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Khandwalla has served as a consultant for Novartis Pharmaceuticals Corporation and has received a research grant from General Electric. Kade Birkeland has served as a consultant for Novartis Pharmaceuticals Corporation. J. Thomas Heywood has served as a consultant for Actelion Pharmaceuticals, Medtronic, and Abbott; was a speaker for Actelion Pharmaceuticals, Medtronic, Abbott, Otsuka, and Novartis Pharmaceuticals Corporation; has received grant funding from Medtronic, Abbott, and Impedimed; and has received fellowship grant support from Abbott. Robert L. Owens has received honoraria and travel reimbursements from ResMed, LLC, and Itamar Medical and has served as a consultant for Novartis Pharmaceuticals Corporation. Steven Steinhubl has received financial compensation from Novartis Pharmaceuticals Corporation for serving as an adviser. Emmanuel Fombu was an employee of Novartis Pharmaceuticals at the time of this study. Daniel Grant is an employee of Novartis Pharmaceuticals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants in the trial signed an informed consent upon enrollment.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All co-authors have consented for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Data and materials were made available to the co-investigators.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Availability of data and materials"}},{"value":"Not applicable.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"All authors contributed to the conception and design of the study and\/or data analysis\/interpretation, drafting, and\/or critical review of the manuscript, and all provided final approval to submit the manuscript for publication. RMK wrote the first draft of the manuscript, and the other authors, as part of the steering committee, revised subsequent drafts. Medical writing and editing assistance was provided by ApotheCom (Yardley, PA, USA), funded by Novartis Pharmaceuticals Corporation. All authors agree to be accountable for all aspects of the work and to ensure that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. A full list of all investigators and institutions involved in the study is provided in Table S1 in the ESM.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}}]}}