{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:07:40Z","timestamp":1793066860789,"version":"4.5.0"},"reference-count":107,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,9,14]],"date-time":"2013-09-14T00:00:00Z","timestamp":1379116800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Clin Dermatol"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s40257-013-0043-7","type":"journal-article","created":{"date-parts":[[2013,9,13]],"date-time":"2013-09-13T09:33:53Z","timestamp":1379064833000},"page":"401-411","source":"Crossref","is-referenced-by-count":86,"title":["Inflammatory Nodules Following Soft Tissue Filler Use: A Review of Causative Agents, Pathology and Treatment Options"],"prefix":"10.1007","volume":"14","author":[{"given":"Jennifer A.","family":"Ledon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica A.","family":"Savas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katlein","family":"Franca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyvan","family":"Nouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,9,14]]},"reference":[{"key":"43_CR1","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1046\/j.1524-4725.2000.00512.x","volume":"26","author":"AW Klein","year":"2000","unstructured":"Klein AW, Elson ML. The history of substances for soft tissue augmentation. Dermatol Surg. 2000;26:1096\u2013105.","journal-title":"Dermatol Surg"},{"key":"43_CR2","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1097\/01.prs.0000267580.92163.33","volume":"120","author":"PE Chasan","year":"2007","unstructured":"Chasan PE. The history of injectable silicone fluids for soft-tissue augmentation. Plast Reconstr Surg. 2007;120:2034\u201340 discussion 41\u20133.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR3","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.anplas.2006.05.003","volume":"52","author":"J Glicenstein","year":"2007","unstructured":"Glicenstein J. The first \u201cfillers\u201d, vaseline and paraffin: from miracle to disaster. Annales de chirurgie plastique et esthetique. 2007;52:157\u201361.","journal-title":"Annales de chirurgie plastique et esthetique"},{"key":"43_CR4","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1097\/01.prs.0000234900.26676.0b","volume":"118","author":"KW Broder","year":"2006","unstructured":"Broder KW, Cohen SR. An overview of permanent and semipermanent fillers. Plast Reconstr Surg. 2006;118:7S\u201314S.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cps.2004.12.002","volume":"32","author":"RS Narins","year":"2005","unstructured":"Narins RS, Bowman PH. Injectable skin fillers. Clin Plast Surg. 2005;32:151\u201362.","journal-title":"Clin Plast Surg"},{"key":"43_CR6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0030-6665(03)00095-1","volume":"35","author":"JT Cheng","year":"2002","unstructured":"Cheng JT, Perkins SW, Hamilton MM. Collagen and injectable fillers. Otolaryngol Clin N Am. 2002;35:73\u201385 vi.","journal-title":"Otolaryngol Clin N Am"},{"issue":"Suppl 2","key":"43_CR7","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/j.1524-4725.2009.01338.x","volume":"35","author":"LH Christensen","year":"2009","unstructured":"Christensen LH. Host tissue interaction, fate, and risks of degradable and nondegradable gel fillers. Dermatol Surg. 2009;35(Suppl 2):1612\u20139.","journal-title":"Dermatol Surg"},{"key":"43_CR8","first-page":"1627","volume":"16","author":"M Omranifard","year":"2011","unstructured":"Omranifard M, Taheri S. Filler augmentation, safe or unsafe: a case series of severe complications of fillers. J Res Med Sci. 2011;16:1627\u201331.","journal-title":"J Res Med Sci"},{"key":"43_CR9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/IOP.0b013e31825ca73e","volume":"28","author":"AG Buchanan","year":"2012","unstructured":"Buchanan AG, Holds JB, Vagefi MR, Bidar M, McCann JD, Anderson RL. Anterior filler displacement following injection of calcium hydroxylapatite gel (Radiesse) for anophthalmic orbital volume augmentation. Ophthalmic Plast Reconstr Surg. 2012;28:335\u20137.","journal-title":"Ophthalmic Plast Reconstr Surg"},{"key":"43_CR10","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.bjps.2012.06.008","volume":"65","author":"TH Park","year":"2012","unstructured":"Park TH, Yeo KK, Seo SW, et al. Clinical experience with complications of hand rejuvenation. J Plast Reconstr Aesthet Surg. 2012;65:1627\u201331.","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"43_CR11","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/00006534-199509000-00015","volume":"96","author":"G Lemperle","year":"1995","unstructured":"Lemperle G, Hazan-Gauthier N, Lemperle M. PMMA microspheres (Artecoll) for skin and soft-tissue augmentation. Part II: clinical investigations. Plast Reconstr Surg. 1995;96:627\u201334.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR12","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/PRS.0b013e3182442363","volume":"129","author":"D Lazzeri","year":"2012","unstructured":"Lazzeri D, Agostini T, Figus M, Nardi M, Pantaloni M, Lazzeri S. Blindness following cosmetic injections of the face. Plast Reconstr Surg. 2012;129:995\u20131012.