull"},{"issue":"4","key":"539_CR3","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1176\/appi.ajp.2011.11030459","volume":"169","author":"WT Hegelstad","year":"2012","unstructured":"Hegelstad\u00a0WT, Larsen\u00a0TK, Auestad\u00a0B, Evensen\u00a0J, Haahr\u00a0U, Joa\u00a0I, et\u00a0al. Long-term follow-up of the TIPS early detection in psychosis study: effects on 10-year outcome. Amj Psychiatry. 2012;169(4):374\u201380.","journal-title":"Amj Psychiatry"},{"issue":"6","key":"539_CR4","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1001\/jamapsychiatry.2018.0623","volume":"75","author":"CU Correll","year":"2018","unstructured":"Correll\u00a0CU, Galling\u00a0B, Pawar\u00a0A, Krivko\u00a0A, Bonetto\u00a0C, Ruggeri\u00a0M, et\u00a0al. Comparison of early intervention services vs treatment as usual for early-phase psychosis: a\u00a0systematic review, meta-analysis, and Meta-regression. JAMA Psychiatry. 2018;75(6):555\u201365.","journal-title":"JAMA Psychiatry"},{"issue":"7517","key":"539_CR5","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1136\/bmj.38565.415000.E01","volume":"331","author":"L Petersen","year":"2005","unstructured":"Petersen\u00a0L, Jeppesen\u00a0P, Thorup\u00a0A, Abel\u00a0MB, Ohlenschlaeger\u00a0J, Christensen\u00a0TO, et\u00a0al. A\u00a0randomised multicentre trial of integrated versus standard treatment for patients with a\u00a0first episode of psychotic illness. BMJ. 2005;331(7517):602.","journal-title":"BMJ"},{"key":"539_CR6","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1192\/bjp.bp.112.112300","volume":"202","author":"LH Hastrup","year":"2013","unstructured":"Hastrup\u00a0LH, Kronborg\u00a0C, Bertelsen\u00a0M, Jeppesen\u00a0P, Jorgensen\u00a0P, Petersen\u00a0L, et\u00a0al. Cost-effectiveness of early intervention in first-episode psychosis: economic evaluation of a\u00a0randomised controlled trial (the OPUS study). Brj Psychiatry. 2013;202:35\u201341.","journal-title":"Brj Psychiatry"},{"key":"539_CR7","doi-asserted-by":"crossref","unstructured":"Posselt CM, Albert N, Nordentoft M, Hjorthoj C. The Danish OPUS early intervention services for first-episode psychosis: a\u00a0phase\u00a04 prospective cohort study with comparison of randomized trial and real-world data. 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