{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:28:49Z","timestamp":1789921729558,"version":"4.0.1"},"reference-count":141,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Am J Clin Dermatol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s40257-025-00937-9","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T23:40:37Z","timestamp":1743723637000},"page":"395-409","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiological, Genetic, Clinical, and Treatment Differences of Generalized Pustular Psoriasis and Acrodermatitis Continua of Hallopeau Across Ethnicities: A Systematic Review"],"prefix":"10.1007","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9130-9913","authenticated-orcid":false,"given":"Francis Li-Tien","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-1474","authenticated-orcid":false,"given":"Tsen-Fang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"issue":"11","key":"937_CR1","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1111\/jdv.14386","volume":"31","author":"AA Navarini","year":"2017","unstructured":"Navarini AA, Burden AD, Capon F, Mrowietz U, Puig L, Koks S, et al. European consensus statement on phenotypes of pustular psoriasis. J Eur Acad Dermatol Venereol. 2017;31(11):1792\u20139.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"3","key":"937_CR2","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.jaci.2018.06.038","volume":"143","author":"S Twelves","year":"2019","unstructured":"Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R, et al. Clinical and genetic differences between pustular psoriasis subtypes. J Allergy Clin Immunol. 2019;143(3):1021\u20136.","journal-title":"J Allergy Clin Immunol"},{"issue":"7","key":"937_CR3","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1001\/jamadermatol.2024.0915","volume":"160","author":"SE Choon","year":"2024","unstructured":"Choon SE, van de Kerkhof P, Gudjonsson JE, de la Cruz C, Barker J, Morita A, et al. International consensus definition and diagnostic criteria for generalized pustular psoriasis from the International Psoriasis Council. JAMA Dermatol. 2024;160(7):758\u201368.","journal-title":"JAMA Dermatol"},{"issue":"4","key":"937_CR4","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1111\/jdv.18851","volume":"37","author":"L Puig","year":"2023","unstructured":"Puig L, Choon SE, Gottlieb AB, Marrakchi S, Prinz JC, Romiti R, et al. Generalized pustular psoriasis: a global Delphi consensus on clinical course, diagnosis, treatment goals and disease management. J Eur Acad Dermatol Venereol. 2023;37(4):737\u201352.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"9","key":"937_CR5","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1111\/jdv.18127","volume":"36","author":"F Assan","year":"2022","unstructured":"Assan F, Husson B, Hegazy S, Seneschal J, Aubin F, Mahe E, et al. Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort. J Eur Acad Dermatol Venereol. 2022;36(9):1578\u201383.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"937_CR6","doi-asserted-by":"publisher","first-page":"91","DOI":"10.4103\/idoj.idoj_312_22","volume":"14","author":"D Mitra","year":"2023","unstructured":"Mitra D, Bhatnagar A, Kumar M. Acrodermatitis continua of hallopeau: a diagnostic challenge. Indian Dermatol Online J. 2023;14(1):91\u20133.","journal-title":"Indian Dermatol Online J"},{"issue":"3","key":"937_CR7","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1111\/bjd.15867","volume":"178","author":"R Mossner","year":"2018","unstructured":"Mossner R, Wilsmann-Theis D, Oji V, Gkogkolou P, Lohr S, Schulz P, et al. The genetic basis for most patients with pustular skin disease remains elusive. Br J Dermatol. 2018;178(3):740\u20138.","journal-title":"Br J Dermatol"},{"issue":"7","key":"937_CR8","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1056\/NEJMoa1013068","volume":"365","author":"S Marrakchi","year":"2011","unstructured":"Marrakchi S, Guigue P, Renshaw BR, Puel A, Pei XY, Fraitag S, et al. Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis. N Engl J Med. 2011;365(7):620\u20138.","journal-title":"N Engl J Med"},{"key":"937_CR9","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/1346-8138.17585","volume":"52","author":"M Akiyama","year":"2024","unstructured":"Akiyama M. Updated genetic background of generalized pustular psoriasis as an autoinflammatory keratinization disease. J Dermatol. 2024;52:400\u20137.","journal-title":"J Dermatol"},{"issue":"2","key":"937_CR10","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.343","volume":"4","author":"JG Krueger","year":"2024","unstructured":"Krueger JG, Pagotto A, Haftel S, Gradl B. Targeted review of IL36RN mutations in patients with generalised pustular psoriasis. Skin Health Dis. 2024;4(2): e343.","journal-title":"Skin Health Dis."},{"issue":"Suppl 1","key":"937_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s40257-021-00664-x","volume":"23","author":"M Zheng","year":"2022","unstructured":"Zheng M, Jullien D, Eyerich K. The prevalence and disease characteristics of generalized pustular psoriasis. Am J Clin Dermatol. 2022;23(Suppl 1):5\u201312.","journal-title":"Am J Clin Dermatol"},{"issue":"4","key":"937_CR12","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1093\/bjd\/ljad158","volume":"189","author":"SE Choon","year":"2023","unstructured":"Choon SE, Wright AK, Griffiths CEM, Wong KW, Tey KE, Lim YT, et al. Incidence and prevalence of generalized pustular psoriasis in multiethnic Johor Bahru, Malaysia: a population-based cohort study using routinely captured electronic health records in the Teleprimary Care (TPC(R)) clinical information system from 2010 to 2020. Br J Dermatol. 2023;189(4):410\u20138.","journal-title":"Br J Dermatol"},{"issue":"1","key":"937_CR13","first-page":"1","volume":"22","author":"R Hussain","year":"2004","unstructured":"Hussain R, Bittles AH. Assessment of association between consanguinity and fertility in Asian populations. J Health Popul Nutr. 2004;22(1):1\u201312.","journal-title":"J Health Popul Nutr"},{"issue":"2","key":"937_CR14","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s12687-012-0128-7","volume":"4","author":"N Ben Halim","year":"2013","unstructured":"Ben Halim N, Ben Alaya Bouafif N, Romdhane L, Kefi Ben Atig R, Chouchane I, Bouyacoub Y, et al. Consanguinity, endogamy, and genetic disorders in Tunisia. J Community Genet. 2013;4(2):273\u201384.","journal-title":"J Community Genet"},{"issue":"6","key":"937_CR15","doi-asserted-by":"publisher","first-page":"761","DOI":"10.5021\/ad.2017.29.6.761","volume":"29","author":"JY Lee","year":"2017","unstructured":"Lee JY, Kang S, Park JS, Jo SJ. Prevalence of psoriasis in Korea: a population-based epidemiological study using the Korean National Health Insurance Database. Ann Dermatol. 2017;29(6):761\u20137.","journal-title":"Ann Dermatol"},{"issue":"6","key":"937_CR16","first-page":"669","volume":"16","author":"F Augey","year":"2006","unstructured":"Augey F, Renaudier P, Nicolas JF. Generalized pustular psoriasis (Zumbusch): a French epidemiological survey. Eur J Dermatol. 2006;16(6):669\u201373.","journal-title":"Eur J Dermatol"},{"key":"937_CR17","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jdin.2021.12.001","volume":"6","author":"GV Duarte","year":"2022","unstructured":"Duarte GV, Esteves de Carvalho AV, Romiti R, Gaspar A, Gomes de Melo T, Soares CP, et al. Generalized pustular psoriasis in Brazil: a public claims database study. JAAD Int. 2022;6:61\u20137.","journal-title":"JAAD Int."