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR13","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.bjps.2011.01.008","volume":"64","author":"TH Park","year":"2011","unstructured":"Park TH, Seo SW, Kim JK, Chang CH. Clinical experience with hyaluronic acid-filler complications. J Plast Reconstr Aesthet Surg. 2011;64:892\u20136.","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"43_CR14","first-page":"1616","volume":"31","author":"NJ Lowe","year":"2005","unstructured":"Lowe NJ, Maxwell CA, Patnaik R. Adverse reactions to dermal fillers: review. Dermatol Surg. 2005;31:1616\u201325.","journal-title":"Dermatol Surg"},{"key":"43_CR15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1054\/jcms.2001.0222","volume":"29","author":"H Heise","year":"2001","unstructured":"Heise H, Zimmermann R, Heise P. Temporary granulomatous inflammation following collagen implantation. J Cranio Maxillo-Facial Surg. 2001;29:238\u201341.","journal-title":"J Cranio Maxillo-Facial Surg"},{"key":"43_CR16","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.sder.2006.08.008","volume":"25","author":"SL Matarasso","year":"2006","unstructured":"Matarasso SL. The use of injectable collagens for aesthetic rejuvenation. Semin Cutan Med Surg. 2006;25:151\u20137.","journal-title":"Semin Cutan Med Surg"},{"key":"43_CR17","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1097\/PRS.0b013e3181d0ac75","volume":"125","author":"ZP Lorenc","year":"2010","unstructured":"Lorenc ZP, Nir E, Azachi M. Characterization of physical properties and histologic evaluation of injectable Dermicol-p35 porcine-collagen dermal filler. Plast Reconstr Surg. 2010;125:1805\u201313.","journal-title":"Plast Reconstr Surg"},{"issue":"Suppl 2","key":"43_CR18","doi-asserted-by":"crossref","first-page":"S152","DOI":"10.1111\/j.1524-4725.2007.33355.x","volume":"33","author":"D Shoshani","year":"2007","unstructured":"Shoshani D, Markovitz E, Cohen Y, Heremans A, Goldlust A. Skin test hypersensitivity study of a cross-linked, porcine collagen implant for aesthetic surgery. Dermatol Surg. 2007;33(Suppl 2):S152\u20138.","journal-title":"Dermatol Surg"},{"key":"43_CR19","first-page":"579","volume":"7","author":"M Braun","year":"2008","unstructured":"Braun M, Braun S. Nodule formation following lip augmentation using porcine collagen-derived filler. J Drugs Dermatol. 2008;7:579\u201381.","journal-title":"J Drugs Dermatol"},{"key":"43_CR20","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1046\/j.1365-4362.2001.01111.x","volume":"40","author":"C Naoum","year":"2001","unstructured":"Naoum C, Dasiou-Plakida D. Dermal filler materials and botulin toxin. Int J Dermatol. 2001;40:609\u201321.","journal-title":"Int J Dermatol"},{"key":"43_CR21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1080\/09546630601121052","volume":"18","author":"F Bardazzi","year":"2007","unstructured":"Bardazzi F, Ruffato A, Antonucci A, Balestri R, Tabanelli M. Cutaneous granulomatous reaction to injectable hyaluronic acid gel: another case. J Dermatol Treat. 2007;18:59\u201362.","journal-title":"J Dermatol Treat"},{"key":"43_CR22","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1111\/j.1468-3083.2004.00934.x","volume":"18","author":"P Andre","year":"2004","unstructured":"Andre P. Evaluation of the safety of a non-animal stabilized hyaluronic acid (NASHA-Q-Medical, Sweden) in European countries: a retrospective study from 1997 to 2001. J Eur Acad Dermatol Venereol. 2004;18:422\u20135.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"43_CR23","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1097\/00006534-200010000-00048","volume":"106","author":"R Shafir","year":"2000","unstructured":"Shafir R, Amir A, Gur E. Long-term complications of facial injections with Restylane (injectable hyaluronic acid). Plast Reconstr Surg. 2000;106:1215\u20136.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/14764170500344393","volume":"7","author":"P Andre","year":"2005","unstructured":"Andre P, Lowe NJ, Parc A, Clerici TH, Zimmermann U. Adverse reactions to dermal fillers: a review of European experiences. J Cosmet Laser Ther. 2005;7:171\u20136.","journal-title":"J Cosmet Laser Ther"},{"key":"43_CR25","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.3174\/ajnr.A3161","volume":"34","author":"DT Ginat","year":"2013","unstructured":"Ginat DT, Schatz CJ. Imaging features of midface injectable fillers and associated complications. AJNR Am J Neuroradiol. 