{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:19:52Z","timestamp":1788200392295,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T00:00:00Z","timestamp":1457136000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Am J Clin Dermatol"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1007\/s40257-016-0178-4","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T07:36:13Z","timestamp":1457163373000},"page":"293-303","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Moderate and Severe Inflammatory Acne Vulgaris Effectively Treated with Single-Agent Therapy by a New Fixed-Dose Combination Adapalene 0.3\u00a0%\/Benzoyl Peroxide 2.5\u00a0% Gel: A Randomized, Double-Blind, Parallel-Group, Controlled Study"],"prefix":"10.1007","volume":"17","author":[{"given":"Linda","family":"Stein Gold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jose","family":"Rueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil","family":"Tanghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,5]]},"reference":[{"issue":"6","key":"178_CR1","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/jid.2013.446","volume":"134","author":"RJ Hay","year":"2014","unstructured":"Hay RJ, Johns NE, Williams HC, et al. The global burden of skin disease in 2010: an analysis of the prevalence and impact of skin conditions. J Invest Dermatol. 2014;134(6):1527\u201334.","journal-title":"J Invest Dermatol"},{"issue":"3","key":"178_CR2","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/ced.12270","volume":"39","author":"K Bhate","year":"2014","unstructured":"Bhate K, Williams HC. What\u2019s new in acne? An analysis of systematic reviews published in 2011-2012. Clin Exp Dermatol. 2014;39(3):273\u20137.","journal-title":"Clin Exp Dermatol"},{"key":"178_CR3","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/1523-1747.ep12676801","volume":"62","author":"AM Kligman","year":"1974","unstructured":"Kligman AM. An overview of acne. J Invest Dermatol. 1974;62:268\u201387.","journal-title":"J Invest Dermatol"},{"issue":"Suppl 5","key":"178_CR4","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jaad.2009.01.019","volume":"60","author":"D Thiboutot","year":"2009","unstructured":"Thiboutot D, Gollnick H, Bettoli V, et al. Global Alliance to Improve Outcomes in Acne. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J Am Acad Dermatol. 2009;60(Suppl 5):S1\u201350.","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"178_CR5","first-page":"145","volume":"76","author":"DM Pariser","year":"2005","unstructured":"Pariser DM, Thiboutot DM, Clark SD, et al. The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris: a randomized, multicenter, investigator-blinded, controlled comparison study versus adapalene gel 0.1% and vehicle. Cutis. 2005;76(2):145\u201351.","journal-title":"Cutis"},{"issue":"2","key":"178_CR6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jaad.2004.10.879","volume":"54","author":"D Thiboutot","year":"2006","unstructured":"Thiboutot D, Pariser DM, Egan N, et al. Adapalene gel 0.3% for the treatment of acne vulgaris: a multicenter, randomized, double-blind, controlled, phase III trial. J Am Acad Dermatol. 2006;54(2):242\u201350.","journal-title":"J Am Acad Dermatol"},{"issue":"6 Suppl","key":"178_CR7","first-page":"s24","volume":"7","author":"JS Weiss","year":"2008","unstructured":"Weiss JS, Thiboutot DM, Hwa J, Liu Y, Graeber M. Long-term safety and efficacy study of adapalene 0.3% gel. J Drugs Dermatol. 2008;7(6 Suppl):s24\u20138.","journal-title":"J Drugs Dermatol"},{"issue":"6 Suppl","key":"178_CR8","first-page":"s3","volume":"7","author":"D Thiboutot","year":"2008","unstructured":"Thiboutot D, Arsonnaud S, Soto P. Efficacy and tolerability of adapalene 0.3% gel compared to tazarotene 0.1% gel in the treatment of acne vulgaris. J Drugs Dermatol. 2008;7(6 Suppl):s3\u201310.","journal-title":"J Drugs Dermatol"},{"issue":"Suppl 52","key":"178_CR9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2133.1998.1390s2003.x","volume":"139","author":"S Michel","year":"1998","unstructured":"Michel S, Jomard A, Demarchez M. Pharmacology of adapalene. Br J Dermatol. 