},{"key":"937_CR18","unstructured":"Feldman S, Kotowsky N, Gao R, Brodovicz KG, Leonardi C, Menter A. Prevalence of generalized pustular psoriasis in the USA: results from multiple administrative claims databases. In: The 30th European academy of dermatology and venereology congress (virtual). 2021."},{"issue":"2","key":"937_CR19","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/jdv.18720","volume":"37","author":"JC Prinz","year":"2023","unstructured":"Prinz JC, Choon SE, Griffiths CEM, Merola JF, Morita A, Ashcroft DM, et al. Prevalence, comorbidities and mortality of generalized pustular psoriasis: a literature review. J Eur Acad Dermatol Venereol. 2023;37(2):256\u201373.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"2","key":"937_CR20","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1159\/000528850","volume":"239","author":"JN Feng","year":"2023","unstructured":"Feng JN, Guo JZ, Zhang Q, Zhuo L, Xu L, Liu LL, et al. Higher prevalence of generalized pustular psoriasis in Asia? A population-based study using claim data in china and a systematic review. Dermatology. 2023;239(2):195\u2013205.","journal-title":"Dermatology"},{"issue":"1","key":"937_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.2340\/00015555766871","volume":"76","author":"A Ohkawara","year":"1996","unstructured":"Ohkawara A, Yasuda H, Kobayashi H, Inaba Y, Ogawa H, Hashimoto I, et al. Generalized pustular psoriasis in Japan: two distinct groups formed by differences in symptoms and genetic background. Acta Derm Venereol. 1996;76(1):68\u201371.","journal-title":"Acta Derm Venereol"},{"issue":"6","key":"937_CR22","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1111\/jdv.19901","volume":"38","author":"M Viguier","year":"2024","unstructured":"Viguier M, Bentayeb M, Azzi J, de Pouvourville G, Gloede T, Langellier B, et al. Generalized pustular psoriasis: a nationwide population-based study using the National Health Data System in France. J Eur Acad Dermatol Venereol. 2024;38(6):1131\u20139.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"937_CR23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s00403-015-1611-x","volume":"308","author":"TS Wang","year":"2016","unstructured":"Wang TS, Chiu HY, Hong JB, Chan CC, Lin SJ, Tsai TF. Correlation of IL36RN mutation with different clinical features of pustular psoriasis in Chinese patients. Arch Dermatol Res. 2016;308(1):55\u201363.","journal-title":"Arch Dermatol Res"},{"issue":"3","key":"937_CR24","doi-asserted-by":"publisher","first-page":"e15056","DOI":"10.1111\/exd.15056","volume":"33","author":"FL Hsu","year":"2024","unstructured":"Hsu FL, Hsieh CY, Tsai TF. Acquired diffuse palmoplantar erythema with keratoderma in Chinese patients with pustular psoriasis: a predictor for IL36 receptor antagonist c.115+6T>C mutation? Exp Dermatol. 2024;33(3):e15056.","journal-title":"Exp Dermatol"},{"issue":"6","key":"937_CR25","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00403-024-03063-4","volume":"316","author":"CY Hsieh","year":"2024","unstructured":"Hsieh CY, Chen PH, Huang CM, Tsai TF. Characteristics of psoriatic plaques in generalized pustular psoriasis patients with or without IL36RN mutation. Arch Dermatol Res. 2024;316(6):321.","journal-title":"Arch Dermatol Res"},{"issue":"9","key":"937_CR26","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1016\/j.jid.2016.04.038","volume":"136","author":"M Tauber","year":"2016","unstructured":"Tauber M, Bal E, Pei XY, Madrange M, Khelil A, Sahel H, et al. IL36RN mutations affect protein expression and function: a basis for genotype-phenotype correlation in pustular diseases. J Investig Dermatol. 2016;136(9):1811\u20139.","journal-title":"J Investig Dermatol"},{"issue":"3","key":"937_CR27","doi-asserted-by":"publisher","first-page":"378","DOI":"10.25259\/IJDVL_1054_2021","volume":"89","author":"NN Trai","year":"2023","unstructured":"Trai NN, Van Em D, Van BT, My LH, Van Tro C, Hao NT, et al. Correlation of IL36RN and CARD14 mutations with clinical manifestations and laboratory findings in patients with generalised pustular psoriasis. Indian J Dermatol Venereol Leprol. 2023;89(3):378\u201384.","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"8","key":"937_CR28","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1111\/exd.14776","volume":"32","author":"SE Choon","year":"2023","unstructured":"Choon SE, Tok PSK, Wong KW, Lim YT, Nanu NM, Barker JN, et al. Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi-ethnic Johor Bahru, Malaysia. Exp Dermatol. 2023;32(8):1263\u201371.","journal-title":"Exp Dermatol"},{"issue":"11","key":"937_CR29","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1038\/jid.2013.230","volume":"133","author":"K Sugiura","year":"2013","unstructured":"Sugiura K, Takemoto A, Yamaguchi M, Takahashi H, Shoda Y, Mitsuma T, et al. The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist. J Investig Dermatol. 2013;133(11):2514\u201321.","journal-title":"J Investig Dermatol"},{"key":"937_CR30","unstructured":"Gharbi H, Bahloul E, Nouri M, Bougacha N, Boudaya S, Masmoudi A, et al. Characteristics of generalized pustular psoriasis in the south of Tunisia. In: 24th World congress of dermatology. 2018."},{"issue":"5","key":"937_CR31","doi-asserted-by":"publisher","first-page":"S71","DOI":"10.1016\/j.jid.2023.03.419","volume":"143","author":"C Lu","year":"2023","unstructured":"Lu C, Tseng C, Lin F, Chung W. 413 Clinical characteristics and disease burden of patients with generalized pustular psoriasis in Taiwan: a study using electronic medical records & national claims databases. J Investig Dermatol. 2023;143(5):S71.","journal-title":"J Investig Dermatol"},{"issue":"8","key":"937_CR32","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1111\/exd.14783","volume":"32","author":"CY Hsieh","year":"2023","unstructured":"Hsieh CY, Huang YW, Huang YH, Tsai TF. Deficiency of interleukin-36 receptor antagonist (DITRA): an analysis of 58 Chinese patients in a tertiary hospital in Taiwan. Exp Dermatol. 2023;32(8):1272\u20138.","journal-title":"Exp Dermatol"},{"issue":"45","key":"937_CR33","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023068","volume":"99","author":"ZJ Liu","year":"2020","unstructured":"Liu ZJ, Tian YT, Shi BY, Zhou Y, Jia XS. Association between mutation of interleukin 36 receptor antagonist and generalized pustular psoriasis: A PRISMA-compliant systematic review and meta-analysis. Medicine. 2020;99(45): e23068.","journal-title":"Medicine"},{"issue":"4","key":"937_CR34","first-page":"193","volume":"35","author":"L Li","year":"2019","unstructured":"Li L, Fu X, Wang Z, Yu G. Detection of IL36RN gene mutation and genotype-phenotype correlation analysis in 107 cases of generalized pustular psoriasis. China J Leprosy Skin Dis. 2019;35(4):193\u20136.","journal-title":"China J Leprosy Skin Dis"},{"issue":"11","key":"937_CR35","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1038\/jid.2013.267","volume":"133","author":"M Li","year":"2013","unstructured":"Li M, Han J, Lu Z, Li H, Zhu K, Cheng R, et al. Prevalent and rare mutations in IL-36RN gene in Chinese patients with generalized pustular psoriasis and psoriasis vulgaris. J Investig Dermatol. 