2013;34:1488\u201395.","journal-title":"AJNR Am J Neuroradiol"},{"key":"43_CR26","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/lsm.20283","volume":"38","author":"RJ Hirsch","year":"2006","unstructured":"Hirsch RJ, Narurkar V, Carruthers J. Management of injected hyaluronic acid induced Tyndall effects. Lasers Surg Med. 2006;38:202\u20134.","journal-title":"Lasers Surg Med"},{"key":"43_CR27","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.asj.2005.05.009","volume":"25","author":"KL Grossman","year":"2005","unstructured":"Grossman KL. Hyaluronic acid gel fillers: hypersensitivity reactions. Aesthet Surg J Am Soc Aesthet Plast Surg. 2005;25:403\u20135.","journal-title":"Aesthet Surg J Am Soc Aesthet Plast Surg"},{"key":"43_CR28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1524-4725.2001.00248.x","volume":"27","author":"P Micheels","year":"2001","unstructured":"Micheels P. Human anti-hyaluronic acid antibodies: is it possible? Dermatol Surg. 2001;27:185\u201391.","journal-title":"Dermatol Surg"},{"issue":"Suppl 2","key":"43_CR29","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/j.1524-4725.2009.01346.x","volume":"35","author":"AP Sclafani","year":"2009","unstructured":"Sclafani AP, Fagien S. Treatment of injectable soft tissue filler complications. Dermatol Surg. 2009;35(Suppl 2):1672\u201380.","journal-title":"Dermatol Surg"},{"key":"43_CR30","doi-asserted-by":"crossref","first-page":"92e","DOI":"10.1097\/01.prs.0000209926.79944.36","volume":"117","author":"VJ Patel","year":"2006","unstructured":"Patel VJ, Bruck MC, Katz BE. Hypersensitivity reaction to hyaluronic acid with negative skin testing. Plast Reconstr Surg. 2006;117:92e\u20134e.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00001665-200303000-00011","volume":"14","author":"JF Honig","year":"2003","unstructured":"Honig JF, Brink U, Korabiowska M. Severe granulomatous allergic tissue reaction after hyaluronic acid injection in the treatment of facial lines and its surgical correction. J Craniofac Surg. 2003;14:197\u2013200.","journal-title":"J Craniofac Surg"},{"key":"43_CR32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s002660010131","volume":"25","author":"C Bergeret-Galley","year":"2001","unstructured":"Bergeret-Galley C, Latouche X, Illouz YG. The value of a new filler material in corrective and cosmetic surgery: DermaLive and DermaDeep. Aesthet Plast Surg. 2001;25:249\u201355.","journal-title":"Aesthet Plast Surg"},{"key":"43_CR33","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1365-2230.2004.01625.x","volume":"29","author":"RU Sidwell","year":"2004","unstructured":"Sidwell RU, Dhillon AP, Butler PE, Rustin MH. Localized granulomatous reaction to a semi-permanent hyaluronic acid and acrylic hydrogel cosmetic filler. Clin Exp Dermatol. 2004;29:630\u20132.","journal-title":"Clin Exp Dermatol"},{"key":"43_CR34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s00266-004-0113-6","volume":"29","author":"L Christensen","year":"2005","unstructured":"Christensen L, Breiting V, Janssen M, Vuust J, Hogdall E. Adverse reactions to injectable soft tissue permanent fillers. Aesthet Plast Surg. 2005;29:34\u201348.","journal-title":"Aesthet Plast Surg"},{"key":"43_CR35","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/PRS.0b013e3181cb4620","volume":"125","author":"RJ Rohrich","year":"2010","unstructured":"Rohrich RJ, Monheit G, Nguyen AT, Brown SA, Fagien S. Soft-tissue filler complications: the important role of biofilms. Plast Reconstr Surg. 2010;125:1250\u20136.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR36","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1080\/09546630902817879","volume":"20","author":"NS Sadick","year":"2009","unstructured":"Sadick NS, Palmisano L. Case study involving use of injectable poly-l-lactic acid (PLLA) for acne scars. J Dermatol Treat. 2009;20:302\u20137.","journal-title":"J Dermatol Treat"},{"key":"43_CR37","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00266-008-9242-7","volume":"33","author":"R Sadove","year":"2009","unstructured":"Sadove R. Injectable poly-l-lactic acid: a novel sculpting agent for the treatment of dermal fat atrophy after severe acne. Aesthet Plast Surg. 2009;33:113\u20136.","journal-title":"Aesthet Plast Surg"},{"key":"43_CR38","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1097\/00002030-200311210-00009","volume":"17","author":"MA Valantin","year":"2003","unstructured":"Valantin MA, Aubron-Olivier C, Ghosn J, et al. Polylactic acid implants (New-Fill) to correct facial lipoatrophy in HIV-infected patients: results of the open-label study VEGA. AIDS. 2003;17:2471\u20137.","journal-title":"AIDS"},{"key":"43_CR39","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1159\/000243804","volume":"219","author":"J Alijotas-Reig","year":"2009","unstructured":"Alijotas-Reig J, Garcia-Gimenez V, Vilardell-Tarres M. Late-onset immune-mediated adverse effects after poly-l-lactic acid injection in non-HIV patients: clinical findings and long-term follow-up. Dermatology. 2009;219:303\u20138.","journal-title":"Dermatology"},{"key":"43_CR40","doi-asserted-by":"crossref","first-page":"76e","DOI":"10.1097\/01.PRS.0000157022.61766.5D","volume":"115","author":"SJ Dijkema","year":"2005","unstructured":"Dijkema SJ, van der Lei B, Kibbelaar RE. New-fill injections may induce late-onset foreign body granulomatous reaction. Plast Reconstr Surg. 2005;115:76e\u20138e.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1473-2165.2009.00417.x","volume":"8","author":"F Rossner","year":"2009","unstructured":"Rossner F, Rossner M, Hartmann V, Erdmann R, Wiest LG, Rzany B. Decrease of reported adverse events to injectable polylactic acid after recommending an increased dilution: 8-year results from the Injectable Filler Safety study. J Cosmetic Dermatol. 