1998;139(Suppl 52):3\u20137.","journal-title":"Br J Dermatol"},{"issue":"Suppl 1","key":"178_CR10","first-page":"123","volume":"16","author":"B Vega","year":"2002","unstructured":"Vega B, Jomard A, Michel S. Regulation of human monocyte toll-like receptor 2 (TLR2) expression by adapalene. J Eur Acad Dermatol Venereol. 2002;16(Suppl 1):123\u20134.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"178_CR11","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.1016\/S0190-9622(97)70056-2","volume":"36","author":"WJ Cunliffe","year":"1997","unstructured":"Cunliffe WJ, Caputo R, Dreno B, et al. Clinical efficacy and safety comparison of adapalene gel and tretinoin gel in the treatment of acne vulgaris: Europe and US multicenter trials. J Am Acad Dermatol. 1997;36:S126\u201334.","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"178_CR12","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1600-0625.2007.00552.x","volume":"16","author":"I Tenaud","year":"2007","unstructured":"Tenaud I, Khammari A, Dreno B. In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions. Exp Dermatol. 2007;16(6):500\u20136.","journal-title":"Exp Dermatol"},{"issue":"2","key":"178_CR13","first-page":"100","volume":"36","author":"OA Bakry","year":"2014","unstructured":"Bakry OA, Samaka RM, Sebika H, Seleit I. Toll-like receptor 2 and P. acnes: do they trigger initial acne vulgaris lesions? Anal Quant Cytopathol Histpathol. 2014;36(2):100\u201310.","journal-title":"Anal Quant Cytopathol Histpathol"},{"issue":"Suppl 1","key":"178_CR14","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1067\/mjd.2003.618","volume":"49","author":"H Gollnick","year":"2003","unstructured":"Gollnick H, Cunliffe W, Berson D, et al. Global alliance to improve outcomes in acne. management of acne: a report from a global alliance to improve outcomes in acne. J Am Acad Dermatol. 2003;49(Suppl 1):S1\u201337.","journal-title":"J Am Acad Dermatol"},{"issue":"Suppl 1","key":"178_CR15","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/j.1468-3083.2011.04375.x","volume":"26","author":"A Nast","year":"2012","unstructured":"Nast A, Rosumeck S, Sammain A, Sporbeck B, Rzany B. Methods report on the development of the European S3 guidelines for the treatment of acne. J Eur Acad Dermatol Venereol. 2012;26(Suppl 1):e1\u201341.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"Suppl 3","key":"178_CR16","doi-asserted-by":"crossref","first-page":"S163","DOI":"10.1542\/peds.2013-0490B","volume":"131","author":"LF Eichenfield","year":"2013","unstructured":"Eichenfield LF, Krakowski AC, Piggott C, et al. Evidence-based recommendations for the diagnosis and treatment of pediatric acne. Pediatrics. 2013;131(Suppl 3):S163\u201386.","journal-title":"Pediatrics"},{"issue":"4","key":"178_CR17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/09546631003681094","volume":"22","author":"J Tan","year":"2011","unstructured":"Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS. Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients. J Dermatolog Treat. 2011;22(4):197\u2013205.","journal-title":"J Dermatolog Treat"},{"issue":"6","key":"178_CR18","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.jaad.2010.03.036","volume":"64","author":"SR Feldman","year":"2011","unstructured":"Feldman SR, Tan J, Poulin Y, Dirschka T, Kerrouche N, Manna V. The efficacy of adapalene-benzoyl peroxide combination increases with number of acne lesions. J Am Acad Dermatol. 2011;64(6):1085\u201391.","journal-title":"J Am Acad Dermatol"},{"issue":"9","key":"178_CR19","first-page":"1083","volume":"13","author":"DM Pariser","year":"2014","unstructured":"Pariser DM, Rich P, Cook-Bolden FE, Korotzer A. An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 3.75% for the once-daily treatment of moderate to severe acne vulgaris. J Drugs Dermatol. 