2013;133(11):2637\u20139.","journal-title":"J Investig Dermatol"},{"issue":"31","key":"937_CR36","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011741","volume":"97","author":"Z Li","year":"2018","unstructured":"Li Z, Yang Q, Wang S. Genetic polymorphism of IL36RN in Han patients with generalized pustular psoriasis in Sichuan region of China: a case-control study. Medicine (Baltimore). 2018;97(31): e11741.","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"937_CR37","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1159\/000528753","volume":"239","author":"Z Wang","year":"2023","unstructured":"Wang Z, Xiang X, Chen Y, Qi Z, Miao C, Liu Y, et al. Different clinical features of pediatric generalized pustular psoriasis in patients with or without IL36RN variants. Dermatology. 2023;239(2):217\u201326.","journal-title":"Dermatology"},{"issue":"5","key":"937_CR38","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/jid.2012.490","volume":"133","author":"N Setta-Kaffetzi","year":"2013","unstructured":"Setta-Kaffetzi N, Navarini AA, Patel VM, Pullabhatla V, Pink AE, Choon SE, et al. Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes. J Investig Dermatol. 2013;133(5):1366\u20139.","journal-title":"J Investig Dermatol"},{"issue":"11","key":"937_CR39","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1038\/jid.2013.214","volume":"133","author":"A Korber","year":"2013","unstructured":"Korber A, Mossner R, Renner R, Sticht H, Wilsmann-Theis D, Schulz P, et al. Mutations in IL36RN in patients with generalized pustular psoriasis. J Investig Dermatol. 2013;133(11):2634\u20137.","journal-title":"J Investig Dermatol"},{"issue":"2","key":"937_CR40","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1111\/j.1365-2133.2012.11195.x","volume":"168","author":"M Li","year":"2013","unstructured":"Li M, Lu Z, Cheng R, Li H, Guo Y, Yao Z. IL36RN gene mutations are not associated with sporadic generalized pustular psoriasis in Chinese patients. Br J Dermatol. 2013;168(2):452\u20135.","journal-title":"Br J Dermatol"},{"issue":"2","key":"937_CR41","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jdcr.2017.08.019","volume":"4","author":"E Cuperus","year":"2018","unstructured":"Cuperus E, Koevoets R, van der Smagt JJ, Toonstra J, de Graaf M, Frenkel J, et al. Juvenile interleukin-36 receptor antagonist deficiency (DITRA) with c.80T>C (p.Leu27Pro) mutation successfully treated with etanercept and acitretin. JAAD Case Rep. 2018;4(2):192\u20135.","journal-title":"JAAD Case Rep."},{"issue":"6","key":"937_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ijmm.2021.4951","volume":"47","author":"J Zhou","year":"2021","unstructured":"Zhou J, Luo Q, Cheng Y, Wen X, Liu J. An update on genetic basis of generalized pustular psoriasis (review). Int J Mol Med. 2021;47(6):1\u201312.","journal-title":"Int J Mol Med"},{"issue":"12","key":"937_CR43","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1016\/j.jid.2023.06.191","volume":"143","author":"NK Hassi","year":"2023","unstructured":"Hassi NK, Weston T, Rinaldi G, Ng JC, Smahi A, Twelves S, et al. In silico and in vitro analysis of IL36RN alterations reveals critical residues for the function of the interleukin-36 receptor complex. J Investig Dermatol. 2023;143(12):2468\u201375.","journal-title":"J Investig Dermatol"},{"issue":"2","key":"937_CR44","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/bjd.14003","volume":"174","author":"N Rajan","year":"2016","unstructured":"Rajan N, Sinclair N, Nakai H, Shimomura Y, Natarajan S. A tale of two sisters: identical IL36RN mutations and discordant phenotypes. Br J Dermatol. 2016;174(2):417\u201320.","journal-title":"Br J Dermatol"},{"issue":"3","key":"937_CR45","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.jdermsci.2016.11.008","volume":"85","author":"Y Wang","year":"2017","unstructured":"Wang Y, Cheng R, Lu Z, Guo Y, Yan M, Liang J, et al. Clinical profiles of pediatric patients with GPP alone and with different IL36RN genotypes. J Dermatol Sci. 2017;85(3):235\u201340.","journal-title":"J Dermatol Sci"},{"issue":"9","key":"937_CR46","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/1346-8138.12227","volume":"40","author":"N Kanazawa","year":"2013","unstructured":"Kanazawa N, Nakamura T, Mikita N, Furukawa F. Novel IL36RN mutation in a Japanese case of early onset generalized pustular psoriasis. J Dermatol. 2013;40(9):749\u201351.","journal-title":"J Dermatol"},{"issue":"5","key":"937_CR47","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1111\/1346-8138.15788","volume":"48","author":"M Yoshikawa","year":"2021","unstructured":"Yoshikawa M, Rokunohe D, Kimura A, Takahashi M, Korekawa A, Nakajima K, et al. Significance of IL36RN mutation analyses in the management of impetigo herpetiformis: a case report and review of published cases. J Dermatol. 2021;48(5):699\u2013702.","journal-title":"J Dermatol"},{"issue":"3","key":"937_CR48","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.tjog.2024.02.001","volume":"63","author":"CY Hsieh","year":"2024","unstructured":"Hsieh CY, Tsai YJ, Tsai TF. Use of biologics in Chinese pregnant patients with deficiency of interleukin-36 receptor antagonist (DITRA): a case series. Taiwan J Obstet Gynecol. 2024;63(3):405\u20138.","journal-title":"Taiwan J Obstet Gynecol"},{"issue":"1","key":"937_CR49","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/ced.14890","volume":"47","author":"Z Wang","year":"2022","unstructured":"Wang Z, Xiang X, Chen Y, Zhao X, Liu Y, Xu Z, et al. Treating paediatric acrodermatitis continua of Hallopeau with adalimumab: a case series. Clin Exp Dermatol. 2022;47(1):195\u20136.","journal-title":"Clin Exp Dermatol"},{"key":"937_CR50","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.3389\/fimmu.2018.02239","volume":"9","author":"L Israel","year":"2018","unstructured":"Israel L, Mellett M. Clinical and genetic heterogeneity of CARD14 mutations in psoriatic skin disease. Front Immunol. 2018;9:2239.","journal-title":"Front Immunol"},{"issue":"2","key":"937_CR51","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1111\/bjd.17392","volume":"180","author":"L Li","year":"2019","unstructured":"Li L, You J, Fu X, Wang Z, Sun Y, Liu H, et al. Variants of CARD14 are predisposing factors for generalized pustular psoriasis (GPP) with psoriasis vulgaris but not for GPP alone in a Chinese population. Br J Dermatol. 2019;180(2):425\u20136.","journal-title":"Br J Dermatol"},{"issue":"12","key":"937_CR52","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1038\/jid.2014.269","volume":"134","author":"P Qin","year":"2014","unstructured":"Qin P, Zhang Q, Chen M, Fu X, Wang C, Wang Z, et al. Variant analysis of CARD14 in a Chinese Han population with psoriasis vulgaris and generalized pustular psoriasis. J Investig Dermatol. 2014;134(12):2994\u20136.","journal-title":"J Investig Dermatol"},{"issue":"6","key":"937_CR53","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1038\/jid.2014.46","volume":"134","author":"K Sugiura","year":"2014","unstructured":"Sugiura K, Muto M, Akiyama M. CARD14 c.526G>C (p.Asp176His) is a significant risk factor for generalized pustular psoriasis with psoriasis vulgaris in the Japanese cohort. J Investig Dermatol. 2014;134(6):1755\u20137.","journal-title":"J Investig Dermatol"},{"issue":"12","key":"937_CR54","doi-asserted-by":"publisher","first-page":"2964","DOI":"10.1038\/jid.2015.288","volume":"135","author":"DM Berki","year":"2015","unstructured":"Berki DM, Liu L, Choon SE, David Burden A, Griffiths CEM, Navarini AA, et al. Activating CARD14 mutations are associated with generalized pustular psoriasis but rarely account for familial recurrence in psoriasis vulgaris. J Investig Dermatol. 