2009;8:14\u20138.","journal-title":"J Cosmetic Dermatol"},{"key":"43_CR42","doi-asserted-by":"crossref","first-page":"22S","DOI":"10.1097\/01.prs.0000234903.55310.6a","volume":"118","author":"DA Jansen","year":"2006","unstructured":"Jansen DA, Graivier MH. Evaluation of a calcium hydroxylapatite-based implant (Radiesse) for facial soft-tissue augmentation. Plast Reconstr Surg. 2006;118:22S\u201330S discussion 1S-3S.","journal-title":"Plast Reconstr Surg"},{"issue":"Suppl 2","key":"43_CR43","doi-asserted-by":"crossref","first-page":"S122","DOI":"10.1111\/j.1524-4725.2007.33351.x","volume":"33","author":"NS Sadick","year":"2007","unstructured":"Sadick NS, Katz BE, Roy D. A multicenter, 47-month study of safety and efficacy of calcium hydroxylapatite for soft tissue augmentation of nasolabial folds and other areas of the face. Dermatol Surg. 2007;33(Suppl 2):S122\u20136 discussion S6\u20137.","journal-title":"Dermatol Surg"},{"key":"43_CR44","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1001\/archfaci.6.4.234","volume":"6","author":"TL Tzikas","year":"2004","unstructured":"Tzikas TL. Evaluation of the radiance FN soft tissue filler for facial soft tissue augmentation. Arch Facial Plast Surg. 2004;6:234\u20139.","journal-title":"Arch Facial Plast Surg"},{"key":"43_CR45","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1001\/archdermatol.2012.901","volume":"148","author":"KK Reddy","year":"2012","unstructured":"Reddy KK, Brauer JA, Anolik R, et al. Calcium hydroxylapatite nodule resolution after fractional carbon dioxide laser therapy. Arch Dermatol. 2012;148:634\u20136.","journal-title":"Arch Dermatol"},{"key":"43_CR46","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s002669900032","volume":"20","author":"MJ Rapaport","year":"1996","unstructured":"Rapaport MJ, Vinnik C, Zarem H. Injectable silicone: cause of facial nodules, cellulitis, ulceration, and migration. Aesthet Plast Surg. 1996;20:267\u201376.","journal-title":"Aesthet Plast Surg"},{"key":"43_CR47","doi-asserted-by":"crossref","first-page":"121e","DOI":"10.1097\/PRS.0b013e318213a15c","volume":"127","author":"TH Park","year":"2011","unstructured":"Park TH, Seo SW, Kim JK, Chang CH. The efficacy of perilesional surgical approach for foreign body granuloma. Plast Reconstr Surg. 2011;127:121e\u20133e.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bjps.2011.07.033","volume":"65","author":"TH Park","year":"2012","unstructured":"Park TH, Seo SW, Kim JK, Chang CH. Clinical outcome in a series of 173 cases of foreign body granuloma: improved outcomes with a novel surgical technique. J Plast Reconstr Aesthet Surg. 2012;65:29\u201334.","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"43_CR49","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/SAP.0b013e318065c4e1","volume":"60","author":"CH Chui","year":"2008","unstructured":"Chui CH, Fong PH. Carbon dioxide laser vaporization of facial siliconomas: flash in the pan or way of the future? Ann Plast Surg. 2008;60:272\u20135.","journal-title":"Ann Plast Surg"},{"key":"43_CR50","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1524-4725.2005.31122","volume":"31","author":"P Lloret","year":"2005","unstructured":"Lloret P, Espana A, Leache A, et al. Successful treatment of granulomatous reactions secondary to injection of esthetic implants. Dermatol Surg. 2005;31:486\u201390.","journal-title":"Dermatol Surg"},{"key":"43_CR51","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1524-4725.2011.01978.x","volume":"37","author":"MC Lopiccolo","year":"2011","unstructured":"Lopiccolo MC, Workman BJ, Chaffins ML, Kerr HA. Silicone granulomas after soft-tissue augmentation of the buttocks: a case report and review of management. Dermatol Surg. 2011;37:720\u20135.","journal-title":"Dermatol Surg"},{"key":"43_CR52","first-page":"952","volume":"8","author":"K Beer","year":"2009","unstructured":"Beer K. Delayed onset nodules from liquid injectable silicone: report of a case, evaluation of associated histopathology and results of treatment with minocycline and celocoxib. J Drugs Dermatol. 2009;8:952\u20134.","journal-title":"J Drugs Dermatol"},{"key":"43_CR53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jaad.2004.07.014","volume":"52","author":"MJ Arin","year":"2005","unstructured":"Arin MJ, Bate J, Krieg T, Hunzelmann N. Silicone granuloma of the face treated with minocycline. J Am Acad Dermatol. 2005;52:53\u20136.","journal-title":"J Am Acad Dermatol"},{"key":"43_CR54","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/BF02507113","volume":"288","author":"P Celerier","year":"1996","unstructured":"Celerier P, Litoux P, Dreno B. In vitro modulation of epidermal inflammatory cytokines (IL-1 alpha, IL-6, TNF alpha) by minocycline. Arch Dermatol Res. 1996;288:411\u20134.","journal-title":"Arch Dermatol Res"},{"key":"43_CR55","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1067\/moe.2002.124459","volume":"94","author":"G Ficarra","year":"2002","unstructured":"Ficarra G, Mosqueda-Taylor A, Carlos R. Silicone granuloma of the facial tissues: a report of seven cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:65\u201373.