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Its unique physicochemical profile, including its high thermostability and proton relaxation times, means that gadobutrol is formulated at twice the gadolinium ion concentration of other GBCAs, resulting in a narrower bolus and consequently, improved dynamic image enhancement. Based on\u2009&gt;\u2009\u202f20\u00a0years of experience in the clinical trial and real-world settings (&gt;\u2009\u202f50 million doses) and its low risk for developing nephrogenic systemic fibrosis (NSF), gadobutrol represents an effective and safe diagnostic GBCA for use in CE MRI and MRA to visualize pathological lesions and vascular perfusion and flow-related abnormalities in all body regions in a broad spectrum of patients, including term neonates and other paediatric patients, young and elderly adult patients, and those with moderate or severe renal or hepatic impairment or cardiovascular (CV) disease.<\/jats:p>","DOI":"10.1007\/s40261-018-0674-9","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T04:27:20Z","timestamp":1531456040000},"page":"773-784","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Gadobutrol: A Review in Contrast-Enhanced MRI and MRA"],"prefix":"10.1007","volume":"38","author":[{"given":"Lesley J.","family":"Scott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"key":"674_CR1","unstructured":"American College of Rheumatology. 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