2015;135(12):2964\u201370.","journal-title":"J Investig Dermatol"},{"issue":"10","key":"937_CR55","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1038\/jid.2015.186","volume":"135","author":"R M\u00f6ssner","year":"2015","unstructured":"M\u00f6ssner R, Frambach Y, Wilsmann-Theis D, L\u00f6hr S, Jacobi A, Weyergraf A, et al. Palmoplantar pustular psoriasis is associated with missense variants in CARD14, but not with loss-of-function mutations in IL36RN in European patients. J Investig Dermatol. 2015;135(10):2538.","journal-title":"J Investig Dermatol"},{"issue":"2","key":"937_CR56","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1136\/jmg.2004.018564","volume":"42","author":"WL Hwu","year":"2005","unstructured":"Hwu WL, Yang CF, Fann CS, Chen CL, Tsai TF, Chien YH, et al. Mapping of psoriasis to 17q terminus. J Med Genet. 2005;42(2):152\u20138.","journal-title":"J Med Genet"},{"issue":"5","key":"937_CR57","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.ajhg.2012.03.012","volume":"90","author":"CT Jordan","year":"2012","unstructured":"Jordan CT, Cao L, Roberson EDO, Pierson KC, Yang C-F, Joyce CE, et al. PSORS2 is due to mutations in CARD14. Am J Hum Genet. 2012;90(5):784\u201395.","journal-title":"Am J Hum Genet"},{"issue":"3","key":"937_CR58","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.jaad.2018.02.034","volume":"79","author":"BG Craiglow","year":"2018","unstructured":"Craiglow BG, Boyden LM, Hu R, Virtanen M, Su J, Rodriguez G, et al. CARD14-associated papulosquamous eruption: a spectrum including features of psoriasis and pityriasis rubra pilaris. J Am Acad Dermatol. 2018;79(3):487\u201394.","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"937_CR59","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12969","volume":"40","author":"CJ Hsu","year":"2024","unstructured":"Hsu CJ, Tsai TF. Report of a case with CARD14-associated papulosquamous eruptions and multiple skin cancers. Photodermatol Photoimmunol Photomed. 2024;40(3): e12969.","journal-title":"Photodermatol Photoimmunol Photomed"},{"issue":"3","key":"937_CR60","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.ajhg.2020.06.020","volume":"107","author":"M Vergnano","year":"2020","unstructured":"Vergnano M, Mockenhaupt M, Benzian-Olsson N, Paulmann M, Grys K, Mahil SK, et al. Loss-of-function myeloperoxidase mutations are associated with increased neutrophil counts and pustular skin disease. Am J Hum Genet. 2020;107(3):539\u201343.","journal-title":"Am J Hum Genet"},{"issue":"3","key":"937_CR61","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ajhg.2020.07.001","volume":"107","author":"S Haskamp","year":"2020","unstructured":"Haskamp S, Bruns H, Hahn M, Hoffmann M, Gregor A, Lohr S, et al. Myeloperoxidase modulates inflammation in generalized pustular psoriasis and additional rare pustular skin diseases. Am J Hum Genet. 2020;107(3):527\u201338.","journal-title":"Am J Hum Genet"},{"issue":"5","key":"937_CR62","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/1346-8138.16700","volume":"50","author":"M Onitsuka","year":"2023","unstructured":"Onitsuka M, Farooq M, Iqbal MN, Yasuno S, Shimomura Y. A homozygous loss-of-function variant in the MPO gene is associated with generalized pustular psoriasis. J Dermatol. 2023;50(5):664\u201371.","journal-title":"J Dermatol"},{"issue":"7","key":"937_CR63","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1016\/j.jid.2019.11.024","volume":"140","author":"S Frey","year":"2020","unstructured":"Frey S, Sticht H, Wilsmann-Theis D, Gerschutz A, Wolf K, Lohr S, et al. Rare loss-of-function mutation in SERPINA3 in generalized pustular psoriasis. J Investig Dermatol. 2020;140(7):1451\u20135.","journal-title":"J Investig Dermatol"},{"issue":"6","key":"937_CR64","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/s10038-023-01139-z","volume":"68","author":"Y Liu","year":"2023","unstructured":"Liu Y, Li H, Meng S, Xu Y, Ni S, Sun Y, et al. Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G. J Hum Genet. 2023;68(6):419\u201325.","journal-title":"J Hum Genet"},{"issue":"10","key":"937_CR65","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1111\/1346-8138.16081","volume":"48","author":"P Kantaputra","year":"2021","unstructured":"Kantaputra P, Chaowattanapanit S, Kiratikanon S, Chaiwarith R, Choonhakarn C, Intachai W, et al. SERPINA1, generalized pustular psoriasis, and adult-onset immunodeficiency. J Dermatol. 2021;48(10):1597\u2013601.","journal-title":"J Dermatol"},{"issue":"2","key":"937_CR66","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3390\/genes14020266","volume":"14","author":"P Kantaputra","year":"2023","unstructured":"Kantaputra P, Daroontum T, Chuamanochan M, Chaowattanapanit S, Kiratikanon S, Choonhakarn C, et al. SERPINB3, adult-onset immunodeficiency, and generalized pustular psoriasis. Genes (Basel). 2023;14(2):226.","journal-title":"Genes (Basel)."},{"issue":"3","key":"937_CR67","first-page":"131","volume":"34","author":"L Li","year":"2018","unstructured":"Li L, Yu J, Fu X, Yu G. Association of AP1S3 mutation with generalized pustular psoriasis. China J Leprosy Skin Dis. 2018;34(3):131\u20134.","journal-title":"China J Leprosy Skin Dis."},{"key":"937_CR68","unstructured":"Sugiura K. Elucidation of pathomechanisms and development of new treatment strategies for aseptic pustuloses. https:\/\/kaken.nii.ac.jp\/grant\/KAKENHI-PROJECT-15H04886\/. Accessed 3 Sept 2024."},{"issue":"8","key":"937_CR69","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.jid.2023.01.023","volume":"143","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Shi P, Wang Z, Sun L, Li W, Zhao Q, et al. Identification of the BTN3A3 gene as a molecule implicated in generalized pustular psoriasis in a Chinese population. J Investig Dermatol. 2023;143(8):1439-48e21.","journal-title":"J Investig Dermatol"},{"issue":"4","key":"937_CR70","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/j.jaad.2023.10.070","volume":"90","author":"T Yoshikawa","year":"2024","unstructured":"Yoshikawa T, Takeichi T, Nishida K, Kobayashi Y, Sano H, Shibata A, et al. MEFV variants are a predisposing factor for generalized pustular psoriasis. J Am Acad Dermatol. 2024;90(4):852\u20134.","journal-title":"J Am Acad Dermatol"},{"issue":"13","key":"937_CR71","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.4103\/0366-6999.184470","volume":"129","author":"JW Han","year":"2016","unstructured":"Han JW, Wang Y, Alateng C, Li HB, Bai YH, Lyu XX, et al. Tumor necrosis factor-alpha induced protein 3 interacting protein 1 gene polymorphisms and pustular psoriasis in Chinese Han population. Chin Med J (Engl). 2016;129(13):1519\u201324.","journal-title":"Chin Med J (Engl)"},{"issue":"2","key":"937_CR72","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.18","volume":"1","author":"Y Liu","year":"2021","unstructured":"Liu Y, Cui ZY, Bao J, Zhang XL, Guo Y, Su MJ, et al. Metabolic syndrome-related SNPs in HLA and TNF7L2 may be risk factors for generalized pustular psoriasis in Chinese Han population. Skin Health Dis. 2021;1(2): e18.","journal-title":"Skin Health Dis."