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"43_CR56","first-page":"E1","volume":"11","author":"R Poveda","year":"2006","unstructured":"Poveda R, Bagan JV, Murillo J, Jimenez Y. Granulomatous facial reaction to injected cosmetic fillers: a presentation of five cases. Medicina oral patologia oral y cirugia bucal. 2006;11:E1\u20135.","journal-title":"Medicina oral patologia oral y cirugia bucal"},{"key":"43_CR57","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1600-0560.2006.00607.x","volume":"34","author":"V Mustacchio","year":"2007","unstructured":"Mustacchio V, Cabibi D, Minervini MI, Barresi E, Amato S. A diagnostic trap for the dermatopathologist: granulomatous reactions from cutaneous microimplants for cosmetic purposes. J Cutan Pathol. 2007;34:281\u20133.","journal-title":"J Cutan Pathol"},{"key":"43_CR58","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1016\/j.tripleo.2008.12.044","volume":"107","author":"ES Goncales","year":"2009","unstructured":"Goncales ES, Almeida AS, Soares S, Oliveira DT. Silicone implant for chin augmentation mimicking a low-grade liposarcoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:e21\u20133.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"43_CR59","doi-asserted-by":"crossref","first-page":"20","DOI":"10.5070\/D37JX780XV","volume":"14","author":"EM Schwartzfarb","year":"2008","unstructured":"Schwartzfarb EM, Hametti JM, Romanelli P, Ricotti C. Foreign body granuloma formation secondary to silicone injection. Dermatol Online J. 2008;14:20.","journal-title":"Dermatol Online J"},{"key":"43_CR60","first-page":"1747","volume":"124","author":"YC Chen","year":"2011","unstructured":"Chen YC, Chen ML, Chiu YM. A case of mimicking angioedema: chin silicone granulomatous reaction spreading all over the face after receiving liquid silicone injection forty years previously. Chin Med J. 2011;124:1747\u201350.","journal-title":"Chin Med J"},{"key":"43_CR61","doi-asserted-by":"crossref","unstructured":"Gundeslioglu AO, Hakverdi S, Erdem O, Ozen EC, Inan I, Emlik D. Axillary lipogranuloma mimicking carcinoma metastasis after silicone breast implant rupture: a case report. J Plast Reconstr Aesthet Surg. 2013;66:e72\u20135.","DOI":"10.1016\/j.bjps.2012.11.025"},{"key":"43_CR62","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1524-4741.2010.00948.x","volume":"16","author":"SM Shepherd","year":"2010","unstructured":"Shepherd SM, Makariou E. Silicone granuloma mimicking breast cancer recurrence on PET CT. Breast J. 2010;16:551\u20133.","journal-title":"Breast J"},{"key":"43_CR63","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00000478-199901000-00013","volume":"23","author":"CM Rudolph","year":"1999","unstructured":"Rudolph CM, Soyer HP, Schuller-Petrovic S, Kerl H. Foreign body granulomas due to injectable aesthetic microimplants. Am J Surg Pathol. 1999;23:113\u20137.","journal-title":"Am J Surg Pathol"},{"key":"43_CR64","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1586\/17434440.3.3.281","volume":"3","author":"KW Broder","year":"2006","unstructured":"Broder KW, Cohen SR. ArteFill: a permanent skin filler. Expert Rev Med Devices. 2006;3:281\u20139.","journal-title":"Expert Rev Med Devices"},{"key":"43_CR65","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.sder.2004.08.002","volume":"23","author":"E Haneke","year":"2004","unstructured":"Haneke E. Polymethyl methacrylate microspheres in collagen. Semin Cutan Med Surg. 2004;23:227\u201332.","journal-title":"Semin Cutan Med Surg"},{"key":"43_CR66","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0190-9622(99)70536-0","volume":"40","author":"C Hoffmann","year":"1999","unstructured":"Hoffmann C, Schuller-Petrovic S, Soyer HP, Kerl H. Adverse reactions after cosmetic lip augmentation with permanent biologically inert implant materials. J Am Acad Dermatol. 1999;40:100\u20132.","journal-title":"J Am Acad Dermatol"},{"key":"43_CR67","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1046\/j.1524-4725.2003.29140.x","volume":"29","author":"G Lemperle","year":"2003","unstructured":"Lemperle G, Romano JJ, Busso M. Soft tissue augmentation with artecoll: 10-year history, indications, techniques, and complications. Dermatol Surg. 2003;29:573\u201387 discussion 87.","journal-title":"Dermatol Surg"},{"key":"43_CR68","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00266-011-9803-z","volume":"36","author":"TH Park","year":"2012","unstructured":"Park TH, Seo SW, Kim JK, Chang CH. Clinical experience with polymethylmethacrylate microsphere filler complications. Aesthetic Plast Surg. 2012;36:421\u20136.","journal-title":"Aesthetic Plast Surg"},{"key":"43_CR69","doi-asserted-by":"crossref","first-page":"64S","DOI":"10.1097\/01.prs.0000234873.00905.a4","volume":"118","author":"SR Cohen","year":"2006","unstructured":"Cohen SR, Berner CF, Busso M, et al. ArteFill: a long-lasting injectable wrinkle filler material\u2014summary of the U.S. Food and Drug Administration trials and a progress report on 4- to 5-year outcomes. Plast Reconstr Surg. 2006;118:64S\u201376S.