{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:11:58Z","timestamp":1766049118052},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Drug Investig"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s40261-019-00766-9","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T13:14:48Z","timestamp":1551964488000},"page":"491-494","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Early Treatment of Systemic Juvenile Idiopathic Arthritis with Canakinumab and Complete Remission After 2\u00a0Years of Treatment Suspension: Case Report of an Adolescent Girl"],"prefix":"10.1007","volume":"39","author":[{"given":"Maria Cristina","family":"Maggio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saveria Sabrina","family":"Ragusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Corsello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"766_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.2147\/AHMT.S109495","volume":"8","author":"S Grevich","year":"2017","unstructured":"Grevich S, Shenoi S. Update on the management of systemic juvenile idiopathic arthritis and role of IL-1 and IL-6 inhibition. Adolesc Health Med Ther. 2017;8:125\u201335.","journal-title":"Adolesc Health Med Ther"},{"issue":"1","key":"766_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12969-017-0219-4","volume":"16","author":"A Sura","year":"2018","unstructured":"Sura A, Failing C, Sturza J, Stannard J, Riebschleger M. Patient characteristics associated with response to NSAID monotherapy in children with systemic juvenile idiopathic arthritis. Pediatr Rheumatol Online J. 2018;16(1):2.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"10","key":"766_CR3","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1002\/art.38092","volume":"65","author":"S Ringold","year":"2013","unstructured":"Ringold S, Weiss PF, Beukelman T, DeWitt EM, Ilowite NT, Kimura Y, American College of Rheumatology, et al. 2013 update of the 2011 American College of Rheumatology Recommendations for the treatment of juvenile idiopathic arthritis. Arthritis Rheum. 2013;65(10):2499\u2013512.","journal-title":"Arthritis Rheum"},{"issue":"1","key":"766_CR4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12969-016-0126-0","volume":"14","author":"S Verazza","year":"2016","unstructured":"Verazza S, Dav\u00ec S, Consolaro A, Bovis F, Insalaco A, Magni-Manzoni S, Italian Pediatric Rheumatology Study Group, et al. Disease status, reasons for discontinuation and adverse events in 1038 Italian children with juvenile idiopathic arthritis treated with etanercept. Pediatr Rheumatol Online J. 2016;14(1):68.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"25","key":"766_CR5","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1056\/NEJMoa1205099","volume":"367","author":"N Ruperto","year":"2012","unstructured":"Ruperto N, Brunner HI, Quartier P, Constantin T, Wulffraat N, Horneff G, PRINTO; PRCSG, et al. Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis. N Engl J Med. 2012;367(25):2396\u2013406.","journal-title":"N Engl J Med"},{"issue":"1","key":"766_CR6","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12969-017-0157-1","volume":"15","author":"Y Kimura","year":"2017","unstructured":"Kimura Y, Grevich S, Beukelman T, Morgan E, Nigrovic PA, Mieszkalski K, CARRA Registry Investigators, et al. Pilot study comparing the Childhood Arthritis and Rheumatology Research Alliance (CARRA) systemic juvenile idiopathic arthritis consensus treatment plans. Pediatr Rheumatol Online J. 2017;15(1):23.","journal-title":"Pediatr Rheumatol Online J"},{"issue":"25","key":"766_CR7","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1056\/NEJMoa1112802","volume":"367","author":"F Benedetti De","year":"2012","unstructured":"De Benedetti F, Brunner HI, Ruperto N, Kenwright A, Wright S, Calvo I, PRINTO; PRCSG, et al. Randomized trial of tocilizumab in systemic juvenile idiopathic arthritis. N Engl J Med. 2012;367(25):2385\u201395 (Erratum in: N Engl J Med. 2015;372(9):887).","journal-title":"N Engl J Med."},{"issue":"3","key":"766_CR8","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/MEG.0b013e32832b8e10","volume":"23","author":"MC Maggio","year":"2011","unstructured":"Maggio MC, Liotta A, Cardella F, Corsello G. Stevens\u2013Johnson syndrome and cholestatic hepatitis induced by acute Epstein\u2013Barr virus infection. Eur J Gastroenterol Hepatol. 2011;23(3):289.","journal-title":"Eur J Gastroenterol Hepatol."},{"key":"766_CR9","unstructured":"EMA. Ilaris. \n                    https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/ilaris\n                    \n                  . Accessed Jan 2019."},{"key":"766_CR10","unstructured":"EMA. Kineret. \n                    https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/kineret\n                    \n                  . Accessed Jan 2019."},{"key":"766_CR11","unstructured":"EMA. RoActemra. \n                    https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/roactemra\n                    \n                  . Accessed Jan 2019."}],"container-title":["Clinical Drug Investigation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40261-019-00766-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s40261-019-00766-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s40261-019-00766-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:18:07Z","timestamp":1583453887000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s40261-019-00766-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,7]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["766"],"URL":"https:\/\/doi.org\/10.1007\/s40261-019-00766-9","relation":{},"ISSN":["1173-2563","1179-1918"],"issn-type":[{"value":"1173-2563","type":"print"},{"value":"1179-1918","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,7]]},"assertion":[{"value":"7 March 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors did not receive any funding for this case report.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"Maria Cristina Maggio, Saveria Sabrina Ragusa and Giovanni Corsello declare that they have no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The consent of the parents of the patient is included in the hospital clinical documents.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}