},{"issue":"6","key":"937_CR73","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.jid.2017.12.024","volume":"138","author":"A Arakawa","year":"2018","unstructured":"Arakawa A, Vollmer S, Besgen P, Galinski A, Summer B, Kawakami Y, et al. Unopposed IL-36 activity promotes clonal CD4(+) T-cell responses with IL-17A production in generalized pustular psoriasis. J Investig Dermatol. 2018;138(6):1338\u201347.","journal-title":"J Investig Dermatol"},{"issue":"4","key":"937_CR74","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2340\/00015555-0253","volume":"87","author":"X Fan","year":"2007","unstructured":"Fan X, Yang S, Sun LD, Liang YH, Gao M, Zhang KY, et al. Comparison of clinical features of HLA-Cw* 0602-positive and-negative psoriasis patients in a Han Chinese population. Acta Derm Venereol. 2007;87(4):335\u201340.","journal-title":"Acta Derm Venereol"},{"issue":"3","key":"937_CR75","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s40257-020-00585-1","volume":"22","author":"YW Huang","year":"2021","unstructured":"Huang YW, Tsai TF. HLA-Cw1 and psoriasis. Am J Clin Dermatol. 2021;22(3):339\u201347.","journal-title":"Am J Clin Dermatol"},{"key":"937_CR76","unstructured":"Lin ITP. HLA-C*06:02 is not detected in autochthonous Generalized Pustular Psoriasis in Sarawak, Malaysia. In: 26th Regional conference of dermatology. Kuala Lumpur, Malaysia. 2024."},{"issue":"4","key":"937_CR77","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1002\/jvc2.233","volume":"2","author":"JH Haugaard","year":"2023","unstructured":"Haugaard JH, Thein D, Egeberg A. Prevalence and incidence of patients with generalized pustular psoriasis in Denmark\u2014a nationwide registry-based study. JEADV Clin Pract. 2023;2(4):893\u2013900.","journal-title":"JEADV Clin Pract."},{"issue":"6","key":"937_CR78","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1111\/bjd.20966","volume":"186","author":"S Lofvendahl","year":"2022","unstructured":"Lofvendahl S, Norlin JM, Schmitt-Egenolf M. Prevalence and incidence of generalized pustular psoriasis in Sweden: a population-based register study. Br J Dermatol. 2022;186(6):970\u20136.","journal-title":"Br J Dermatol"},{"issue":"9","key":"937_CR79","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1111\/1346-8138.15958","volume":"48","author":"J Zheng","year":"2021","unstructured":"Zheng J, Chen W, Gao Y, Chen F, Yu N, Ding Y, et al. Clinical analysis of generalized pustular psoriasis in Chinese patients: a retrospective study of 110 patients. J Dermatol. 2021;48(9):1336\u201342.","journal-title":"J Dermatol"},{"issue":"6","key":"937_CR80","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1016\/j.jaad.2021.06.008","volume":"86","author":"H Miyachi","year":"2022","unstructured":"Miyachi H, Konishi T, Kumazawa R, Matsui H, Shimizu S, Fushimi K, et al. Treatments and outcomes of generalized pustular psoriasis: a cohort of 1516 patients in a nationwide inpatient database in Japan. J Am Acad Dermatol. 2022;86(6):1266\u201374.","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"937_CR81","first-page":"260","volume":"35","author":"S Yu","year":"2019","unstructured":"Yu S, Luo Z. Clinical analysis of 120 cases with generalized pustular psoriasis. China J Leprosy Skin Dis. 2019;35(5):260\u20135.","journal-title":"China J Leprosy Skin Dis"},{"issue":"5","key":"937_CR82","first-page":"266","volume":"15","author":"X Chen","year":"2022","unstructured":"Chen X, Zhang M, Wang C, Wang H. Clinical analysis of 138 cases of generalized pustular psoriasis. Pract J Dermatol. 2022;15(5):266\u201370.","journal-title":"Pract J Dermatol."},{"issue":"9","key":"937_CR83","first-page":"557","volume":"39","author":"X He","year":"2010","unstructured":"He X, Duan X, Chen X. Clinical analysis of 42 cases of generalized pustular psoriasis. J Clin Dermatol. 2010;39(9):557\u20138.","journal-title":"J Clin Dermatol"},{"issue":"4","key":"937_CR84","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1097\/JD9.0000000000000275","volume":"5","author":"X-N Li","year":"2022","unstructured":"Li X-N, Peng B, Geng S-M. Characterization of generalized pustular psoriasis in northwest china: a single-center retrospective study. Int J Dermatol Venereol. 2022;5(4):191\u20138.","journal-title":"Int J Dermatol Venereol."},{"issue":"1","key":"937_CR85","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/1346-8138.16217","volume":"49","author":"C Ohata","year":"2022","unstructured":"Ohata C, Tsuruta N, Yonekura K, Higashi Y, Saito K, Katayama E, et al. Clinical characteristics of Japanese pustular psoriasis: a multicenter observational study. J Dermatol. 2022;49(1):142\u201350.","journal-title":"J Dermatol"},{"issue":"4","key":"937_CR86","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1111\/1346-8138.17132","volume":"51","author":"M Tokuyama","year":"2024","unstructured":"Tokuyama M, Fan P, Wang G, Choe YB, Song HJ, Tsai D, et al. Epidemiological analysis of the patients with psoriasis in Asian countries and region using the same clinical case cards between 2020 and 2022. J Dermatol. 2024;51(4):567\u201383.","journal-title":"J Dermatol"},{"issue":"10","key":"937_CR87","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1080\/1744666X.2022.2118716","volume":"18","author":"J Lu","year":"2022","unstructured":"Lu J, Shi Y. A review of disease burden and clinical management for generalized pustular psoriasis in China. Expert Rev Clin Immunol. 2022;18(10):1023\u201332.","journal-title":"Expert Rev Clin Immunol"},{"issue":"1","key":"937_CR88","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/1346-8138.16583","volume":"50","author":"K Kamiya","year":"2023","unstructured":"Kamiya K, Ohtsuki M. Epidemiological survey of patients with pustular psoriasis in the Japanese Society for Psoriasis Research from 2017 to 2020. J Dermatol. 2023;50(1):3\u201311.","journal-title":"J Dermatol"},{"issue":"4","key":"937_CR89","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1007\/s40257-017-0274-0","volume":"18","author":"D Hagg","year":"2017","unstructured":"Hagg D, Sundstrom A, Eriksson M, Schmitt-Egenolf M. Severity of psoriasis differs between men and women: a study of the clinical outcome measure psoriasis area and severity index (PASI) in 5438 Swedish register patients. Am J Clin Dermatol. 2017;18(4):583\u201390.","journal-title":"Am J Clin Dermatol"},{"issue":"8","key":"937_CR90","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1111\/jdv.19808","volume":"38","author":"P Wolf","year":"2024","unstructured":"Wolf P, Ceovic R, Conrad C, Falkensteiner K, Graier T, Kolt-Kaminska M, et al. Characteristics and management of generalized pustular psoriasis (GPP): experience from the Central and Eastern Europe (CEE) GPP Expert Network. J Eur Acad Dermatol Venereol. 2024;38(8):1531\u201342.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"937_CR91","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1001\/jamadermatol.2021.4640","volume":"158","author":"MH Noe","year":"2022","unstructured":"Noe MH, Wan MT, Mostaghimi A, Gelfand JM, Agnihothri R, et al. Evaluation of a case series of patients with generalized pustular psoriasis in the United States. JAMA Dermatol. 2022;158(1):73\u20138.","journal-title":"JAMA Dermatol"},{"issue":"4","key":"937_CR92","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2165\/11586900-000000000-00000","volume":"12","author":"J Borges-Costa","year":"2011","unstructured":"Borges-Costa J, Silva R, Goncalves L, Filipe P, Soares de Almeida L, Marques Gomes M. Clinical and laboratory features in acute generalized pustular psoriasis: a retrospective study of 34 patients. Am J Clin Dermatol. 