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR70","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/00006534-197861060-00010","volume":"61","author":"RM Pearl","year":"1978","unstructured":"Pearl RM, Laub DR, Kaplan EN. Complications following silicone injections for augmentation of the contours of the face. Plast Reconstr Surg. 1978;61:888\u201391.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR71","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1001\/archderm.139.1.17","volume":"139","author":"EM Reisberger","year":"2003","unstructured":"Reisberger EM, Landthaler M, Wiest L, Schroder J, Stolz W. Foreign body granulomas caused by polymethylmethacrylate microspheres: successful treatment with allopurinol. Arch Dermatol. 2003;139:17\u201320.","journal-title":"Arch Dermatol"},{"key":"43_CR72","first-page":"945205","volume":"2012","author":"LK Barros Silveira de","year":"2012","unstructured":"de Barros Silveira LK, de Oliveira FL, AlvesTde B, et al. The therapeutic benefit of allopurinol in the treatment of foreign body granulomas caused by polymethylmethacrylate microspheres. Case Rep Dermatol Med. 2012;2012:945205.","journal-title":"Case Rep Dermatol Med"},{"key":"43_CR73","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1136\/bjo.2010.180547","volume":"95","author":"HS Sa","year":"2011","unstructured":"Sa HS, Woo KI, Suh YL, Kim YD. Periorbital lipogranuloma: a previously unknown complication of autologous fat injections for facial augmentation. Br J Ophthalmol. 2011;95:1259\u201363.","journal-title":"Br J Ophthalmol"},{"key":"43_CR74","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1097\/00006534-200012000-00018","volume":"106","author":"JD Latoni","year":"2000","unstructured":"Latoni JD, Marshall DM, Wolfe SA. Overgrowth of fat autotransplanted for correction of localized steroid-induced atrophy. Plast Reconstr Surg. 2000;106:1566\u20139.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR75","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00002341-200205000-00015","volume":"18","author":"JJ Miller","year":"2002","unstructured":"Miller JJ, Popp JC. Fat hypertrophy after autologous fat transfer. Ophthalmic Plast Reconst Surg. 2002;18:228\u201331.","journal-title":"Ophthalmic Plast Reconst Surg"},{"key":"43_CR76","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.4315\/0362-028X-72.9.1987","volume":"72","author":"K Bjornsdottir","year":"2009","unstructured":"Bjornsdottir K, Bolton GE, McClellan-Green PD, Jaykus LA, Green DP. Detection of gram-negative histamine-producing bacteria in fish: a comparative study. J Food Protect. 2009;72:1987\u201391.","journal-title":"J Food Protect"},{"key":"43_CR77","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1097\/01.prs.0000254824.13065.3b","volume":"119","author":"G Bello","year":"2007","unstructured":"Bello G, Jackson IT, Keskin M, et al. The use of polyacrylamide gel in soft-tissue augmentation: an experimental assessment. Plast Reconstr Surg. 2007;119:1326\u201336.","journal-title":"Plast Reconstr Surg"},{"issue":"Suppl 2","key":"43_CR78","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1111\/j.1524-4725.2009.01313.x","volume":"35","author":"T Bjarnsholt","year":"2009","unstructured":"Bjarnsholt T, Tolker-Nielsen T, Givskov M, Janssen M, Christensen LH. Detection of bacteria by fluorescence in situ hybridization in culture-negative soft tissue filler lesions. Dermatol Surg. 2009;35(Suppl 2):1620\u20134.","journal-title":"Dermatol Surg"},{"issue":"Suppl 1","key":"43_CR79","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1524-4725.2008.01041.x","volume":"35","author":"J Alijotas-Reig","year":"2009","unstructured":"Alijotas-Reig J, Garcia-Gimenez V, Miro-Mur F, Vilardell-Tarres M. Delayed immune-mediated adverse effects related to polyacrylamide dermal fillers: clinical findings, management, and follow-up. Dermatol Surg. 2009;35(Suppl 1):360\u20136.","journal-title":"Dermatol Surg"},{"key":"43_CR80","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1093\/cid\/cit067","volume":"56","author":"L Christensen","year":"2013","unstructured":"Christensen L, Breiting V, Bjarnsholt T, et al. Bacterial infection as a likely cause of adverse reactions to polyacrylamide hydrogel fillers in cosmetic surgery. Clin Infect Dis. 2013;56:1438\u201344.","journal-title":"Clin Infect Dis"},{"key":"43_CR81","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.bjps.2008.03.042","volume":"62","author":"Y Yagi","year":"2009","unstructured":"Yagi Y, Kato K, Murakami D, et al. Use of Aquamid as a filler for facial rejuvenation in orientals. J Plast Reconstr Aesthet Surg. 2009;62:1245\u20139.","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"43_CR82","doi-asserted-by":"crossref","first-page":"85S","DOI":"10.1097\/01.prs.0000234844.59251.3f","volume":"118","author":"S Buelow von","year":"2006","unstructured":"von Buelow S, Pallua N. Efficacy and safety of polyacrylamide hydrogel for facial soft-tissue augmentation in a 2-year follow-up: a prospective multicenter study for evaluation of safety and aesthetic results in 101 patients. Plast Reconstr Surg. 2006;118:85S\u201391S.