{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:21:11Z","timestamp":1790803271639,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Am J Cardiovasc Drugs"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s40256-023-00589-2","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T06:02:09Z","timestamp":1686031329000},"page":"471-475","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Etripamil Nasal Spray: Therapeutic Potential for Treating Paroxysmal Supraventricular Tachycardia"],"prefix":"10.1007","volume":"23","author":[{"given":"Jessica","family":"Huston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Genovese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ashchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"DeLuca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordyn","family":"Wiener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Deeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Deeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6401-4888","authenticated-orcid":false,"given":"Rebecca F.","family":"Goldfaden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"issue":"4","key":"589_CR1","first-page":"586","volume":"14","author":"D Sohinki","year":"2014","unstructured":"Sohinki D, Obel OA. Current trends in supraventricular tachycardia management. Ochsner J. 2014;14(4):586\u201395.","journal-title":"Ochsner J"},{"key":"589_CR2","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1111\/jce.15109","volume":"32","author":"M Rehorn","year":"2021","unstructured":"Rehorn M, Sacks NC, Emden MR, et al. Prevalence and incidence of patients with paroxysmal supraventricular tachycardia in the United States. J Cardiovasc Electrophysiol. 2021;32:2199\u2013206. https:\/\/doi.org\/10.1111\/jce.15109.","journal-title":"J Cardiovasc Electrophysiol"},{"key":"589_CR3","unstructured":"Anon. Paroxysmal supraventricular tachycardia (PSVT). Johns Hopkins Medicine. 2020. https:\/\/www.hopkinsmedicine.org\/health\/conditions-and-diseases\/paroxysmal-supraventricular-tachycardia. Accessed 8 May 2023."},{"key":"589_CR4","unstructured":"Hafeez Y, Quintanilla Rodriguez BS, Ahmed I, et al. Paroxysmal Supraventricular Tachycardia. [Updated 2023 Feb 5]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK507699\/."},{"issue":"9","key":"589_CR5","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/j.1751-7176.2011.00513.x","volume":"13","author":"WJ Elliott","year":"2011","unstructured":"Elliott WJ, Ram CV. Calcium channel blockers. J Clin Hypertens (Greenwich). 2011;13(9):687\u20139. https:\/\/doi.org\/10.1111\/j.1751-7176.2011.00513.x.","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"589_CR6","unstructured":"Anon. Supraventricular tachycardia. Mayo Clinic. 2022. https:\/\/www.mayoclinic.org\/diseases-conditions\/supraventricular-tachycardia\/symptoms-causes\/syc-20355243. Accessed 7 Jan 2023."},{"key":"589_CR7","unstructured":"Milestone Pharmaceuticals Inc. Registration statement filed with the United States Securities and Exchange Commission on April 12, 2019. https:\/\/www.sec.gov\/Archives\/edgar\/data\/1408443\/000104746919002213\/a2238338zs-1.htm. Accessed 8 May 2023."},{"issue":"5","key":"589_CR8","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.jacc.2018.04.082","volume":"72","author":"BS Stambler","year":"2018","unstructured":"Stambler BS, Dorian P, Sager PT, et al. Etripamil nasal spray for rapid conversion of supraventricular tachycardia to sinus rhythm. J Am Coll Cardiol. 2018;72(5):489\u201397. https:\/\/doi.org\/10.1016\/j.jacc.2018.04.082.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"589_CR9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.17925\/HI.2021.15.1.2","volume":"15","author":"GS Chu","year":"2021","unstructured":"Chu GS, Gupta D. Update on etripamil nasal spray for the at-home treatment of acute paroxysmal supraventricular tachycardia. Heart Int. 2021;15(1):2\u20136. https:\/\/doi.org\/10.17925\/HI.2021.15.1.2.","journal-title":"Heart Int"},{"key":"589_CR10","unstructured":"Milestone Pharma. Press release dated March 30, 2021. https:\/\/milestonepharma.com\/research-development\/etripamil. Accessed 8 May 2023."},{"issue":"10","key":"589_CR11","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.hrcr.2017.07.011","volume":"3","author":"WC Choe","year":"2017","unstructured":"Choe WC, Sundaram S, Boorman C, et al. High-density mapping of the slow pathway in a patient with atrioventricular nodal reentry given intranasal etripamil during the NODE-1 study. HeartRhythm Case Rep. 2017;3(10):479\u201382. https:\/\/doi.org\/10.1016\/j.hrcr.2017.07.011.","journal-title":"HeartRhythm Case Rep."},{"issue":"12","key":"589_CR12","doi-asserted-by":"publisher","first-page":"e010915","DOI":"10.1161\/CIRCEP.122.010915","volume":"15","author":"BS Stambler","year":"2022","unstructured":"Stambler BS, Plat F, Sager PT, et al. First randomized, multicenter, placebo-controlled study of self-administered intranasal etripamil for acute conversion of spontaneous paroxysmal supraventricular tachycardia (NODE-301). Circ Arrhythm Electrophysiol. 