2014;13(9):1083\u20139.","journal-title":"J Drugs Dermatol"},{"issue":"3","key":"178_CR20","doi-asserted-by":"crossref","first-page":"439.e1","DOI":"10.1016\/j.jaad.2006.10.005","volume":"56","author":"ZD Draelos","year":"2007","unstructured":"Draelos ZD, Carter E, Maloney JM, et al. Two randomized studies demonstrate the efficacy and safety of dapsone gel, 5% for the treatment of acne vulgaris. J Am Acad Dermatol. 2007;56(3):439.e1\u201310.","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"178_CR21","first-page":"44","volume":"2","author":"MH Gold","year":"2009","unstructured":"Gold MH. A new, once-daily, optimized, fixed combination of clindamycin phosphate 1.2% and low-concentration benzoyl peroxide 2.5% gel for the treatment of moderate-to-severe acne. J Clin Aesthet Dermatol. 2009;2(5):44\u20138.","journal-title":"J Clin Aesthet Dermatol"},{"issue":"2","key":"178_CR22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1684\/ejd.2014.2293","volume":"24","author":"B Dr\u00e9no","year":"2014","unstructured":"Dr\u00e9no B, Bettoli V, Ochsendorf F, et al. Efficacy and safety of clindamycin phosphate 1.2%\/tretinoin 0.025% formulation for the treatment of acne vulgaris: pooled analysis of data from three randomised, double-blind, parallel-group, phase III studies. Eur J Dermatol. 2014;24(2):201\u20139.","journal-title":"Eur J Dermatol"},{"key":"178_CR23","first-page":"123","volume":"6","author":"EL Epstein","year":"2013","unstructured":"Epstein EL, Stein Gold L. Safety and efficacy of tazarotene foam for the treatment of acne vulgaris. Clin Cosmet Investig Dermatol. 2013;6:123\u20135.","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"2","key":"178_CR24","first-page":"131","volume":"9","author":"JM Jackson","year":"2010","unstructured":"Jackson JM, Fu JJ, Almekinder JL. A randomized, investigator-blinded trial to assess the antimicrobial efficacy of a benzoyl peroxide 5%\/clindamycin phosphate 1% gel compared with a clindamycin phosphate 1.2%\/tretinoin 0.025% gel in the topical treatment of acne vulgaris. J Drugs Dermatol. 2010;9(2):131\u20136.","journal-title":"J Drugs Dermatol"},{"issue":"10","key":"178_CR25","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/j.1600-0625.2011.01339.x","volume":"20","author":"T Zuliani","year":"2011","unstructured":"Zuliani T, Khammari A, Chaussy H, Knol AC, Dr\u00e9no B. Ex vivo demonstration of a synergistic effect of Adapalene and benzoyl peroxide on inflammatory acne lesions. Exp Dermatol. 2011;20(10):850\u20133.","journal-title":"Exp Dermatol"},{"issue":"6 Suppl","key":"178_CR26","doi-asserted-by":"crossref","first-page":"S143","DOI":"10.1067\/mjd.2003.274","volume":"48","author":"RM Halder","year":"2003","unstructured":"Halder RM, Nootheti PK. Ethnic skin disorders overview. J Am Acad Dermatol. 2003;48(6 Suppl):S143\u20138.","journal-title":"J Am Acad Dermatol"},{"issue":"2 Suppl","key":"178_CR27","doi-asserted-by":"crossref","first-page":"S41","DOI":"10.1067\/mjd.2002.120790","volume":"46","author":"SC Taylor","year":"2002","unstructured":"Taylor SC. Skin of color: biology, structure, function, and implications for dermatologic disease. J Am Acad Dermatol. 2002;46(2 Suppl):S41\u201362.","journal-title":"J Am Acad Dermatol"}],"container-title":["American Journal of Clinical Dermatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40257-016-0178-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40257-016-0178-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40257-016-0178-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T17:55:32Z","timestamp":1600278932000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40257-016-0178-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,5]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["178"],"URL":"https:\/\/doi.org\/10.1007\/s40257-016-0178-4","relation":{},"ISSN":["1175-0561","1179-1888"],"issn-type":[{"value":"1175-0561","type":"print"},{"value":"1179-1888","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,5]]}}}