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR83","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1097\/PRS.0b013e3181d18158","volume":"125","author":"N Pallua","year":"2010","unstructured":"Pallua N, Wolter TP. A 5-year assessment of safety and aesthetic results after facial soft-tissue augmentation with polyacrylamide hydrogel (Aquamid): a prospective multicenter study of 251 patients. Plast Reconstr Surg. 2010;125:1797\u2013804.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR84","doi-asserted-by":"crossref","first-page":"138e","DOI":"10.1097\/PRS.0b013e3181e3b506","volume":"126","author":"TP Wolter","year":"2010","unstructured":"Wolter TP, Pallua N. Removal of the permanent filler polyacrylamide hydrogel (aquamid) is possible and easy even after several years. Plast Reconstr Surg. 2010;126:138e\u20139e.","journal-title":"Plast Reconstr Surg"},{"issue":"Suppl 3","key":"43_CR85","doi-asserted-by":"crossref","first-page":"e277","DOI":"10.1016\/j.ijid.2009.11.025","volume":"14","author":"S Males","year":"2010","unstructured":"Males S, Joly V, Adle-Biassette H, et al. Silicone in HIV-1-infected patients: a cause of misdiagnosed granulomatous disease. Int J Infect Dis. 2010;14(Suppl 3):e277\u20139.","journal-title":"Int J Infect Dis"},{"key":"43_CR86","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/j.1524-4725.2005.31223","volume":"31","author":"R Bennett","year":"2005","unstructured":"Bennett R, Taher M. Restylane persistent for 23\u00a0months found during Mohs micrographic surgery: a source of confusion with hyaluronic acid surrounding basal cell carcinoma. Dermatol Surg. 2005;31:1366\u20139.","journal-title":"Dermatol Surg"},{"key":"43_CR87","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/DAD.0b013e3181b9e5ab","volume":"32","author":"F Anatelli","year":"2010","unstructured":"Anatelli F, Chapman MS, Brennick J. Amorphous basophilic deposit in the superficial dermis of the lip in an 80\u00a0year old. Am J Dermatopathol. 2010;32:306\u20139.","journal-title":"Am J Dermatopathol"},{"key":"43_CR88","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.2310\/6350.2005.31238","volume":"31","author":"DM Duffy","year":"2005","unstructured":"Duffy DM. Liquid silicone for soft tissue augmentation. Dermatol Surg. 2005;31:1530\u201341.","journal-title":"Dermatol Surg"},{"key":"43_CR89","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.2310\/6350.2005.31239","volume":"31","author":"JG Barnett","year":"2005","unstructured":"Barnett JG, Barnett CR. Treatment of acne scars with liquid silicone injections: 30-year perspective. Dermatol Surg. 2005;31:1542\u20139.","journal-title":"Dermatol Surg"},{"key":"43_CR90","doi-asserted-by":"crossref","first-page":"92S","DOI":"10.1097\/01.prs.0000234672.69287.77","volume":"118","author":"G Lemperle","year":"2006","unstructured":"Lemperle G, Rullan PP, Gauthier-Hazan N. Avoiding and treating dermal filler complications. Plast Reconstr Surg. 2006;118:92S\u2013107S.","journal-title":"Plast Reconstr Surg"},{"key":"43_CR91","first-page":"257","volume":"46","author":"AR Cabral","year":"1994","unstructured":"Cabral AR, Alcocer-Varela J, Orozco-Topete R, Reyes E, Fernandez-Dominguez L, Alarcon-Segovia D. Clinical, histopathological, immunological and fibroblast studies in 30 patients with subcutaneous injections of modelants including silicone and mineral oils. Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion. 1994;46:257\u201366.","journal-title":"Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion"},{"key":"43_CR92","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jaut.2010.07.003","volume":"36","author":"Y Shoenfeld","year":"2011","unstructured":"Shoenfeld Y, Agmon-Levin N. \u2018ASIA\u2019\u2014autoimmune\/inflammatory syndrome induced by adjuvants. J Autoim. 2011;36:4\u20138.","journal-title":"J Autoim"},{"key":"43_CR93","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1177\/0961203312458838","volume":"21","author":"J Alijotas-Reig","year":"2012","unstructured":"Alijotas-Reig J, Garcia-Gimenez V, Llurba E, Vilardell-Tarres M. Autoimmune\/inflammatory syndrome (ASIA) induced by biomaterials injection other than silicone medical grade. Lupus. 2012;21:1326\u201334.","journal-title":"Lupus"},{"key":"43_CR94","first-page":"178","volume":"43","author":"C Raulin","year":"2000","unstructured":"Raulin C, Greve B, Hartschuh W, Soegding K. Exudative granulomatous reaction to hyaluronic acid (Hylaform). Contact Dermat. 2000;43:178\u20139.","journal-title":"Contact Dermat"},{"key":"43_CR95","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1524-4725.2000.99202.x","volume":"26","author":"JR Lupton","year":"2000","unstructured":"Lupton JR, Alster TS. Cutaneous hypersensitivity reaction to injectable hyaluronic acid gel. Dermatol Surg. 2000;26:135\u20137.","journal-title":"Dermatol Surg"},{"key":"43_CR96","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1067\/mjd.2001.117381","volume":"45","author":"NJ Lowe","year":"2001","unstructured":"Lowe NJ, Maxwell CA, Lowe P, Duick MG, Shah K. Hyaluronic acid skin fillers: adverse reactions and skin testing. J Am Acad Dermatol. 