2011;12(4):271\u20136.","journal-title":"Am J Clin Dermatol"},{"issue":"2","key":"937_CR93","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14814","volume":"34","author":"C Kromer","year":"2021","unstructured":"Kromer C, Loewe E, Schaarschmidt ML, Pinter A, Gerdes S, Herr R, et al. Drug survival in the treatment of generalized pustular psoriasis: a retrospective multicenter study. Dermatol Ther. 2021;34(2): e14814.","journal-title":"Dermatol Ther"},{"issue":"2","key":"937_CR94","first-page":"173","volume":"42","author":"X Wu","year":"2017","unstructured":"Wu X, Li Y. Clinical analysis of 82 cases of generalized pustular psoriasis. J Cent South Univ Med Sci. 2017;42(2):173\u20138.","journal-title":"J Cent South Univ Med Sci"},{"issue":"4","key":"937_CR95","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1046\/j.1365-4362.1997.00170.x","volume":"36","author":"YK Tay","year":"1997","unstructured":"Tay YK, Tham SN. The profile and outcome of pustular psoriasis in Singapore: a report of 28 cases. Int J Dermatol. 1997;36(4):266\u201371.","journal-title":"Int J Dermatol"},{"issue":"12","key":"937_CR96","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1111\/j.1365-2133.1968.tb11947.x","volume":"80","author":"H Baker","year":"1968","unstructured":"Baker H, Ryan TJ. Generalized pustular psoriasis: a clinical and epidemiologicai. Study of 104 cases. Br J Dermatol. 1968;80(12):771\u201393.","journal-title":"Br J Dermatol"},{"issue":"10","key":"937_CR97","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1111\/1346-8138.16022","volume":"48","author":"A Morita","year":"2021","unstructured":"Morita A, Kotowsky N, Gao R, Shimizu R, Okubo Y. Patient characteristics and burden of disease in Japanese patients with generalized pustular psoriasis: Results from the Medical Data Vision claims database. J Dermatol. 2021;48(10):1463\u201373.","journal-title":"J Dermatol"},{"issue":"1","key":"937_CR98","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1177\/12034754231211341","volume":"28","author":"M Shergill","year":"2024","unstructured":"Shergill M, McAdam RF, Tarafdar N, Sachdeva M, Maliyar K, Georgakopoulos JR, et al. Elderly onset generalized pustular psoriasis: a systematic review. J Cutan Med Surg. 2024;28(1):89\u201390.","journal-title":"J Cutan Med Surg"},{"issue":"9","key":"937_CR99","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1001\/archderm.1991.01680080075005","volume":"127","author":"BD Zelickson","year":"1991","unstructured":"Zelickson BD, Muller SA. Generalized pustular psoriasis. A review of 63 cases. Arch Dermatol. 1991;127(9):1339\u201345.","journal-title":"Arch Dermatol"},{"issue":"2","key":"937_CR100","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1684\/ejd.2018.3245","volume":"28","author":"T Zhu","year":"2018","unstructured":"Zhu T, Jin H, Shu D, Li F, Wu C. Association of IL36RN mutations with clinical features, therapeutic response to acitretin, and frequency of recurrence in patients with generalized pustular psoriasis. Eur J Dermatol. 2018;28(2):217\u201324.","journal-title":"Eur J Dermatol"},{"issue":"5\u20136","key":"937_CR101","first-page":"750","volume":"240","author":"T Nguyen Thi Thuy","year":"2024","unstructured":"Nguyen Thi Thuy T, Trung Nguyen K, Le Nguyen B, Tran Thi Minh T, Do Tran H, Gia Tran H. IL36RN mutations and correlated characteristics in generalized pustular psoriasis patients in Can Tho City, Vietnam: a cross-sectional study. Dermatology. 2024;240(5\u20136):750\u20137.","journal-title":"Dermatology"},{"issue":"12","key":"937_CR102","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.1007\/s13555-024-01306-w","volume":"14","author":"M Kolt-Kaminska","year":"2024","unstructured":"Kolt-Kaminska M, Marek-Jozefowicz L, Krajewski P, Nowowiejska J, Siekierko A, Duchnik E, et al. Characteristics of patients with generalized pustular psoriasis: a report of the Polish Generalized Pustular Psoriasis Group. Dermatol Ther (Heidelb). 2024;14(12):3379\u201393.","journal-title":"Dermatol Ther (Heidelb)."},{"issue":"1","key":"937_CR103","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14891","volume":"33","author":"Z Xu","year":"2024","unstructured":"Xu Z, Liu Y, Qu H, Bai Y, Ma J, Hao J, et al. Clinical characteristics and heterogeneity of generalized pustular psoriasis: a comparative study in a large retrospective cohort. Exp Dermatol. 2024;33(1): e14891.","journal-title":"Exp Dermatol"},{"issue":"5","key":"937_CR104","first-page":"565","volume":"100","author":"S Prasertyothin","year":"2017","unstructured":"Prasertyothin S, Chularojanamontri L, Wongpraparut C, Silpa-Archa N. Clinical characteristics and treatment outcomes of 53 pustular psoriasis patients. J Med Assoc Thai. 2017;100(5):565\u201372.","journal-title":"J Med Assoc Thai"},{"issue":"3","key":"937_CR105","doi-asserted-by":"publisher","DOI":"10.1111\/exd.15055","volume":"33","author":"L Chularojanamontri","year":"2024","unstructured":"Chularojanamontri L, Silpa-Archa N, Pattamadilok B, Julanon N, Chuamanochan M, Pongcharoen P, et al. A retrospective analysis of 65 patients with acrodermatitis continua of Hallopeau. Exp Dermatol. 2024;33(3): e15055.","journal-title":"Exp Dermatol"},{"issue":"9","key":"937_CR106","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1111\/1346-8138.15466","volume":"47","author":"C Kromer","year":"2020","unstructured":"Kromer C, Loewe E, Schaarschmidt ML, Pinter A, Gerdes S, Celis D, et al. Treatment of acrodermatitis continua of Hallopeau: a case series of 39 patients. J Dermatol. 2020;47(9):989\u201397.","journal-title":"J Dermatol"},{"issue":"5","key":"937_CR107","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1046\/j.1365-2133.2001.04189.x","volume":"144","author":"BM Piraccini","year":"2001","unstructured":"Piraccini BM, Tosti A, Iorizzo M, Misciali C. Pustular psoriasis of the nails: treatment and long-term follow-up of 46 patients. Br J Dermatol. 2001;144(5):1000\u20135.","journal-title":"Br J Dermatol"},{"issue":"8","key":"937_CR108","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1111\/jdv.18103","volume":"36","author":"A Kara Polat","year":"2022","unstructured":"Kara Polat A, Alpsoy E, Kalkan G, Aytekin S, Ucmak D, Yasak Guner R, et al. Sociodemographic, clinical, laboratory, treatment and prognostic characteristics of 156 generalized pustular psoriasis patients in Turkey: a multicentre case series. J Eur Acad Dermatol Venereol. 2022;36(8):1256\u201365.","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"10","key":"937_CR109","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1001\/jamadermatol.2022.3142","volume":"158","author":"CL Zema","year":"2022","unstructured":"Zema CL, Valdecantos WC, Weiss J, Krebs B, Menter AM. Understanding flares in patients with generalized pustular psoriasis documented in US electronic health records. JAMA Dermatol. 2022;158(10):1142\u20138.","journal-title":"JAMA Dermatol"},{"key":"937_CR110","first-page":"858","volume":"23","author":"T Jiayong","year":"2007","unstructured":"Jiayong T. Clinical analysis of 100 cases of psoriasis treated by acitretin. J Leprosy China. 