2022;15(12):e010915. https:\/\/doi.org\/10.1161\/CIRCEP.122.010915.","journal-title":"Circ Arrhythm Electrophysiol."},{"key":"589_CR13","unstructured":"Efficacy and safety study of etripamil nasal spray self-administration for the termination of spontaneous episodes of paroxysmal supraventricular tachycardia. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05410860. Accessed 8 May 2023."},{"key":"589_CR14","unstructured":"Neale T. Rapid: positive top-line results for etripamil nasal spray in paroxysmal SVT. TCTMD.com. 2022. https:\/\/www.tctmd.com\/news\/rapid-positive-top-line-results-etripamil-nasal-spray-paroxysmal-svt. Accessed 8 May 2023."},{"key":"589_CR15","unstructured":"Etripamil nasal spray in patients with paroxysmal supraventricular tachycardia. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04952610. Accessed 8 May 2023."},{"issue":"1","key":"589_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13543784.2020.1703180","volume":"29","author":"AH Kashou","year":"2020","unstructured":"Kashou AH, Noseworthy PA. Etripamil nasal spray: an investigational agent for the rapid termination of paroxysmal supraventricular tachycardia (SVT). Expert Opin Investig Drugs. 2020;29(1):1\u20134. https:\/\/doi.org\/10.1080\/13543784.2020.1703180. (Epub 2019 Dec 12).","journal-title":"Expert Opin Investig Drugs"},{"key":"589_CR17","unstructured":"Safety study ofetripamil nasal spray for patients with paroxysmal supraventricular tachycardia. NODE-303. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04072835. Accessed 8 May 2023."},{"key":"589_CR18","unstructured":"Safety study of intranasaletripamil for the termination of spontaneous episodes of paroxysmal supraventricular tachycardia (PSVT). NODE-302. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03635996. Accessed 8 May 2023."},{"key":"589_CR19","unstructured":"The NODE-202 Study (study ofetripamil nasal spray in pediatric patients). https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05763953. Accessed 8 May 2023."}],"updated-by":[{"DOI":"10.1007\/s40256-023-00595-4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000}}],"container-title":["American Journal of Cardiovascular Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40256-023-00589-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40256-023-00589-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40256-023-00589-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T09:27:15Z","timestamp":1693214835000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40256-023-00589-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,6]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["589"],"URL":"https:\/\/doi.org\/10.1007\/s40256-023-00589-2","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s40256-023-00595-4","asserted-by":"object"}]},"ISSN":["1175-3277","1179-187X"],"issn-type":[{"value":"1175-3277","type":"print"},{"value":"1179-187X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,6]]},"assertion":[{"value":"10 May 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 June 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2023","order":3,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":4,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":5,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s40256-023-00595-4","URL":"https:\/\/doi.org\/10.1007\/s40256-023-00595-4","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No external funding was used in the preparation of this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Jessica Huston, Ariana Genovese, Andrea Ashchi, Amanda DeLuca, Jordyn Wiener, Elias Deeb, Alexander Deeb, and Rebecca F. Goldfaden declare that they have no potential conflicts of interest that might be relevant to the contents of this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Data sharing not applicable to this article as no datasets were generated.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability statement"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Jessica Huston was involved in supervision, data curation, analysis, reviewing, editing, and writing. Ariana Genovese was involved in data curation, analysis, and writing. Andrea Ashchi was involved in data curation, writing, and analysis. Amanda DeLuca was involved in data curation, analysis, and writing. Jordyn Wiener was involved in data curation, analysis, and writing. Elias Deeb was involved in data curation, analysis, and writing. Alexander Deeb was involved in data curation, analysis, and writing. Rebecca Goldfaden was involved in the conceptualization, project administration, reviewing, and editing.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authors\u2019 contributions"}}]}}