2001;45:930\u20133.","journal-title":"J Am Acad Dermatol"},{"key":"43_CR97","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1473-2165.2005.00309.x","volume":"4","author":"MV Pinheiro","year":"2005","unstructured":"Pinheiro MV, Bagatin E, Hassun KM, Talarico S. Adverse effect of soft tissue augmentation with hyaluronic acid. J Cosmet Dermatol. 2005;4:184\u20136.","journal-title":"J Cosmet Dermatol"},{"key":"43_CR98","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1365-2133.2005.07074.x","volume":"154","author":"M Ghislanzoni","year":"2006","unstructured":"Ghislanzoni M, Bianchi F, Barbareschi M, Alessi E. Cutaneous granulomatous reaction to injectable hyaluronic acid gel. Br J Dermatol. 2006;154:755\u20138.","journal-title":"Br J Dermatol"},{"key":"43_CR99","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1468-3083.2007.02354.x","volume":"22","author":"J Alijotas-Reig","year":"2008","unstructured":"Alijotas-Reig J, Garcia-Gimenez V. Delayed immune-mediated adverse effects related to hyaluronic acid and acrylic hydrogel dermal fillers: clinical findings, long-term follow-up and review of the literature. J Eur Acad Dermatol Venereol. 2008;22:150\u201361.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"43_CR100","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12105-011-0304-9","volume":"6","author":"S Shahrabi Farahani","year":"2012","unstructured":"Shahrabi Farahani S, Sexton J, Stone JD, Quinn K, Woo SB. Lip nodules caused by hyaluronic acid filler injection: report of three cases. Head Neck Pathol. 2012;6:16\u201320.","journal-title":"Head Neck Pathol"},{"key":"43_CR101","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1046\/j.1365-2133.1999.02853.x","volume":"140","author":"P Senet","year":"1999","unstructured":"Senet P, Bachelez H, Ollivaud L, Vignon-Pennamen D, Dubertret L. Minocycline for the treatment of cutaneous silicone granulomas. Br J Dermatol. 1999;140:985\u20137.","journal-title":"Br J Dermatol"},{"key":"43_CR102","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1111\/j.1365-2133.2005.06525.x","volume":"152","author":"P Redondo","year":"2005","unstructured":"Redondo P, Del Olmo J, Alberola I. In situ and distant foreign body granulomas caused by silicone: treatment with allopurinol. Br J Dermatol. 2005;152:1064\u20135.","journal-title":"Br J Dermatol"},{"key":"43_CR103","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1524-4725.2011.02221.x","volume":"38","author":"J Alijotas-Reig","year":"2012","unstructured":"Alijotas-Reig J, Garcia-Gimenez V, Vilardell-Tarres M. Tacrolimus in the treatment of chronic and refractory late-onset immune-mediated adverse effects related to silicone injections. Dermatol Surg. 2012;38:38\u201347.","journal-title":"Dermatol Surg"},{"key":"43_CR104","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/archderm.141.1.13","volume":"141","author":"FR Pasternack","year":"2005","unstructured":"Pasternack FR, Fox LP, Engler DE. Silicone granulomas treated with etanercept. Arch Dermatol. 2005;141:13\u20135.","journal-title":"Arch Dermatol"},{"key":"43_CR105","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1001\/archderm.141.9.1171-a","volume":"141","author":"MJ Rapaport","year":"2005","unstructured":"Rapaport MJ. Silicone granulomas treated with etanercept. Arch Dermatol. 2005;141:1171.","journal-title":"Arch Dermatol"},{"key":"43_CR106","first-page":"894","volume":"5","author":"AM Desai","year":"2006","unstructured":"Desai AM, Browning J, Rosen T. Etanercept therapy for silicone granuloma. J Drugs Dermatol. 2006;5:894\u20136.","journal-title":"J Drugs Dermatol"},{"key":"43_CR107","doi-asserted-by":"crossref","first-page":"e120","DOI":"10.1016\/j.ejim.2008.11.010","volume":"20","author":"N Kluger","year":"2009","unstructured":"Kluger N, Plantier F, Carlotti A, Guillevin L. Facial granuloma after occult silicone injection (siliconoma): a diagnosis not to be missed. Eur J Int Med. 2009;20:e120\u20131.","journal-title":"Eur J Int Med"}],"container-title":["American Journal of Clinical Dermatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40257-013-0043-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40257-013-0043-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40257-013-0043-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T21:38:16Z","timestamp":1715981896000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40257-013-0043-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,14]]},"references-count":107,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["43"],"URL":"https:\/\/doi.org\/10.1007\/s40257-013-0043-7","relation":{},"ISSN":["1175-0561","1179-1888"],"issn-type":[{"value":"1175-0561","type":"print"},{"value":"1179-1888","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,14]]}}}