2007;23:858.","journal-title":"J Leprosy China"},{"issue":"11","key":"937_CR111","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1111\/1346-8138.14523","volume":"45","author":"H Fujita","year":"2018","unstructured":"Fujita H, Terui T, Hayama K, Akiyama M, Ikeda S, Mabuchi T, et al. Japanese guidelines for the management and treatment of generalized pustular psoriasis: the new pathogenesis and treatment of GPP. J Dermatol. 2018;45(11):1235\u201370.","journal-title":"J Dermatol"},{"issue":"4","key":"937_CR112","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1080\/09546634.2017.1395798","volume":"29","author":"P Chen","year":"2018","unstructured":"Chen P, Li C, Xue R, Chen H, Tian X, Zeng K, et al. Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review. J Dermatol Treat. 2018;29(4):353\u201363.","journal-title":"J Dermatol Treat"},{"issue":"5","key":"937_CR113","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1111\/pde.12296","volume":"31","author":"S Popadic","year":"2014","unstructured":"Popadic S, Nikolic M. Pustular psoriasis in childhood and adolescence: a 20-year single-center experience. Pediatr Dermatol. 2014;31(5):575\u20139.","journal-title":"Pediatr Dermatol"},{"issue":"2","key":"937_CR114","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.det.2012.12.005","volume":"31","author":"AL Marqueling","year":"2013","unstructured":"Marqueling AL, Cordoro KM. Systemic treatments for severe pediatric psoriasis: a practical approach. Dermatol Clin. 2013;31(2):267\u201388.","journal-title":"Dermatol Clin"},{"issue":"9","key":"937_CR115","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1080\/1744666X.2021.1961580","volume":"17","author":"M Komine","year":"2021","unstructured":"Komine M, Morita A. Generalized pustular psoriasis: current management status and unmet medical needs in Japan. Expert Rev Clin Immunol. 2021;17(9):1015\u201327.","journal-title":"Expert Rev Clin Immunol"},{"key":"937_CR116","doi-asserted-by":"publisher","first-page":"1359481","DOI":"10.3389\/fimmu.2024.1359481","volume":"15","author":"EC Gwillim","year":"2024","unstructured":"Gwillim EC, Nichols AJ. Spesolimab for generalized pustular psoriasis: a review of two key clinical trials supporting initial US regulatory approval. Front Immunol. 2024;15:1359481.","journal-title":"Front Immunol"},{"issue":"3","key":"937_CR117","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1159\/000529274","volume":"239","author":"SE Choon","year":"2023","unstructured":"Choon SE, Lebwohl MG, Turki H, Zheng M, Burden AD, Li L, et al. Clinical characteristics and outcomes of generalized pustular psoriasis flares. Dermatology. 2023;239(3):345\u201354.","journal-title":"Dermatology"},{"issue":"12","key":"937_CR118","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1111\/1346-8138.14664","volume":"45","author":"A Morita","year":"2018","unstructured":"Morita A, Yamazaki F, Matsuyama T, Takahashi K, Arai S, Asahina A, et al. Adalimumab treatment in Japanese patients with generalized pustular psoriasis: results of an open-label phase 3 study. J Dermatol. 2018;45(12):1371\u201380.","journal-title":"J Dermatol"},{"issue":"10","key":"937_CR119","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1111\/exd.13699","volume":"27","author":"A Boehner","year":"2018","unstructured":"Boehner A, Navarini AA, Eyerich K. Generalized pustular psoriasis\u2014a model disease for specific targeted immunotherapy, systematic review. Exp Dermatol. 2018;27(10):1067\u201377.","journal-title":"Exp Dermatol"},{"issue":"9","key":"937_CR120","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1111\/1346-8138.13306","volume":"43","author":"S Imafuku","year":"2016","unstructured":"Imafuku S, Honma M, Okubo Y, Komine M, Ohtsuki M, Morita A, et al. Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: a 52-week analysis from phase III open-label multicenter Japanese study. J Dermatol. 2016;43(9):1011\u20137.","journal-title":"J Dermatol"},{"key":"937_CR121","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1007\/s13555-024-01230-z","volume":"14","author":"L Puig","year":"2024","unstructured":"Puig L, Fujita H, Tha\u00e7i D, Zheng M, Hernandez Daly AC, Leonardi C, et al. Current treatments for generalized pustular psoriasis: a narrative summary of a systematic literature search. Dermatol Ther. 2024;14:2331\u201378.","journal-title":"Dermatol Ther"},{"key":"937_CR122","doi-asserted-by":"publisher","first-page":"6707","DOI":"10.2147\/JIR.S472338","volume":"17","author":"SF Ruan","year":"2024","unstructured":"Ruan SF, Su X, Xiao Z, Zhang Y, Lin T, Luo R, et al. Comparative efficacy and safety of ustekinumab and secukinumab in the treatment of generalized pustular psoriasis: a 48-week retrospective cohort study with genetic background analysis. J Inflamm Res. 2024;17:6707\u201321.","journal-title":"J Inflamm Res"},{"issue":"1","key":"937_CR123","doi-asserted-by":"publisher","first-page":"2443121","DOI":"10.1080\/09546634.2024.2443121","volume":"36","author":"L Xing","year":"2025","unstructured":"Xing L, Long L, Wu T, Yin L, Yu L, Wu J, et al. Long-term efficacy and safety analysis of secukinumab in the treatment of pediatric generalized pustular psoriasis: a real-world study. J Dermatol Treat. 2025;36(1):2443121.","journal-title":"J Dermatol Treat"},{"issue":"2","key":"937_CR124","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/1346-8138.16609","volume":"50","author":"A Morita","year":"2023","unstructured":"Morita A, Tsai TF, Yee EYW, Okubo Y, Imafuku S, Zheng M, et al. Efficacy and safety of spesolimab in Asian patients with a generalized pustular psoriasis flare: results from the randomized, double-blind, placebo-controlled Effisayil 1 study. J Dermatol. 2023;50(2):183\u201394.","journal-title":"J Dermatol"},{"issue":"1\u20132","key":"937_CR125","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1080\/14712598.2024.2309301","volume":"24","author":"CY Hsieh","year":"2024","unstructured":"Hsieh CY, Tsai TF. Clinical advances in biological therapy for generalized pustular psoriasis: a review. Expert Opin Biol Ther. 2024;24(1\u20132):37\u201350.","journal-title":"Expert Opin Biol Ther"},{"issue":"10412","key":"937_CR126","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1016\/S0140-6736(23)01378-8","volume":"402","author":"A Morita","year":"2023","unstructured":"Morita A, Strober B, Burden AD, Choon SE, Anadkat MJ, Marrakchi S, et al. Efficacy and safety of subcutaneous spesolimab for the prevention of generalised pustular psoriasis flares (Effisayil 2): an international, multicentre, randomised, placebo-controlled trial. Lancet. 2023;402(10412):1541\u201351.","journal-title":"Lancet"},{"issue":"12","key":"937_CR127","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1111\/1346-8138.16164","volume":"48","author":"T Tosukhowong","year":"2021","unstructured":"Tosukhowong T, Kiratikanon S, Wonglamsam P, Netiviwat J, Innu T, Rujiwetpongstorn R, et al. Epidemiology and clinical features of pustular psoriasis: a 15-year retrospective cohort. J Dermatol. 2021;48(12):1931\u20135.","journal-title":"J Dermatol"},{"issue":"3","key":"937_CR128","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12899","volume":"32","author":"M Galluzzo","year":"2019","unstructured":"Galluzzo M, D\u2019Adamio S, Teoli M, Bianchi L, Talamonti M. Biologic therapy for acrodermatitis continua of Hallopeau: successful treatment with secukinumab and review of the literature. Dermatol Ther. 2019;32(3): e12899.","journal-title":"Dermatol Ther"},{"issue":"4","key":"937_CR129","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1001\/jamadermatol.2023.6349","volume":"160","author":"Y Wang","year":"2024","unstructured":"Wang Y, Zhang L, Zheng J, Li X, Chen L. Spesolimab response in a girl with acrodermatitis continua of Hallopeau. JAMA Dermatol. 2024;160(4):476\u20137.","journal-title":"JAMA Dermatol"},{"key":"937_CR130","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1338285","volume":"15","author":"P Wen","year":"2024","unstructured":"Wen P, Liu C, Wang T, Jiang X, Wang P, Wang S. Successful treatment of acrodermatitis continua of Hallopeau coexisting with generalized pustular psoriasis with spesolimab: a case report. Front Immunol. 2024;15: e1338285.","journal-title":"Front Immunol"},{"issue":"5","key":"937_CR131","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.jaci.2015.08.015","volume":"136","author":"S Noda","year":"2015","unstructured":"Noda S, Suarez-Farinas M, Ungar B, Kim SJ, de Guzman SC, Xu H, et al. The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization. J Allergy Clin Immunol. 2015;136(5):1254\u201364.","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"937_CR132","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/JID.2015.378","volume":"136","author":"J Kim","year":"2016","unstructured":"Kim J, Oh CH, Jeon J, Baek Y, Ahn J, Kim DJ, et al. Molecular phenotyping small (Asian) versus large (Western) plaque psoriasis shows common activation of IL-17 pathway genes but different regulatory gene sets. J Investig Dermatol. 2016;136(1):161\u201372.","journal-title":"J Investig Dermatol"},{"issue":"2","key":"937_CR133","doi-asserted-by":"publisher","first-page":"98","DOI":"10.4103\/ds.DS-D-24-00070","volume":"42","author":"C-K Hsu","year":"2024","unstructured":"Hsu C-K, Huang Y-H, Chang C-H, Chen Y-J, Chiu T-M, Chung W-H, et al. Taiwanese Dermatological Association consensus recommendations for the diagnosis, treatment, and management of generalized pustular psoriasis. Dermatol Sin. 2024;42(2):98\u2013109.","journal-title":"Dermatol Sin"},{"issue":"12","key":"937_CR134","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1111\/1346-8138.17471","volume":"51","author":"SE Choon","year":"2024","unstructured":"Choon SE, Foley PA, Asawanonda P, Fujita H, Jo SJ, Shi YL, et al. Asia-Pacific consensus recommendations on the management of generalized pustular psoriasis. J Dermatol. 2024;51(12):1579\u201395.","journal-title":"J Dermatol"},{"issue":"3","key":"937_CR135","first-page":"187","volume":"55","author":"Group WCE","year":"2022","unstructured":"Group WCE. Diagnosis and treatment of pustular psoriasis: a Chinese expert consensus statement (2022). Chin J Dermatol. 2022;55(3):187\u201395.","journal-title":"Chin J Dermatol."},{"issue":"1","key":"937_CR136","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2340\/00015555746869","volume":"74","author":"BM Piraccini","year":"1994","unstructured":"Piraccini BM, Fanti PA, Morelli R, Tosti A. Hallopeau\u2019s acrodermatitis continua of the nail apparatus: a clinical and pathological study of 20 patients. Acta Derm Venereol. 1994;74(1):65\u20137.","journal-title":"Acta Derm Venereol"},{"issue":"8","key":"937_CR137","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.3390\/vaccines10081171","volume":"10","author":"P Gisondi","year":"2022","unstructured":"Gisondi P, Bellinato F, Girolomoni G. Clinical characteristics of patients with pustular psoriasis: a single-center retrospective observational study. Vaccines (Basel). 2022;10(8):1171.","journal-title":"Vaccines (Basel)."},{"issue":"9","key":"937_CR138","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1111\/j.1346-8138.1998.tb02461.x","volume":"25","author":"A Ozawa","year":"1998","unstructured":"Ozawa A, Miyahara M, Sugai J, Iizuka M, Kawakubo Y, Matsuo I, et al. HLA class I and II alleles and susceptibility to generalized pustular psoriasis: significant associations with HLA-Cw1 and HLA-DQB1*0303. J Dermatol. 1998;25(9):573\u201381.","journal-title":"J Dermatol"},{"issue":"1","key":"937_CR139","first-page":"5","volume":"31","author":"S Zhou","year":"2008","unstructured":"Zhou S, Wang X, Han Z, Yang L. Study on the localization of susceptibility genes in Han Chinese patients from Shandong with generalized pustular psoriasis. J Binzhou Med Univ. 2008;31(1):5\u20137.","journal-title":"J Binzhou Med Univ."},{"issue":"2","key":"937_CR140","first-page":"109","volume":"25","author":"H Fu","year":"2009","unstructured":"Fu H, Gong X, Dan X, Zhang F. Correlation between palmoplantar pustulosis, pustular psoriasis, and HLA-DQB1 alleles. China J Leprosy Skin Dis. 2009;25(2):109\u201310.","journal-title":"China J Leprosy Skin Dis."},{"issue":"3","key":"937_CR141","first-page":"137","volume":"38","author":"H Fu","year":"2005","unstructured":"Fu H, Zhang F. The association of HLA-DQB1 alleles and generalized pustular psoriasis. Chin J Dermatol. 2005;38(3):137\u20139.","journal-title":"Chin J Dermatol."}],"container-title":["American Journal of Clinical Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40257-025-00937-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s40257-025-00937-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s40257-025-00937-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T05:03:26Z","timestamp":1747458206000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s40257-025-00937-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":141,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["937"],"URL":"https:\/\/doi.org\/10.1007\/s40257-025-00937-9","relation":{},"ISSN":["1175-0561","1179-1888"],"issn-type":[{"value":"1175-0561","type":"print"},{"value":"1179-1888","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"3 March 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors did not receive support from any organization for the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Francis Li-Tien Hsu has no conflict of interest to disclose. Tsen-Fang Tsai has conducted clinical trials or received honoraria for serving as a consultant for Abbvie, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eli-Lilly, Galderma, GSK, Janssen-Cilag, Leo Pharma, Merck Sharp & Dohme, Novartis International, Pfizer, PharmaEssentia, Sanofi, and UCB Pharma. Tsen-Fang Tsai is an Editorial Board member of the American Journal of Clinical Dermatology. Tsen-Fang Tsai was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This article is a review of previously published research and does not involve any new studies with human participants or animals conducted by the authors. As such, no ethical approval or informed consent was required.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"This is a review article and does not present original research data. All data discussed in this article are derived from published studies and can be accessed from the respective original sources.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data Availability"}},{"value":"Not applicable.","order":8,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code availability"}},{"value":"Material preparation, data collection and analysis were performed by F.L.T. Hsu. The first draft of the manuscript was written by F.L.T. Hsu. T.F. Tsai is responsible for study conception, supervision and critical revision. All authors read and approved the final manuscript.","order":9,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}}]}}